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DSM staff profile

Associate Professor Gerard Wilkins

PositionAssociate Professor
DepartmentDepartment of Medicine (Dunedin)
QualificationsMB ChB(Otago) FRACP
Research summaryInterventional Cardiology; Clinical trials

Research

I have several strands of research associated with clinical work including: 1) Collaborative research with the Heart Otago members in basic sciences and the Vascular Biology Group ; 2) Interventional device trials (new device development, often 'First in Man' Clinical Trials) 3) Involvement in multinational trials largely acting as Regional Primary Investigator, that frequently produce pivotal changes in clinical practice.

Publications

Leader, C. J., Kelly, D. J., Sammut, I. A., Wilkins, G. T., & Walker, R. J. (2020). Spironolactone mitigates, but does not reverse, the progression of renal fibrosis in a transgenic hypertensive rat. Physiological Reports, 8(10), e14448. doi: 10.14814/phy2.14448

Coffey, S., Moynagh, A., Green, B., Edmond, J., Wilkins, G. T., Pemberton, J., … Williams, M. J. A., & Arnold, B. (2020). Changes to management of a non-pandemic illness during the COVID-19 pandemic: Case study of invasive management of acute coronary syndrome. New Zealand Medical Journal, 133(1513), 101-106. Retrieved from https://www.nzma.org.nz/journal

Bussey, C. T., Babakr, A. A., Iremonger, R. R., van Hout, I., Wilkins, G. T., Lamberts, R. R., & Erickson, J. R. (2020). Carvedilol and metoprolol are both able to preserve myocardial function in type 2 diabetes. Physiological Reports, 8(5), e14394. doi: 10.14814/phy2.14394

Dassanayake, S., Sole, G., Wilkins, G., & Skinner, M. (2020). Exercise: A therapeutic modality to treat blood pressure in resistant hypertension. Physical Therapy Reviews, 25(3), 149-158. doi: 10.1080/10833196.2020.1733781

Dassanayake, S., Sole, G., Wilkins, G., & Skinner, M. (2020). Effect of exercise and physical activity on blood pressure in adults with resistant hypertension: A protocol for a systematic review. Physical Therapy Reviews, 25(2), 128-134. doi: 10.1080/10833196.2020.1728986

Bussey, C. T., Babakr, A. A., Iremonger, R. R., van Hout, I., Wilkins, G. T., Lamberts, R. R., & Erickson, J. R. (2020). Carvedilol and metoprolol are both able to preserve myocardial function in type 2 diabetes. Physiological Reports, 8(5), e14394. doi: 10.14814/phy2.14394

Journal - Research Article

Dassanayake, S., Sole, G., Wilkins, G., & Skinner, M. (2020). Exercise: A therapeutic modality to treat blood pressure in resistant hypertension. Physical Therapy Reviews, 25(3), 149-158. doi: 10.1080/10833196.2020.1733781

Journal - Research Article

Leader, C. J., Kelly, D. J., Sammut, I. A., Wilkins, G. T., & Walker, R. J. (2020). Spironolactone mitigates, but does not reverse, the progression of renal fibrosis in a transgenic hypertensive rat. Physiological Reports, 8(10), e14448. doi: 10.14814/phy2.14448

Journal - Research Article

Leader, C. J., Moharram, M., Coffey, S., Sammut, I. A., Wilkins, G., & Walker, R. J. (2019). Myocardial global longitudinal strain: An early indicator of cardiac interstitial fibrosis modified by spironolactone, in a unique hypertensive rat model. PLoS ONE, 14(8), e0220837. doi: 10.1371/journal.pone.0220837

Journal - Research Article

Wilson, G. A., Wilkins, G. T., Cotter, J. D., Lamberts, R. R., Lal, S., & Baldi, J. C. (2019). HIIT improves left ventricular exercise response in adults with type 2 diabetes. Medicine & Science in Sports & Exercise, 51(6), 1099-1105. doi: 10.1249/mss.0000000000001897

