Professor Michael Williams
Position | Clinical Professor |
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Department | Department of Medicine (Dunedin) |
Qualifications | MD FRACP FACC |
Research summary | Cardiology |
Teaching | Integration of cardiac investigations into clinical practice. |
Clinical |
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Research
Michael Williams' research interests include studying the effect of lifestyle factors and diet on arterial function and the development of arterial disease. He has investigated the influence of physical fitness on measures of arterial inflammation and the risk of developing chest pain and heart attack in later life. His other clinical research has focussed on understanding the biology of restenosis in stents inserted in patients' heart arteries to open blockages. Studies of cardiovascular genetics have contributed to international collaborative research and the identification of novel genetic markers of arterial disease. Michael's current investigations include the regulation of gene expression on the development of narrowing and stiffening of cardiac valves with the aim of developing therapies to delay or prevent the requirement for surgical valve replacement. He is presently Chair of the Medicine Department Peer Review Committee.
Publications
Barrett-Young, A., Ambler, A., Cheyne, K., Guiney, H., Kokaua, J., Tham, Y. C., Williams, M. J. A., Wilson, G. A., … Poulton, R. (2023). Childhood social isolation as a predictor of retinal neuronal thickness in middle age: A lifecourse birth cohort study. Psychosomatic Medicine. Advance online publication. doi: 10.1097/psy.0000000000001177
McLeod, P., Coffey, S., Sneddon, K., Williams, M., Kerr, A., & Pemberton, J. (2022). Clinically acquired high sensitivity cardiac troponin T is a poor predictor of reduced left ventricular ejection fraction after ST elevation myocardial infarction: A national cohort study–ANZACS-QI 65. Heart, Lung & Circulation. Advance online publication. doi: 10.1016/j.hlc.2022.07.014
Pons, A., Whalley, G., Sneddon, K., Williams, M., & Coffey, S. (2022). A systematic review of non-procedural contributors to quality of life in heart valve disease. Health Sciences Review, 4, 100050. doi: 10.1016/j.hsr.2022.100050
Ghosh, N., Fenton, S., van Hout, I., Jones, G. T., Coffey, S., Williams, M. J. A., Sugunesegran, R., Parry, D., … Schwenke, D. O., Chatterjee, A., & Katare, R. (2022). Therapeutic knockdown of miR-320 improves deteriorated cardiac function in a pre-clinical model of non-ischemic diabetic heart disease. Molecular Therapy: Nucleic Acids, 29, 330-342. doi: 10.1016/j.omtn.2022.07.007
Pons, A., Whalley, G., Sneddon, K., Williams, M., & Coffey, S. (2022). Predictors of quality of life after revascularization for ischemic heart disease: A systematic review. Health Sciences Review, 2, 100017. doi: 10.1016/j.hsr.2022.100017
Williams, M. J. A. (2004). The importance of echocardiography to the interventionalist. In I. P. Kay, M. Sabaté & M. A. Costa (Eds.), Cardiac catheterization and percutaneous interventions. (pp. 407-416). London: Taylor & Francis.
Chapter in Book - Research
Swope, J. A., Kasabov, N. K., & Williams, M. J. A. (2000). Neuro-fuzzy modelling of heart rate signals and applications to diagnostics. In P. S. Szczepaniak, P. J. G. Lisboa & J. Kacprzyk (Eds.), Fuzzy Systems in Medicine. (pp. 519-542). Heidelberg: Physica Verlag.
