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PHAL221 Drug Discovery and Development

In-depth exploration of critical decision points in the development of new medicines, from discovery and refinement, to preclinical assay selection, clinical trial design, and societal, ethical and regulatory challenges.

An in-depth exploration of critical decision points in the development of new medicines, from discovery and refinement, to preclinical assay selection, clinical trial design, and societal, ethical and regulatory challenges.

Paper title Drug Discovery and Development
Paper code PHAL221
Subject Pharmacology
EFTS 0.1500
Points 18 points
Teaching period Second Semester
Domestic Tuition Fees Tuition Fees for 2020 have not yet been set
International Tuition Fees Tuition Fees for international students are elsewhere on this website.

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Prerequisite
Two of (BIOC 192, CELS 191, CHEM 111, CHEM 191, HUBS 191, HUBS 192, BIOL 112, BIOL 123) and 54 further points
Schedule C
Science
Contact

Coure coordinator: Dr Lyn Wise (lyn.wise@otago.ac.nz)

Teaching staff

Dr Lyn Wise
Dr Greg Giles
Prof. Paul Smith
Dr Belinda Cridge

Paper Structure

Lecture Modules:

  • The Drug Pipeline
  • Nature is the Best Medicine
  • Drug Design
  • Drugs, Biologics and Cell therapies
  • Drug Safety
  • Disease Models
  • Clinical Trials
  • Challenges

Practical Series:

  • Industry Research Contract: to extract, characterise and test the anti-microbial efficacy of a NZ-derived natural product.
  • Drug Refinement Challenge: to use in silico tools to modify a drug structure and to predict changes in its safety and efficacy.
  • Regulatory Panel: to simulate the processes involved in approving drugs for human use.

Assessments:

  • Electronic Lab Book - 10%
  • Dragons' Den Group Presentation - 10%
  • Panel Participation 10%
  • Mid-term test - 10%
  • Final exam - 60%
Textbooks

No textbooks required.

Graduate Attributes Emphasised
Global perspective, Interdisciplinary perspective, Scholarship, Communication, Critical thinking, Cultural understanding, Ethics, Information literacy, Research, Self-motivation, Teamwork.
View more information about Otago's graduate attributes.
Learning Outcomes

Students who sucessfully complete this paper will:

  • demonstrate an understanding of the critical steps and decision points in drug discovery and development
  • explore the laboratory, computer and clinical models and tools used to assess drug safety and efficacy
  • develop an awareness of the societal, ethical, and regulatory challenges associated with developing medicines
  • demonstrate the principles of good laboratory practice and experimental design
  • develop skills to identify, use and critically evaluate information from appropriate and reliable sources
  • demonstrate an ability to communicate effectively, through written and oral means, to scientific and non-scientific audiences

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Timetable

Second Semester

Location
Dunedin
Teaching method
This paper is taught On Campus
Learning management system
Blackboard

Lecture

Stream Days Times Weeks
Attend
A1 Tuesday 13:00-13:50 28-34, 36-41
Thursday 13:00-13:50 28-34, 36-41

Practical

Stream Days Times Weeks
Attend one stream from
A1 Thursday 14:00-17:50 28-30, 32-34, 36-41
A2 Friday 14:00-17:50 28-30, 32-34, 36-41