Professor Rhonda Rosengren
| Position | Professor |
|---|---|
| Department | Department of Pharmacology and Toxicology |
| Qualifications | BS PhD(Texas A & M) |
| Research summary | Breast and prostate cancer, nanomedicine, drug metabolism |
| Memberships | Professor Rhonda Rosengren is a member of the Auckland Cancer Research Network |
Research
Toxicological research in my laboratory involves the identification of novel treatments for various cancers including estrogen receptor negative breast cancer, hormone refractory prostate cancer and ovarian cancer. In conjunction with Dr. Bill Hawkins in the department of Chemistry we are synthesizing novel curcumin derivatives and examining their activity in both in vitro and in vivo models of cancer. We have also discovered new roles for tamoxifen and raloxifene in breast and prostate cancer when given as part of a novel combination therapy or in novel formulations. We also have research collaborations with Dr. Andrew Cridge in the Department of Biochemistry, Dr. Jonathan Bray Head of Small Animal Surgery at Massey University Veterinary School, Dr. Heather Cunliffe in the Department of Pathology and Dr. Mihnea Bostina in the Department of Microbiology and Immunology. The Otago Medical Research Foundation and grants from the University of Otago currently fund our work.
Additional details
- Professor Rhonda Rosengren's research group
- Professor Rhonda Rosengren's contact details
- Professor Rhonda Rosengren's publications on ResearchGate
In the news
- Breast cancer breakthrough (New Zealand Herald)
- Cancer research funding (Otago Daily Times)
- $300K made available to support innovative breast cancer research in NZ (New Zealand Breast Cancer Foundation)
- New projects take NZBCF research spend to $800,000 over the next two years (New Zealand Doctor)
- Research targets better drug treatment for breast cancers (Scoop)
- University promotes academics (Otago Daily Times)
- Otago announces professorial promotions (Scoop)
Publications
Rana, Z., Tyndall, J. D. A., Hanif, M., Hartinger, C. G., & Rosengren, R. J. (2021). Cytostatic action of novel histone deacetylase inhibitors in androgen receptor-null prostate cancer cells. Pharmaceuticals, 14, 103. doi: 10.3390/ph14020103
Shakil, M. S., Parveen, S., Rana, Z., Walsh, F., Movassaghi, S., Söhnel, T., Azam, M., … Rosengren, R. J., & Hartinger, C. G. (2021). High antiproliferative activity of hydroxythiopyridones over hydroxypyridones and their organoruthenium complexes. Biomedicines, 9, 123. doi: 10.3390/biomedicines9020123
Hanif, M., Arshad, J., Astin, J. W., Rana, Z., Zafari, A., Movassaghi, S., … Rosengren, R. J., … Hartinger, C. G. (2020). A multitargeted approach: Organorhodium anticancer agent based on vorinostat as a potent histone deacetylase inhibitor. Angewandte Chemie International Edition, 59, 14609-14614. doi: 10.1002/anie.202005758
Shrestha, N., Bland, A. R., Bower, R. L., Rosengren, R. J., & Ashton, J. C. (2020). Inhibition of mitogen-activated protein kinase kinase alone and in combination with anaplastic lymphoma kinase (ALK) inhibition suppresses tumor growth in a mouse model of ALK-positive lung cancer. Journal of Pharmacology & Experimental Therapeutics, 374, 134-140. doi: 10.1124/jpet.120.266049
Niloy, M. S., Shakil, M. S., Hossen, M. S., Alam, M., & Rosengren, R. J. (2021). Promise of gold nanomaterials as a lung cancer theranostic agent: A systematic review. International Nano Letters, 11, 111, 93-111. doi: 10.1007/s40089-021-00332-2
Rana, Z., Tyndall, J. D. A., Hanif, M., Hartinger, C. G., & Rosengren, R. J. (2021). Cytostatic action of novel histone deacetylase inhibitors in androgen receptor-null prostate cancer cells. Pharmaceuticals, 14, 103. doi: 10.3390/ph14020103
Journal - Research Article
Shakil, M. S., Parveen, S., Rana, Z., Walsh, F., Movassaghi, S., Söhnel, T., Azam, M., … Rosengren, R. J., & Hartinger, C. G. (2021). High antiproliferative activity of hydroxythiopyridones over hydroxypyridones and their organoruthenium complexes. Biomedicines, 9, 123. doi: 10.3390/biomedicines9020123
Journal - Research Article
