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Contact Details

Phone
+64 3 364 0544
Email
logan.walker@otago.ac.nz
Position
Research Associate Professor
Department
Department of Pathology and Biomedical Science (Christchurch)
Qualifications
MSc, PhD
Research summary
Cancer research

Research

Associate Professor Logan Walker's primary research is focused on understanding how genetic changes cause an increased risk of cancer and/or affect tumour pathology.

Genetic variation and breast cancer development

Breast cancer is the most common cancer in women yet for most women the genetic changes underlying their disease remain undetermined or poorly understood. This research aims to determine the clinical and biological impact of:

  • DNA sequence variants in known breast cancer susceptibility genes (eg. BRCA1 and BRCA2)
  • DNA copy number variants across the genome, in breast cancer development
  • The New Zealand Familial Breast Cancer Study

    The New Zealand Familial Breast Cancer Study commenced in 2013 with the key goal of better understanding DNA sequence changes in genes that alter the risk of developing breast cancer. Genetic testing of breast cancer susceptibility genes, BRCA1 and BRCA2, has become common practice for patients with a strong family history of the disease. However, a significant proportion of tests result in the detection of a genetic change for which disease association is not known. This study will address this important issue through collaborative links with the international scientific consortia, ENIGMA (Evidence-based Network for the Interpretation of Germline Mutant Alleles) and CIMBA (Consortium of Investigators of Modifiers of BRCA1/2).

    The role of germline copy number variation in endometrial cancer risk and development

    Endometrial cancer is the most common gynaecological cancer in New Zealand and the incidence is increasing as the population ages. Mutations in the mismatch repair genes MLH1, MSH2, MSH6 and PMS2 are known to confer increased risk in a proportion of endometrial cancer cases. There are several other genes encoding proteins that act in the mismatch repair pathway, but evidence for the involvement of these and other genes in endometrial cancer susceptibility is currently limited. We are utilising large genetic datasets to identify common and rare genetic changes in these genes that are associated with endometrial cancer risk.

    Molecular markers of prognosis for colorectal cancer patients

    Colorectal cancer (CRC) prognosis is currently predicted by clinicopathological stage which confers significant prognostic variability. Substantial progress has occurred in the understanding of the molecular basis of CRC. Molecular techniques offer promise in improving staging and therefore targeting of therapy. However, limitations in current technology have seen few molecular biomarkers implemented in clinical practice. The Mackenzie Cancer Research Group are using a powerful new mRNA in situ hybridisation technology (RNAscope) that measures RNA in histologically preserved cells while overcoming limitations of existing techniques. This research aims to establish RNAscope as a valid method to identify mRNA markers for CRC prognosis.

    Publications

    Walker, L. C., de la Hoya, M., Wiggins, G. A. R., Lindy, A., Vincent, L. M., Parsons, M. T., … & ClinGen Sequence Variant Interpretation Working Group. (2023). Using the ACMG/AMP framework to capture evidence related to predicted and observed impact on splicing: Recommendations from the ClinGen SVI Splicing Subgroup. American Journal of Human Genetics, 110(7), 1046-1067. doi: 10.1016/j.ajhg.2023.06.002

    Jasiak, A., Koczkowska, M., Stukan, M., Wydra, D., Biernat, W., Izycka-Swieszewska, E., … Eccles, M. R., Walker, L., … Ratajska, M. (2023). Analysis of BRCA1 and BRCA2 alternative splicing in predisposition to ovarian cancer. Experimental & Molecular Pathology. Advance online publication. doi: 10.1016/j.yexmp.2023.104856

    Hakkaart, C., Pearson, J. F., Marquart, L., Dennis, J., Wiggins, G. A. R., Barnes, D. R., Robinson, B. A., Mace, P. D., … Walker, L. C. (2022). Copy number variants as modifiers of breast cancer risk for BRCA1/BRCA2 pathogenic variant carriers. Communications Biology, 5, 1061. doi: 10.1038/s42003-022-03978-6

