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Enhancing CAR T cell therapy

Researchers:


CAR-T cell therapy

CAR-T cell therapy is a treatment which utilises cells from a patient’s own immune system. T-Cells are part of the immune system which responds to specific pathogens they’re targeted to. They can be removed from the blood of a patient and grown in a laboratory.

Genes for a special antigen receptor that binds specifically to the patient’s tumour is then added to the T-Cells, making them chimeric antigen receptor (CAR) T-cells. These CAR T cells can then be infused back into a patient’s blood. The chimeric antigen receptor, specific to the patient’s tumour, then binds to the tumour, allowing the T-cells to respond to the tumour as if it were a pathogen.

Enhancing CAR T cell therapy effects

Work in the McLellan group is focusing on the addition of different genes of interest (GOI) which can be added to the CAR cassette to enhance both T cell memory and survival.

CAR-T_644
Chimeric Antigen Receptor (CAR) T cells directly attack tumour cells via surface antigens. Additional genes of interest (GOI) may be added to the CAR cassette to enhance CAR T cell memory and survival