Accessibility Skip to Global Navigation Skip to Local Navigation Skip to Content Skip to Search Skip to Site Map Menu

DSM staff profile

Dr Sean Coffey

PositionSenior Lecturer
DepartmentDepartment of Medicine (Dunedin)
QualificationsMB BS FRACP Phd
Research summaryCardiovascular medicine
Clinical
  • Clinical cardiology
  • Cardiovascular imaging – echocardiography, cardiac CT, and cardiac MRI

Research

I am interested in many aspects of cardiovascular medicine, especially valvular heart disease, but also ischaemic heart disease, cardiomyopathies, and atrial fibrillation.

To tackle these, I, along with collaborators, use basic science techniques in molecular biology and genomics, population based approaches, and advanced phenotyping techniques using echocardiography, cardiac CT, and cardiac MRI. We have started running clinical trials in-house, with the aim of developing therapies for testing in wider clinical settings.

Publications

Aitken-Buck, H. M., Krause, J., van Hout, I., Davis, P. J., Bunton, R. W., Parry, D. J., Williams, M. J. A., Coffey, S., … Jones, P. P., & Lamberts, R. R. (2021). Long-chain acylcarnitine 18:1 acutely increases human atrial myocardial contractility and arrhythmia susceptibility. American Journal of Physiology: Heart & Circulatory Physiology, 321, H162-H174. doi: 10.1152/ajpheart.00184.2021

Coffey, S., Roberts-Thomson, R., Brown, A., Carapetis, J., Chen, M., Enriquez-Sarano, M., … Prendergast, B. D. (2021). Global epidemiology of valvular heart disease. Nature Reviews Cardiology. Advance online publication. doi: 10.1038/s41569-021-00570-z

Vernon, S. T., Kott, K. A., Hansen, T., Zhang, K. J., Cole, B. R., Coffey, S., … Figtree, G. A. (2021). Coronary artery disease burden in women poorly explained by traditional risk factors: Sex disaggregated analyses from the BioHEART-CT Study. Atherosclerosis. Advance online publication. doi: 10.1016/j.atherosclerosis.2021.05.004

Munro, M. L., van Hout, I., Aitken-Buck, H., Sugunesegran, R., Bhagwat, K., Davis, P. J., Lamberts, R. R., Coffey, S., … Jones, P. P. (2021). Human atrial fibrillation is not associated with remodeling of ryanodine receptor clusters. Frontiers in Cell & Developmental Biology, 9, 633704. doi: 10.3389/fcell.2021.633704

Forshaw, A., Younger, J. F., Coffey, S., & Whalley, G. A. (2021). Is Australasia ready for sonographer-led stress echocardiography? Heart, Lung & Circulation. Advance online publication. doi: 10.1016/j.hlc.2021.03.002

Aitken-Buck, H. M., Krause, J., van Hout, I., Davis, P. J., Bunton, R. W., Parry, D. J., Williams, M. J. A., Coffey, S., … Jones, P. P., & Lamberts, R. R. (2021). Long-chain acylcarnitine 18:1 acutely increases human atrial myocardial contractility and arrhythmia susceptibility. American Journal of Physiology: Heart & Circulatory Physiology, 321, H162-H174. doi: 10.1152/ajpheart.00184.2021

Journal - Research Article

Frisk, M., Le, C., Shen, X., Røe, Å., Hou, Y., Manfra, O., … van Hout, I., … Lamberts, R. R., … Coffey, S., … Jones, P. P., … Louch, W. E. (2021). Etiology-dependent impairment of diastolic cardiomyocyte calcium homeostasis in heart failure with preserved ejection fraction. JACC, 77(4), 405-419. doi: 10.1016/j.jacc.2020.11.044

Journal - Research Article

Munro, M. L., van Hout, I., Aitken-Buck, H., Sugunesegran, R., Bhagwat, K., Davis, P. J., Lamberts, R. R., Coffey, S., … Jones, P. P. (2021). Human atrial fibrillation is not associated with remodeling of ryanodine receptor clusters. Frontiers in Cell & Developmental Biology, 9, 633704. doi: 10.3389/fcell.2021.633704