    Thomassen, M., Mesman, R. L. S., Hansen, T. V. O., Menendez, M., Rossing, M., Esteban-Sánchez, A., … Walker, L. C., … Spurdle, A. B. (2022). Clinical, splicing and functional analysis to classify BRCA2 exon 3 variants: Application of a points-based ACMG/AMP approach. Human Mutation, 43, 1921-1944. doi: 10.1002/humu.24449

    Dennis, J., Tyrer, J. P., Walker, L. C., Michailidou, K., Dorling, L., Bolla, M. K., … Easton, D. F. (2022). Rare germline copy number variants (CNVs) and breast cancer risk. Communications Biology, 5(1), 65. doi: 10.1038/s42003-021-02990-6

    Walker, L. C., de la Hoya, M., Wiggins, G. A. R., Lindy, A., Vincent, L. M., Parsons, M. T., … & ClinGen Sequence Variant Interpretation Working Group. (2023). Using the ACMG/AMP framework to capture evidence related to predicted and observed impact on splicing: Recommendations from the ClinGen SVI Splicing Subgroup. American Journal of Human Genetics, 110(7), 1046-1067. doi: 10.1016/j.ajhg.2023.06.002

    Journal - Research Article

    Jasiak, A., Koczkowska, M., Stukan, M., Wydra, D., Biernat, W., Izycka-Swieszewska, E., … Eccles, M. R., Walker, L., … Ratajska, M. (2023). Analysis of BRCA1 and BRCA2 alternative splicing in predisposition to ovarian cancer. Experimental & Molecular Pathology. Advance online publication. doi: 10.1016/j.yexmp.2023.104856

    Journal - Research Article

    Hakkaart, C., Pearson, J. F., Marquart, L., Dennis, J., Wiggins, G. A. R., Barnes, D. R., Robinson, B. A., Mace, P. D., … Walker, L. C. (2022). Copy number variants as modifiers of breast cancer risk for BRCA1/BRCA2 pathogenic variant carriers. Communications Biology, 5, 1061. doi: 10.1038/s42003-022-03978-6

    Journal - Research Article

    Thomassen, M., Mesman, R. L. S., Hansen, T. V. O., Menendez, M., Rossing, M., Esteban-Sánchez, A., … Walker, L. C., … Spurdle, A. B. (2022). Clinical, splicing and functional analysis to classify BRCA2 exon 3 variants: Application of a points-based ACMG/AMP approach. Human Mutation, 43, 1921-1944. doi: 10.1002/humu.24449

    Journal - Research Article

    Dennis, J., Tyrer, J. P., Walker, L. C., Michailidou, K., Dorling, L., Bolla, M. K., … Easton, D. F. (2022). Rare germline copy number variants (CNVs) and breast cancer risk. Communications Biology, 5(1), 65. doi: 10.1038/s42003-021-02990-6

    Journal - Research Article

    Morley-Bunker, A. E., Wiggins, G. A. R., Currie, M. J., Morrin, H. R., Whitehead, M. R., Eglinton, T., Pearson, J., & Walker, L. C. (2021). RNAscope compatibility with image analysis platforms for the quantification of tissue-based colorectal cancer biomarkers in archival formalin-fixed paraffin-embedded tissue. Acta Histochemica, 123, 151765. doi: 10.1016/j.acthis.2021.151765

    Journal - Research Article

    Wiggins, G. A. R., Black, M. A., Dunbier, A., Morley-Bunker, A. E., kConFab Investigators, Pearson, J. F., & Walker, L. C. (2021). Increased gene expression variability in BRCA1-associated and basal-like breast tumours. Breast Cancer Research & Treatment, 189, 363-375. doi: 10.1007/s10549-021-06328-y

    Journal - Research Article

    Wiggins, G. A. R., Black, M. A., Dunbier, A., Merriman, T. R., Pearson, J. F., & Walker, L. C. (2021). Variable expression quantitative trait loci analysis of breast cancer risk variants. Scientific Reports, 11(1), 7192. doi: 10.1038/s41598-021-86690-5