Hanif, M., Arshad, J., Astin, J. W., Rana, Z., Zafari, A., Movassaghi, S., … Rosengren, R. J., … Hartinger, C. G. (2020). A multitargeted approach: Organorhodium anticancer agent based on vorinostat as a potent histone deacetylase inhibitor. Angewandte Chemie International Edition, 59, 14609-14614. doi: 10.1002/anie.202005758
Journal - Research Article
Shrestha, N., Bland, A. R., Bower, R. L., Rosengren, R. J., & Ashton, J. C. (2020). Inhibition of mitogen-activated protein kinase kinase alone and in combination with anaplastic lymphoma kinase (ALK) inhibition suppresses tumor growth in a mouse model of ALK-positive lung cancer. Journal of Pharmacology & Experimental Therapeutics, 374, 134-140. doi: 10.1124/jpet.120.266049
Journal - Research Article
Niloy, M. S., Shakil, M. S., Hossen, M. S., Alam, M., & Rosengren, R. J. (2021). Promise of gold nanomaterials as a lung cancer theranostic agent: A systematic review. International Nano Letters, 11, 111, 93-111. doi: 10.1007/s40089-021-00332-2
Journal - Research Other
Rana, Z., Diermeier, S., Hanif, M., & Rosengren, R. J. (2020). Understanding failure and improving treatment using HDAC inhibitors for prostate cancer. Biomedicines, 8(2), 22. doi: 10.3390/biomedicines8020022
Journal - Research Other
Singh, R. J., Martin, C. E., Barr, D., & Rosengren, R. J. (2019). Cucumber peel bead biosorbent for multi-ion decontamination of drinking water collected from a mine region in New Zealand. Environmental Technology, 42(16), 2461-2477. doi: 10.1080/09593330.2019.1703824
Journal - Research Article
Bland, A. R., Shrestha, N., Rosengren, R. J., & Ashton, J. C. (2020). Does crizotinib auto-inhibit CYP3A in vivo? [Brief report]. Pharmacology, 105, 715-718. doi: 10.1159/000506996
Journal - Research Other
Martey, O. N. K., Greish, K., Smith, P. F., & Rosengren, R. J. (2019). A multivariate statistical analysis of the effects of styrene maleic acid encapsulated RL71 in a xenograft model of triple negative breast cancer. Journal of Biological Methods, 6(4). doi: 10.14440/jbm.2019.306
Journal - Research Article
Shrestha, N., Nimick, M., Dass, P., Rosengren, R. J., & Ashton, J. C. (2019). Mechanisms of suppression of cell growth by dual inhibition of ALK and MEK in ALK-positive non-small cell lung cancer. Scientific Reports, 9, 18842. doi: 10.1038/s41598-019-55376-4
Journal - Research Article
Bland, A. R., Bower, R. L., Nimick, M., Hawkins, B. C., Rosengren, R. J., & Ashton, J. C. (2019). Cytotoxicity of curcumin derivatives in ALK positive non-small cell lung cancer. European Journal of Pharmacology, 865, 172749. doi: 10.1016/j.ejphar.2019.172749
Journal - Research Article
Smith, R. J., Bower, R. L., Ferguson, S. A., Rosengren, R. J., Cook, G. M., & Hawkins, B. C. (2019). The synthesis of (±)-oxyisocyclointegrin. European Journal of Organic Chemistry, (7), 1571-1573. doi: 10.1002/ejoc.201801751
Journal - Research Article
Mortezaee, K., Salehi, E., Mirtavoos-mahyari, H., Motevaseli, E., Najafi, M., Farhood, B., Rosengren, R. J., & Sahebkar, A. (2019). Mechanisms of apoptosis modulation by curcumin: Implications for cancer therapy. Journal of Cellular Physiology, 234(8), 12537-12550. doi: 10.1002/jcp.28122
Journal - Research Other
Salmaninejad, A., Valilou, S. F., Soltani, A., Ahmadi, S., Abarghan, Y. J., Rosengren, R. J., & Sahebkar, A. (2019). Tumor-associated macrophages: role in cancer development and therapeutic implications. Cellular Oncology, 42, 591-608. doi: 10.1007/s13402-019-00453-z
Journal - Research Other
Chen, S., Nimick, M., Cridge, A. G., Hawkins, B. C., & Rosengren, R. J. (2018). Anticancer potential of novel curcumin analogs towards castrate-resistant prostate cancer. International Journal of Oncology, 52(2), 579-588. doi: 10.3892/ijo.2017.4207
Journal - Research Article
Martey, O., Nimick, M., Taurin, S., Sundararajan, V., Greish, K., & Rosengren, R. J. (2017). Styrene maleic acid-encapsulated RL71 micelles suppress tumor growth in a murine xenograft model of triple negative breast cancer. International Journal of Nanomedicine, 12, 7225-7237. doi: 10.2147/ijn.s148908
Journal - Research Article