Journal - Research Article

Leader, C. J., Clark, B. J., Hannah, A. R., Sammut, I. A., Wilkins, G. T., & Walker, R. J. (2018). Breeding characteristics and dose-dependent blood pressure responses of transgenic Cyp1a1-Ren2 rats. Comparative Medicine, 68(5), 360-366. doi: 10.30802/AALAS-CM-17-18000026

Journal - Research Article

Pearson, J. T., Collie, N., Lamberts, R. R., Inagaki, T., Yoshimoto, M., Umetani, K., … Wilkins, G., Jones, P. P., … Schwenke, D. O. (2018). Ghrelin preserves ischemia-induced vasodilation of male rat coronary vessels following beta-adrenergic receptor blockade. Endocrinology, 159(4), 1763-1773. doi: 10.1210/en.2017-03070

Journal - Research Article

Hoye, N. A., Wilson, L. C., Wilkins, G. T., Jardine, D. L., Putt, T. L., Samaranayaka, A., Schollum, J. B. W., & Walker, R. J. (2017). Endovascular renal denervation in end-stage kidney disease patients: Cardiovascular protection: A proof-of-concept study. Kidney International Reports, 2(5), 856-865. doi: 10.1016/j.ekir.2017.04.012

Journal - Research Article

Vaduganathan, M., Harrington, R. A., Stone, G. W., Deliargyris, E. N., Steg, G., Gibson, C. M., … on behalf of the CHAMPION Investigators, including Harding, S., Elliott, J., Wilkins, G., & Sasse, A. (2017). Cangrelor with and without glycoprotain IIb/IIIa inhibitors in patients undergoing percutaneous coronary intervention. JACC, 69(2), 176-185. doi: 10.1016/j.jacc.2016.10.055

Journal - Research Article

Wilson, G. A., Wilkins, G. T., Cotter, J. D., Lamberts, R. R., Lal, S., & Baldi, J. C. (2017). Impaired ventricular filling limits cardiac reserve during submaximal exercise in people with type 2 diabetes. Cardiovascular Diabetology, 16, 160. doi: 10.1186/s12933-017-0644-1

Journal - Research Article

Wilson, G. A., Wilson, L. C., Lamberts, R. R., Majeed, K., Lal, S., Wilkins, G. T., & Baldi, J. C. (2017). β-adrenergic responsiveness in the type 2 diabetic heart: Effects on cardiac reserve. Medicine & Science in Sports & Exercise, 49(5), 907-914. doi: 10.1249/mss.0000000000001184

Journal - Research Article

Wilson, L. C., Peebles, K. C., Hoye, N. A., Manning, P., Sheat, C., Williams, M. J. A., Wilkins, G. T., Wilson, G. A., & Baldi, J. C. (2017). Resting heart rate variability and exercise capacity in Type 1 diabetes. Physiological Reports, 5(8), e13248. doi: 10.14814/phy2.13248

Journal - Research Article

Worthley, S. G., Wilkins, G. T., Webster, M. W., Montarello, J. K., Delacroix, S., Whitbourn, R. J., & Warren, R. J. (2017). Safety and performance of the second generation EnligHTN™ Renal Denervation System in patients with drug-resistant, uncontrolled hypertension. Atherosclerosis, 262, 94-100. doi: 10.1016/j.atherosclerosis.2017.04.022

Journal - Research Article

Baldi, J. C., Wilson, G. A., Wilson, L. C., Wilkins, G. T., & Lamberts, R. R. (2016). The type 2 diabetic heart: Its role in exercise intolerance and the challenge to find effective exercise interventions. Sports Medicine, 46, 1605-1617. doi: 10.1007/s40279-016-0542-9

Journal - Research Article

Pokorney, S. D., Piccini, J. P., Stevens, S. R., Patel, M. R., Pieper, K. S., Halperin, J. L., … for the ROCKET AF Steering Committee & Investigators, including Richards, M., Mann, S., & Wilkins, G. (2016). Cause of death and predictors of all-cause mortality in anticoagulated patients with nonvalvular atrial fibrilation: Data from ROCKET AF. Journal of the American Heart Association, 5(3), e002197. doi: 10.1161/JAHA.115.002197

