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DSM staff profile

Professor Michael Williams

PositionClinical Professor
DepartmentDepartment of Medicine (DSM)
QualificationsMD FRACP FACC
Research summaryCardiology
TeachingIntegration of cardiac investigations into clinical practice.
Clinical
  • Echocardiography.
  • Interventional cardiology.
  • General cardiology.

Research

Michael Williams' research interests include studying the effect of lifestyle factors and diet on arterial function and the development of arterial disease. He has investigated the influence of physical fitness on measures of arterial inflammation and the risk of developing chest pain and heart attack in later life. His other clinical research has focussed on understanding the biology of restenosis in stents inserted in patients' heart arteries to open blockages. Studies of cardiovascular genetics have contributed to international collaborative research and the identification of novel genetic markers of arterial disease. Michael's current investigations include the regulation of gene expression on the development of narrowing and stiffening of cardiac valves with the aim of developing therapies to delay or prevent the requirement for surgical valve replacement. He is presently Chair of the Medicine Department Peer Review Committee.

Publications

Williams, M. J. A., Milne, B. J., Ambler, A., Theodore, R., Ramrakha, S., Caspi, A., Moffitt, T. E., & Poulton, R. (2017). Childhood body mass index and endothelial dysfunction evaluated by peripheral arterial tonometry in early midlife. International Journal of Obesity, 41, 1355-1360. doi: 10.1038/ijo.2017.108

Jones, G. T., Tromp, G., Kuivaniemi, H., Gretarsdottir, S., Baas, A. F., Giusti, B., … Phillips, L. V., Williams, M. J. A., Wei, W., … Thomson, I. A., Krysa, J., Hill, G. B., Roake, J., Merriman, T. R., … van Rij, A., … Bown, M. J. (2017). Meta-analysis of genome-wide association studies for abdominal aortic aneurysm identifies four new disease-specific risk loci. Circulation Research, 120, 341-353. doi: 10.1161/circresaha.116.308765

Sharma, M., Redpath, G. M., Williams, M. J. A., & McCormick, S. P. A. (2017). Recycling of apolipoprotein(a) after PlgRKT-mediated endocytosis of lipoprotein(a). Circulation Research, 120(7), 1091-1102. doi: 10.1161/circresaha.116.310272

Nioi, P., Sigurdsson, A., Thorleifsson, G., Helgason, H., Agustsdottir, A. B., Norddahl, G. L., … Williams, M. J. A., van Rij, A. M., Jones, G. T., … Stefansson, K. (2016). Variant ASGR1 associated with a reduced risk of coronary artery disease. New England Journal of Medicine, 374, 2131-2141. doi: 10.1056/NEJMoa1508419

Coffey, S., Cox, B., & Williams, M. J. A. (2014). The prevalence, incidence, progression, and risks of aortic valve sclerosis: A systematic review and meta-analysis. JACC, 63(25), 2852-2861. doi: 10.1016/j.jacc.2014.04.018

Journal - Research Article

Fomison-Nurse, I., Saw, E. E. L., Gandhi, S., Munasinghe, P. E., van Hout, I., Williams, M. J. A., Galvin, I., Bunton, R., Davis, P., Cameron, V., & Katare, R. (2018). Diabetes induces the activation of pro-ageing miR-34a in the heart, but has differential effects on cardiomyocytes and cardiac progenitor cells. Cell Death & Differentiation. Advance online publication. doi: 10.1038/s41418-017-0047-6

Wilson, L. C., Peebles, K. C., Hoye, N. A., Manning, P., Sheat, C., Williams, M. J. A., Wilkins, G. T., Wilson, G. A., & Baldi, J. C. (2017). Resting heart rate variability and exercise capacity in Type 1 diabetes. Physiological Reports, 5(8), e13248. doi: 10.14814/phy2.13248

Williams, M. J. A., Milne, B. J., Ambler, A., Theodore, R., Ramrakha, S., Caspi, A., Moffitt, T. E., & Poulton, R. (2017). Childhood body mass index and endothelial dysfunction evaluated by peripheral arterial tonometry in early midlife. International Journal of Obesity, 41, 1355-1360. doi: 10.1038/ijo.2017.108

Jones, G. T., Tromp, G., Kuivaniemi, H., Gretarsdottir, S., Baas, A. F., Giusti, B., … Phillips, L. V., Williams, M. J. A., Wei, W., … Thomson, I. A., Krysa, J., Hill, G. B., Roake, J., Merriman, T. R., … van Rij, A., … Bown, M. J. (2017). Meta-analysis of genome-wide association studies for abdominal aortic aneurysm identifies four new disease-specific risk loci. Circulation Research, 120, 341-353. doi: 10.1161/circresaha.116.308765

Sharma, M., Redpath, G. M., Williams, M. J. A., & McCormick, S. P. A. (2017). Recycling of apolipoprotein(a) after PlgRKT-mediated endocytosis of lipoprotein(a). Circulation Research, 120(7), 1091-1102. doi: 10.1161/circresaha.116.310272

