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Health Sciences staff profiles

Dr Jithendra Ratnayake

PositionLecturer / Biomaterials
DepartmentDepartment of Oral Sciences
QualificationsBEng(Hons) (Sheffield) PhD (Otago)
Research summaryBiomaterials and regenerative medicine
TeachingOral biology, biomaterials and bioengineering
Memberships
  • International Association of Dental Research (IADR)
  • European Society of Biomaterials (ESB)
  • Australasian Society for Biomaterials & Tissue Engineering (ASBTE)
  • Materials Research Society (MRS)

Research

My main area of research is focused on developing novel biomaterials from waste resources for biomedical applications.

I became interested in adding value to the waste products from New Zealand’s annual $NZ6 billion red meat export industry. I have significant expertise in characterising biomaterials using various analytical techniques and evaluating the biocompatibility using in-vitro and in-vivo techniques.

My secondary research interests lie in the field of developing medical devices, dental materials, management of temporomandibular disorders, endodontic applications and treatments, restorative dentistry and dental education.

Current research strategies are focused on:

  1. Developing novel bone grafts from bovine and Ovine bone for bone regeneration applications
  2. Developing bio-composite materials for biomedical applications (wound dressing, cleft lip palate repair, and orthopaedic applications)
  3. Development and testing of a bovine-derived nanohydroxyapatite toothpaste for caries management
  4. Development of a novel hydroxyapatite-based vital pulp therapy material synthesized from waste bovine bone
  5. A novel approach for the diagnosis and monitoring of temporomandibular disorders

I have commercial collaborations with Colgate Palmolive Ltd, ANZCO foods and Intuitive 8 Healthcare LLC (India) and Universities in the UK, Australia, Saudi Arabia, China, Sri Lanka and the USA.

Additional details

I am a member of the Sir John Walsh Research Institute (SJWRI) at the Faculty of Dentistry. I collaborate with Professor Paul Brunton (Pro-Vice-Chancellor Health Sciences), Professor George Dias (Department of Anatomy) and Professor Paul Cooper.

In 2017 I concluded my PhD on Developing a novel bone graft from New Zealand sourced bovine bone at the Department of Anatomy, from which a provisional patent was filed. Before my PhD, I completed a Bachelor of Biomaterial Science and Tissue Engineering (Hons) at the University of Sheffield, UK, where I was awarded the Sheffield Graduate Award for the most outstanding student in the Department of Materials Science and Engineering.

Before moving to New Zealand, I served in the British and Sri Lankan military. Outside of work, you can find me on the cricket field.

Publications

Khurshid, Z., Asiri, F. Y. I., Najeeb, S., & Ratnayake, J. (2022). The impact of autologous platelet concentrates on the periapical tissues and root development of replanted teeth: A systematic review. Materials, 15, 2776. doi: 10.3390/ma15082776

Yong, D., Choi, J. J. E., Cathro, P., Cooper, P. R., Dias, G., Huang, J., & Ratnayake, J. (2022). Development and analysis of a hydroxyapatite supplemented calcium silicate cement for endodontic treatment. Materials, 15(3), 1176. doi: 10.3390/ma15031176

Kumar Yadalam, P., Madapusi Balaji, T., Varadarajan, S., Alzahrani, K. J., Al-Ghamdi, M. S., Ali Baeshen, H., … Ratnayake, J., & Patil, S. (2022). Assessing the therapeutic potential of angomelatine, ramelteon, and melatonin against SARS-Cov-2. Saudi Journal of Biological Sciences. Advance online publication. doi: 10.1016/j.sjbs.2022.01.049

Ratnayake, J., Guan, G., Polonowita, A., Gray, A. R., Loch, C., Li, K. C., Waddell, J. N., Lyons, K., & Brunton, P. A. (2022). Measuring changes in jaw opening forces to assess the degree of improvement in patients with temporomandibular disorders. Applied Sciences, 12(3), 1224. doi: 10.3390/app12031224