    Journal - Research Article

    McDougall, L. I., Powell, R. M., Ratajska, M., Lynch-Sutherland, C. F., Hossain, S. M., Wiggins, G. A. R., … Motwani, J., Macaulay, E. C., Reid, G., Walker, L. C., … Eccles, M. R. (2021). Differential expression of BARD1 isoforms in melanoma. Genes, 12(2), 320. doi: 10.3390/genes12020320

    Journal - Research Article

    Stamp, L. K., Cameron, V. A., Woodfield, T. B. F., Walker, L., Currie, M., Templeton, E., Pilbrow, A. P., Tabakakis, K., Phillips, E., & Lim, K. S. (2021). Impact of COVID-19 on health research in New Zealand: A case study of a research-intensive campus. Journal of the Royal Society of New Zealand, 51(Suppl. 1), S75-S85. doi: 10.1080/03036758.2020.1867202

    Journal - Research Article

    Lattimore, V., Parsons, M. T., Spurdle, A. B., Pearson, J., Lehnert, K., Sullivan, J., … Morrin, H., Robinson, B., & Walker, L. (2021). Under-ascertainment of breast cancer susceptibility gene carriers in a cohort of New Zealand female breast cancer patients. Breast Cancer Research & Treatment, 185, 583-590. doi: 10.1007/s10549-020-05986-8

    Journal - Research Article

    Wiggins, G. A. R., Walker, L. C., & Pearson, J. F. (2020). Genome-wide gene expression analyses of BRCA1- and BRCA2-associated breast and ovarian tumours. Cancers, 12(10), 3015. doi: 10.3390/cancers12103015

    Journal - Research Other

    Dennis, J., Walker, L., Tyrer, J., Michailidou, K., & Easton, D. F. (2021). Detecting rare copy number variants from Illumina genotyping arrays with the CamCNV pipeline: Segmentation of z-scores improves detection and reliability. Genetic Epidemiology, 45, 237-248. doi: 10.1002/gepi.22367

    Journal - Research Article

    Leman, R., Tubeuf, H., Raad, S., Tournier, I., Derambure, C., Lanos, R., … Walker, L. C., … Krieger, S. (2020). Assessment of branch point prediction tools to predict physiological branch points and their alteration by variants. BMC Genomics, 21, 86. doi: 10.1186/s12864-020-6484-5

    Journal - Research Article

    Walker, L. C., Lattimore, V. L., Kvist, A., Kleiblova, P., Zemankova, P., de Jong, L., Wiggins, G. A. R., Hakkaart, C., Cree, S. L., … Kennedy, M. A., … de la Hoya, M. (2019). Comprehensive assessment of BARD1 messenger ribonucleic acid splicing with implications for variant classification. Frontiers in Genetics, 10, 1139. doi: 10.3389/fgene.2019.01139

    Journal - Research Article

    Spurdle, A. B., Greville-Heygate, S., Antoniou, A. C., Brown, M., Burke, L., de la Hoya, M., … Walker, L. C., … Eccles, D. M. (2019). Towards controlled terminology for reporting germline cancer susceptibility variants: An ENIGMA report. Journal of Medical Genetics, 56, 347-357. doi: 10.1136/jmedgenet-2018-105872

    Journal - Research Other

    Fischer, J., Walker, L. C., Robinson, B. A., Frizelle, F. A., Church, J. M., & Eglinton, T. W. (2019). Clinical implications of the genetics of sporadic colorectal cancer. ANZ Journal of Surgery, 89(10), 1224-1229. doi: 10.1111/ans.15074

    Journal - Research Other

    Lopez-Perolio, I., Leman, R., Behar, R., Lattimore, V., Pearson, J. F., Castéra, L., … Walker, L. C., … de la Hoya, M. (2019). Alternative splicing and ACMG-AMP-2015-based classification of PALB2 genetic variants: An ENIGMA report. Journal of Medical Genetics, 56, 453-460. doi: 10.1136/jmedgenet-2018-105834