Rawal, S., Munasinghe, P. E., Shindikar, A., Paulin, J., Cameron, V., Manning, P., Williams, M. J. A., Jones, G. T., Bunton, R., Galvin, I., & Katare, R. (2017). Down-regulation of proangiogenic microRNA-126 and microRNA-132 are early modulators of diabetic cardiac microangiopathy. Cardiovascular Research, 113(1), 90-101. doi: 10.1093/cvr/cvw235

Rawal, S., Munasinghe, E. P., Nagesh, P. T., Lew, J. K. S., Jones, G. T., Williams, M. J. A., Davis, P., Bunton, R. W., Galvin, I. F., Manning, P., Lamberts, R. R., & Katare, R. (2017). Downregulation of miR-15a/b accelerates fibrotic remodelling in the Type-2 diabetic human and mouse heart. Clinical Science, 131(9), 847-863. doi: 10.1042/cs20160916

Kerr, A. J., Williams, M., White, H., Grey, C., Jiang, Y., Nunn, C., on behalf of the ANZACS-QI investigators. (2017). 30-day mortality aft er percutaneous coronary intervention in New Zealand public hospitals (ANZACS-QI 18). New Zealand Medical Journal, 130(1459), 54-63. Retrieved from http://www.nzma.org.nz/journal

Elliott, J. M., Wang, T. K. M., Gamble, G., Williams, M., Matsis, P., Troughton, R., … Mann, S., Richards, M., … Ellis, C. (2017). A decade of improvement in the management of New Zealand ST-elevation myocardial infarction (STEMI) patients: Results from the New Zealand Acute Coronary Syndrome (ACS) Audit Group national audits of 2002, 2007 and 2012. New Zealand Medical Journal, 130(1453), 17-28. Retrieved from https://www.nzma.org.nz/journal

van 't Hof, F. N. G., Ruigrok, Y. M., Lee, C. H., Ripke, S., Anderson, G., de Andrade, M., … Jones, G. T., … van Rij, A. M., … Vascular Research Consortium of New Zealand, including Phillips, L. V., Hill, G. B., Williams, M. J. A., Thomson, I. A., Krysa, J., Wilkins, G. T., Merriman, T. R., Lewis, D. R., … de Bakker, P. I. W. (2016). Shared genetic risk factors of intracranial, abdominal, and thoracic aneurysms. Journal of the American Heart Association, 5(7), e002603. doi: 10.1161/jaha.115.002603

Thomas, K. N., Cotter, J. D., Williams, M. J. A., & van Rij, A. M. (2016). Diagnosis, incidence, and clinical implications of perioperative myocardial injury in vascular surgery. Vascular & Endovascular Surgery, 50(4), 247-255. doi: 10.1177/1538574416637441

Thomas, K. N., Cotter, J. D., Williams, M. J. A., & van Rij, A. M. (2016). Repeated episodes of remote ischemic preconditioning for the prevention of myocardial injury in vascular surgery. Vascular & Endovascular Surgery, 50(3), 140-146. doi: 10.1177/1538574416639150

Kerr, A. J., Williams, M. J. A., Harding, S., White, H., Doughty, R. N., Nunn, C., … on behalf of the ANZACS-QI Investigators. (2016). The All New Zealand Acute Coronary Syndrome Quality Improvement programme: Implementation, methodology and cohorts (ANZACS-QI 9). New Zealand Medical Journal, 129(1439), 23-36. Retrieved from https://www.nzma.org.nz/journal

Jones, G. T., Phillips, V., Williams, M. J. A., van Rij, A. M., & Kabir, T. D. (2016). Two C-C family chemokines, eotaxin and RANTES, are novel independent plasma biomarkers for abdominal aortic aneurysm. Journal of the American Heart Association, 5(5), e002993. doi: 10.1161/jaha.115.002993

Barr, P., Smyth, D., Harding, S. A., El-Jack, S., Williams, M. J. A., Devlin, G., … on behalf of the ANZACS-QI Investigators. (2016). Variation in arterial access for invasive coronary procedures in New Zealand: A national analysis (ANZACS-QI 5). Heart, Lung & Circulation, 25, 451-458. doi: 10.1016/j.hlc.2015.10.009

Coffey, S., Williams, M. J. A., Phillips, L. V., Galvin, I. F., Bunton, R. W., & Jones, G. T. (2016). Integrated microRNA and messenger RNA analysis in aortic stenosis. Scientific Reports, 6, 36904. doi: 10.1038/srep36904

Jones, G. T., Hill, B. G., Curtis, N., Kabir, T. D., Wong, L. E., Tilyard, M. W., Williams, M. J. A., & van Rij, A. M. (2016). Comparison of three targeted approaches to screening for abdominal aortic aneurysm based on cardiovascular risk. British Journal of Surgery, 103(9), 1139-1146. doi: 10.1002/bjs.10224

