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Centre for Translational Cancer Research staff profile

Professor Ros Kemp

PositionProfessor
DepartmentDepartment of Microbiology and Immunology
QualificationsBSc(Hons) PhD
Research summaryApplied and molecular immunology, cancer immunobiology, vaccines – immunology and technology

Research

My research focuses on T cells as mediators of anti-tumour immunity and inflammation. Specifically, we study the role of inflammation and the unique features of different subsets of T cells and myeloid cells, focussing on cancer and gut-specific immune responses; and how these cell subsets are involved in patient outcome.

We are currently looking at T cell and myeloid cell subsets in colorectal cancer and inflammatory bowel disease to improve diagnosis, prognosis and treatment. We are generating site-specific T cell memory using novel slow release vaccines and analysing the molecular signalling pathways required to maintain these populations.

Publications

Marsh-Wakefield, F. M. D., Mitchell, A. J., Norton, S. E., Ashurst, T. M., Leman, J. K. H., Roberts, J. M., Harte, J. E., … Kemp, R. A. (2021). Making the most of high-dimensional cytometry data. Immunology & Cell Biology. Advance online publication. doi: 10.1111/imcb.12456

Leman, J. K. H., Munoz-Erazo, L., & Kemp, R. A. (2020). The intestinal tumour microenvironment. In A. Birbrair (Ed.), Tumor microenvironments in organs: From the brain to the skin: Part A. (pp. 1-22). Cham, Switzerland: Springer. doi: 10.1007/978-3-030-36214-0_1

Niemi, V., Gaskarth, D., & Kemp, R. A. (2020). Extensive variability in the composition of immune infiltrate in different mouse models of cancer. Laboratory Animal Research, 36, 43. doi: 10.1186/s42826-020-00075-9

Naciute, M., Niemi, V., Kemp, R. A., & Hook, S. (2020). Lipid-encapsulated oral therapeutic peptide vaccines reduce tumour growth in an orthotopic mouse model of colorectal cancer. European Journal of Pharmaceutics & Biopharmaceutics, 153, 183-192. doi: 10.1016/j.ejpb.2020.04.020

Norton, S. E., Leman, J. K. H., Khong, T., Spencer, A., Fazekas de St Groth, B., McGuire, H. M., & Kemp, R. A. (2020). Brick plots: An intuitive platform for visualizing multiparametric immunophenotyped cell clusters. BMC Bioinformatics, 21, 145. doi: 10.1186/s12859-020-3469-y

Chapter in Book - Research

Leman, J. K. H., Munoz-Erazo, L., & Kemp, R. A. (2020). The intestinal tumour microenvironment. In A. Birbrair (Ed.), Tumor microenvironments in organs: From the brain to the skin: Part A. (pp. 1-22). Cham, Switzerland: Springer. doi: 10.1007/978-3-030-36214-0_1

Norton, S., & Kemp, R. (2019). Computational analysis of high-dimensional mass cytometry data from clinical tissue samples. In H. M. McGuire & T. M. Ashhurst (Eds.), Mass cytometry: Methods and protocols: Methods in molecular biology (Vol. 1989). (pp. 295-308). New York, NY: Humana Press. doi: 10.1007/978-1-4939-9454-0_19

Highton, A. J., & Kemp, R. A. (2015). Immunological background. In C. Foged, T. Rades, Y. Perrie & S. Hook (Eds.), Subunit vaccine delivery. (pp. 3-14). New York: Springer. doi: 10.1007/978-1-4939-1417-3

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Journal - Research Article

Marsh-Wakefield, F. M. D., Mitchell, A. J., Norton, S. E., Ashurst, T. M., Leman, J. K. H., Roberts, J. M., Harte, J. E., … Kemp, R. A. (2021). Making the most of high-dimensional cytometry data. Immunology & Cell Biology. Advance online publication. doi: 10.1111/imcb.12456