Journal - Research Article

Williams, M. J. A., Harding, S. A., Devlin, G., Nunn, C., El-Jack, S., Scott, T., … on behalf of the ANZACS-QI Investigators, including Matsis, P., Smyth, D., Blake, J., Elliott, J., Lainchbury, J., Bridgman, P., Troughton, R., Wilkins, G., Green, B., Edmond, J., & Milburn, K. (2016). National variation in coronary angiography rates and timing after an acute coronary syndrome in New Zealand (ANZACS-QI 6). New Zealand Medical Journal, 129(1428), 65-77. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

van 't Hof, F. N. G., Ruigrok, Y. M., Lee, C. H., Ripke, S., Anderson, G., de Andrade, M., … Jones, G. T., … van Rij, A. M., … Vascular Research Consortium of New Zealand, including Phillips, L. V., Hill, G. B., Williams, M. J. A., Thomson, I. A., Krysa, J., Wilkins, G. T., Merriman, T. R., Lewis, D. R., … de Bakker, P. I. W. (2016). Shared genetic risk factors of intracranial, abdominal, and thoracic aneurysms. Journal of the American Heart Association, 5(7), e002603. doi: 10.1161/jaha.115.002603

Journal - Research Article

Majeed, K., Hamer, A. W., White, S. C., Pegg, T. J., Wilkins, G. T., Williams, S. M., … Williams, M. J. A. (2015). Prevalence of abdominal aortic aneurysm in patients referred for transthoracic echocardiography. Internal Medicine Journal, 45(1), 32-39. doi: 10.1111/imj.12592

Journal - Research Article

Sakata, K., Koo, B.-K., Waseda, K., Nakatani, D., Yock, P. G., Whitbourn, R., … Wilkins, G. T., … Fitzgerald, P. J. (2015). A Y-shaped bifurcation-dedicated stent for the treatment of de novo coronary bifurcation lesions: An IVUS analysis from the BRANCH trial. EuroIntervention, 10(11). doi: 10.4244/eijy14m08_16

Journal - Research Article

Siriwardena, M., Pilbrow, A., Frampton, C., MacDonald, S. M., Wilkins, G. T., & Richards, A. M. (2015). Complications of intra-aortic balloon pump use: Does the final position of the IABP tip matter? Anaesthesia & Intensive Care, 43(1), 66-73.

Journal - Research Article

Worthley, S. G., Wilkins, G. T., Webster, M. W., Montarello, J. K., Antonis, P. R., Whitbourn, R. J., & Warren, R. J. (2015). Safety and performance of the next generation EnligHTN™ renal denervation system in patients with drug-resistant, uncontrolled hypertension: The EnligHTN III first-in-human multicentre study. Clinical Trials & Regulatory Science in Cardiology, 8, 4-10. doi: 10.1016/j.ctrsc.2015.08.007

Journal - Research Article

Blattner, K., Nixon, G., Horgan, C., Coutts, J., Rogers, M., Wong, B., … Wilkins, G. (2014). Evaluation of a rural primary-referred cardiac exercise tolerance test service. New Zealand Medical Journal, 127(1406). Retrieved from http://www.nzma.org.nz/journal

Journal - Research Article

Hoye, N. A., Baldi, J. C., Putt, T. L., Schollum, J. B., Wilkins, G. T., & Walker, R. J. (2014). Endovascular renal denervation: A novel sympatholytic with relevance to chronic kidney disease. Clinical Kidney Journal, 7(1), 3-10. doi: 10.1093/ckj/sft130