Chapter in Book - Research
Barrett-Young, A., Ambler, A., Cheyne, K., Guiney, H., Kokaua, J., Tham, Y. C., Williams, M. J. A., Wilson, G. A., … Poulton, R. (2023). Childhood social isolation as a predictor of retinal neuronal thickness in middle age: A lifecourse birth cohort study. Psychosomatic Medicine. Advance online publication. doi: 10.1097/psy.0000000000001177
Journal - Research Article
Ghosh, N., Fenton, S., van Hout, I., Jones, G. T., Coffey, S., Williams, M. J. A., Sugunesegran, R., Parry, D., … Schwenke, D. O., Chatterjee, A., & Katare, R. (2022). Therapeutic knockdown of miR-320 improves deteriorated cardiac function in a pre-clinical model of non-ischemic diabetic heart disease. Molecular Therapy: Nucleic Acids, 29, 330-342. doi: 10.1016/j.omtn.2022.07.007
Journal - Research Article
McLeod, P., Coffey, S., Sneddon, K., Williams, M., Kerr, A., & Pemberton, J. (2022). Clinically acquired high sensitivity cardiac troponin T is a poor predictor of reduced left ventricular ejection fraction after ST elevation myocardial infarction: A national cohort study–ANZACS-QI 65. Heart, Lung & Circulation. Advance online publication. doi: 10.1016/j.hlc.2022.07.014
Journal - Research Article
Aitken-Buck, H. M., Krause, J., van Hout, I., Davis, P. J., Bunton, R. W., Parry, D. J., Williams, M. J. A., Coffey, S., … Jones, P. P., & Lamberts, R. R. (2021). Long-chain acylcarnitine 18:1 acutely increases human atrial myocardial contractility and arrhythmia susceptibility. American Journal of Physiology: Heart & Circulatory Physiology, 321, H162-H174. doi: 10.1152/ajpheart.00184.2021
Journal - Research Article
Coffey, S., Dixit, P., Saw, E. L., Babakr, A. A., van Hout, I., Galvin, I. F., Saxena, P., Bunton, R. W., Davis, P. J., Lamberts, R. R., Katare, R., & Williams, M. J. A. (2021). Thiamine increases resident endoglin positive cardiac progenitor cells and atrial contractile force in humans: A randomised controlled trial. International Journal of Cardiology, 341, 70-73. doi: 10.1016/j.ijcard.2021.08.039
Journal - Research Article
Ho, C. Y.-C., Lee, M., El-Jack, S., Barr, P., Simmonds, M., Devlin, G., Adamson, P. D., Williams, M., & Kerr, A. J. (2021). How common are non-acute coronary syndrome (ACS) diagnoses in patients with suspected ACS investigated with coronary angiography in New Zealand? (ANZACS-QI 58). New Zealand Medical Journal, 134(1537), 43-55. Retrieved from https://www.nzma.org.nz/journal
Journal - Research Article
Pasupathy, S., Lindahl, B., Litwin, P., Tavella, R., Williams, M. J. A., Air, T., … Beltrame, J. F. (2021). Survival in patients with suspected myocardial infarction with nonobstructive coronary arteries: A comprehensive systematic review and meta-analysis from the MINOCA Global Collaboration. Circulation: Cardiovascular Quality & Outcomes, 14(11), e007880. doi: 10.1161/circoutcomes.121.007880
Journal - Research Article
Purvis, N., Kumari, S., Chandrasekera, D., Bellae Papannarao, J., Gandhi, S., van Hout, I., Coffey, S., Bunton, R., Sugunesegran, R., Parry, D., Davis, P., Williams, M. J. A., Bahn, A., & Katare, R. (2021). Diabetes induces dysregulation of microRNAs associated with survival, proliferation and self-renewal in cardiac progenitor cells. Diabetologia, 64, 1422-1435. doi: 10.1007/s00125-021-05405-7
Journal - Research Article