Rawal, S., Parshu Ram, T., Coffey, S., Williams, M. J. A., Saxena, P., Bunton, R. W., Galvin, I. F., & Katare, R. (2016). Differential expression pattern of cardiovascular microRNAs in the human type-2 diabetic heart with normal ejection fraction. International Journal of Cardiology, 202, 40-43. doi: 10.1016/j.ijcard.2015.08.161

Nioi, P., Sigurdsson, A., Thorleifsson, G., Helgason, H., Agustsdottir, A. B., Norddahl, G. L., … Williams, M. J. A., van Rij, A. M., Jones, G. T., … Stefansson, K. (2016). Variant ASGR1 associated with a reduced risk of coronary artery disease. New England Journal of Medicine, 374, 2131-2141. doi: 10.1056/NEJMoa1508419

Coffey, S., Cox, B., & Williams, M. J. A. (2016). Changing causes of heart valve disease mortality in New Zealand from 1988 to 2007. New Zealand Medical Journal, 129(1428), 55-64. Retrieved from https://www.nzma.org.nz/journal

Devlin, G., Williams, M., Elliott, J., White, H., French, J., Gamble, G., Matsis, P., Troughton, R., Richards, M., & Ellis, C. (2016). Management of non ST-elevation acute coronary syndrome patients in New Zealand: A longitudinal analysis: Results from the New Zealand Acute Coronary Syndrome national audits of 2002, 2007 and 2012. New Zealand Medical Journal, 129(1428), 9-15. Retrieved from https://www.nzma.org.nz/journal

Mandic, S., Stevens, E., Hodge, C., Brown, C., Walker, R., Body, D., … Nye, E. R., & Williams, M. J. A. (2016). Long-term effects of cardiac rehabilitation in elderly individuals with stable coronary artery disease. Disability & Rehabilitation, 38(9), 837-843. doi: 10.3109/09638288.2015.1061611

Williams, M. J. A., Harding, S. A., Devlin, G., Nunn, C., El-Jack, S., Scott, T., … on behalf of the ANZACS-QI Investigators, including Matsis, P., Smyth, D., Blake, J., Elliott, J., Lainchbury, J., Bridgman, P., Troughton, R., Wilkins, G., Green, B., Edmond, J., & Milburn, K. (2016). National variation in coronary angiography rates and timing after an acute coronary syndrome in New Zealand (ANZACS-QI 6). New Zealand Medical Journal, 129(1428), 65-77. Retrieved from https://www.nzma.org.nz/journal

Majeed, K., Hamer, A. W., White, S. C., Pegg, T. J., Wilkins, G. T., Williams, S. M., … Williams, M. J. A. (2015). Prevalence of abdominal aortic aneurysm in patients referred for transthoracic echocardiography. Internal Medicine Journal, 45(1), 32-39. doi: 10.1111/imj.12592

Sharma, M., Von Zychlinski-Kleffmann, A., Porteous, C. M., Jones, G. T., Williams, M. J. A., & McCormick, S. P. A. (2015). Lipoprotein (a) upregulates ABCA1 in liver cells via scavenger receptor-B1 through its oxidized phospholipids. Journal of Lipid Research, 56, 1318-1328. doi: 10.1194/jlr.M056150

Ellis, C., Hammett, C., Ranasinghe, I., French, J., Briffa, T., Devlin, G., Elliott, J., … Williams, M., Troughton, R., … on behalf of Bi-National Acute Coronary Syndromes (ACS) 'SNAPSHOT' Audit Group. (2015). Comparison of the management and in-hospital outcomes of acute coronary syndrome patients in Australia and New Zealand: Results from the binational SNAPSHOT acute coronary syndrome 2012 audit. Internal Medicine Journal, 45(5), 497-509. doi: 10.1111/imj.12739

Mandic, S., Body, D., Barclay, L., Walker, R., Nye, E. R., Grace, S. L., & Williams, M. J. A. (2015). Community-based cardiac rehabilitation maintenance programs: Use and effects. Heart, Lung & Circulation, 24, 710-718. doi: 10.1016/j.hlc.2015.01.014

Horwood, H., Williams, M. J. A., & Mandic, S. (2015). Examining motivations and barriers for attending maintenance community-based cardiac rehabilitation using the Health-Belief Model. Heart, Lung & Circulation, 24, 980-987. doi: 10.1016/j.hlc.2015.03.023

Theodore, R. F., Broadbent, J., Nagin, D., Ambler, A., Hogan, S., Ramrakha, S., … Williams, M. J. A., Harrington, H., Moffitt, T. E., … Milne, B., & Poulton, R. (2015). Childhood to early-midlife systolic blood pressure trajectories: Early-life predictors, effect modifiers, and adult cardiovascular outcomes. Hypertension, 66, 1108-1115. doi: 10.1161/HYPERTENSIONAHA.115.05831