Arora, S., Cooper, P. R., Ratnayake, J. T., Friedlander, L. T., Rizwan, S. B., Seo, B., & Hussaini, H. M. (2022). A critical review of in vitro research methodologies used to study mineralization in human dental pulp cell cultures. International Endodontic Journal, 55(Suppl. 1), 3-13. doi: 10.1111/iej.13684

Ramesh, N., Ratnayake, J. T. B., & Dias, G. J. (2021). Calcium-based ceramic biomaterials. In C. Wen (Ed.), Structural biomaterials: Properties, characteristics, and selection. (pp. 333-394). Duxford, UK: Woodhead Publishing. doi: 10.1016/B978-0-12-818831-6.00011-2

Chapter in Book - Research

Kumar Yadalam, P., Madapusi Balaji, T., Varadarajan, S., Alzahrani, K. J., Al-Ghamdi, M. S., Ali Baeshen, H., … Ratnayake, J., & Patil, S. (2022). Assessing the therapeutic potential of angomelatine, ramelteon, and melatonin against SARS-Cov-2. Saudi Journal of Biological Sciences. Advance online publication. doi: 10.1016/j.sjbs.2022.01.049

Journal - Research Article

Ratnayake, J., Guan, G., Polonowita, A., Gray, A. R., Loch, C., Li, K. C., Waddell, J. N., Lyons, K., & Brunton, P. A. (2022). Measuring changes in jaw opening forces to assess the degree of improvement in patients with temporomandibular disorders. Applied Sciences, 12(3), 1224. doi: 10.3390/app12031224

Journal - Research Article

Yong, D., Choi, J. J. E., Cathro, P., Cooper, P. R., Dias, G., Huang, J., & Ratnayake, J. (2022). Development and analysis of a hydroxyapatite supplemented calcium silicate cement for endodontic treatment. Materials, 15(3), 1176. doi: 10.3390/ma15031176

Journal - Research Article

Aghoghovwia, B. E., Okpe, O., McIntyre, E. A., Taniyohwo, E. M., & Ratnayake, J. T. (2021). A Brief Review on Erythropoietin and Mesenchymal Stem Cell Therapies for Paediatric Neurological Disorders. Current Stem Cell Reports. Advance online publication. doi: 10.1007/s40778-021-00189-3

Journal - Research Article

Brunton, P. A., Ratnayake, J., Bodansky, H. J., Mei, L., Veerasamy, A., & Hall, R. (2021). An intraoral device for weight loss: Initial clinical findings. British Dental Journal. Advance online publication. doi: 10.1038/s41415-021-3081-1

Journal - Research Article

Ngah, N. A., Dias, G. J., Tong, D. C., Mohd Noor, S. N. F., Ratnayake, J., Cooper, P. R., & Hussaini, H. M. (2021). Lyophilised platelet-rich fibrin: Physical and biological characterisation. Molecules, 26(23), 7131. doi: 10.3390/molecules26237131

Journal - Research Article

Olson, H., Ratnayake, J., Senthilkumar, A., Quaranta, A., & Meldrum, A. (2021). Working characteristics for practicing dental hygienists in two countries in different hemispheres. International Journal of Dental Hygiene. Advance online publication. doi: 10.1111/idh.12538

Journal - Research Article

Huang, J., Ratnayake, J., Ramesh, N., & Dias, G. J. (2020). Development and characterization of a biocomposite material from chitosan and New Zealand-sourced bovine-derived hydroxyapatite for bone regeneration. ACS Omega, 5, 16537-16546. doi: 10.1021/acsomega.0c01168

Journal - Research Article

Ramesh, N., Ratnayake, J. T. B., Moratti, S. C., & Dias, G. J. (2020). Effect of chitosan infiltration on hydroxyapatite scaffolds derived from New Zealand bovine cancellous bones for bone regeneration. International Journal of Biological Macromolecules, 160, 1009-1020. doi: 10.1016/j.ijbiomac.2020.05.269

