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Health Sciences staff profiles

Dr Benedict Seo

PositionSenior Lecturer
DepartmentDepartment of Oral Diagnostic and Surgical Sciences
Research summaryDiagnostic oral pathology; unfolded protein response, ER stress, oral cancer; molecular biology; epithelial cell culture

Research

Dr Seo investigates the pathogenesis of oral cancer, odontogenic lesions and immune-mediated oral diseases, with a particular focus on unfolded protein response (UPR) and endoplasmic reticulum (ER) stress. Techniques such as qRT2-PCR, IHC, histochemistry, western blot, cell culture and in vitro assays (viability, caspase-based, TUNEL) are employed in his research. He has an active research partnership with the University of Malaysia, Oral Cancer Research and Coordination Centre and the National University of Malaysia, as well as with Dunedin Public Hospital.

Dr Seo is also a reviewer for the Journal of Periodontal Research, Pathology and BMC Oral Health.

He received the Oral Presentation Award from the International Association of Oral Pathologists (IAOP), Elman Poole Fellowship, International Association for Dental Research-Colgate Postgraduate Award and Sir Thomas Hunter Scholarship, amongst others.

Publications

Firth, F. A., Milne, T. J., Seo, B., & Farella, M. (2020). An in-vitro mechanical strain three-dimensional culture model: Periodontal ligament cell viability, apoptosis, and endoplasmic reticulum stress response. European Journal of Oral Sciences, 128, 120-127. doi: 10.1111/eos.12681

Guan, G., Mei, L., Polonowita, A., Hussaini, H., Seo, B., & Rich, A. M. (2020). Malignant transformation in oral lichen planus and lichenoid lesions: A 14-year longitudinal cohort study of 829 patients in New Zealand. Oral Surgery, Oral Medicine, Oral Pathology & Oral Radiology. Advance online publication. doi: 10.1016/j.oooo.2020.07.002

Yu, Z., Seo, B., Hussaini, H. M., Meldrum, A. M., & Rich, A. M. (2020). The relative frequency of paediatric oral and maxillofacial pathology in New Zealand: A 10-year review of a national specialist centre. International Journal of Paediatric Dentistry, 30, 209-215. doi: 10.1111/ipd.12590

McElroy, K. E., Seo, B. L., Hussaini, H. M., & Rich, A. M. (2020). Graft versus host disease: Cases from New Zealand with oral manifestations. New Zealand Dental Journal, 116(2), 47-54.

Rich, A. M., Hussaini, H. M., Seo, B., & Zain, R. B. (2020). Understanding the complex microenvironment in oral cancer: The contribution of the Faculty of Dentistry, University of Otago over the last 100 years. Journal of the Royal Society of New Zealand, 50(1), 15-34. doi: 10.1080/03036758.2020.1736586

Journal - Research Article

Firth, F. A., Milne, T. J., Seo, B., & Farella, M. (2020). An in-vitro mechanical strain three-dimensional culture model: Periodontal ligament cell viability, apoptosis, and endoplasmic reticulum stress response. European Journal of Oral Sciences, 128, 120-127. doi: 10.1111/eos.12681

McElroy, K. E., Seo, B. L., Hussaini, H. M., & Rich, A. M. (2020). Graft versus host disease: Cases from New Zealand with oral manifestations. New Zealand Dental Journal, 116(2), 47-54.

Yu, Z., Seo, B., Hussaini, H. M., Meldrum, A. M., & Rich, A. M. (2020). The relative frequency of paediatric oral and maxillofacial pathology in New Zealand: A 10-year review of a national specialist centre. International Journal of Paediatric Dentistry, 30, 209-215. doi: 10.1111/ipd.12590

Guan, G., Mei, L., Polonowita, A., Hussaini, H., Seo, B., & Rich, A. M. (2020). Malignant transformation in oral lichen planus and lichenoid lesions: A 14-year longitudinal cohort study of 829 patients in New Zealand. Oral Surgery, Oral Medicine, Oral Pathology & Oral Radiology. Advance online publication. doi: 10.1016/j.oooo.2020.07.002

Al-Hassiny, A., Hussani, H., Milne, T., Seo, B., Rich, A. M., & Friedlander, L. T. (2019). Vascularity and angiogenic signaling in the dentine-pulp complex of immature and mature permanent teeth. European Endodontic Journal, 4(2), 80-85. doi: 10.14744/eej.2019.26349

Yakin, M., Seo, B., & Rich, A. (2019). Tunicamycin-induced endoplasmic reticulum stress up-regulates tumour-promoting cytokines in oral squamous cell carcinoma. Cytokine, 120, 130-143. doi: 10.1016/j.cyto.2019.04.013

Al-Hassiny, A., Friedlander, L. T., Parachuru, V. P. B., Seo, B., Hussaini, H. M., & Rich, A. M. (2018). Upregulation of angiogenesis in oral lichen planus. Journal of Oral Pathology & Medicine, 47(2), 173-178. doi: 10.1111/jop.12665

Seo, B., Hussaini, H. M., & Rich, A. M. (2017). Second opinion oral pathology referrals in New Zealand. Pathology, 49(3), 277-284. doi: 10.1016/j.pathol.2016.11.007

Kazantseva, M., Hung, N. A., Mehta, S., Roth, I., Eiholzer, R., Rich, A. M., Seo, B., Baird, M. A., Braithwaite, A. W., & Slatter, T. L. (2017). Tumor protein 53 mutations are enriched in diffuse large B-cell lymphoma with irregular CD19 marker expression. Scientific Reports, 7, 1566. doi: 10.1038/s41598-017-01800-6

Seo, B., Coates, D. E., Seymour, G. J., & Rich, A. M. (2016). Unfolded protein response-related gene regulation in inflamed periodontal tissues with and without Russell bodies. Archives of Oral Biology, 69, 1-6. doi: 10.1016/j.archoralbio.2016.04.009

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Journal - Research Other

Rich, A. M., Hussaini, H. M., Seo, B., & Zain, R. B. (2020). Understanding the complex microenvironment in oral cancer: The contribution of the Faculty of Dentistry, University of Otago over the last 100 years. Journal of the Royal Society of New Zealand, 50(1), 15-34. doi: 10.1080/03036758.2020.1736586

Yakin, M., Seo, B., Hussaini, H., Rich, A., & Hunter, K. (2019). Human papillomavirus and oral and oropharyngeal carcinoma: The essentials. Australian Dental Journal, 64, 11-18. doi: 10.1111/adj.12652

Rich, A. M., Seo, B., Parachuru, V., & Hussaini, H. M. (2017). The nexus between periodontics and oral pathology. Periodontology 2000, 74(1), 176-181. doi: 10.1111/prd.12197

Goldsmith, S. M., Seo, B. L., de Silva, R. K., Parachuru, P., Rich, A. M., & Seymour, G. J. (2014). Oral mycosis fungoides: Report with immune profile. Oral Surgery, Oral Medicine, Oral Pathology & Oral Radiology, 118(2), e48-e52. doi: 10.1016/j.oooo.2013.10.005

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