Journal - Research Article

Nicholls, S. J., Kastelein, J. J. P., Schwartz, G. M., Bash, D., Rosenson, R. S., Cavender, M. A., … for the VISTA-16 Investigators, including Elliott, J., Wilkins, G., & Harding, S. (2014). Varespladib and cardiovascular events in patients with an acute coronary syndrome: The VISTA-16 randomized clinical trial. JAMA, 311(3), 252-262. doi: 10.1001/jama.2013.282836

Journal - Research Article

O'Donoghue, M. L., Braunwald, E., White, H. D., Steen, D. L., Lukas, M. A., Tarka, E., … for the SOLID-TIMI 52 Investigators, including Elliott, J., Wilkins, G., & Chen, V. (2014). Effect of darapladib on major coronary events after an acute coronary syndrome: The SOLID-TIMI 52 randomized clinical trial. JAMA, 312(10), 1006-1015. doi: 10.1001/jama.2014.11061

Journal - Research Article

Chu, J. W., Jones, G. T., Tarr, G. P., Phillips, L. V., Wilkins, G. T., van Rij, A. M., & Williams, M. J. A. (2013). Plasma active matrix metalloproteinase 9 and indices of diastolic function in patients with preserved systolic function. International Journal of Cardiology, 167(4), 1242-1246. doi: 10.1016/j.ijcard.2012.03.147

Journal - Research Article

Tarr, G. P., Williams, M. J. A., Wilkins, G. T., Chen, V. H. T., Phillips, L. V., van Rij, A. M., & Jones, G. T. (2013). Intra-individual changes of active matrix metalloproteinase-9 are associated with clinical in-stent restenosis of bare metal stents. Cardiology, 124(1), 28-35. doi: 10.1159/000345591

Journal - Research Article

Miller, J. C., Thomson, C. D., Williams, S. M., van Havre, N., Wilkins, G. T., Morison, I. M., Ludgate, J. L., & Skeaff, C. M. (2012). Influence of the glutathione peroxidase 1 Pro200Leu polymorphism on the response of glutathione peroxidase activity to selenium supplementation: A randomized controlled trial. American Journal of Clinical Nutrition, 96, 923-931. doi: 10.3945/ajcn.112.043125

Journal - Research Article

Nadarasa, K., Robertson, M. C., Wong, C.-K., Green, B. K. W., Chen, V. H. T., Wilkins, G. T., & Williams, M. J. A. (2012). Rapid cycle change to predominantly radial access coronary angiography and percutaneous coronary intervention: Effect on vascular access site complications. Catheterization & Cardiovascular Interventions, 79(4), 589-594. doi: 10.1002/ccd.23120

Journal - Research Article

Schwartz, G. G., Olsson, A. G., Abt, M., Ballantyne, C. M., Barter, P. J., Brumm, J., … for the dal-OUTCOMES Investigators, including Troughton, R., Wilkins, G., & Harding, S. (2012). Effects of dalcetrapib in patients with a recent acute coronary syndrome. New England Journal of Medicine, 367(22), 2089-2099. doi: 10.1056/NEJMoa1206797

Journal - Research Article

Slaughter, R. J., Beasley, D. M. G., Lambie, B. S., Wilkins, G. T., & Schep, L. J. (2012). Poisonous plants in New Zealand: A review of those that are most commonly enquired about to the National Poisons Centre. New Zealand Medical Journal, 125(1367). Retrieved from http://www.nzma.org.nz/journal

Journal - Research Article

Nixon, G., Blattner, K., Dawson, J., Dovey, S., Black, M. A., Wilkins, G., Dunn, A. C., & McLellan, A. D. (2011). Streptokinase antibodies in patients presenting with acute coronary syndrome in three rural New Zealand populations. Journal of Clinical Pathology, 64, 426-429. doi: 10.1136/jcp.2010.085837

Journal - Research Article

Meredith, I. T., Worthley, S. G., Whitbourn, R., Walters, D., McClean, D., Ormiston, J., … Wilkins, G. T., … Matsis, P., … Cutlip, D. E. (2010). Long-term clinical outcomes with the next-generation Resolute Stent System: A report of the two-year follow-up from the RESOLUTE clinical trial. EuroIntervention, 5(6), 692-697.