    Journal - Research Article

    Lattimore, V. L., Pearson, J. F., Morley-Bunker, A. E., kConFab Investigators, Spurdle, A. B., Robinson, B. A., Currie, M. J., & Walker, L. C. (2019). Quantifying BRCA1 and BRCA2 mRNA isoform expression levels in single cells. International Journal of Molecular Sciences, 20(3), 693. doi: 10.3390/ijms20030693

    Journal - Research Article

    Morley-Bunker, A., Pearson, J., Currie, M. J., Morrin, H., Whitehead, M. R., Eglinton, T., & Walker, L. C. (2019). Assessment of intra-tumoural colorectal cancer prognostic biomarkers using RNA in situ hybridisation. Oncotarget, 10(14), 1425-1439. doi: 10.18632/oncotarget.26675

    Journal - Research Article

    Richardson, A. K., Walker, L. C., Cox, B., Rollag, H., Robinson, B. A., Morrin, H., Pearson, J. F., … Currie, M. J. (2020). Breast cancer and cytomegalovirus. Clinical & Translational Oncology, 22, 585-602. doi: 10.1007/s12094-019-02164-1

    Journal - Research Article

    Brandão, R. D., Mensaert, K., López-Perolio, I., Tserpelis, D., Xenakis, M., Lattimore, V., Walker, L. C., … Blok, M. J. (2019). Targeted RNA-seq successfully identifies normal and pathogenic splicing events in breast/ovarian cancer susceptibility and Lynch syndrome genes. International Journal of Cancer, 145, 401-414. doi: 10.1002/ijc.32114

    Journal - Research Article

    Cline, M. S., Liao, R. G., Parsons, M. T., Paten, B., Alquaddoomi, F., Antoniou, A., … BRCA Challenge Authors, including Walker, L., … Spurdle, A. B. (2018). BRCA Challenge: BRCA Exchange as a global resource for variants in BRCA1 and BRCA2. PLoS Genetics, 14(12), e1007752. doi: 10.1371/journal.pgen.1007752

    Journal - Research Other

    Lattimore, V. L., Pearson, J. F., Currie, M. J., Spurdle, A. B., kConFab Investigators, Robinson, B. A., & Walker, L. C. (2018). Investigation of experimental factors that underlie BRCA1/2 mRNA isoform expression variation: Recommendations for utilising targeted RNA sequencing to evaluate potential spliceogenic variants. Frontiers in Oncology, 8, 140. doi: 10.3389/fonc.2018.00140

    Journal - Research Article

    de Jong, L. C., Cree, S., Lattimore, V., Wiggins, G. A. R., Spurdle, A. B., kConFab Investigators, Miller, A., Kennedy, M. A., & Walker, L. C. (2017). Nanopore sequencing of full-length BRCA1 mRNA transcripts reveals co-occurrence of known exon skipping events. Breast Cancer Research, 19, 127. doi: 10.1186/s13058-017-0919-1

    Journal - Research Article

    Walker, L. C., Marquart, L., Pearson, J. F., Wiggins, G. A. R., O'Mara, T. A., Parsons, M. T., … Spurdle, A. B. (2017). Evaluation of copy-number variants as modifiers of breast and ovarian cancer risk for BRCA1 pathogenic variant carriers. European Journal of Human Genetics, 25, 432-438. doi: 10.1038/ejhg.2016.203

    Journal - Research Article

    Walker, L. C., Pearson, J. F., Wiggins, G. A. R., Giles, G. G., Hopper, J. L., & Southey, M. C. (2017). Increased genomic burden of germline copy number variants is associated with early onset breast cancer: Australian breast cancer family registry. Breast Cancer Research, 19, 30. doi: 10.1186/s13058-017-0825-6

    Journal - Research Article

    Shimelis, H., Mesman, R. L. S., Von Nicolai, C., Ehlen, A., Guidugli, L., Martin, C., … Walker, L., … Couch, F. J. (2017). BRCA2 hypomorphic missense variants confer moderate risks of breast cancer. Cancer Research, 77(11), 2789-2799. doi: 10.1158/0008-5472.can-16-2568