Journal - Research Article

Purvis, N., Kumari, S., Chandrasekera, D., Bellae Papannarao, J., Gandhi, S., van Hout, I., Coffey, S., Bunton, R., Sugunesegran, R., Parry, D., Davis, P., Williams, M. J. A., Bahn, A., & Katare, R. (2021). Diabetes induces dysregulation of microRNAs associated with survival, proliferation and self-renewal in cardiac progenitor cells. Diabetologia. Advance online publication. doi: 10.1007/s00125-021-05405-7

Journal - Research Article

Saw, E. L., Pearson, J. T., Schwenke, D. O., Munasinghe, P. E., Tsuchimochi, H., Rawal, S., Coffey, S., … Bunton, R., Van Hout, I., … Williams, M. J. A., … Fronius, M., & Katare, R. (2021). Activation of the cardiac non-neuronal cholinergic system prevents the development of diabetes-associated cardiovascular complications. Cardiovascular Diabetology, 20, 50. doi: 10.1186/s12933-021-01231-8

Journal - Research Article

Vernon, S. T., Kott, K. A., Hansen, T., Zhang, K. J., Cole, B. R., Coffey, S., … Figtree, G. A. (2021). Coronary artery disease burden in women poorly explained by traditional risk factors: Sex disaggregated analyses from the BioHEART-CT Study. Atherosclerosis. Advance online publication. doi: 10.1016/j.atherosclerosis.2021.05.004

Journal - Research Article

Aitken-Buck, H. M., Babakr, A. A., Fomison-Nurse, I. C., van Hout, I., Davis, P. J., Bunton, R. W., Williams, M. J. A., Coffey, S., Jones, P. P., & Lamberts, R. R. (2020). Inotropic and lusitropic, but not arrhythmogenic, effects of adipocytokine resistin on human atrial myocardium. American Journal of Physiology: Endocrinology & Metabolism. Advance online publication. doi: 10.1152/ajpendo.00202.2020

Journal - Research Article

Babakr, A. A., Fomison-Nurse, I. C., van Hout, I., Aitken-Buck, H. M., Sugunesegran, R., Davis, P. J., Bunton, R. W., Williams, M. J. A., Coffey, S., Stiles, M. K., Jones, P. P., & Lamberts, R. R. (2020). Acute interaction between human epicardial adipose tissue and human atrial myocardium induce arrhythmic susceptibility. American Journal of Physiology: Endocrinology & Metabolism, 318, E164-E172. doi: 10.1152/ajpendo.00374.2019

Journal - Research Article

Chandrasekera, D. N. K., Neale, J. P. H., van Hout, I., Rawal, S., Coffey, S., Jones, G. T., … Manning, P., Williams, M. J. A., & Katare, R. (2020). Upregulation of microRNA-532 enhances cardiomyocyte apoptosis in the diabetic heart. Apoptosis, 25(5-6), 388-399. doi: 10.1007/s10495-020-01609-1

Journal - Research Article

Jones, G. T., Drinkwater, B., Blake-Barlow, A., Hill, G. B., Williams, M. J. A., Krysa, J., van Rij, A. M., & Coffey, S. (2020). Both small and large infrarenal aortic size is associated with an increased prevalence of ischaemic heart disease. European Journal of Vascular & Endovascular Surgery, 60, 594-601. doi: 10.1016/j.ejvs.2020.06.025

Journal - Research Article

Moharram, M. A., Aitken-Buck, H. M., Reijers, R., van Hout, I., Williams, M. J. A., Jones, P. P., Whalley, G. A., Lamberts, R. R., & Coffey, S. (2020). Correlation between epicardial adipose tissue and body mass index in New Zealand ethnic populations. New Zealand Medical Journal, 133(1516), 22-32. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Moharram, M. A., Wilson, L. C., Williams, M. J. A., & Coffey, S. (2020). Beat-to-beat blood pressure measurement using a cuffless device does not accurately reflect invasive blood pressure. International Journal of Cardiology Hypertension, 5, 100030. doi: 10.1016/j.ijchy.2020.100030