Journal - Research Article

Jones, G. T., Tarr, G. P., Phillips, L. V., Wilkins, G. T., van Rij, A. M., & Williams, M. J. A. (2009). Active matrix metalloproteinases 3 and 9 are independently associated with coronary artery in-stent restenosis. Atherosclerosis, 207(2), 603-607. doi: 10.1016/j.atherosclerosis.2009.05.036

Journal - Research Article

Al-Sallami, H., Ferguson, R., Wilkins, G., Gray, A., & Medlicott, N. J. (2008). Bleeding events in patients receiving enoxaparin for the management of non-ST-elevation acute coronary syndrome (NSTEACS) at Dunedin Public Hospital, New Zealand. New Zealand Medical Journal, 121(1285). Retrieved from http://journal.nzma.org.nz/journal/121-1285/3342/content.pdf

Journal - Research Article

Bardy, G. H., Lee, K. L., Mark, D. B., Poole, J. E., Toff, W. D., Tonkin, A. M., … for the HAT Investigators, including Wilkins, G., & Gulliver, L. (2008). Home use of automated external defibrillators for sudden cardiac arrest. New England Journal of Medicine, 358, 1793-1804. doi: 10.1056/NEJMoa0801651

Journal - Research Article

Bardy, G. H., Lee, K. L., Mark, D. B., Poole, J. E., Toff, W. D., Tonkin, A. M., … for the HAT Investigators, including Wilkins, G., Gulliver, L., & Oskam-Schmidt, R. (2008). Rationale and design of the Home Automatic External Defibrillator Trial (HAT). American Heart Journal, 155(3), 445-454. doi: 10.1016/j.ahj.2007.12.008

Journal - Research Article

Jones, G. T., van Rij, A. M., Hill, G. B., Wilkins, G. T., & Williams, M. J. A. (2008). Common carotid intimal-medial thickness is associated with coronary in-stent restenosis. Journal for Vascular Ultrasound, 32(3), 129-132.

Journal - Research Article

Tie, S., Wong, C.-K., Yap, J., Wilkins, G., Williams, M., & Kay, P. (2007). Timing of thrombotic events in patients receiving 2 weeks of clopidogrel therapy post bare metal coronary artery stenting: A New Zealand retrospective study. New Zealand Medical Journal, 120(1255). Retrieved from http://journal.nzma.org.nz/journal/120-1255/2553/content.pdf

Journal - Research Article

Jones, G. T., Kay, I. P., Chu, J. W. S., Wilkins, G. T., Phillips, L. V., McCormick, M., van Rij, A. M., & Williams, M. J. A. (2006). Elevated plasma active matrix metalloproteinase-9 level is associated with coronary artery in-stent restenosis. Arteriosclerosis, Thrombosis, & Vascular Biology, 26, e121-e125.

Journal - Research Article

Tang, E. W., Wong, C.-K., Restieaux, N. J., Herbison, P., Williams, M. J. A., Kay, P., & Wilkins, G. T. (2006). Clinical outcome of older patients with acute coronary syndrome over the last three decades. Age & Ageing, 35, 280-285.

Journal - Research Article

Parry, D. J., Winburn, I. C., Wilkins, G. T., & Bunton, R. W. (2005). Expanding retrograde saphenous vein graft aneurysm treated with endovascular coiling. Annals of Thoracic Surgery, 80, 2374-2376.

Journal - Research Article

Skinner, M. A., Choudhury, M. S., Homan, S. D., Cowan, J. O., Wilkins, G. T., & Taylor, D. R. (2005). Accuracy of monitoring for sleep-related breathing disorders in the coronary care unit. Chest, 127(1), 66-71.