    Journal - Research Article

    de la Hoya, M., Soukarieh, O., López-Perolio, I., Vega, A., Walker, L. C., van Ierland, Y., … Lattimore, V., … Spurdle, A. B. (2016). Combined genetic and splicing analysis of BRCA1 c.[594-2A>C; 641A>G] highlights the relevance of naturally occurring in-frame transcripts for developing disease gene variant classification algorithms. Human Molecular Genetics, 25(11), 2256-2268. doi: 10.1093/hmg/ddw094

    Journal - Research Article

    Fackenthal, J. D., Yoshimatsu, T., Zhang, B., de Garibay, G. R., Colombo, M., De Vecchi, G., … Walker, L. C., … de la Hoya, M. (2016). Naturally occurring BRCA2 alternative mRNA splicing events in clinically relevant samples. Journal of Medical Genetics, 53, 548-558. doi: 10.1136/jmedgenet-2015-103570

    Journal - Research Article

    Walker, L. C., Nones, K., Patch, A.-M., & Waddell, N. (2016). Studying genomic and epigenetic aberrations by microarray profiling. In Encyclopedia of Life Sciences. Chichester, UK: John Wiley & Sons. doi: 10.1002/9780470015902.a0022417.pub2

    Chapter in Book - Research

    Morley-Bunker, A., Walker, L. C., Currie, M. J., Pearson, J., & Eglinton, T. (2016). Translating colorectal cancer genetics into clinically useful biomarkers. Colorectal Disease, 18(8), 749-762. doi: 10.1111/codi.13334

    Journal - Research Article

    Gerring, Z., Pearson, J. F., Morrin, H. R., Robinson, B. A., Harris, G. C., & Walker, L. C. (2015). Phosphohistone H3 outperforms Ki67 as a marker of outcome for breast cancer patients. Histopathology, 67(4), 538-547. doi: 10.1111/his.12678

    Journal - Research Article

    Walker, L. C., Wiggins, G. A. R., & Pearson, J. F. (2015). The role of constitutional copy number variants in breast cancer. Microarrays, 4(3), 407-423. doi: 10.3390/microarrays4030407

    Journal - Research Article

    Richardson, A. K., Currie, M. J., Robinson, B. A., Morrin, H., Phung, Y., Pearson, J. F., … Walker, L. C. (2015). Cytomegalovirus and Epstein-Barr Virus in breast cancer. PLoS ONE, 10(2), e0118989. doi: 10.1371/journal.pone.0118989

    Journal - Research Article

    Peterlongo, P., Chang-Claude, J., Moysich, K. B., Rudolph, A., Schmutzler, R. K., Simard, J., … Walker, L. C., … Friedman, E. (2015). Candidate genetic modifiers for breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. Cancer Epidemiology, Biomarkers & Prevention, 24(1), 308-316. doi: 10.1158/1055-9965.epi-14-0532

    Journal - Research Article

    Lattimore, V., Currie, M., Lintott, C., Sullivan, J., Robinson, B. A., & Walker, L. C. (2015). Meeting the challenges of interpreting variants of unknown clinical significance in BRCA testing. New Zealand Medical Journal, 128(1419). Retrieved from http://www.nzma.org.nz/journal

    Journal - Research Other

    Moir-Meyer, G. L., Pearson, J. F., Lose, F., The Australian National Endometrial Cancer Study Group, Scott, R. J., McEvoy, M., … Walker, L. C. (2015). Rare germline copy number deletions of likely functional importance are implicated in endometrial cancer predisposition. Human Genetics, 134(3), 269-278. doi: 10.1007/s00439-014-1507-4

    Journal - Research Article

    Colombo, M., Blok, M. J., Whiley, P., Santamariña, M., Gutiérrez-Enríquez, S., Romero, A., … Walker, L., … de la Hoya, M. (2014). Comprehensive annotation of splice junctions supports pervasive alternative splicing at the BRCA1 locus: A report from the ENIGMA consortium. Human Molecular Genetics, 23(14), 3666-3680. doi: 10.1093/hmg/ddu075