Journal - Research Article

Thavapalachandran, S., Grieve, S. M., Hume, R. D., Le, T. Y. L., Raguram, K., Hudson, J. E., … Coffey, S., … Chong, J. J. H. (2020). Platelet-derived growth factor-AB improves scar mechanics and vascularity after myocardial infarction. Science Translational Medicine, 12(524), eaay2140. doi: 10.1126/scitranslmed.aay2140

Journal - Research Article

Aitken-Buck, H. M., Babakr, A. A., Coffey, S., Jones, P. P., Tse, R. D., & Lamberts, R. R. (2019). Epicardial adipocyte size does not correlate with body mass index. Cardiovascular Pathology, 43, 107144. doi: 10.1016/j.carpath.2019.07.003

Journal - Research Article

Aitken-Buck, H. M., Moharram, M., Babakr, A. A., Reijers, R., Van Hout, I., Fomison-Nurse, I. C., Sugunesegran, R., … Bunton, R. W., Williams, M. J. A., … Jones, P. P., Coffey, S., & Lamberts, R. R. (2019). Relationship between epicardial adipose tissue thickness and epicardial adipocyte size with increasing body mass index. Adipocyte, 8(1), 412-420. doi: 10.1080/21623945.2019.1701387

Journal - Research Article

Leader, C. J., Moharram, M., Coffey, S., Sammut, I. A., Wilkins, G., & Walker, R. J. (2019). Myocardial global longitudinal strain: An early indicator of cardiac interstitial fibrosis modified by spironolactone, in a unique hypertensive rat model. PLoS ONE, 14(8), e0220837. doi: 10.1371/journal.pone.0220837

Journal - Research Article

Rawal, S., Nagesh, P. T., Coffey, S., Van Hout, I., Galvin, I. F., Bunton, R. W., Davis, P., Williams, M. J. A., & Katare, R. (2019). Early dysregulation of cardiac-specific microRNA-208a is linked to maladaptive cardiac remodelling in diabetic myocardium. Cardiovascular Diabetology, 18, 13. doi: 10.1186/s12933-019-0814-4

Journal - Research Article

Vernon, S. T., Coffey, S., D'Souza, M., Chow, C. K., Kilian, J., Hyun, K., … Figtree, G. A. (2019). ST-segment-elevation myocardial infarction (STEMI) patients without standard modifiable cardiovascular risk factors: How common are they, and what are their outcomes? Journal of the American Heart Association, 8(21), e013296. doi: 10.1161/JAHA.119.013296

Journal - Research Article

Gardezi, S. K. M., Coffey, S., Prendergast, B. D., & Myerson, S. G. (2018). Serum biomarkers in valvular heart disease. Heart, 104(4), 349-358. doi: 10.1136/heartjnl-2016-310482

Journal - Research Article

Gardezi, S. K. M., Myerson, S. G., Chambers, J., Coffey, S., d'Arcy, J., Hobbs, F. D. R., … Prendergast, B. D. (2018). Cardiac auscultation poorly predicts the presence of valvular heart disease in asymptomatic primary care patients. Heart, 104(22), 1832-1835. doi: 10.1136/heartjnl-2018-313082

Journal - Research Article

Coffey, S., Harper, A. R., Cairns, B. J., Roberts, I. S. D., & Prendergast, B. D. (2017). Clinical information has low sensitivity for postmortem diagnosis of heart valve disease. Heart, 103(13), 1031-1035. doi: 10.1136/heartjnl-2016-310718

Journal - Research Article

Coffey, S., Lewandowski, A. J., Garratt, S., Meijer, R., Lynum, S., Bedi, R., … Leeson, P. (2017). Protocol and quality assurance for carotid imaging in 100,000 participants of UK Biobank: Development and assessment. European Journal of Preventive Cardiology, 24(17), 1799-1806. doi: 10.1177/2047487317732273

Journal - Research Article

Vernon, S. T., Coffey, S., Bhindi, R., Hoo, S. Y. S., Nelson, G. I., Ward, M. A., … Figtree, G. A. (2017). Increasing proportion of ST elevation myocardial infarction patients with coronary atherosclerosis poorly explained by standard modifiable risk factors. European Journal of Preventive Cardiology, 24(17), 1824-1830. doi: 10.1177/2047487317720287