Roxburgh, B. H., Campbell, H. A., Cotter, J. D., Reymann, U., Williams, M. J. A., Gwynne-Jones, D., & Thomas, K. N. (2021). Cardiopulmonary exercise testing in severe osteoarthritis: A crossover comparison of four exercise modalities. Anaesthesia, 76, 72-81. doi: 10.1111/anae.15162
Journal - Research Article
Roxburgh, B. H., Campbell, H. A., Cotter, J. D., Reymann, U., Williams, M. J. A., Gwynne-Jones, D., & Thomas, K. N. (2021). The absolute and relative reliability of hand-held dynamometry in patients with severe lower-limb osteoarthritis scheduled for total joint replacement surgery. International Journal of Research in Exercise Physiology, 16(2), 81-91. Retrieved from https://ijrep.org
Journal - Research Article
Saw, E. L., Pearson, J. T., Schwenke, D. O., Munasinghe, P. E., Tsuchimochi, H., Rawal, S., Coffey, S., … Bunton, R., Van Hout, I., … Williams, M. J. A., … Fronius, M., & Katare, R. (2021). Activation of the cardiac non-neuronal cholinergic system prevents the development of diabetes-associated cardiovascular complications. Cardiovascular Diabetology, 20, 50. doi: 10.1186/s12933-021-01231-8
Journal - Research Article
Williams, M. J. A., Lee, M., Alfadhel, M., & Kerr, A. J. (2021). Obesity and all cause mortality following acute coronary syndrome (ANZACS QI 53). Heart, Lung & Circulation, 30, 1854-1862. doi: 10.1016/j.hlc.2021.04.014
Journal - Research Article
Aitken-Buck, H. M., Babakr, A. A., Fomison-Nurse, I. C., van Hout, I., Davis, P. J., Bunton, R. W., Williams, M. J. A., Coffey, S., Jones, P. P., & Lamberts, R. R. (2020). Inotropic and lusitropic, but not arrhythmogenic, effects of adipocytokine resistin on human atrial myocardium. American Journal of Physiology: Endocrinology & Metabolism, 319, E540-E547. doi: 10.1152/ajpendo.00202.2020
Journal - Research Article
Babakr, A. A., Fomison-Nurse, I. C., van Hout, I., Aitken-Buck, H. M., Sugunesegran, R., Davis, P. J., Bunton, R. W., Williams, M. J. A., Coffey, S., Stiles, M. K., Jones, P. P., & Lamberts, R. R. (2020). Acute interaction between human epicardial adipose tissue and human atrial myocardium induce arrhythmic susceptibility. American Journal of Physiology: Endocrinology & Metabolism, 318, E164-E172. doi: 10.1152/ajpendo.00374.2019
Journal - Research Article
Chan, D. Z. L., Stewart, R. A. H., Kerr, A. J., Dicker, B., Kyle, C. V., Adamson, P. D., … Edmond, J., … Elliott, J. M., … Swain, A. H., … Williams, M. J. A., … Somaratne, J. B. (2020). The impact of a national COVID-19 lockdown on acute coronary syndrome hospitalisations in New Zealand (ANZACS-QI 55). Lancet Regional Health: Western Pacific, 5, 100056. doi: 10.1016/j.lanwpc.2020.100056
Journal - Research Article
Chandrasekera, D. N. K., Neale, J. P. H., van Hout, I., Rawal, S., Coffey, S., Jones, G. T., … Manning, P., Williams, M. J. A., & Katare, R. (2020). Upregulation of microRNA-532 enhances cardiomyocyte apoptosis in the diabetic heart. Apoptosis, 25(5-6), 388-399. doi: 10.1007/s10495-020-01609-1
Journal - Research Article
Hancox, R. J., Thomas, L., Williams, M. J. A., & Sears, M. R. (2020). Associations between lung and endothelial function in early middle age. Respirology, 25, 89-96. doi: 10.1111/resp.13556
Journal - Research Article
