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    Overview

    Physicochemical principles and formulation of solid dosage forms; principles of drug release, manufacture, quality control and stability.

    PSCI204 brings together aspects of the chemical, physical and biological sciences, with an emphasis on physical chemistry, to provide the basis for pharmaceutical formulation.

    About this paper

    Paper title Formulation Principles II
    Subject Pharmaceutical Science
    EFTS 0.1500
    Points 18 points
    Teaching period Semester 2 (On campus)
    Domestic Tuition Fees ( NZD ) $1,173.30
    International Tuition Fees Tuition Fees for international students are elsewhere on this website.
    Prerequisite
    BIOC 192
    Restriction
    PHCY 255
    Contact

    greg.walker@otago.ac.nz

    Teaching staff

    Paper Co-ordinator: Associate Professor Greg Walker

    Associate Professor Shyamal Das

    Dr Shakila Rizwan

    Textbooks

    Available on reserve in Health Sciences library:

    • Allen, L., Popovich, N., Ansel, H., (2011) Ansel's pharmaceutical dosage forms and drug delivery systems 9th Ed, Lippincott, Williams & Wilkins.
    • Aulton, M. E. (2013) Aulton’s Pharmaceutics: The Design and Manufacture of Medicines, 4th Ed, Edinburgh, Churchill Livingston.
    • Barber, J., Rostron, C., (2013) Pharmaceutical Chemistry, Oxford University Press.
    • Florence, A.T. and Attwood, D. (2011) Physicochemical Principles of Pharmacy, 5th Ed, Pharmaceutical Press.
    • Patrick, G. L. (2013) An Introduction to Medicinal Chemistry, 5th Ed, Oxford University Press.
    • Perrie, Y. and Rades, T. (2012) FASTtrack: Pharmaceutics - Drug delivery and targeting. Pharmaceutical Press.
    • Ritter, J., Flower, R., Henderson, G., Rang, H. (2015) Rang and Dale’s Pharmacology, 8th Ed, Elsevier Churchill Livingston.
    Graduate Attributes Emphasised

    Lifelong learning, Scholarship, Communication, Critical thinking, Research, Self-motivation, Teamwork.
    View more information about Otago's graduate attributes.

    Learning Outcomes

    Students who successfully complete the paper will be able to:

    1. Explain the importance of stability and hence the need for appropriate storage of medicines and importance of expiry date.
    2. Outline common mechanisms of chemical and physical degradation of drugs.
    3. Describe what formulation and storage factors can be controlled to maximise the stability of medicines.
    4. State the methods used to determine shelf-life and storage conditions of medicines and estimate shelf-life.
    5. Describe how physical properties and processes influence the production and efficacy of oral solid dosage forms.
    6. Describe the process of formulating and assessing the quality of oral solid dosage forms (tablets and capsules).
    7. Describe the principles of drug release such as disintegration, dissolution, absorption.

    Timetable

    Semester 2

    Location
    Dunedin
    Teaching method
    This paper is taught On Campus
    Learning management system
    Blackboard

    Lecture

    Stream Days Times Weeks
    Attend
    A1 Monday 13:00-13:50 29-35, 37-42
    Tuesday 14:00-14:50 30
    Wednesday 13:00-13:50 29-35, 37, 39-42
    Friday 11:00-11:50 31-34, 37-39

    Practical

    Stream Days Times Weeks
    Attend
    A1 Tuesday 14:00-16:50 31-32, 34, 37, 39, 41

    Tutorial

    Stream Days Times Weeks
    Attend
    A1 Tuesday 13:00-14:50 33, 35, 38, 40, 42
    Friday 11:00-12:50 30
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