Journal - Research Article

Coffey, S., Cox, B., & Williams, M. J. A. (2016). Changing causes of heart valve disease mortality in New Zealand from 1988 to 2007. New Zealand Medical Journal, 129(1428), 55-64. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Coffey, S., Williams, M. J. A., Phillips, L. V., Galvin, I. F., Bunton, R. W., & Jones, G. T. (2016). Integrated microRNA and messenger RNA analysis in aortic stenosis. Scientific Reports, 6, 36904. doi: 10.1038/srep36904

Journal - Research Article

Rawal, S., Parshu Ram, T., Coffey, S., Williams, M. J. A., Saxena, P., Bunton, R. W., Galvin, I. F., & Katare, R. (2016). Differential expression pattern of cardiovascular microRNAs in the human type-2 diabetic heart with normal ejection fraction. International Journal of Cardiology, 202, 40-43. doi: 10.1016/j.ijcard.2015.08.161

Journal - Research Article

d'Arcy, J. L., Coffey, S., Loudon, M. A., Kennedy, A., Pearson-Stuttard, J., Birks, J., … Prendergast, B. D. (2016). Large-scale community echocardiographic screening reveals a major burden of undiagnosed valvular heart disease in older people: The OxVALVE Population Cohort Study. European Heart Journal, 37(47), 3515-3522. doi: 10.1093/eurheartj/ehw229

Journal - Research Article

Bussey, C. T., Hughes, G., Saxena, P., Galvin, I. F., Bunton, R. W., Noye, M. K., Coffey, S., Williams, M. J. A., Baldi, J. C., Jones, P. P., & Lamberts, R. R. (2015). Chamber-specific changes in calcium-handling proteins in the type 2 diabetic human heart with preserved ejection fraction. International Journal of Cardiology, 193, 53-55. doi: 10.1016/j.ijcard.2015.05.053

Journal - Research Article

Coffey, S., Williams, M. J. A., Phillips, L. V., & Jones, G. T. (2015). Circulating microRNA profiling needs further refinement before clinical use in patients with aortic stenosis. Journal of the American Heart Association, 4(8), e002150. doi: 10.1161/jaha.115.002150

Journal - Research Article

Coffey, S., & Jones, G. T. (2014). MicroRNAs are central to osteogenesis: A review with a focus on cardiovascular calcification. microRNA Diagnostics & Therapeutics, 1, 113-125. doi: 10.2478/micrnat-2014-0005

Journal - Research Article

Coffey, S., Cox, B., & Williams, M. J. A. (2014). Lack of progress in valvular heart disease in the pre—transcatheter aortic valve replacement era: Increasing deaths and minimal change in mortality rate over the past three decades. American Heart Journal, 167(4), 562-567. doi: 10.1016/j.ahj.2013.12.030

Journal - Research Article

Coffey, S., Cox, B., & Williams, M. J. A. (2014). The prevalence, incidence, progression, and risks of aortic valve sclerosis: A systematic review and meta-analysis. JACC, 63(25), 2852-2861. doi: 10.1016/j.jacc.2014.04.018

Journal - Research Article

Coffey, S., Rayner, J., Newton, J., & Prendergast, B. D. (2014). Right-sided valve disease. International Journal of Clinical Practice, 68(10), 1221-1226. doi: 10.1111/ijcp.12485

Journal - Research Article

Lamberts, R. R., Lingam, S. J., Wang, H.-Y., Bollen, I. A. E., Hughes, G., Galvin, I. F., Bunton, R. W., Bahn, A., Katare, R., Baldi, J. C., Williams, M. J. A., Saxena, P., Coffey, S., & Jones, P. P. (2014). Impaired relaxation despite upregulated calcium-handling protein atrial myocardium from type 2 diabetic patients with preserved ejection fraction. Cardiovascular Diabetology, 13, 72. doi: 10.1186/1475-2840-13-72