Niemi, V., Gaskarth, D., & Kemp, R. A. (2020). Extensive variability in the composition of immune infiltrate in different mouse models of cancer. Laboratory Animal Research, 36, 43. doi: 10.1186/s42826-020-00075-9

Naciute, M., Niemi, V., Kemp, R. A., & Hook, S. (2020). Lipid-encapsulated oral therapeutic peptide vaccines reduce tumour growth in an orthotopic mouse model of colorectal cancer. European Journal of Pharmaceutics & Biopharmaceutics, 153, 183-192. doi: 10.1016/j.ejpb.2020.04.020

Lepletier, A., Lutzky, V. P., Mittal, D., Stannard, K., Watkins, T. S., Ratnatunga, C. N., … Kemp, R. A., … Miles, J. J. (2019). The immune checkpoint CD96 defines a distinct lymphocyte phenotype and is highly expressed on tumor-infiltrating T cells. Immunology & Cell Biology, 97, 152-164. doi: 10.1111/imcb.12205

Norton, S. E., Ward-Hartstonge, K. A., McCall, J. L., Leman, J. K. H., Taylor, E. S., Munro, F., Black, M. A., … Kemp, R. A. (2019). High-dimensional mass cytometric analysis reveals an increase in effector regulatory T cells as a distinguishing feature of colorectal tumors. Journal of Immunology, 202, 1871-1884. doi: 10.4049/jimmunol.1801368

Taylor, E. S., McCall, J. L., Shen, S., Girardin, A., Munro, F. M., Black, M. A., Ward-Hartstonge, K. A., & Kemp, R. A. (2018). Prognostic roles for IL-2-producing and CD69+ T cell subsets in colorectal cancer patients. International Journal of Cancer, 143(8), 2008-2016. doi: 10.1002/ijc.31598

Leman, J. K. H., Sandford, S. K., Rhodes, J. L., & Kemp, R. A. (2018). Multiparametric analysis of colorectal cancer immune responses. World Journal of Gastroenterology, 24(27), 2995-3005. doi: 10.3748/wjg.v24.i27.2995

Ward-Hartstonge, K. A., McCall, J. L., McCulloch, T. R., Kamps, A.-K., Girardin, A., Cretney, E., Munro, F. M., & Kemp, R. A. (2017). Inclusion of BLIMP-1+ effector regulatory T cells improves the Immunoscore in a cohort of New Zealand colorectal cancer patients: A pilot study. Cancer Immunology, Immunotherapy, 66(4), 515-522. doi: 10.1007/s00262-016-1951-1

Taylor, E. S., McCall, J. L., Girardin, A., Munro, F. M., Black, M. A., & Kemp, R. A. (2016). Functional impairment of infiltrating T cells in human colorectal cancer. OncoImmunology, 5(11), e1234573. doi: 10.1080/2162402X.2016.1234573

Norton, S. E., Dunn, E. T. J., McCall, J. L., Munro, F., & Kemp, R. A. (2016). Gut macrophage phenotype is dependent on the tumor microenvironment in colorectal cancer. Clinical & Translational Immunology, 5(4), e76. doi: 10.1038/cti.2016.21

Parayath, N. N., Nehoff, H., Norton, S. E., Highton, A. J., Taurin, S., Kemp, R. A., & Greish, K. (2016). Styrene maleic acid-encapsulated paclitaxel micelles: Antitumor activity and toxicity studies following oral administration in a murine orthotopic colon cancer model. International Journal of Nanomedicine, 11, 3979-3991. doi: 10.2147/IJN.S110251

Neumann, S., Shirley, S. A., Kemp, R. A., & Hook, S. M. (2016). Improved antitumor activity of a therapeutic melanoma vaccine through the use of the dual COX-2/5-LO inhibitor licofelone. Frontiers in Immunology, 7(537), 537. doi: 10.3389/fimmu.2016.00537