Coffey, S., Williams, M. J. A., Phillips, L. V., & Jones, G. T. (2015). Circulating microRNA profiling needs further refinement before clinical use in patients with aortic stenosis. Journal of the American Heart Association, 4(8), e002150. doi: 10.1161/jaha.115.002150

Bussey, C. T., Hughes, G., Saxena, P., Galvin, I. F., Bunton, R. W., Noye, M. K., Coffey, S., Williams, M. J. A., Baldi, J. C., Jones, P. P., & Lamberts, R. R. (2015). Chamber-specific changes in calcium-handling proteins in the type 2 diabetic human heart with preserved ejection fraction. International Journal of Cardiology, 193, 53-55. doi: 10.1016/j.ijcard.2015.05.053

Jin, C., Phillips, L. V., Williams, M. J. A., van Rij, A. M., & Jones, G. T. (2014). Plasma heat shock protein 27 is associated with coronary artery disease, abdominal aortic aneurysm and peripheral artery disease. SpringerPlus, 3, 635. doi: 10.1186/2193-1801-3-635

Coffey, S., Cox, B., & Williams, M. J. A. (2014). The prevalence, incidence, progression, and risks of aortic valve sclerosis: A systematic review and meta-analysis. JACC, 63(25), 2852-2861. doi: 10.1016/j.jacc.2014.04.018

Kader, T., Porteous, C. M., Williams, M. J. A., Gieseg, S. P., & McCormick, S. P. A. (2014). Ribose-cysteine increases glutathione-based antioxidant status and reduces LDL in human lipoprotein(a) mice. Atherosclerosis, 237(2), 725-733. doi: 10.1016/j.atherosclerosis.2014.10.101

Coffey, S., Cox, B., & Williams, M. J. A. (2014). Lack of progress in valvular heart disease in the pre—transcatheter aortic valve replacement era: Increasing deaths and minimal change in mortality rate over the past three decades. American Heart Journal, 167(4), 562-567. doi: 10.1016/j.ahj.2013.12.030

Moore, A., Shindikar, A., Fomison-Nurse, I., Riu, F., Munasinghe, P. E., Parshu Ram, T., Saxena, P., Coffey, S., Bunton, R. W., Galvin, I. F., Williams, M. J. A., … Katare, R. (2014). Rapid onset of cardiomyopathy in STZ-induced female diabetic mice involves the downregulation of pro-survival Pim-1. Cardiovascular Diabetology, 13, 68. doi: 10.1186/1475-2840-13-68

Lamberts, R. R., Lingam, S. J., Wang, H.-Y., Bollen, I. A. E., Hughes, G., Galvin, I. F., Bunton, R. W., Bahn, A., Katare, R., Baldi, J. C., Williams, M. J. A., Saxena, P., Coffey, S., & Jones, P. P. (2014). Impaired relaxation despite upregulated calcium-handling protein atrial myocardium from type 2 diabetic patients with preserved ejection fraction. Cardiovascular Diabetology, 13, 72. doi: 10.1186/1475-2840-13-72

Francois, M. E., Baldi, J. C., Manning, P. J., Lucas, S. J. E., Hawley, J. A., Williams, M. J. A., & Cotter, J. D. (2014). ‘Exercise snacks’ before meals: A novel strategy to improve glycaemic control in individuals with insulin resistance. Diabetologia, 57(7), 1437-1445. doi: 10.1007/s00125-014-3244-6

von Zychilinski, A., Williams, M., McCormick, S., & Kleffmann, T. (2014). Absolute quantification of apolipoproteins and associated proteins on human plasma lipoproteins. Journal of Proteomics, 106, 181-190. doi: 10.1016/j.jprot.2014.04.030

Mandic, S., Hodge, C., Stevens, E., Walker, R., Nye, E. R., Body, D., Barclay, L., & Williams, M. J. A. (2013). Effects of community-based cardiac rehabilitation on body composition and physical function in individuals with stable coronary artery disease: 1.6-year followup. BioMed Research International, 2013, 903604. doi: 10.1155/2013/903604

Tarr, G. P., Williams, M. J. A., Wilkins, G. T., Chen, V. H. T., Phillips, L. V., van Rij, A. M., & Jones, G. T. (2013). Intra-individual changes of active matrix metalloproteinase-9 are associated with clinical in-stent restenosis of bare metal stents. Cardiology, 124(1), 28-35. doi: 10.1159/000345591

Ellis, C., Gamble, G., Devlin, G., Elliott, J., Hamer, A., Williams, M., Matsis, P., Troughton, R., … for the New Zealand Acute Coronary Syndromes (NZACS) 'SNAPSHOT' Audit Group. (2013). The management of acute coronary syndrome patients across New Zealand in 2012: Results of a third comprehensive nationwide audit and observations of current interventional care. New Zealand Medical Journal, 126(1387). Retrieved from http://www.nzma.org.nz/journal