Journal - Research Article

Moore, A., Shindikar, A., Fomison-Nurse, I., Riu, F., Munasinghe, P. E., Parshu Ram, T., Saxena, P., Coffey, S., Bunton, R. W., Galvin, I. F., Williams, M. J. A., … Katare, R. (2014). Rapid onset of cardiomyopathy in STZ-induced female diabetic mice involves the downregulation of pro-survival Pim-1. Cardiovascular Diabetology, 13, 68. doi: 10.1186/1475-2840-13-68

Journal - Research Article

Rayner, J., Coffey, S., Newton, J., & Prendergast, B. D. (2014). Aortic valve disease. International Journal of Clinical Practice, 68(10), 1209-1215. doi: 10.1111/ijcp.12471

Journal - Research Article

Coffey, S., & Adamson, P. D. (2021). Microvascular obstruction: Time to bust the clot hypothesis? Heart. Advance online publication. doi: 10.1136/heartjnl-2020-318324

Journal - Research Other

Coffey, S., Roberts-Thomson, R., Brown, A., Carapetis, J., Chen, M., Enriquez-Sarano, M., … Prendergast, B. D. (2021). Global epidemiology of valvular heart disease. Nature Reviews Cardiology. Advance online publication. doi: 10.1038/s41569-021-00570-z

Journal - Research Other

Daniels, L. J., Annandale, M., Koutsifeli, P., Li, X., Bussey, C. T., van Hout, I., Bunton, R. W., … Coffey, S., Katare, R., Lamberts, R. R., … Mellor, K. M. (2021). Elevated myocardial fructose and sorbitol levels are associated with diastolic dysfunction in diabetic patients, and cardiomyocyte lipid inclusions in vitro [Brief communication]. Nutrition & Diabetes, 11, 8. doi: 10.1038/s41387-021-00150-7

Journal - Research Other

Forshaw, A., Younger, J. F., Coffey, S., & Whalley, G. A. (2021). Is Australasia ready for sonographer-led stress echocardiography? Heart, Lung & Circulation. Advance online publication. doi: 10.1016/j.hlc.2021.03.002

Journal - Research Other

Martin, J., Coffey, S., & Whalley, G. A. (2021). Sex disparity in cardiovascular disease outcomes: Do our current echocardiographic reference ranges measure up? Heart, Lung & Circulation, 30, e1-e5. doi: 10.1016/j.hlc.2020.10.004

Journal - Research Other

Moharram, M., Whalley, G., & Coffey, S. (2021). Interval imaging to guide treatment in constrictive pericarditis. Heart. Advance online publication. doi: 10.1136/heartjnl-2020-318723

Journal - Research Other

Coffey, S., Moynagh, A., Green, B., Edmond, J., Wilkins, G. T., Pemberton, J., … Williams, M. J. A., & Arnold, B. (2020). Changes to management of a non-pandemic illness during the COVID-19 pandemic: Case study of invasive management of acute coronary syndrome. New Zealand Medical Journal, 133(1513), 101-106. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Other

Van der Giessen, H., Wilson, L. C., Coffey, S., & Whalley, G. A. (2020). Review: Detection of patient foramen ovale using transcranial Doppler or standard echocardiography. Australasian Journal of Ultrasound in Medicine, 23(4), 210-219. doi: 10.1002/ajum.12232

Journal - Research Other

Kott, K. A., Vernon, S. T., Hansen, T., Yu, C., Bubb, K. J., Coffey, S., … Figtree, G. A. (2019). Biobanking for discovery of novel cardiovascular biomarkers using imaging-quantified disease burden: Protocol for the longitudinal, prospective, BioHEART-CT cohort study. BMJ Open, 9, e028649. doi: 10.1136/bmjopen-2018-028649

Journal - Research Other

Martin, J., Coffey, S., & Whalley, G. A. (2019). Identifying patients at risk post-infarct: Is it time for routine CMR? Heart, Lung & Circulation, 28(3), 354-357. doi: 10.1016/j.hlc.2019.01.002

Journal - Research Other

Moharram, M. A., Lamberts, R. R., Whalley, G., Williams, M. J. A., & Coffey, S. (2019). Myocardial tissue characterisation using echocardiographic deformation imaging. Cardiovascular Ultrasound, 17, 27. doi: 10.1186/s12947-019-0176-9

