Dr Kenny Chitcholtan
Position | Senior Research Fellow |
---|---|
Department | Department of Obstetrics and Gynaecology (Christchurch) |
Qualifications | BSc(N Territory), PhD(Cant) |
Research summary | Ovarian and endometrial cancer |
Research
My research interests are focusing on the activity of tyrosine kinases, targeted inhibitors, effects of ascitic fluid ,and anti-tumour properties of natural food compounds in the progression of advanced ovarian cancer. To understand these factors, I am using three dimensional (3D) cell cultures, chicken embryos and a syngeneic mouse model to investigate the biological activity in ovarian cancer.Publications
Dunn, E., Chitcholtan, K., Sykes, P., & Garrill, A. (2022). The anti-proliferative effect of PI3K/mTOR and ERK inhibition in monolayer and three-dimensional ovarian cancer cell models. Cancers, 14, 395. doi: 10.3390/cancers14020395
Sarwar, M., Sykes, P. H., Chitcholtan, K., & Evans, J. J. (2022). Collagen I dysregulation is pivotal for ovarian cancer progression. Tissue & Cell, 74, 101704. doi: 10.1016/j.tice.2021.101704
Sarwar, M., Sykes, P. H., Chitcholtan, K., & Evans, J. J. (2021). Deciphering biophysical modulation in ovarian cancer cells. Cell Biochemistry & Biophysics. Advance online publication. doi: 10.1007/s12013-020-00964-9
Sarwar, M., Sykes, P. H., Chitcholtan, K., & Evans, J. J. (2020). Extracellular biophysical environment: Guilty of being a modulator of drug sensitivity in ovarian cancer cells [Short communication]. Biochemical & Biophysical Research Communications, 527(1), 180-186. doi: 10.1016/j.bbrc.2020.04.107
Chitcholtan, K., Harker, D., Simcock, B., & Sykes, P. (2020). Sensitivity of EGFR/HER-2 positive cells isolated from ascitic fluid of advanced ovarian cancer patients to EGFR/HER-2 inhibitors. Applied Sciences, 10(7), 2343. doi: 10.3390/app10072343
Dunn, E., Chitcholtan, K., Sykes, P., & Garrill, A. (2022). The anti-proliferative effect of PI3K/mTOR and ERK inhibition in monolayer and three-dimensional ovarian cancer cell models. Cancers, 14, 395. doi: 10.3390/cancers14020395
Journal - Research Article
Sarwar, M., Sykes, P. H., Chitcholtan, K., & Evans, J. J. (2022). Collagen I dysregulation is pivotal for ovarian cancer progression. Tissue & Cell, 74, 101704. doi: 10.1016/j.tice.2021.101704
Journal - Research Article
Sarwar, M., Sykes, P. H., Chitcholtan, K., & Evans, J. J. (2021). Deciphering biophysical modulation in ovarian cancer cells. Cell Biochemistry & Biophysics. Advance online publication. doi: 10.1007/s12013-020-00964-9
Journal - Research Article
Chitcholtan, K., Harker, D., Simcock, B., & Sykes, P. (2020). Sensitivity of EGFR/HER-2 positive cells isolated from ascitic fluid of advanced ovarian cancer patients to EGFR/HER-2 inhibitors. Applied Sciences, 10(7), 2343. doi: 10.3390/app10072343
Journal - Research Article
Sarwar, M., Sykes, P. H., Chitcholtan, K., Alkaisi, M. M., & Evans, J. J. (2019). The extracellular topographical environment influences ovarian cancer cell behaviour. Biochemical & Biophysical Research Communications, 508, 1188-1194. doi: 10.1016/j.bbrc.2018.12.067
Journal - Research Article
Hassan, W., Chitcholtan, K., Sykes, P., & Garrill, A. (2018). Ascitic fluid from advanced ovarian cancer patients compromises the activity of receptor tyrosine kinase inhibitors in 3D cell clusters of ovarian cancer cells. Cancer Letters, 420, 168-181. doi: 10.1016/j.canlet.2018.02.013
Journal - Research Article
Kumar, D., Mutreja, I., Chitcholtan, K., & Sykes, P. (2017). Cytotoxicity and cellular uptake of different sized gold nanoparticles in ovarian cancer cells. Nanotechnology, 28, 475101. doi: 10.1088/1361-6528/aa935e
Journal - Research Article
Hassan, W., Chitcholtan, K., Sykes, P., & Garrill, A. (2016). A combination of two receptor tyrosine kinase inhibitors, canertinib and PHA665752 comprises ovarian cancer cell growth in 3D cell models. Oncology & Therapy, 4(2), 257-274. doi: 10.1007/s40487-016-0031-1
Journal - Research Article
Lassé, M., Ulluwishewa, D., Healy, J., Thompson, D., Miller, A., Roy, N., Chitcholtan, K., & Gerrard, J. A. (2016). Evaluation of protease resistance and toxicity of amyloid-like food fibrils from whey, soy, kidney bean, and egg white. Food Chemistry, 192, 491-498. doi: 10.1016/j.foodchem.2015.07.044
Journal - Research Article
Tino, A. B., Chitcholtan, K., Sykes, P. H., & Garrill, A. (2016). Resveratrol and acetyl-resveratrol modulate activity of VEGF and IL-8 in ovarian cancer cell aggregates via attenuation of the NF-κB protein. Journal of Ovarian Research, 9, 84. doi: 10.1186/s13048-016-0293-0
Journal - Research Article
Hogg, S. J., Chitcholtan, K., Hassan, W., Sykes, P. H., & Garrill, A. (2015). Resveratrol, acetyl-resveratrol, and polydatin exhibit antigrowth activity against 3D cell aggregates of the SKOV-3 and OVCAR-8 ovarian cancer cell lines. Obstetrics & Gynecology International, 2015, 279591. doi: 10.1155/2015/279591
Journal - Research Article
Hogg, S. J., Evans, J. J., Sykes, P. H., & Chitcholtan, K. (2015). A method to investigate the anti-metabolic activity of anti-cancer agents on ovarian cancer cells cultured in a 96-well high throughput format. Journal of Ovarian Research, 8, 43. doi: 10.1186/s13048-015-0172-0
Journal - Research Article
Yoshida, A., Chitcholtan, K., Evans, J. J., Uemura, S., & Beasley, S. W. (2014). Provision of optimal conditions for in vitro differentiation into peristaltic smooth muscle from a murine induced pluripotent stem cell line. JSM Regenerative Medicine & Bioengineering, 2(1), 1011.