Jones, G. T., Drinkwater, B., Blake-Barlow, A., Hill, G. B., Williams, M. J. A., Krysa, J., van Rij, A. M., & Coffey, S. (2020). Both small and large infrarenal aortic size is associated with an increased prevalence of ischaemic heart disease. European Journal of Vascular & Endovascular Surgery, 60, 594-601. doi: 10.1016/j.ejvs.2020.06.025
Journal - Research Article
Jones, G. T., Marsman, J., Bhat, B., Phillips, V. L., Chatterjee, A., Rodger, E. J., Williams, M. J. A., van Rij, A. M., & McCormick, S. P. A. (2020). DNA methylation profiling identifies a high effect genetic variant for lipoprotein(a) levels. Epigenetics, 15(9), 949-958. doi: 10.1080/15592294.2020.1739797
Journal - Research Article
Lal, S., Gray, A., Kim, E., Bunton, R. W., Davis, P., Galvin, I. F., & Williams, M. J. A. (2020). Frailty in elderly patients undergoing cardiac surgery increases hospital stay and 12-month readmission rate. Heart, Lung & Circulation, 29, 1187-1194. doi: 10.1016/j.hlc.2019.10.007
Journal - Research Article
Moharram, M. A., Aitken-Buck, H. M., Reijers, R., van Hout, I., Williams, M. J. A., Jones, P. P., Whalley, G. A., Lamberts, R. R., & Coffey, S. (2020). Correlation between epicardial adipose tissue and body mass index in New Zealand ethnic populations. New Zealand Medical Journal, 133(1516), 22-32. Retrieved from https://www.nzma.org.nz/journal
Journal - Research Article
Moharram, M. A., Wilson, L. C., Williams, M. J. A., & Coffey, S. (2020). Beat-to-beat blood pressure measurement using a cuffless device does not accurately reflect invasive blood pressure. International Journal of Cardiology Hypertension, 5, 100030. doi: 10.1016/j.ijchy.2020.100030
Journal - Research Article
Morgan, B. M., Brown, A. N., Deo, N., Harrop, T. W. R., Taiaroa, G., Mace, P. D., Wilbanks, S. M., Merriman, T. R., Williams, M. J. A., & McCormick, S. P. A. (2020). Nonsynonymous SNPs in LPA homologous to plasminogen deficiency mutants represent novel null apo(a) alleles. Journal of Lipid Research, 61, 432-444. doi: 10.1194/jlr.M094540
Journal - Research Article
Wang, T. K. M., Kasargod, C., Chan, D., Cicovic, S., Dimalapang, E., Webster, M., … Smyth, D., Williams, M., … Somaratne, J. (2020). Diagnostic coronary angiography and percutaneous coronary intervention practices in New Zealand: The All New Zealand Acute Coronary Syndrome-Quality Improvement CathPCI Registry 3-year study (ANZACS- QI 37). International Journal of Cardiology, 312, 37-41. doi: 10.1016/j.ijcard.2020.02.063
Journal - Research Article
Aitken-Buck, H. M., Moharram, M., Babakr, A. A., Reijers, R., Van Hout, I., Fomison-Nurse, I. C., Sugunesegran, R., … Bunton, R. W., Williams, M. J. A., … Jones, P. P., Coffey, S., & Lamberts, R. R. (2019). Relationship between epicardial adipose tissue thickness and epicardial adipocyte size with increasing body mass index. Adipocyte, 8(1), 412-420. doi: 10.1080/21623945.2019.1701387
Journal - Research Article
Ellis, C. J., Gamble, G. D., Williams, M. J. A., Matsis, P., Elliott, J. M., Devlin, G., Mann, S., … for the Regional Cardiac Society NZ ACS Audit Group, including Richards, M., & Nixon, G. (2019). All-cause mortality following an acute coronary syndrome: 12-year follow-up of the comprehensive 2002 New Zealand Acute Coronary Syndrome Audit. Heart, Lung & Circulation, 28(2), 245-256. doi: 10.1016/j.hlc.2017.10.015
Journal - Research Article