Dunn, E. T. J., Taylor, E. S., Stebbings, S., Schultz, M., Butt, A. G., & Kemp, R. A. (2016). Distinct immune signatures in the colon of Crohn's disease and ankylosing spondylitis patients in the absence of inflammation. Immunology & Cell Biology, 94(5), 421-429. doi: 10.1038/icb.2015.112

Highton, A. J., Girardin, A., Bell, G. M., Hook, S. M., & Kemp, R. A. (2016). Chitosan gel vaccine protects against tumour growth in an intracaecal mouse model of cancer by modulating systemic immune responses. BMC Immunology, 17, 39. doi: 10.1186/s12865-016-0178-4

Highton, A. J., Kojarunchitt, T., Girardin, A., Hook, S., & Kemp, R. A. (2015). Chitosan hydrogel vaccine generates protective CD8 T cell memory against mouse melanoma. Immunology & Cell Biology, 93, 634-640. doi: 10.1038/icb.2015.14

Norton, S. E., Ward-Hartstonge, K. A., Taylor, E. S., & Kemp, R. A. (2015). Immune cell interplay in colorectal cancer prognosis. World Journal of Gastrointestinal Oncology, 7(10), 221-232. doi: 10.4251/wjgo.v7.i10.221

Neumann, S., Burkert, K., Kemp, R., Rades, T., Dunbar, P. R., & Hook, S. (2014). Activation of the NLRP3 inflammasome is not a feature of all particulate vaccine adjuvants. Immunology & Cell Biology, 92, 535-542. doi: 10.1038/icb.2014.21

Girardin, A., McCall, J., Black, M. A., Edwards, F., Phillips, V., Taylor, E. S., Reeve, A. E., & Kemp, R. A. (2013). Inflammatory and regulatory T cells contribute to a unique immune microenvironment in tumor tissue of colorectal cancer patients. International Journal of Cancer, 132(8), 1842-1850. doi: 10.1002/ijc.27855

Schultz, M., Dunn, E., Taylor, E., Butt, G. A., & Kemp, R. (2013). The Gut Map Project: T cell distribution in inflammation of the gut. Journal of Gastroenterology & Hepatology, 28(Suppl. 3), 588. doi: 10.1111/jgh.12363_2

Kemp, R., Dunn, E., & Schultz, M. (2013). Immunomodulators in inflammatory bowel disease: An emerging role for biologic agents. BioDrugs, 27(6), 585-590. doi: 10.1007/s40259-013-0045-2

Gordon, S., Young, K., Wilson, R., Rizwan, S., Kemp, R., Rades, T., & Hook, S. (2012). Chitosan hydrogels containing liposomes and cubosomes as particulate sustained release vaccine delivery systems. Journal of Liposome Research, 22(3), 193-204. doi: 10.3109/08982104.2011.637502

Kemp, R. A., Black, M. A., McCall, J., Yoon, H.-S., Phillips, V., Anjomshoaa, A., & Reeve, A. E. (2011). T cell subpopulations in lymph nodes may not be predictive of patient outcome in colorectal cancer. Journal of Experimental & Clinical Cancer Research, 30, 78. doi: 10.1186/1756-9966-30-78

Bouwer, A. L., Netter, P., Kemp, R. A., & McLellan, A. D. (2010). A defined serum-free medium useful for monitoring anti-melanoma responses induced by dendritic cell immunotherapy. Journal of Immunological Methods, 352, 178-181. doi: 10.1016/j.jim.2009.11.001

Kemp, R. A., Pearson, C. F., Cornish, G. H., & Seddon, B. P. (2010). Evidence of STAT5-dependent and -independent routes to CD8 memory formation and a preferential role for IL-7 over IL-15 in STAT5 activation. Immunology & Cell Biology, 88, 213-219. doi: 10.1038/icb.2009.95