Journal - Research Article

Tang, E. W., Wong, C.-K., Wilkins, G., Herbison, P., Williams, M., Kay, P., & Restieaux, N. (2005). Use of evidence-based management for acute coronary syndrome. New Zealand Medical Journal, 118(1223). Retrieved from http://journal.nzma.org.nz/journal/118-1223/1678/content.pdf

Journal - Research Article

Chu, J., Wilkins, G., & Williams, M. (2004). Review of 65 cases of infective endocarditis in Dunedin Public Hospital. New Zealand Medical Journal, 117(1200). Retrieved from http://journal.nzma.org.nz/journal/117-1200/1021/content.pdf

Journal - Research Article

Pfeffer, M. A., McMurray, J. J. V., Velazquez, E. J., Rouleau, J.-L., Køber, L., Maggioni, A. P., … Wilkins, G., Williams, M., & Wong, C. K. (2003). Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both. New England Journal of Medicine, 349(20), 1893-1906. doi: 10.1056/NEJMoa032292

Journal - Research Article

Williams, M. J. A., Low, C., Wilkins, G. T., & Stewart, R. A. (2000). Randomised comparison of the effects of nicardipine and esmolol on coronary artery wall stress: implications for the risk of plaque rupture and acute coronary events. Heart, 84, 383-389.

Journal - Research Article

Williams, M. J. A., Stewart, R. A., Low, C., & Wilkins, G. T. (1999). Assessment of the mechanical properties of coronary arteries using intravascular ultrasound: an in vivo study. International Journal of Cardiac Imaging, 15, 287-294.

Journal - Research Article

Williams, M. J., Sutherland, W. H. F., McCormick, M. P., de Jong, S. A., Walker, R. J., & Wilkins, G. T. (1999). Impaired endothelial function after a meal rich in used cooking fat. JACC, 33, 1050-1055.

Journal - Research Article

Williams, M. J. A., Kay, I. P., & Wilkins, G. T. (1998). Spontaneous coronary artery dissection presenting as unstable angina. Journal of Invasive Cardiology, 10, 274-276.

Journal - Research Article

Kerr, A. J., Williams, M. J. A., & Wilkins, G. T. (1997). Primary stenting as treatment for coronary-subclavian steal syndrome. Australian & New Zealand Journal of Medicine, 27(1), 80-81.

Journal - Research Article

Stewart, R. A., Robertson, M. C., Low, C., Wilkins, G. T., & Restieaux, N. J. A. (1997). Differences in easily recognised coronary risk factors by age at first myocardial infarction. New Zealand Medical Journal, 110(1051), 339-340.

Journal - Research Article

Stewart, R. A., Robertson, M. C., Wilkins, G. T., Low, C. J., & Restieaux, N. J. A. (1997). Association between activity at onset of symptoms and outcome of acute myocardial infarction. JACC, 29(2), 250-253.

Journal - Research Article

Coffey, S., Moynagh, A., Green, B., Edmond, J., Wilkins, G. T., Pemberton, J., … Williams, M. J. A., & Arnold, B. (2020). Changes to management of a non-pandemic illness during the COVID-19 pandemic: Case study of invasive management of acute coronary syndrome. New Zealand Medical Journal, 133(1513), 101-106. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Other

Dassanayake, S., Sole, G., Wilkins, G., & Skinner, M. (2020). Effect of exercise and physical activity on blood pressure in adults with resistant hypertension: A protocol for a systematic review. Physical Therapy Reviews, 25(2), 128-134. doi: 10.1080/10833196.2020.1728986

Journal - Research Other

Lal, S., Pemberton, J., & Wilkins, G. T. (2018). Cough-induced takotsubo (stress) cardiomyopathy. CASE, 2(6), 240-242. doi: 10.1016/j.case.2018.03.004

Journal - Research Other

Chu, J. W., Jones, G. T., Tarr, G. P., Phillips, L. V., Wilkins, G. T., van Rij, A. M., & Williams, M. J. A. (2011). Plasma active matrix metalloproteinase 9 associated to diastolic dysfunction in patients with coronary artery disease [Letter]. International Journal of Cardiology, 147(2), 336-338. doi: 10.1016/j.ijcard.2010.12.093

Journal - Research Other

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