Jones, G. T., Sandiford, P., Hill, G. B., Williams, M. J. A., Khashram, M., Tilyard, M. W., Hammond-Tooke, G. D., Krysa, J., & van Rij, A. M. (2019). Correcting for body surface area identifies the true prevalence of abdominal aortic aneurysm in screened women. European Journal of Vascular & Endovascular Surgery, 57(2), 221-228. doi: 10.1016/j.ejvs.2018.08.048
Journal - Research Article
Kerr, A. J., Lee, M., Grey, C., Pegg, T. J., Fisher, N. G., White, H. H., … Williams, M. J. A., Smyth, D., … on behalf of the ANZACS-QI investigators. (2019). Acute reperfusion for ST-elevation myocardial infarction in New Zealand (2015-2017): Patient and system delay (ANZACS-QI 29). New Zealand Medical Journal, 132(1498), 41-59. Retrieved from https://www.nzma.org.nz/journal
Journal - Research Article
Kerr, A. J., Lee, M., Jiang, Y., Grey, C., Wells, S., Williams, M., … on behalf of the ANZACS-QI Investigators. (2019). High level of capture of coronary intervention and associated acute coronary syndromes in the all New Zealand acute coronary syndrome quality improvement cardiac registry and excellent agreement with national administrative datasets (ANZACS-QI 25). New Zealand Medical Journal, 132(1492), 19-29. Retrieved from https://www.nzma.org.nz/journal
Journal - Research Article
Rawal, S., Nagesh, P. T., Coffey, S., Van Hout, I., Galvin, I. F., Bunton, R. W., Davis, P., Williams, M. J. A., & Katare, R. (2019). Early dysregulation of cardiac-specific microRNA-208a is linked to maladaptive cardiac remodelling in diabetic myocardium. Cardiovascular Diabetology, 18, 13. doi: 10.1186/s12933-019-0814-4
Journal - Research Article
Williams, M. J. A., Barr, P. R., Lee, M., Poppe, K. K., & Kerr, A. J. (2019). Outcome after myocardial infarction without obstructive coronary artery disease. Heart, 105(7), 524-530. doi: 10.1136/heartjnl-2018-313665
Journal - Research Article
Fomison-Nurse, I., Saw, E. E. L., Gandhi, S., Munasinghe, P. E., Van Hout, I., Williams, M. J. A., Galvin, I., Bunton, R., Davis, P., Cameron, V., & Katare, R. (2018). Diabetes induces the activation of pro-ageing miR-34a in the heart, but has differential effects on cardiomyocytes and cardiac progenitor cells. Cell Death & Differentiation, 25, 1336-1349. doi: 10.1038/s41418-017-0047-6
Journal - Research Article
Shearer, D. M., Thomson, W. M., Cameron, C. M., Ramrakha, S., Wilson, G., Wong, T. Y., Williams, M. J. A., McLean, R., Theodore, R., & Poulton, R. (2018). Periodontitis and multiple markers of cardiometabolic risk in the fourth decade: A cohort study. Community Dentistry & Oral Epidemiology, 46(6), 615-623. doi: 10.1111/cdoe.12414
Journal - Research Article
Elliott, J. M., Wang, T. K. M., Gamble, G., Williams, M., Matsis, P., Troughton, R., … Mann, S., Richards, M., … Ellis, C. (2017). A decade of improvement in the management of New Zealand ST-elevation myocardial infarction (STEMI) patients: Results from the New Zealand Acute Coronary Syndrome (ACS) Audit Group national audits of 2002, 2007 and 2012. New Zealand Medical Journal, 130(1453), 17-28. Retrieved from https://www.nzma.org.nz/journal
Journal - Research Article
Jones, G. T., Tromp, G., Kuivaniemi, H., Gretarsdottir, S., Baas, A. F., Giusti, B., … Phillips, L. V., Williams, M. J. A., Wei, W., … Thomson, I. A., Krysa, J., Hill, G. B., Roake, J., Merriman, T. R., … van Rij, A., … Bown, M. J. (2017). Meta-analysis of genome-wide association studies for abdominal aortic aneurysm identifies four new disease-specific risk loci. Circulation Research, 120, 341-353. doi: 10.1161/circresaha.116.308765
