Thursday 13 February 2020 9:46pm
The Ageing Well National Science Challenge vision is to add life to years for all older New Zealanders. This will be achieved by harnessing science to sustain health and wellbeing into the later years of life. The mission of Ageing Well is to push back disability thresholds to enable all New Zealanders to reach their full potential through the life course with particular reference to the latter years of life.
ASPIRE2025 is a partnership between major New Zealand research groups carrying out research to help achieve the Government's goal of a tobacco-free Aotearoa by 2025. ASPIRE2025 brings together leading tobacco-free researchers and health service groups in New Zealand and strengthens existing collaborations. ASPIRE2025 was awarded the status of a University of Otago Research Theme in November 2011.
The Burden of Disease Epidemiology, Equity and Cost-Effectiveness Programme has an aim to build capacity and academic rigour in New Zealand in the estimation of disease burden, cost-effectiveness and equity impacts of proposed interventions, and undertake a range of such assessments. It is a Health Research Council (HRC) funded programme, from 2010 to 2015. Major collaborative partners include the University of Queensland and the Ministry of Health.
The Cardiology Research Unit's research involves contributing to multi-centre trials, including trials of new devices for coronary angioplasty, and clinical trials of new drugs for management of heart attacks, cholesterol levels, and arrhythmia.
Local research includes assessment of biomarkers as predictors of coronary stent re-stenosis after implantation.
The Research Unit is also performing a prospective study in patients with aortic valve disease evaluating what genes might be important in the development of narrowed heart valves in older persons.
Within the Department of Physiology several laboratories conduct research concerned with the regulation of cardiovascular and respiratory function in both health and disease.
Specific areas of interest include:
- How hormonal, neuronal and intrinsic processes control the heart
- Understanding the vasculature of the lungs
- Describing calcium regulation of heart rhythms
- Identifying pathogenic mechanisms operating in diseases such as obesity, diabetes, heart failure, hypertension and cardiac arrhythmia.
The Cardiovascular Systems Laboratory, University of Otago Wellington, is a group of dedicated human integrative physiologists. Together with our collaborators, we aim to better understand the mechanisms that underpin cardiovascular disease processes such as hypertension and stroke.
- Effects of alcohol consumption of brain blood flow regulation
- Influence of tobacco smoking on dynamic cerebral autoregulation
- Mechanisms of cerebral autoregulation
- The cardiovascular effects of renal nerve ablation in resistant hypertension
- Baroreflex sensitivity and cerebral autoregulation in heart failure
Pharmacogenomics is the study of how genes influence a patient's responses to drugs. This research area is helping to clarify how genetic differences contribute to the risk of side effects or failure of drug treatment, and how we might better tailor treatment to each patient, leading to improved safety and effectiveness.
The Centre comprises a cluster of interacting research groups at the University of Otago and elsewhere, with a major focus in Christchurch. Together these groups span a wide range of clinical, pharmacological and genetic expertise. We have a strongly collaborative, multidisciplinary approach to pharmacogenomics with current research programmes in:
- Heart disease
- Mental disorders, particularly depression and bipolar disorder
- Inflammatory bowel disease
- Rheumatoid arthritis
- Asthma and airways disease
- Drugs in breast milk
We use a range of methods including pharmacokinetic and pharmacodynamic studies, analysis of genetic variation in relation to drug responses, and genomic or proteomic methods for examining molecular aspects of drug action.
We're advancing health by exploring the biology of free radicals and antioxidants.
We are an internationally-recognised leader in the field of free radical research. We apply basic scientific knowledge to underpin research into the roles of free radicals and antioxidants in human health and disease.
Our mission is to discover how free radicals and antioxidants work inside the body and how this knowledge can be used to diagnose and treat human disease and maintain optimal health.
Alongside our high quality postgraduate and research programmes, research at the School of Physiotherapy is managed through our dedicated Centre for Health, Activity, and Rehabilitation Research. Research and knowledge transfer are integral parts of the School of Physiotherapy's activities.
Research project areas:
- Physical Activity and Health
- Healthy Ageing
- Sports Concussion and Injury Prevention
- Clinical Biomechanics and Medical Technologies
The Centre for Health Systems and Technology (CHeST) has a particular focus on the applied end of health system and technology research, supporting the translation of research into practice.
CHeST features five core themes:
- Health Care Delivery
- Health System Architecture, Management, and Performance
- Health Quality, Safety, and Community Engagement
- Health Workforce
- Health Technology
The Centre for Translational Physiology (CTP) is a central research facility at the University of Otago, Wellington. It is designed to forge world-class research programmes that will accelerate the transfer of clinically-relevant scientific knowledge.
