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7 June 2017, Being overweight or obese in childhood closely linked to heart health risk in middle age: Otago research


Wednesday, 7 June 2017

Michael Williams image
Professor Michael Williams

Being overweight or obese from as early as three years of age is associated with measures of cardiovascular risk in early midlife, according to new findings from the world-renowned Dunedin Study.

The Study has closely tracked nearly every aspect of the health and development of more than 1,000 people born in Dunedin in 1972-73 until the present day. This latest research from the internationally lauded longitudinal study appears in the International Journal of Obesity.

Lead author of the new research paper, Professor Michael Williams, says that being overweight or obese in adulthood is a known risk factor for developing cardiovascular disease, which is the number one cause of death worldwide.

Endothelial dysfunction (a disease of the inner lining of blood vessels) was used to measure cardiovascular risk at age 38 in the Study members. Using body mass index information collected at ages 3, 5, 7, 9, 11, 13, 15, 18, 21, 26, 32 and 38 years, researchers identified people as belonging to one of four different weight groups. Compared to those of normal weight, those children who were in the overweight, obese, or severely obese groups over time were more likely to develop endothelial dysfunction by age 38.

“Our research indicates that children who were overweight or obese at age three, or were in overweight or obese trajectory groups from that age to 38, are at higher risk of developing cardiovascular disease, says Professor Williams.

“These findings are important because determining an association early on may help provide further impetus for interventions to prevent overweight and obesity beginning in early childhood with the goal of improving long-term cardiovascular health,” he says.

The study also showed that endothelial dysfunction at age 38 years was associated with poorer physical fitness and other measures of cardiovascular risk such as lower high-density cholesterol levels - otherwise known as “good” cholesterol - and markers of inflammation at age 38.

Professor Williams says “overall, our findings suggest an early influence of overweight or obesity on long-term cardiovascular risk”.

According to a recent New Zealand health survey, one in nine children (11 per cent) are obese and a further 21 per cent are overweight.

“This means we are facing a real time-bomb in terms of the potentially enormous burden of ill-health in a substantial proportion of our population,” he says.

This research was supported by the New Zealand Health Research Council, the New Zealand Ministry of Business, Innovation and Employment, the US National Institute on Aging, and the UK Medical Research Council.

Publication details:
Childhood body mass index and endothelial dysfunction evaluated by peripheral arterial tonometry in early midlife
Michael J A Williams, Barry J Milne, Antony Ambler, Reremoana Theodore, Sandhya
Ramrakha, Avshalom Caspi, Terrie E Moffitt, Richie Poulton. International Journal of Obesity. doi:10.1038/ijo.2017.108.

For more information, contact:

Professor Michael Williams
Department of Medicine
Dunedin School of Medicine
University of Otago
Tel 03 474 0999

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