Sorrenson, B., Suetani, R. J., Williams, M. J. A., Bickley, V. M., George, P. M., Jones, G. T., & McCormick, S. P. A. (2013). Functional rescue of mutant ABCA1 proteins by sodium 4-phenylbutyrate. Journal of Lipid Research, 54, 55-62. doi: 10.1194/jlr.M027193

Murrell, C. J., Cotter, J. D., Thomas, K. N., Lucas, S. J. E., Williams, M. J. A., & Ainslie, P. N. (2013). Cerebral blood flow and cerebrovascular reactivity at rest and during sub-maximal exercise: Effect of age and 12-week exercise training. Age, 35(3), 905-920. doi: 10.1007/s11357-012-9414-x

Chu, J. W., Jones, G. T., Tarr, G. P., Phillips, L. V., Wilkins, G. T., van Rij, A. M., & Williams, M. J. A. (2013). Plasma active matrix metalloproteinase 9 and indices of diastolic function in patients with preserved systolic function. International Journal of Cardiology, 167(4), 1242-1246. doi: 10.1016/j.ijcard.2012.03.147

Mandic, S., Walker, R., Stevens, E., Nye, E. R., Body, D., Barclay, L., & Williams, M. J. A. (2013). Estimating exercise capacity from walking tests in elderly individuals with stable coronary artery disease. Disability & Rehabilitation, 35(22), 1853-1858. doi: 10.3109/09638288.2012.759629

Jones, G. T., Bown, M. J., Gretarsdottir, S., Romaine, S. P. R., Helgadottir, A., Yu, G., … Jin, C., … Phillips, L. V., Williams, M. J. A., Topless, R., Merriman, T. R., … Lewis, D. R., … van Rij, A. M. (2013). A sequence variant associated with sortilin-1 (SORT1) on 1p13.3 is independently associated with abdominal aortic aneurysm. Human Molecular Genetics, 22(14), 2941-2947. doi: 10.1093/hmg/ddt141

Nadarasa, K., Robertson, M. C., Wong, C.-K., Green, B. K. W., Chen, V. H. T., Wilkins, G. T., & Williams, M. J. A. (2012). Rapid cycle change to predominantly radial access coronary angiography and percutaneous coronary intervention: Effect on vascular access site complications. Catheterization & Cardiovascular Interventions, 79(4), 589-594. doi: 10.1002/ccd.23120

Nadarasa, K., & Williams, M. J. A. (2012). Single high oral dose amiodarone for cardioversion of recent onset atrial fibrillation. Heart, Lung & Circulation, 21(8), 444-448. doi: 10.1016/j.hlc.2012.03.015

von Zychlinski, A., Kleffmann, T., Williams, M. J. A., & McCormick, S. P. (2011). Proteomics of Lipoprotein(a) identifies a protein complement associated with response to wounding. Journal of Proteomics, 74, 2881-2891. doi: 10.1016/j.jprot.2011.07.008

Suetani, R. J., Sorrenson, B., Tyndall, J. D. A., Williams, M. J. A., & McCormick, S. P. A. (2011). Homology modeling and functional testing of an ABCA1 mutation causing Tangier disease. Atherosclerosis, 218(2), 404-410. doi: 10.1016/j.atherosclerosis.2011.06.019

Sorrenson, B., Suetani, R. J., Bickley, V. M., George, P. M., Williams, M. J. A., Scott, R. S., & McCormick, S. P. A. (2011). An ABCA1 truncation shows no dominant negative effect in a familial hypoalphalipoproteinemia pedigree with three ABCA1 mutations. Biochemical & Biophysical Research Communications, 409(3), 400-405. doi: 10.1016/j.bbrc.2011.05.006

Tarr, G. P., Williams, M. J. A., Phillips, L. V., van Rij, A. M., & Jones, G. T. (2011). Seasonal variation and stability of matrix metalloproteinase-9 activity and tissue inhibitor of matrix metalloproteinase-1 with storage at -80 oC. Clinical Biochemistry, 44(16), 1346-1348. doi: 10.1016/j.clinbiochem.2011.08.1139

Murrell, C. J., Cotter, J. D., George, K., Shave, R., Wilson, L., Thomas, K., Williams, M. J. A., & Ainslie, P. N. (2011). Syncope is unrelated to supine and postural hypotension following prolonged exercise. European Journal of Applied Physiology, 111(3), 469-476. doi: 10.1007/s00421-010-1671-8

Murrell, C. J., Cotter, J. D., George, K., Shave, R., Wilson, L., Thomas, K., Williams, M. J. A., & Ainslie, P. N. (2011). Cardiorespiratory and cerebrovascular responses to head-up tilt I: Influence of age and training status. Experimental Gerontology, 46(1), 9-17. doi: 10.1016/j.exger.2010.06.005