Journal - Research Article
Kerr, A. J., Williams, M., White, H., Grey, C., Jiang, Y., Nunn, C., on behalf of the ANZACS-QI investigators. (2017). 30-day mortality aft er percutaneous coronary intervention in New Zealand public hospitals (ANZACS-QI 18). New Zealand Medical Journal, 130(1459), 54-63. Retrieved from http://www.nzma.org.nz/journal
Journal - Research Article
Rawal, S., Munasinghe, E. P., Nagesh, P. T., Lew, J. K. S., Jones, G. T., Williams, M. J. A., Davis, P., Bunton, R. W., Galvin, I. F., Manning, P., Lamberts, R. R., & Katare, R. (2017). Downregulation of miR-15a/b accelerates fibrotic remodelling in the Type-2 diabetic human and mouse heart. Clinical Science, 131(9), 847-863. doi: 10.1042/cs20160916
Journal - Research Article
Rawal, S., Munasinghe, P. E., Shindikar, A., Paulin, J., Cameron, V., Manning, P., Williams, M. J. A., Jones, G. T., Bunton, R., Galvin, I., & Katare, R. (2017). Down-regulation of proangiogenic microRNA-126 and microRNA-132 are early modulators of diabetic cardiac microangiopathy. Cardiovascular Research, 113(1), 90-101. doi: 10.1093/cvr/cvw235
Journal - Research Article
Sharma, M., Redpath, G. M., Williams, M. J. A., & McCormick, S. P. A. (2017). Recycling of apolipoprotein(a) after PlgRKT-mediated endocytosis of lipoprotein(a). Circulation Research, 120(7), 1091-1102. doi: 10.1161/circresaha.116.310272
Journal - Research Article
Williams, M. J. A., Milne, B. J., Ambler, A., Theodore, R., Ramrakha, S., Caspi, A., Moffitt, T. E., & Poulton, R. (2017). Childhood body mass index and endothelial dysfunction evaluated by peripheral arterial tonometry in early midlife. International Journal of Obesity, 41, 1355-1360. doi: 10.1038/ijo.2017.108
Journal - Research Article
Wilson, L. C., Peebles, K. C., Hoye, N. A., Manning, P., Sheat, C., Williams, M. J. A., Wilkins, G. T., Wilson, G. A., & Baldi, J. C. (2017). Resting heart rate variability and exercise capacity in Type 1 diabetes. Physiological Reports, 5(8), e13248. doi: 10.14814/phy2.13248
Journal - Research Article
Barr, P., Smyth, D., Harding, S. A., El-Jack, S., Williams, M. J. A., Devlin, G., … on behalf of the ANZACS-QI Investigators. (2016). Variation in arterial access for invasive coronary procedures in New Zealand: A national analysis (ANZACS-QI 5). Heart, Lung & Circulation, 25, 451-458. doi: 10.1016/j.hlc.2015.10.009
Journal - Research Article
Coffey, S., Cox, B., & Williams, M. J. A. (2016). Changing causes of heart valve disease mortality in New Zealand from 1988 to 2007. New Zealand Medical Journal, 129(1428), 55-64. Retrieved from https://www.nzma.org.nz/journal
Journal - Research Article
Coffey, S., Williams, M. J. A., Phillips, L. V., Galvin, I. F., Bunton, R. W., & Jones, G. T. (2016). Integrated microRNA and messenger RNA analysis in aortic stenosis. Scientific Reports, 6, 36904. doi: 10.1038/srep36904
Journal - Research Article
Devlin, G., Williams, M., Elliott, J., White, H., French, J., Gamble, G., Matsis, P., Troughton, R., Richards, M., & Ellis, C. (2016). Management of non ST-elevation acute coronary syndrome patients in New Zealand: A longitudinal analysis: Results from the New Zealand Acute Coronary Syndrome national audits of 2002, 2007 and 2012. New Zealand Medical Journal, 129(1428), 9-15. Retrieved from https://www.nzma.org.nz/journal