Journal - Research Article

Ratnayake, J. T., Ross, E. D., Dias, G. J., Shanafelt, K. M., Taylor, S. S., Gould, M. L., Guan, G., & Cathro, P. R. (2020). Preparation, characterisation and in-vitro biocompatibility study of a bone graft developed from waste bovine teeth for bone regeneration. Materials Today Communications, 22, 100732. doi: 10.1016/j.mtcomm.2019.100732

Journal - Research Article

Ratnayake, J., Guan, G., Polonowita, A., Li, K. C., Gray, A., Waddell, J. N., Loch, C., & Brunton, P. A. (2020). Can the measurement of jaw-opening forces assist in the diagnosis of temporomandibular disorders? Journal of Oral & Facial Pain & Headache, 34(3), 199-205. doi: 10.11607/ofph.2587

Journal - Research Article

Sarfaraz, S., Shabbir, J., Mudasser, M. A., Khurshid, Z., Al-Quraini, A. A. A., Abbasi, M. S., Ratnayake, J., & Zafar, M. S. (2020). Knowledge and attitude of dental practitioners related to disinfection during the COVID-19 pandemic. Healthcare, 8(3), 232. doi: 10.3390/healthcare8030232

Journal - Research Article

Brunton, P. A., Ratnayake, J., Loch, C., Veerasamy, A., Cathro, P., & Lee, R. (2019). Indirect restorations and fixed prosthodontics: Materials and techniques used by general dentists of New Zealand. International Journal of Dentistry, 2019, 5210162. doi: 10.1155/2019/5210162

Journal - Research Article

Loch, C., Ratnayake, J., Veerasamy, A., Cathro, P., Lee, R., & Brunton, P. A. (2019). Direct restorations, endodontics, and bleaching: Materials and techniques used by general dentists of New Zealand. International Journal of Dentistry, 2019, 6327171. doi: 10.1155/2019/6327171

Journal - Research Article

Lu, E. M.-C., Ratnayake, J., & Rich, A. M. (2019). Assessment of proliferating cell nuclear antigen (PCNA) expression at the invading front of oral squamous cell carcinoma. BMC Oral Health, 19, 233. doi: 10.1186/s12903-019-0928-9

Journal - Research Article

Race, J., Zilm, P., Ratnayake, J., Fitzsimmons, T., Marchant, C., & Cathro, P. (2019). Efficacy of laser and ultrasonic-activated irrigation on eradicating a mixed-species biofilm in human mesial roots. Australian Endodontic Journal, 45, 317-324. doi: 10.1111/aej.12334

Journal - Research Article

Smith, A., Scott, I., Ratnayake, J., Newsham-West, K., & Cathro, P. (2019). An intervention study: Does a cognitive reappraisal technique reduce the perceived stress in fourth-year dental students in New Zealand? International Journal of Dentistry, 2019, 5864591. doi: 10.1155/2019/5864591

Journal - Research Article

Lee, R. J., Ratnayake, J., Veerasamy, A., Loch, C., Cathro, P., & Brunton, P. A. (2018). Demographics, practising arrangements, and standards: Survey among New Zealand dentists. International Journal of Dentistry, 2018, 7675917. doi: 10.1155/2018/7675917

Journal - Research Article

Plutzer, B., Zilm, P., Ratnayake, J., & Cathro, P. (2018). Comparative efficacy of endodontic medicaments & sodium hypochlorite against Enterococcus faecalis biofilms. Australian Dental Journal, 63(2), 208-216. doi: 10.1111/adj.12580

Journal - Research Article

Stenhouse, M., Zilm, P., Ratnayake, J., & Cathro, P. (2018). Investigation of the effect of rapid and slow external pH increases on Enterococcus faecalis biofilm grown on dentine. Australian Dental Journal, 63(2), 224-230. doi: 10.1111/adj.12582