Translation of non-clinical research that results in real world clinical applications is a major challenge for biomedical researchers. With increasing sub-specialisation in both medical and basic biomedical disciplines, such knowledge transfer can become fragmented unless concerted efforts are made to promote their integration. A hallmark of those involved in the CTP is a willingness to collaborate on projects which utilise both scientific and clinical expertise. This is in recognition of the importance we believe translational physiological research provides in generating answers to clinical problems.
The following topics are of particular interest:
- Energy and metabolism
- Neurocritical care
- Cardiovascular genetics
- Exercise and environmental physiology
- Clinical physiology and biomedical engineering
- Acute and chronic airways disease
- Sleep medicine
Here at the Christchurch Heart Institute we help save thousands of lives through research into improved diagnosis, better prediction and advanced treatments for heart disease. Our team of internationally-renowned experts directly play a role in increasing the survival of New Zealanders with heart disease.
Our research is focused on:
- New blood tests for heart attack diagnosis and prognosis
- Using new methods for treating heart failure and improving outcomes
- Understanding the genetics of heart disease; why heart disease runs in some families
D4—Diagnostics, Drugs, Devices and Discovery focuses on translational research for improving care via:
- Creating novel point-of-care diagnostics and devices enabling targeted and selective treatments
- Developing smart drug delivery systems and devices to improve and optimise therapy
- Drug discovery for innovative treatments
The network draws together the disciplines of bioengineering, pharmaceutical science and drug discovery with an emphasis on collaborating with commerce and industry.
Our mission is Reducing the global burden of diabetes and obesity. We aim to reduce the prevalence, and to improve the management, of diabetes and obesity by finding new ways to prevent and treat these conditions. By striving for research excellence and encouraging international collaboration we can bring the greatest benefit to New Zealanders and the wider world. We’re sharing our discoveries with individuals, communities, teachers, health professionals and policymakers.
Genetics lies at the root of many human diseases. At Genetics Otago, we have a remarkable breadth of human genetics research studying both complex and single-gene diseases. As an example, researchers at the Cancer Genetics Laboratory are world-leaders in their field.
Our human developmental disease research provides an insight into how human embryos work, and how that is related to human health. We study both the genetics and epigenetics of human development and cell division.
Pharmocogenomics is another major area of research—this is a modern approach to understanding the side-effects of, and sensitivities to, drug treatments—by analysing the effect of a person's genes on their response to drugs.
This research aims to collect data on the current levels of established heart disease, levels of previously undiagnosed diabetes, cardiovascular disease and their risk factors in randomly-selected population samples from two diverse Maori communities, Ngati Kahungunu ki Wairoa in Hawkes Bay, and Mana Whenua ki Waitaha in Canterbury, as well as a non-Maori control group in Canterbury.
The Health, Environment and Infection Research Unit is a collaboration of researchers focused on the impact of infectious diseases and adverse environmental factors on population health. We use a range of research methods to investigate these health concerns; to identify effective interventions to reduce the burden of disease and inequalities; and to support the move to greater environmental sustainability. HEIRU aims to provide evidence-based recommendations and advice to support New Zealand and international agencies and practitioners in their disease prevention and control activities.
The Healthier Lives National Science Challenge is a national research collaboration dedicated to achieving healthier lives for all New Zealanders.
We are working on the prevention and treatment of four of New Zealand’s main non-communicable diseases:
- Cardiovascular disease
Our mission is to deliver the right prevention to the right population and the right treatment to the right patient.
The Health Promotion and Policy Research Unit aims to foster excellence in research in health promotion and public health policy. HePPRU works in collaboration with policy-makers and policy advocates to advance the good health of the peoples of Aotearoa/New Zealand through independent, critical and innovative research, teaching, and community service.
Heart Otago is comprised of cardiovascular researchers and clinicians located at the University of Otago and Dunedin Hospital. The goal of the group is to expand upon traditional cell and animal models to better understand the molecular nature of cardiac disease in patients with heart disease and to translate the laboratory-based cardiovascular research into the clinical setting.
The strong link between fundamental researchers and clinicians allows the group to study cardiac disease from genetic mutations within a single protein, through tissue and animal models, to patients presenting with a range of cardiac anomalies.
Investigations involve a wide range of techniques including:
- Cell imaging
- Genetic and biomarker screening
- Multicellular human tissue and whole animal heart function measurements
- Human and animal in vivo cardiac function via echocardiography
He Kainga Oranga, the Housing and Health Research Programme, examines and clarifies the links between Housing and Health. Although the association between poor housing and ill health is known, the links that make up the causal chain have until recently been poorly understood. Conducting our own studies and examining existing evidence enables us to identify and evaluate housing-related interventions to improve individual, family and community health. Our multi-disciplinary team has expertise in both qualitative and quantitative disciplines.
The focus of this research group, in the Centre for Postgraduate Nursing, is the development of evidence-based healthcare to minimise the impact of chronic health needs on people’s lives. Research explores symptom experience, risk assessment, preventative care and symptom control issues, with particular emphasis on the enhancement of patient self-management strategies.
