Publications

Ketharnathan, S., Leask, M., Boocock, J., Phipps-Green, A., Antony, J., O'Sullivan, J., Merriman, T. & Horsfield, J. (2018) A non-coding genetic variant maximally associated with serum urate levels is functionally linked to HNF4A-dependent PDZK1 expression. Human Molecular Genetics, 2018 Aug 14. doi: 10.1093/hmg/ddy295.

Mehta, S., Morten, B., Antony, J., Henderson, L., Lasham, A., Campbell, H., Cunliffe, H., Horsfield, J., Reddel, R., Avery-Kiejda, K., Print, C., and Braithwaite, A. (2018). Regulation of the interferon-gamma (IFN-g) pathway by p63 and D133p53 isoform in different breast cancer subtypes. Oncotarget 9(49): 29146-29161

Cukrov, D., Newman, T. A. C., Leask, M., Leeke, B., Sarogni, P., Patimo, A., Kline, A., Krantz, I. D., Horsfield, J.*, and Musio, A.* (2018) Antioxidant treatment ameliorates phenotypic features of SMC1A-mutated Cornelia de Lange syndrome in vitro and in vivo. Human Molecular Genetics Sep 1;27(17):3002-3011. doi: 10.1093/hmg/ddy203. *Joint corresponding authors.

Kaur, G., Li, C. G., Chantry, A., Stayner, C., Horsfield, J. and Eccles, M. R. (2018). SMAD proteins directly repress PAX2 transcription downstream of transforming growth factor-beta 1 (TGF-β1) signaling in renal cell carcinoma. Oncotarget 9(42):26852-26867 (IF 5.2).

Lee, S. L. J., Horsfield, J. A., Black, M. A., Rutherford, K., Gemmell, N. J. (2018) Identification of sex differences in zebrafish brain during early sexual differentiation and masculinisation using methyltestoterone. Biology of Reproduction (Dec 20, 2017. doi: 10.1093/biolre/iox175).

Meier, M., Grant, J. M., Dowdle, A., Thomas, A., Gerton, J., Collas, P., O'Sullivan, J. M. and Horsfield, J. A. (2018). Cohesin facilitates zygotic genome activation in zebrafish. Development Jan 3; 145(1) doi: 10.1242/dev.156521 Published 20 November 2017).

Marsman, J., Thomas, A., Osato, M., O'Sullivan, J. M. and Horsfield, J. A. (2017). A DNA Contact Map for the Mouse Runx1 Gene Identifies Novel Hematopoietic Enhancers. Scientific Reports 7, 13347. doi: 10.1038/s41598-017-13748-8

Schierding, W., Antony, J., Karhunen, V., Vääräsmaki, M., Franks, S., Elliot, P., Kajantie, E., Sebert, S., Blakemore, A., Horsfield, J. A., Järvelin, M-R., O'Sullivan, J. M., and Cutfield, W. S. GWAS on Prolonged Gestation (Post-term Birth): Analysis of Successive Finnish Birth Cohorts (2017). Journal of Medical Genetics doi:10.1136/jmedgenet-2017-104880.

Lee, S. L. J., Horsfield, J. A., Black, M. A., Rutherford, K., Fisher, A., Gemmell, N. J. (2017) Histological and transcriptomic effects of 17α-methyltestosterone on zebrafish gonad development. BMC Genomics 18:557 doi.org/10.1186/s12864-017-3915-z.

Stayner, C., Poole, A., McGlashan, S., Pilanthananond, M., Brauning, R., Markie, D., Lett, B., Slobbe, L., Chae, A., Johnstone, A., Jensen, C., McEwan, J., Dittmer, K., Parker, K., Wiles, A., Blackburne, W., Leichter, A., Leask, M., Pinnapureddy, A., Jennings, M., Horsfield, J., Walker, R., and Eccles, M. (2017). An ovine hepatorenal fibrocystic model of a Meckel-like syndrome associated with dysmorphic primary cilia and TMEM67 mutations. Scientific Reports 9;7(1):1601. doi: 10.1038/s41598-017-01519-4.

Newman, T. A., Jhinku, N., Meier, M., and Horsfield, J. A. (2016) Dietary intake influences fertility and offspring development in zebrafish. PLoS One. 2016 Nov 21;11(11):e0166394. doi: 10.1371/journal.pone.0166394.

Schierding, W., Antony, J., Cutfield, W., Horsfield, J. A., and O’Sullivan, J. M. Intergenic GWAS SNPs are key components of the spatial and regulatory network for human growth. Human Molecular Genetics (2016). Aug 1;25(15):3372-3382. doi: 10.1093/hmg/ddw165.

Dasgupta, T., Antony, J., Braithwaite, A. W., Horsfield, J. A. (2016) HDAC8 Inhibition Blocks SMC3 Deacetylation and Delays Cell Cycle Progression Without Affecting Cohesin-Dependent Transcription in MCF7 Cancer Cells. J Biol Chem. (2016) Jun 10;291(24):12761-70. doi: 10.1074/jbc.M115.

Chatterjee, A., Lagisz, M., Rodger, E. J., Zhen, L., Stockwell, P. A., Duncan, E. J., Horsfield, J. A., Jeyakani, J., Mathavan, S., Ozaki, Y., Nakagawa, S. (2016). Sex differences in DNA methylation and expression in zebrafish brain: a test of an extended ‘male sex drive hypothesis. Gene, 590(2):307-16. doi: 10.1016/j.gene.2016.05.042.