Tarr, G. P., Williams, M. J. A., Phillips, L. V., van Rij, A. M., & Jones, G. T. (2011). Pro-MMP-9/TIMP-1 ratio correlates poorly with a direct assessment of MMP-9 activity. Clinical Biochemistry, 44(17-18), 1480-1482. doi: 10.1016/j.clinbiochem.2011.09.019

Murrell, C. J., Cotter, J. D., George, K., Shave, R., Wilson, L., Thomas, K., Williams, M. J. A., & Ainslie, P. N. (2011). Cardiorespiratory and cerebrovascular responses to head-up tilt II: Influence of age, training status and acute exercise. Experimental Gerontology, 46(1), 1-8. doi: 10.1016/j.exger.2010.06.004

Stewart, R. A. H., Kerr, A. J., Whalley, G. A., Legget, M. E., Zeng, I., Williams, M. J. A., Lainchbury, J., … Richards, M. A., … for the New Zealand Heart Valve Study Investigators. (2010). Left ventricular systolic and diastolic function assessed by tissue Doppler imaging and outcome in asymptomatic aortic stenosis. European Heart Journal, 31(18), 2216-2222. doi: 10.1093/eurheartj/ehq159

Ellis, C., Devlin, G., Elliott, J., Matsis, P., Williams, M., Gamble, G., … Richards, M., … for the New Zealand Acute Coronary Syndromes (NZACS) Audit Group. (2010). ACS patients in New Zealand experience significant delays to access cardiac investigations and revascularisation treatment especially when admitted to non-interventional centres: Results of the second comprehensive national audit of ACS patients. New Zealand Medical Journal, 123(1319). Retrieved from http://journal.nzma.org.nz/journal/123-1319/4237/content.pdf

Gretarsdottir, S., Baas, A. F., Thorleifsson, G., Holm, H., den Heijer, M., de Vries, J.-P. P. M., … van Rij, A. M., Williams, M. J. A., … Jones, G. T., … Stefansson, K. (2010). Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm. Nature Genetics, 42(8), 692-697. doi: 10.1038/ng.622

Ellis, C., Gamble, G., Hamer, A., Williams, M., Matsis, P., Elliott, J., … Richards, M., … for the New Zealand Acute Coronary Syndromes (NZACS) Audit Group. (2010). Patients admitted with an acute coronary syndrome in New Zealand in 2007: Results of a second comprehensive nationwide audit and a comparison with the first audit from 2002. New Zealand Medical Journal, 123(1319). Retrieved from http://journal.nzma.org.nz/journal/123-1319/4235/content.pdf

Sutherland, W. H. F., de Jong, S. A., Hessian, P. A., & Williams, M. J. A. (2010). Ingestion of native and thermally oxidized polyunsaturated fats acutely increases circulating numbers of endothelial microparticles. Metabolism, 59(3), 446-453. doi: 10.1016/j.metabol.2009.07.033

Thomas, K. N., Galvin, S. D., Williams, M. J. A., Willie, C. K., & Ainslie, P. N. (2010). Identical pattern of cerebral hypoperfusion during different types of syncope. Journal of Human Hypertension, 24(7), 458-466. doi: 10.1038/jhh.2009.93

Thomas, K. N., Cotter, J. D., Galvin, S. D., Williams, M. J. A., Willie, C. K., & Ainslie, P. N. (2009). Initial orthostatic hypotension is unrelated to orthostatic tolerance in healthy young subjects. Journal of Applied Physiology, 107(2), 506-517. doi: 10.1152/japplphysiol.91650.2008

Murrell, C. J., Cotter, J. D., George, K. P., Shave, R., Wilson, L. C., Thomas, K. N., Williams, M. J. A., … Ainslie, P. N. (2009). Influence of age on syncope following prolonged exercise: Differential responses but similar orthostatic intolerance. Journal of Physiology, 587(24), 5959-5969. doi: 10.1113/jphysiol.2009.179549

Jones, G. T., Tarr, G. P., Phillips, L. V., Wilkins, G. T., van Rij, A. M., & Williams, M. J. A. (2009). Active matrix metalloproteinases 3 and 9 are independently associated with coronary artery in-stent restenosis. Atherosclerosis, 207(2), 603-607. doi: 10.1016/j.atherosclerosis.2009.05.036

Gudbjartsson, D. F., Bjornsdottir, U. S., Halapi, E., Helgadottir, A., Sulem, P., Jonsdottir, G. M., … Williams, M. J. A., van Rij, A. M., Jones, G. T., … Stefansson, K. (2009). Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nature Genetics, 41(3), 342-347. doi: 10.1038/ng.323

Ainslie, P. N., Cotter, J. D., George, K. P., Lucas, S., Murrell, C., Shave, R., Thomas, K. N., Williams, M. J. A., & Atkinson, G. (2008). Elevation in cerebral blood flow velocity with aerobic fitness throughout healthy human ageing. Journal of Physiology, 586(16), 4005-4010. doi: 10.1113/jphysiol.2008.158279

Jones, G. T., van Rij, A. M., Hill, G. B., Wilkins, G. T., & Williams, M. J. A. (2008). Common carotid intimal-medial thickness is associated with coronary in-stent restenosis. Journal for Vascular Ultrasound, 32(3), 129-132.