Journal - Research Article

Wang, S., Cathro, P., Heithersay, G., Briggs, N., Ratnayake, J., & Zilm, P. (2018). A colorimetric evaluation of the effect of bacterial contamination on teeth stained with blood in vitro: Evaluation of the efficacy of two different bleaching regimes. Australian Dental Journal, 63(2), 253-260. doi: 10.1111/adj.12604

Journal - Research Article

Ratnayake, J. T. B., Gould, M. L., Shavandi, A., Mucalo, M., & Dias, G. J. (2017). Development and characterization of a xenograft material from New Zealand sourced bovine cancellous bone. Journal of Biomedical Materials Research Part B, 105(5), 1054-1062. doi: 10.1002/jbm.b.33644

Journal - Research Article

Ratnayake, J. T. B., Mucalo, M., & Dias, G. J. (2017). Substituted hydroxyapatites for bone regeneration: A review of current trends. Journal of Biomedical Materials Research Part B, 105(5), 1285-1299. doi: 10.1002/jbm.b.33651

Journal - Research Article

Shavandi, A., Bekhit, A. E.-D. A., Ali, A., Sun, Z., & Ratnayake, J. T. (2015). Microwave-assisted synthesis of high purity β-tricalcium phosphate crystalline powder from the waste of Green mussel shells (Perna canaliculus). Powder Technology, 273, 33-39. doi: 10.1016/j.powtec.2014.12.029

Journal - Research Article

Arora, S., Cooper, P. R., Ratnayake, J. T., Friedlander, L. T., Rizwan, S. B., Seo, B., & Hussaini, H. M. (2022). A critical review of in vitro research methodologies used to study mineralization in human dental pulp cell cultures. International Endodontic Journal, 55(Suppl. 1), 3-13. doi: 10.1111/iej.13684

Journal - Research Other

Khurshid, Z., Asiri, F. Y. I., Najeeb, S., & Ratnayake, J. (2022). The impact of autologous platelet concentrates on the periapical tissues and root development of replanted teeth: A systematic review. Materials, 15, 2776. doi: 10.3390/ma15082776

Journal - Research Other

Chen, L., Al-Bayatee, S., Khurshid, Z., Shavandi, A., Brunton, P., & Ratnayake, J. (2021). Hydroxyapatite in oral care products: A review. Materials, 14, 4865. doi: 10.3390/ma14174865

Journal - Research Other

Ngah, N. A., Ratnayake, J., Cooper, P. R., Dias, G. J., Tong, D. C., Mohd Noor, S. N. F., & Hussaini, H. M. (2021). Potential of lyophilized platelet concentrates for craniofacial tissue regenerative therapies. Molecules, 26, 517. doi: 10.3390/molecules26030517

Journal - Research Other

Oliveira, É. R., Nie, L., Podstawczyk, D., Allahbakhsh, A., Ratnayake, J., Brasil, D. L., & Shavandi, A. (2021). Advances in growth factor delivery for bone tissue engineering. International Journal of Molecular Sciences, 22, 903. doi: 10.3390/ijms22020903

Journal - Research Other

Ratnayake, J. (2021). [Review of the book The tongue]. New Zealand Dental Journal, 117(3), 158. [Book Review].

Journal - Research Other

Zhao, R., Yang, R., Cooper, P. R., Khurshid, Z., Shavandi, A., & Ratnayake, J. (2021). Bone grafts and substitutes in dentistry: A review of current trends and developments. Molecules, 26(10), 3007. doi: 10.3390/molecules26103007

Journal - Research Other

Feroz, S., Muhammad, N., Ratnayake, J., & Dias, G. (2020). Keratin-based materials for biomedical applications. Bioactive Materials, 5(3), 496-509. doi: 10.1016/j.bioactmat.2020.04.007

Journal - Research Other

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