MIHI is based at the University of Otago, Christchurch. We undertake and support research that explores Māori health inequities and building excellence in research evidence that contributes to Māori health advancement.
- Heart Health: The Hauora Manawa community heart study
- Medical education research
- Chronic kidney disease
- Respiratory disease
- Mental health
- Community service
We provide expertise and sequencing resources to New Zealand researchers and industry including:
- Project design and advice
- Illumina HiSeq sequencing
- Illumina MiSeq sequencing
- Nanostring nCounter Analysis System
The Otago Genomics Facility is an Illumina Propel-certified service provider for Illumina HiSeq 2500 and MiSeq sequencing platforms, and is also a Nanostring nCounter Analysis System core facility.
Four well-established and highly respected research-expertise providers have joined together under one umbrella to offer:
All the expertise, highly sophisticated instrumentation, and stellar support remains in place, as do the existing locations of services on our Dunedin campus.
The four units have collaborated on a new website as a central repository of their capabilities and achievements.
For all you need to know about what can be offered, who can help, what services, training, and specialist expertise and advice is available, please contact us.
We are a team of vascular surgeons, technologists and research staff using various diagnostic investigations to research the causes and management of vascular conditions.
The unit provides clinical diagnostic services to the Southern District Health Board, and to the wider community, to assist in the diagnosis and treatment of vascular diseases such as:
- Deep vein thrombosis
- Carotid artery disease
- Peripheral vascular disease
- Aortic aneurysms
- Varicose veins and venous ulcer
Our services include:
- Medical imaging using ultrasound to capture real-time images of blood vessels and blood flow
- Physiological testing to measure how well the vascular system is functioning both during exercise and at rest
- Treatment of varicose veins and vascular malformations using endovenous laser therapy (EVLT) and sclerotherapy
The unit is part of the Vascular Research Group and works closely with other research groups at local, national and international levels.
Talofa lava, kia orana, malo e lelei, fakaalofa lahi atu, bula vinaka, malo ni, halo ola keta, mauri, fakatalofa atu, and warm Pacific greetings!
We're celebrating our Pacific health research in the Division of Health Sciences.
Learn about what's going on in Pacific health research, how we can support researchers, and where to start if you're excited about research.
Research at the Department of Pharmacology and Toxicology uses state-of-the-art technologies, including the use of in-vivo disease models, to undertake integrative, cellular and molecular investigations aimed at understanding animal and human pathophysiology (and to delineate targets for novel drugs).
Academic and research-support staff of the Department are engaged in high quality, internationally-recognised research focused on the following themes:
- Cancer Research
- Cannabionids and Neuropathic Pain Research
- Cardiorenal and Diabetes Research
- Free Radical Research
- Neuroscience Research
- Neurotoxins / Seizures / Stroke Research
- Seizures / SUDEP / Stroke Research
- Vestibular and Auditory Research
The School of Pharmacy has a very active research programme with disciplines ranging from science to humanities.
We have three main research areas:
- Pharmaceutical Sciences: drug discovery, drug metabolism and drug action to extend the range of drugs available and to provide a scientific basis for the quality use of medicines and bioactive substances.
- Clinical Pharmacy: concerned with patient care and the optimisation of medicine use in order to promote health and wellness, and prevent disease.
- Social Pharmacy: our research focuses mainly on access to, and use of medicines.
The Division of Health Sciences promotes research excellence by encouraging the development of products, services, and policies that provide health, social, and economic benefits.
- Support for staff within the Division of Health Sciences
- Research and Enterprise Office
- Opportunities for students
- Support for emerging entrepreneurs and ideas
- Callaghan Innovation
Professor Paul Glue is Health Sciences Associate Dean for Research Commercialisation. He provides strategic overview for the Division in the translation of these discoveries into practical applications.
The Division of Health Sciences has a range of specialist research equipment, facilities, and consulting expertise available on our campuses in Dunedin, Christchurch, and Wellington. These research tools and the associated expertise are available to established and emerging researchers within the University of Otago. Many are also available to external researchers and commercial interests.
The RIPE group uses real-world data to evaluate health outcomes at a population level. The group covers a broad scope of research investigating:
- Drug utilisation
- Prescribing trends
- Prescription adherence
- Guidelines adherence
- Comparative effectiveness
Our researchers are keen in adopting initiatives to advance pharmacoepidemiological research.
Our research group is adept at using propensity score matching, marginal structural models, and disease scores risks.
The Division of Health Sciences benefits from its high calibre of staff and their wide range of skills and research expertise.
Our Staff Expertise Database provides details on University of Otago, Health Sciences staff. Each staff profile provides information on qualifications, current academic position, contact details, and a summary of research and publications.
You can search our database by keyword (eg cardiovascular) or by name.