Slatter, T. L., Jones, G. T., Williams, M. J. A., van Rij, A. M., & McCormick, S. P. A. (2008). Novel rare mutations and promoter haplotypes in ABCA1 contribute to low-HDL-C levels. Clinical Genetics, 73, 179-184. doi: 10.1111/j.1399-0004.2007.00940.x

Peng, T., Ainslie, P. N., Cotter, J. D., Murrell, C., Thomas, K., Williams, M. J. A., … Payne, S. J. (2008). The effects of age on the spontaneous low-frequency oscillations in cerebral and systemic cardiovascular dynamics. Physiological Measurement, 29, 1055-1069.

Manning, P. J., Sutherland, W. H. F., McGrath, M. M., de Jong, S. A., Walker, R. J., & Williams, M. J. A. (2008). Postprandial cytokine concentrations and meal composition in obese and lean women. Obesity, 16(9), 2046-2052. doi: 10.1038/oby.2008.334

Sutherland, W. H., Williams, M. J., & de Jong, S. A. (2007). Plasma protein lipofuscin-like fluorophores in men with coronary artery disease treated with statins. Archives of Medical Research, 38, 757-763.

Hancox, R. J., Poulton, R., Greene, J. M., Filsell, S., McLachlan, C. R., Rasmussen, F., Taylor, D. R., Williams, M. J. A., Williamson, A., & Sears, M. R. (2007). Systemic inflammation and lung function in young adults. Thorax, 62, 1064-1068.

Sutherland, W. H. F., Williams, M. J. A., de Jong, S. A., & McCormick, M. P. (2007). Ingestion of moderately thermally oxidized polyunsaturated fat decreases serum resistance to oxidation in men with coronary artery disease. Nutrition Research, 27, 265-272. doi: 10.1016/j.nutres.2006.12.014

Ainslie, P. N., Murrell, C., Peebles, K., Swart, M., Skinner, M. A., Williams, M. J. A., & Taylor, D. R. (2007). Early morning impairment in cerebral autoregulation and cerebrovascular CO2 reactivity in healthy humans: Relation to endothelial function. Experimental Physiology, 92(4), 769-777.

Tie, S., Wong, C.-K., Yap, J., Wilkins, G., Williams, M., & Kay, P. (2007). Timing of thrombotic events in patients receiving 2 weeks of clopidogrel therapy post bare metal coronary artery stenting: A New Zealand retrospective study. New Zealand Medical Journal, 120(1255). Retrieved from http://journal.nzma.org.nz/journal/120-1255/2553/content.pdf

Jones, G. T., van Rij, A. M., Cole, J., Williams, M. J. A., Bateman, E. H., Marcovina, S. M., Deng, M., & McCormick, S. P. A. (2007). Plasma lipoprotein(a) indicates risk for 4 distinct forms of vascular disease. Clinical Chemistry, 53(4), 679-685.

Jones, G. T., Kay, I. P., Chu, J. W. S., Wilkins, G. T., Phillips, L. V., McCormick, M., van Rij, A. M., & Williams, M. J. A. (2006). Elevated plasma active matrix metalloproteinase-9 level is associated with coronary artery in-stent restenosis. Arteriosclerosis, Thrombosis, & Vascular Biology, 26, e121-e125.

Tang, E. W., Wong, C.-K., Restieaux, N. J., Herbison, P., Williams, M. J. A., Kay, P., & Wilkins, G. T. (2006). Clinical outcome of older patients with acute coronary syndrome over the last three decades. Age & Ageing, 35, 280-285.

Williams, M. J. A., Williams, S. M., & Poulton, R. (2006). Breast feeding is related to C reactive protein concentration in adult women. Journal of Epidemiology & Community Health, 60, 146-148.

Slatter, T. L., Williams, M. J. A., Frikke-Schmidt, R., Tybjærg-Hansen, A., Morison, I. M., & McCormick, S. P. A. (2006). Promoter haplotype of a new ABCA1 mutant influences expression of familial hypoalphalipoproteinemia. Atherosclerosis, 187, 393-400.

Tang, E. W., Wong, C.-K., Wilkins, G., Herbison, P., Williams, M., Kay, P., & Restieaux, N. (2005). Use of evidence-based management for acute coronary syndrome. New Zealand Medical Journal, 118(1223). Retrieved from http://journal.nzma.org.nz/journal/118-1223/1678/content.pdf

Williams, M. J. A., Milne, B. J., Hancox, R. J., & Poulton, R. (2005). C-reactive protein and cardiorespiratory fitness in young adults. European Journal of Cardiovascular Prevention & Rehabilitation, 12(3), 216-220.

