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Physicochemical principles and formulation of solid dosage forms; principles of drug release, manufacture, quality control and stability.
PSCI204 brings together aspects of the chemical, physical and biological sciences, with an emphasis on physical chemistry, to provide the basis for pharmaceutical formulation.
|Paper title||Formulation Principles II|
|Teaching period||Semester 2 (On campus)|
|Domestic Tuition Fees (NZD)||$1,110.75|
|International Tuition Fees||Tuition Fees for international students are elsewhere on this website.|
- BIOC 192
- PHCY 255
- More information link
- Teaching staff
- Paper Co-ordinator: Associate Professor Greg
Associate Professor Shyamal Das
Dr Shakila Rizwan
Associate Professor Natalie Medlicott
Available on reserve in Health Sciences library:
- Allen, L., Popovich, N., Ansel, H., (2011) Ansel's pharmaceutical dosage forms and drug delivery systems 9th Ed, Lippincott, Williams & Wilkins.
- Aulton, M. E. (2013) Aulton’s Pharmaceutics: The Design and Manufacture of Medicines, 4th Ed, Edinburgh, Churchill Livingston.
- Barber, J., Rostron, C., (2013) Pharmaceutical Chemistry, Oxford University Press.
- Florence, A.T. and Attwood, D. (2011) Physicochemical Principles of Pharmacy, 5th Ed, Pharmaceutical Press.
- Patrick, G. L. (2013) An Introduction to Medicinal Chemistry, 5th Ed, Oxford University Press.
- Perrie, Y. and Rades, T. (2012) FASTtrack: Pharmaceutics - Drug delivery and targeting. Pharmaceutical Press.
- Ritter, J., Flower, R., Henderson, G., Rang, H. (2015) Rang and Dale’s Pharmacology, 8th Ed, Elsevier Churchill Livingston.
- Graduate Attributes Emphasised
Lifelong learning, Scholarship, Communication, Critical thinking, Research, Self-motivation, Teamwork.
View more information about Otago's graduate attributes.
- Learning Outcomes
Students who successfully complete the paper will be able to:
- Explain the importance of stability and hence the need for appropriate storage of medicines and importance of expiry date.
- Outline common mechanisms of chemical and physical degradation of drugs.
- Describe what formulation and storage factors can be controlled to maximise the stability of medicines.
- State the methods used to determine shelf-life and storage conditions of medicines and estimate shelf-life.
- Describe how physical properties and processes influence the production and efficacy of oral solid dosage forms.
- Describe the process of formulating and assessing the quality of oral solid dosage forms (tablets and capsules).
- Describe the principles of drug release such as disintegration, dissolution, absorption.