Journal - Research Other

Cairns, B. J., Coffey, S., Travis, R. C., Prendergast, B., Green, J., Engert, J. C., … Clarke, R. (2017). A replicated, genome-wide significant association of aortic stenosis with a genetic variant for lipoprotein(a): Meta-analysis of published and novel data. Circulation, 135(12), 1181-1183. doi: 10.1161/CIRCULATIONAHA.116.026103

Journal - Research Other

Coffey, S., & Prendergast, B. (2017). Valvular heart disease in the elderly: More questions than answers. Journal of Thoracic Disease, 9(1), E97-E98. doi: 10.21037/jtd.2017.01.28

Journal - Research Other

Ram, T. P., Fomison-Nurse, I., Gandhi, S., Coffey, S., Saxena, P., Galvin, I., Bunton, R., Williams, M. J. A., Lamberts, R. R., & Katare, R. (2017). The diagnostic sensitivity of circulating cardio-enriched microRNAs is increased after normalization of high-density lipoprotein levels [Short communication]. International Journal of Cardiology, 236, 498-500. doi: 10.1016/j.ijcard.2017.01.119

Journal - Research Other

Coffey, S., Cairns, B. J., & Lung, B. (2016). The modern epidemiology of heart valve disease. Heart, 102(1), 75-85. doi: 10.1136/heartjnl-2014-307020

Journal - Research Other

Dona, A. C., Coffey, S., & Figtree, G. (2016). Translational and emerging clinical applications of metabolomics in cardiovascular disease diagnosis and treatment. European Journal of Preventive Cardiology, 23(15), 1578-1589. doi: 10.1177/2047487316645469

Journal - Research Other

Yong, M. S., Coffey, S., Prendergast, B. D., Marasco, S. F., Zimmet, A. D., McGiffin, D. C., & Saxena, P. (2016). Surgical management of tricuspid valve endocarditis in the current era: A review. International Journal of Cardiology, 202, 44-48. doi: 10.1016/j.ijcard.2015.08.211

Journal - Research Other

Coffey, S., & Prendergast, B. D. (2015). Public healthcare systems should not pay for private profit. BMJ, 350, g7773. doi: 10.1136/bmj.g7774

Journal - Research Other

Yong, M. S., Saxena, P., Killu, A. M., Coffey, S., Burkhart, H. M., Wan, S.-H., & Malouf, J. F. (2015). The preoperative evaluation of infective endocarditis via 3-dimensional transesophageal echocardiography. Texas Heart Institute Journal, 42(4), 372-376. doi: 10.14503/THIJ-14-4375

Journal - Research Other

Coffey, S., d'Arcy, J. L., Loudon, M. A., Mant, D., Farmer, A. J., Prendergast, B. D., for the OxVALVE-PCS Group. (2014). The OxVALVE population cohort study (OxVALVE-PCS): Population screening for undiagnosed valvular heart disease in the elderly: Study design and objectives. Open Heart, 1(1), e000043. doi: 10.1136/openhrt-2014-000043

Journal - Research Other

Coffey, S., Williams, M. J. A., & Cox, B. (2013). Letter by Coffey et al regarding article, Estimating deaths from cardiovascular disease: A review of global methodologies of mortality measurement. Circulation, 128(6), e84. doi: 10.1161/CIRCULATIONAHA.113.002123

Journal - Research Other

Coffey, S., Nadarasa, K., Pan, A., van der Linden, A., Chu, J., & Schultz, M. (2012). The increasing incidence of Streptococcus bovis endocarditis and bacteraemia: A case series from 1997 to 2010. International Journal of Cardiology, 161(2), 111-113. doi: 10.1016/j.ijcard.2012.06.031

Journal - Research Other

Coffey, S., & Williams, M. (2011). Quetiapine-associated cardiomyopathy [Clinical correspondence]. New Zealand Medical Journal, 124(1337). Retrieved from http://journal.nzma.org.nz/journal/124-1337/4744/content.pdf

Journal - Research Other

More publications...