Williams, M. J., Sutherland, W. H., McCormick, M. P., Yeoman, D. J., & de Jong, S. A. (2005). Aged garlic extract improves endothelial function in men with coronary artery disease. Phytotherapy Research, 19(4), 314-319.

Whelan, A. P., Sutherland, W. H. F., McCormick, M. P., Yeoman, D. J., de Jong, S. A., & Williams, M. J. A. (2004). Effects of white and red wine on endothelial function in subjects with coronary artery disease. Internal Medicine Journal, 34, 224-228.

Ellis, C., Devlin, G., Matsis, P., Elliott, J., Williams, M., Gamble, G., Mann, S., … for the New Zealand Acute Coronary Syndromes (NZACS) Audit Group. (2004). Acute coronary syndrome patients in New Zealand receive less invasive management when admitted to hospitals without invasive facilities. New Zealand Medical Journal, 117(1197). Retrieved from http://journal.nzma.org.nz/journal/117-1197/954/content.pdf

Chu, J., Wilkins, G., & Williams, M. (2004). Review of 65 cases of infective endocarditis in Dunedin Public Hospital. New Zealand Medical Journal, 117(1200). Retrieved from http://journal.nzma.org.nz/journal/117-1200/1021/content.pdf

Ellis, C., Gamble, G., French, J., Devlin, G., Matsis, P., Elliott, J., Mann, S., Williams, M., … for the New Zealand Acute Coronary Syndromes (NZACS) Audit Group. (2004). Management of patients admitted with an acute coronary syndrome in New Zealand: Results of a comprehensive nationwide audit. New Zealand Medical Journal, 117(1197). Retrieved from http://journal.nzma.org.nz/journal/117-1197/953/content.pdf

Williams, M. J. A., Williams, S. M., Milne, B. J., Hancox, R. J., & Poulton, R. (2004). Association between C-reactive protein, metabolic cardiovascular risk factors, obesity and oral contraceptive use in young adults. International Journal of Obesity, 28, 998-1003.

Williams, M. J. A., Sutherland, W. H. F., Whelan, A. P., McCormick, M. P., & de Jong, S. A. (2004). Acute effect of drinking red and white wines on circulating levels of inflammation-sensitive molecules in men with coronary artery disease. Metabolism, 53(3), 318-323.

Cohn, J. N., Pfeffer, M. A., Rouleau, J., Sharpe, N., Swedberg, K., Straub, M., … for the MOXCON Investigators, including Williams, M. (2003). Adverse mortality effect of central sympathetic inhibition with sustained-release moxonidine in patients with heart failure (MOXCON). European Journal of Heart Failure, 5, 659-667. doi: 10.1016/S1388-9842(03)00163-6

Pfeffer, M. A., McMurray, J. J. V., Velazquez, E. J., Rouleau, J.-L., Køber, L., Maggioni, A. P., … Wilkins, G., Williams, M., & Wong, C. K. (2003). Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both. New England Journal of Medicine, 349(20), 1893-1906. doi: 10.1056/NEJMoa032292

Williams, M. J. A., Poulton, R., & Williams, S. M. (2002). Relationship of serum ferritin with cardiovascular risk factors and inflammation in young men and women. Atherosclerosis, 165, 179-184.

Sutherland, W. H. F., de Jong, S. A., Walker, R. J., Williams, M. J. A., Skeaff, C. M., Duncan, A., & Harper, M. J. (2002). Effect of meals rich in heated olive and safflower oils on oxidation of postprandial serum in healthy men. Atherosclerosis, 160, 195-203.

Sutherland, W. H. F., De Jong, S. A., Walker, R. J., Williams, M. J. A., Skeaff, C. M., Duncan, A., & Harper, M. J. (2002). Effect of meals rich in heated olive and safflower oils on oxidation of postprandial serum in healthy men. Atherosclerosis, 160, 195-203.

Pacific Study Group, including Williams, M., & Mann, S. (2002). Effects of the vasopeptidase inhibitor, omapatrilat, in 723 patients with coronary heart disease. Journal of the Renin-Angiotensin-Aldosterone System, 3(4), 270-276.

Aebli, N., Krebs, J., Davis, G., Walton, M. H., Williams, M. J. A., & Theis, J.-C. (2002). Fat embolism and acute hypotension during vertebroplasty: An experimental study in sheep. Spine, 27(5), 460-466.

Whelan, A. P., & Williams, M. J. A. (2001). Spontaneous intramural aortic haematoma. New Zealand Medical Journal, 114, 38-41.

Williams, M. J. A., & Walker, R. J. (2001). When is an ANCA an anchor? Internal Medicine Journal, 31(5), 308-311.

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