    Journal - Research Article

    Whiley, P. J., de la Hoya, M., Thomassen, M., Becker, A., Brandão, R., Sokilde Pedersen, I., … Lattimore, V., … Walker, L., … on behalf of the ENIGMA consortium. (2014). Comparison of mRNA splicing assay protocols across multiple laboratories: Recommendations for best practice in standardized clinical testing. Clinical Chemistry, 60(2), 341-352. doi: 10.1373/clinchem.2013.210658

    Journal - Research Article

    Walker, L. C., Whiley, P. J., Houdayer, C., Hansen, T. V. O., Vega, A., Santamarina, M., … on behalf of the ENIGMA consortium. (2013). Evaluation of a 5-tier scheme proposed for classification of sequence variants using bioinformatic and splicing assay data: Inter-reviewer variability and promotion of minimum reporting guidelines. Human Mutation, 34(10), 1424-1431. doi: 10.1002/humu.22388

    Journal - Research Article

    Walker, L. C., McDonald, M., Wells, J. E., Harris, G. C., Robinson, B. A., & Morris, C. M. (2013). Dual-color fluorescence in situ hybridization reveals an association of chromosome 8q22 but not 8p21 imbalance with high grade invasive breast carcinoma. PLoS ONE, 8(7), e70790. doi: 10.1371/journal.pone.0070790

    Journal - Research Article

    Walker, L. C., Krause, L., kConFab Investigators, Spurdle, A. B., & Waddell, N. (2012). Germline copy number variants are not associated with globally acquired copy number changes in familial breast tumours. Breast Cancer Research & Treatment, 134(3), 1005-1011. doi: 10.1007/s10549-012-2024-6

    Journal - Research Article

    Spurdle, A. B., Thompson, D. J., Ahmed, S., Ferguson, K., Healey, C. S., O'Mara, T., Walker, L. C., … The Australian National Endometrial Cancer Study Group, … National Study of Endometrial Cancer Genetics Group, … Easton, D. F. (2011). Genome-wide association study identifies a common variant associated with risk of endometrial cancer. Nature Genetics, 43(5), 451-454. doi: 10.1038/ng.812

    Journal - Research Article

    Whiley, P. J., Guidugli, L., Walker, L. C., Healey, S., Thompson, B. A., Lakhani, S. R., … Spurdle, A. B. (2011). Splicing and multifactorial analysis of intronic BRCA1 and BRCA2 sequence variants identifies clinically significant splicing aberrations up to 12 nucleotides from the intron/exon boundary. Human Mutation, 32(6), 678-687. doi: 10.1002/humu.21495

    Journal - Research Article

    Walker, L. C., Thompson, B. A., Waddell, N., kConFab Investigators, Grimmond, S. M., & Spurdle, A. B. (2010). Use of DNA–damaging agents and RNA pooling to assess expression profiles associated with BRCA1 and BRCA2 mutation status in familial breast cancer patients. PLoS Genetics, 6(2), e1000850. doi: 10.1371/journal.pgen.1000850

    Journal - Research Article

    Walker, L. C., Whiley, P., Couch, F. J., Farrugia, D. J., Healey, S., Eccles, D. M., … kConFab Investigators, … Spurdle, A. B. (2010). Detection of splicing aberrations caused by BRCA1 and BRCA2 sequence variants encoding missense substitutions: Implications for prediction of pathogenicity. Human Mutation, 31(6), E1484-E1505. doi: 10.1002/humu.21267

    Journal - Research Article

    Walker, L. C., Fredericksen, Z. S., Wang, X., Tarrell, R., Pankratz, V. S., Lindor, N. M., … Couch, F. J. (2010). Evidence for SMAD3 as a modifier of breast cancer risk in BRCA2 mutation carriers. Breast Cancer Research, 12(6), R102. doi: 10.1186/bcr2785

