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PSCI204 Formulation Principles II

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Physicochemical principles and formulation of solid dosage forms; principles of drug release, manufacture, quality control and stability.

PSCI204 brings together aspects of the chemical, physical and biological sciences, with an emphasis on physical chemistry, to provide the basis for pharmaceutical formulation.

Paper title Formulation Principles II
Paper code PSCI204
Subject Pharmacy
EFTS 0.1500
Points 18 points
Teaching period Semester 2 (On campus)
Domestic Tuition Fees (NZD) $1,110.75
International Tuition Fees Tuition Fees for international students are elsewhere on this website.

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Prerequisite
BIOC 192
Restriction
PHCY 255
Contact

greg.walker@otago.ac.nz

Teaching staff
Paper Co-ordinator: Associate Professor Greg Walker
Associate Professor Shyamal Das
Dr Shakila Rizwan
Associate Professor Natalie Medlicott
Textbooks

Available on reserve in Health Sciences library:

  • Allen, L., Popovich, N., Ansel, H., (2011) Ansel's pharmaceutical dosage forms and drug delivery systems 9th Ed, Lippincott, Williams & Wilkins.
  • Aulton, M. E. (2013) Aulton’s Pharmaceutics: The Design and Manufacture of Medicines, 4th Ed, Edinburgh, Churchill Livingston.
  • Barber, J., Rostron, C., (2013) Pharmaceutical Chemistry, Oxford University Press.
  • Florence, A.T. and Attwood, D. (2011) Physicochemical Principles of Pharmacy, 5th Ed, Pharmaceutical Press.
  • Patrick, G. L. (2013) An Introduction to Medicinal Chemistry, 5th Ed, Oxford University Press.
  • Perrie, Y. and Rades, T. (2012) FASTtrack: Pharmaceutics - Drug delivery and targeting. Pharmaceutical Press.
  • Ritter, J., Flower, R., Henderson, G., Rang, H. (2015) Rang and Dale’s Pharmacology, 8th Ed, Elsevier Churchill Livingston.
Graduate Attributes Emphasised

Lifelong learning, Scholarship, Communication, Critical thinking, Research, Self-motivation, Teamwork.
View more information about Otago's graduate attributes.

Learning Outcomes

Students who successfully complete the paper will be able to:

  1. Explain the importance of stability and hence the need for appropriate storage of medicines and importance of expiry date.
  2. Outline common mechanisms of chemical and physical degradation of drugs.
  3. Describe what formulation and storage factors can be controlled to maximise the stability of medicines.
  4. State the methods used to determine shelf-life and storage conditions of medicines and estimate shelf-life.
  5. Describe how physical properties and processes influence the production and efficacy of oral solid dosage forms.
  6. Describe the process of formulating and assessing the quality of oral solid dosage forms (tablets and capsules).
  7. Describe the principles of drug release such as disintegration, dissolution, absorption.

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Timetable

Semester 2

Location
Dunedin
Teaching method
This paper is taught On Campus
Learning management system
Blackboard

Lecture

Stream Days Times Weeks
Attend
A1 Monday 13:00-13:50 28-34, 36-41
Wednesday 13:00-13:50 29-34, 36-41
Friday 11:00-11:50 29, 31-33, 36-38, 40

Practical

Stream Days Times Weeks
Attend
A1 Tuesday 14:00-16:50 30, 32, 34, 37, 39, 41

Tutorial

Stream Days Times Weeks
Attend
A1 Friday 13:00-14:50 30-31, 34, 37-39