Sport and Exercise Medicine, Dunedin School of Medicine, is the study of all human movement, injury prevention, exercise prescription, rehabilitation, and performance enhancement through nutrition, biomechanics and improved cardiorespiratory efficiency.
The prime object of this programme is to provide practising health professionals with current information on Sport and Exercise Medicine from acknowledged academic and clinical staff.
Elevated blood pressure is the strongest risk factor for stroke. It is uncertain whether lowering blood pressure in the first week after a stroke will improve or worsen clinical outcomes. Nitric oxide is a vasodilator for both cerebral and systemic blood vessels. Nitric oxide also possesses anti-apoptotic properties and directly modulates neural function.
Our trial The Efficacy of Nitric Oxide in Stroke (ENOS) has enrolled over 3,800 patients worldwide in an effort to elucidate the best way to treat hypertension in the first week after a stroke. ENOS also hopes to determine whether nitric oxide treatment will provide a clinically significant improvement in patient function 90 days post stroke.
Dr Anna Ranta’s research focuses on stroke and transient ischemic attack (TIA) epidemiology and service delivery optimisation, service integration, health equity, and knowledge translation. She is currently a stroke neurologist with Capital Coast DHB alongside her senior lecturer role with University of Otago, Wellington.
Current projects include:
- Analysis of the NZ Stroke thrombolysis register
- Assessing an atrial fibrillation electronic decision-support tool (HRC project with cardiologist Professor Ralph Stewart)
- Assessing motivational interviews post-stroke (HRC Take Charge Study)
- Assessing TIA / stroke electronic decision support in primary care including the use of TIA scores (HRC FASTEST trial)
- Evaluating NZ Telestroke pilot (MOH)
- TIA incidence in greater Auckland (ARCOS IV)
- Triple antiplatelet therapy in secondary prevention of stroke (International TARDIS trial)
Te Rōpū Rangahau Hauora a Eru Pōmare strives to create a Kaupapa Māori space committed to improving Māori health outcomes and eliminating inequalities through quality science and ongoing theoretical development. It takes a rights-based approach consistent with the Treaty of Waitangi, and is engaged with community through a spectrum of influence from community development, policy advocacy, research dissemination and Māori health research workforce development.
Members are engaged in clinical and laboratory-based research in collaboration with established research groups at University of Otago, Christchurch, and the University of Canterbury.
Clinical research themes include:
- Prioritisation for surgery
- Vascular audit and continuous quality improvement
- Clinical decision modelling in vascular surgery (focused around abdominal aortic aneurysm)
- Wound management (in collaboration with Nurse Maude)
Our research includes collaborations with the University of Canterbury Centre for Bioengineering and Biological Sciences (The Growth Dynamics of Atherosclerotic Plaque) and the Angiogenesis Research Group (University of Otago, Christchurch) and the Department of Plastic Surgery (Skin cancers in renal transplant recipients).
The Vascular Research Group, in the Department of Surgical Sciences, is headed by Professor Andre van Rij and Associate Professor Greg Jones, and conducts a wide range of research in the fields of vascular biology, genetics, and physiology.
This multidisciplinary group has a wide range of basic science and clinical skills, including molecular biology (genomics, transcriptomics, and proteomics), immunohistopathology, cell culture, and vascular physiology (ultrasonography).
The Vascular Research Group's primary research interests:
- The genetic basis of different forms of vascular disease including abdominal aortic aneurysm, coronary artery disease, lower limb arterial disease, stroke, and varicose veins
- Determining the early processes in the formation of atherosclerosis (arterial disease)
- The identification of circulating markers of vascular susceptibility and/or post-interventional outcome
- Determining the pathophysiology of venous disease
The Vascular Research Group is currently funded by the Health Research Council of New Zealand.
Our research group is a leading member of the Vascular Research Consortium of New Zealand, which aims to support collaborative vascular networks nationally.
The Virtual Health Information Network (VHIN) assists researchers to do high quality health research using the Integrated Data Infrastructure (IDI) and other administrative health data.
A deeper understanding of the IDI and increased awareness of data quality issues can be gained via our resources including:
- Website guides
- Online discussions
- Analytical code available from VHIN research
- Meetings about current IDI research
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Cardiovascular disease remains the leading cause of death, and a significant cause or morbidity in the western world. The Wellington Cardiovascular Research Group undertakes basic science projects, translational research and clinical research into ischaemic heart disease, heart failure and cardiac arrhythmia.
Our current areas of research interest include:
- Platelet reactivity and inflammation in ischaemic heart disease
- Technical aspects of interventional cardiology
- Mechanisms of ventricular arrhythmia
- Provision of implantable cardioverter defibrillator therapy
- Applications of novel imaging techniques to aid in diagnostic processes
- Scoring tools for risk stratification in cardiac disease