Journal - Research Article
Chitcholtan, K., Asselin, E., Parent, S., Sykes, P. H., & Evans, J. J. (2013). Differences in growth properties of endometrial cancer in three dimensional (3D) culture and 2D cell monolayer. Experimental Cell Research, 319(1), 75-87. doi: 10.1016/j.yexcr.2012.09.012
Journal - Research Article
Chitcholtan, K., Harris, E., Yu, Y., Harland, C., & Garrill, A. (2012). An investigation into plasmolysis in the oomycete Achlya bisexualis reveals that membrane-wall attachment points are sensitive to peptides containing the sequence RGD and that cell wall deposition can occur despite retraction of the protoplast. Canadian Journal of Microbiology, 58(10), 1212-1220. doi: 10.1139/w2012-099
Journal - Research Article
Chitcholtan, K., Sykes, P. H., & Evans, J. J. (2012). The resistance of intracellular mediators to doxorubicin and cisplatin are distinct in 3D and 2D endometrial cancer. Journal of Translational Medicine, 10(1), 38-53. doi: 10.1186/1479-5876-10-38
Journal - Research Article
Evans, J. J., Chitcholtan, K., Dann, J. M., Guilford, P., Harris, G., Lewis, L. K., Nagase, J., … Sykes, P. H. (2012). Adrenomedullin interacts with VEGF in endometrial cancer and has varied modulation in tumours of different grades. Gynecologic Oncology, 125(1), 214-219. doi: 10.1016/j.ygyno.2011.12.429
Journal - Research Article
Evans, J. J., & Chitcholtan, K. (2011). Extracellular matrix proteins in the anterior pituitary gland. Open Neuroendocrinology Journal, 4, 111-119. doi: 10.2174/1876528901104010111
Journal - Research Article
Samsuri, F., Alkaisi, M. M., Evans, J. J., Chitcholtan, K., & Mitchell, J. S. (2011). Detection of changes in cell membrane structures using the Bioimprint technique. Microelectronic Engineering, 88(8), 1871-1874. doi: 10.1016/j.mee.2010.12.069
Journal - Research Article
Parker, H., Chitcholtan, K., Hampton, M. B., & Keenan, J. I. (2010). Uptake of Helicobacter pylori outer membrane vesicles by gastric epithelial cells. Infection & Immunity, 78(12), 5054-5061. doi: 10.1128/IAI.00299-10
Journal - Research Article
Chitcholtan, K., Hampton, M. B., & Keenan, J. I. (2008). Outer membrane vesicles enhance the carcinogenic potential of Helicobacter pylori. Carcinogenesis, 29(12), 2400-2405. doi: 10.1093/carcin/bgn218
Journal - Research Article
Walker, S. K., Chitcholtan, K., Yu, Y., Christenhusz, G. M., & Garrill, A. (2006). Invasive hyphal growth: An F-actin depleted zone is associated with invasive hyphae of the oomycetes Achlya bisexualis and Phytophthora cinnamomi. Fungal Genetics & Biology, 43(5), 357-365. doi: 10.1016/j.fgb.2006.01.004
Journal - Research Article
Sarwar, M., Sykes, P. H., Chitcholtan, K., & Evans, J. J. (2020). Extracellular biophysical environment: Guilty of being a modulator of drug sensitivity in ovarian cancer cells [Short communication]. Biochemical & Biophysical Research Communications, 527(1), 180-186. doi: 10.1016/j.bbrc.2020.04.107
Journal - Research Other
Chitcholtan, K. (2016). Do we have enough knowledge to win the fight against ovarian cancer? Edorium Journal of Gynecology & Obstetrics, 2, 1-7. doi: 10.5348/G06-2016-7-ED-1
Journal - Research Other