Ting, Y. T., Coates, T. P., Marti, H. P., Dunn, A. C., Parker, R. M., Pickering, J. W., Jack, R. W., Kemp, R. A., Walker, R. J., & McLellan, A. D. (2010). Urinary soluble HLA-DR is a potential biomarker for acute renal transplant rejection. Transplantation, 89(9), 1071-1078. doi: 10.1097/TP.0b013e3181d15492

Kemp, R. A., Bäckström, B. T., & Ronchese, F. (2005). The phenotype of type 1 and type 2 CD8+ T cells activated in vitro is affected by culture conditions and correlates with effector activity. Immunology, 115(3), 315-324. doi: 10.1111/j.1365-2567.2005.02168.x

Begg, D., Kemp, R. A., & Griffin, F. (2004). Normal levels of immunocompetence in possums (Trichosurus vulpecula) exposed to different laboratory housing conditions post capture. Immunology & Cell Biology, 82, 253-256. doi: 10.1046/j.1440-1711.2004.01219.x

Chtanova, T., Kemp, R. A., Sutherland, A., Ronchese, F., & Mackay, C. (2001). Gene microarrays reveal extensive differential gene expression in both CD4+ and CD8+ type 1 and type 2 T cells. Journal of Immunology, 167, 3057-3063.

Kemp, R. A., & Ronchese, F. (2001). Tumor-specific Tc1 but not Tc2 cells deliver protective anti-tumor immunity. Journal of Immunology, 167, 6497-6502.

Ritchie, D., Hermans, I., Lumsden, J., Scanga, C., Roberts, J., Yang, J., Kemp, R. A., & Ronchese, F. (2000). Dendritic cell elimination as an assay of cytotoxic T lymphocyte activity in vivo. Journal of Immunological Methods, 256, 109-117.

Bremer, P. J., Osborne, C. M., Smith, J. J., & Kemp, R. A. (1998). Survival of Listeria monocytogenes in seawater and affect of seawater exposure on thermal resistance. Journal of Applied Microbiology, 85(3), 545-553.

Bremer, P. J., Osborne, C. M., & Kemp, R. A. (1998). Thermal-death times of Hafnia alvei cells in a model suspension and in artifically contaminated hot smoked Kahawai (Arripis trutta). Journal of Food Protection, 61(8), 1047-1051.

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Journal - Research Other

Norton, S. E., Leman, J. K. H., Khong, T., Spencer, A., Fazekas de St Groth, B., McGuire, H. M., & Kemp, R. A. (2020). Brick plots: An intuitive platform for visualizing multiparametric immunophenotyped cell clusters. BMC Bioinformatics, 21, 145. doi: 10.1186/s12859-020-3469-y

Angus, H. C. K., Butt, A. G., Schultz, M., & Kemp, R. A. (2020). Intestinal organoids as a tool for inflammatory bowel disease research. Frontiers in Medicine, 6, 334. doi: 10.3389/fmed.2019.00334

Munoz-Erazo, L., Rhodes, J. L., Marion, V. C., & Kemp, R. A. (2020). Tertiary lymphoid structures in cancer: Considerations for patient prognosis. Cellular & Molecular Immunology, 17, 570-575. doi: 10.1038/s41423-020-0457-0

Laws, G. A., & Kemp, R. A. (2019). Probiotics and health: Understanding probiotic trials. New Zealand Medical Journal, 132(1498), 90-96. Retrieved from https://www.nzma.org.nz/journal

Sarfati, D., Jackson, C. G. C. A., Macfarlane, S., Bissett, I., Robson, B., Gurney, J., Kemp, R., … McMenamin, J. (2019). Cancer Care at a Crossroads: Time to make a choice. New Zealand Medical Journal, 132(1493), 6-11. Retrieved from https://www.nzma.org.nz/journal

Ward-Hartstonge, K. A., & Kemp, R. A. (2017). Regulatory T-cell heterogeneity and the cancer immune response. Clinical & Translational Immunology, 6, e154. doi: 10.1038/cti.2017.43

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