Newman, T. A. C., Carleton, C. R., Leeke, B., Hampton, M. B., and Horsfield, J. A. (2015). Embryonic oxidative stress results in reproductive impairment for adult zebrafish. Redox Biology 6, 648-655. doi:10.1016/j.redox.2015.10.010.

Schuster, K. R., Leeke, B. J., Meier, M., Wang, Y., Newman, T., Burgess, S. and Horsfield J. A. (2015) A neural crest origin for cohesinopathy heart defects. Human Molecular Genetics. 24(24):7005-16. doi: 10.1093/hmg/ddv402.

Antony, J., Dasgupta, T., Rhodes, J. M., McEwan, M. V., Print, C. G., O'Sullivan J. M. and Horsfield, J. A. (2015) Cohesin modulates transcription of estrogen-responsive genes. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1849(3): 257-269.

O’Sullivan, J. M, Doynova, M., Antony, J., Pichlmuller, F. and Horsfield, J. A. (2014) Insights from Space: how diet affects the spatial organisation of chromosomes. Nutrients, 6(12), 5724-5739; doi:10.3390/nu6125724.

Leeke, B., Marsman, J., O'Sullivan, J. M. and Horsfield, J. A. (2014). Cohesin mutations in myeloid malignancies: underlying mechanisms. Experimental Hematology & Oncology 2014, 3:13 doi:10.1186/2162-3619-3-13

Chatterjee, A., Stockwell, P. A., Horsfield, J. A., Morison, I. M., and Nakagawa, S. (2014). Base-resolution DNA methylation landscape of zebrafish brain and liver. Genomics data. DOI: 10.1016/j.gdata.2014.10.008.

Marsman, J., O’Neill, A. C., Kao, B. R.-Y., Rhodes, J. M., Meier, M., Antony, J., Mönnich, M. and Horsfield, J. A. (2014) Cohesin and CTCF differentially regulate spatiotemporal runx1 expression during zebrafish development. BBA Gene Regulatory Mechanisms. Jan;1839 (1):50-61. doi: 10.1016/j.bbagrm.2013.11.007. Epub 2013 Dec 7

Chatterjee, A., Ozaki Y., Stockwell, P. A., Horsfield, J. A., Morison, I. M., and Nakagawa, S. (2013) Mapping the zebrafish brain methylome using reduced representation bisulfite sequencing. Epigenetics 8(9)

Marsman, J. and Horsfield, J. A. (2012) Long distance relationships: enhancer-promoter communication and dynamic gene transcription. BBA Gene Regulatory Mechanisms, 1819(11/12): 1217–1227.

McEwan, M. V., Eccles, M. R. and Horsfield, J. A. (2012). Cohesin is required for activation of MYC by estradiol. PLoS ONE 7(11): e49160. doi:10.1371/journal.pone.0049160

Horsfield J, Print CG and Mönnich M (2012). Diverse developmental disorders from The One Ring: distinct molecular pathways underlie the cohesinopathies. Frontiers in Genetics 3:171. doi: 10.3389/fgene.2012.00171

Deardorff M. A., Wilde J. J, Albrecht M., Dickinson E., Tennstedt S., Braunholz D., Mönnich M., Yan Y., Xu W., Gil-Rodríguez M. C., Clark D., Hakonarson H., Halbach S., Michelis L. D., Rampuria A., Rossier E., Spranger S., Van Maldergem L., Lynch S. A., Gillessen-Kaesbach G. Ludecke H-J, Ramsay R. G., McKay M. J., Krantz I. D., Xu H., Horsfield J. A., Kaiser F. J. (2012) RAD21 Mutations Cause a Human Cohesinopathy. American Journal of Human Genetics 90(6): 1014-1027 (available online doi:10.1016/j.ajhg.2012.04.019)

Rhodes, J. M., McEwan, M. and Horsfield J. A. (2011) Gene regulation by cohesin in cancer: is The Ring An Unexpected Party to proliferation? Molecular Cancer Research 9: 1587-1607.

Mönnich M, Kuriger Z, Print CG, Horsfield JA (2011) A Zebrafish Model of Roberts Syndrome Reveals That Esco2 Depletion Interferes with Development by Disrupting the Cell Cycle. PLoS ONE 6(5): e20051. doi:10.1371/journal.pone.0020051

Rhodes, J. M., Bentley, F. K., Print, C. G., Dorsett, D., Misulovin, Z., Dickinson, E., Crosier, K. E., Crosier, P. S. and Horsfield, J. A. (2010) Positive regulation of c-Myc by cohesin is direct, and evolutionarily conserved. Developmental Biology 344: 637-649.

Mönnich, M., Banks, S., Eccles, M., Dickinson, E. and Horsfield, J. A. (2009). Expression of cohesin and condensin genes during zebrafish development supports a non-proliferative role for cohesin. Gene Expression Patterns 9(8): 586-94.

Horsfield, J.A., Anagnostou, S., Hu, J. Cho, K., Geisler, R., Lieschke, G., Crosier, K. E. and Crosier, P. S.  (2007) Cohesin-dependent regulation of Runx genes.  Development 134(14): 2639-2649.

 

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Department of Pathology
Dunedin School of Medicine
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