    Journal - Research Article

    Walker, L. C., & Spurdle, A. B. (2010). Prioritizing candidate genetic modifiers of BRCA1 and BRCA2 using a combinatorial analysis of global expression and polymorphism association studies of breast cancer. In M. Webb (Ed.), Cancer susceptibility: Methods and protocols (Methods in molecular biology, Vol. 653). (pp. 23-34). New York: Springer. doi: 10.1007/978-1-60761-759-4

    Chapter in Book - Research

    Walker, L. C., & Waddell, N. (2010). Studying genomic aberrations by microarray profiling. In Encyclopedia of Life Sciences. Chichester, UK: John Wiley & Sons. doi: 10.1002/9780470015902.a0022417

    Chapter in Book - Research

    Walker, L. C., Waddell, N., Ten Haaf, A., kConFab Investigators, Grimmond, S., & Spurdle, A. B. (2008). Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers. Breast Cancer Research & Treatment, 112(2), 229-236. doi: 10.1007/s10549-007-9848-5

    Journal - Research Article

    Whiley, P., Pettigrew, C. A., Brewster, B. L., Walker, L. C., for kConFab Investigators, Spurdle, A. B., & Brown, M. A. (2010). Effect of BRCA2 sequence variants predicted to disrupt exonic splice enhancers on BRCA2 transcripts. BMC Medical Genetics, 11, 80. doi: 10.1186/1471-2350-11-80

    Journal - Research Article

    Walker, L. C. (2009). Toward understanding the molecular basis of ovarian cancer. Human Mutation, 30(12), v. doi: 10.1002/humu.21162

    Journal - Research Other

    Walker, L. C., Harris, G. C., Wells, J. E., Robinson, B. A., & Morris, C. M. (2008). Association of chromosome band 8q22 copy number gain with high grade invasive breast carcinomas by assessment of core needle biopsies. Genes Chromosomes & Cancer, 47(5), 405-417. doi: 10.1002/gcc.20545

    Journal - Research Article

    Waddell, N., Ten Haaf, A., Marsh, A., Johnson, J., Walker, L. C., kConFab Investigators, … Spurdle, A. B. (2008). BRCA1 and BRCA2 missense variants of high and low clinical significance influence lymphoblastoid cell line post-irradiation gene expression. PLoS Genetics, 4(5), e1000080. doi: 10.1371/journal.pgen.1000080

    Journal - Research Article

    Walker, L. C., Harris, G. C., Holloway, A. J., McKenzie, G. W., Wells, J. E., Robinson, B. A., & Morris, C. M. (2007). Cytokeratin KRT8/18 expression differentiates distinct subtypes of grade 3 invasive ductal carcinoma of the breast. Cancer Genetics & Cytogenetics, 178, 94-103.

    Journal - Research Article

    Ganly, P. S., Walker, L. C., & Morris, C. M. (2004). Familial mutations of the transcription factor RUNX1 (AML1, CBFA2) predispose to acute myeloid leukemia. Leukemia & Lymphoma, 45(1), 1-10.

    Journal - Research Article

    Walker, L. C., Campbell, H. J., Corbett, R., Spearing, R. L., Heaton, D. C., Macdonald, D. H., Morris, C. M., & Ganly, P. S. (2002). A novel inherited mutation of the transcription factor RUNX1 causes thrombocytopenia and may predispose to acute myeloid leukaemia. British Journal of Haematology, 117(4), 878-881. doi: 10.1046/j.1365-2141.2002.03512.x

    Journal - Research Article

    Walker, L. C., Morrison, M. J., Parfitt, R., & Crossen, P. E. (2001). Translocation (2;14) associated with complex rearrangements of the Ig heavy chain in non-Hodgkin lymphoma. Cancer Genetics & Cytogenetics, 128, 137-140.

    Journal - Research Article

    Sin, F. T. Y., Mukherjee, U. K., Walker, L. C., & Sin, I. L. (1997). The application of gene transfer techniques to marine resource mangement: Recent advances, problems and future directions. Hydrobiologia, 352, 263-278.

    Journal - Research Article

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