Journal - Research Article
Jones, G. T., Hill, B. G., Curtis, N., Kabir, T. D., Wong, L. E., Tilyard, M. W., Williams, M. J. A., & van Rij, A. M. (2016). Comparison of three targeted approaches to screening for abdominal aortic aneurysm based on cardiovascular risk. British Journal of Surgery, 103(9), 1139-1146. doi: 10.1002/bjs.10224
Journal - Research Article
Jones, G. T., Phillips, V., Williams, M. J. A., van Rij, A. M., & Kabir, T. D. (2016). Two C-C family chemokines, eotaxin and RANTES, are novel independent plasma biomarkers for abdominal aortic aneurysm. Journal of the American Heart Association, 5(5), e002993. doi: 10.1161/jaha.115.002993
Journal - Research Article
Kerr, A. J., Williams, M. J. A., Harding, S., White, H., Doughty, R. N., Nunn, C., … on behalf of the ANZACS-QI Investigators. (2016). The All New Zealand Acute Coronary Syndrome Quality Improvement programme: Implementation, methodology and cohorts (ANZACS-QI 9). New Zealand Medical Journal, 129(1439), 23-36. Retrieved from https://www.nzma.org.nz/journal
Journal - Research Article
Mandic, S., Stevens, E., Hodge, C., Brown, C., Walker, R., Body, D., … Nye, E. R., & Williams, M. J. A. (2016). Long-term effects of cardiac rehabilitation in elderly individuals with stable coronary artery disease. Disability & Rehabilitation, 38(9), 837-843. doi: 10.3109/09638288.2015.1061611
Journal - Research Article
Nioi, P., Sigurdsson, A., Thorleifsson, G., Helgason, H., Agustsdottir, A. B., Norddahl, G. L., … Williams, M. J. A., van Rij, A. M., Jones, G. T., … Stefansson, K. (2016). Variant ASGR1 associated with a reduced risk of coronary artery disease. New England Journal of Medicine, 374, 2131-2141. doi: 10.1056/NEJMoa1508419
Journal - Research Article
Rawal, S., Parshu Ram, T., Coffey, S., Williams, M. J. A., Saxena, P., Bunton, R. W., Galvin, I. F., & Katare, R. (2016). Differential expression pattern of cardiovascular microRNAs in the human type-2 diabetic heart with normal ejection fraction. International Journal of Cardiology, 202, 40-43. doi: 10.1016/j.ijcard.2015.08.161
Journal - Research Article
Thomas, K. N., Cotter, J. D., Williams, M. J. A., & van Rij, A. M. (2016). Diagnosis, incidence, and clinical implications of perioperative myocardial injury in vascular surgery. Vascular & Endovascular Surgery, 50(4), 247-255. doi: 10.1177/1538574416637441
Journal - Research Article
Thomas, K. N., Cotter, J. D., Williams, M. J. A., & van Rij, A. M. (2016). Repeated episodes of remote ischemic preconditioning for the prevention of myocardial injury in vascular surgery. Vascular & Endovascular Surgery, 50(3), 140-146. doi: 10.1177/1538574416639150
Journal - Research Article
van 't Hof, F. N. G., Ruigrok, Y. M., Lee, C. H., Ripke, S., Anderson, G., de Andrade, M., … Jones, G. T., … van Rij, A. M., … Vascular Research Consortium of New Zealand, including Phillips, L. V., Hill, G. B., Williams, M. J. A., Thomson, I. A., Krysa, J., Wilkins, G. T., Merriman, T. R., Lewis, D. R., … de Bakker, P. I. W. (2016). Shared genetic risk factors of intracranial, abdominal, and thoracic aneurysms. Journal of the American Heart Association, 5(7), e002603. doi: 10.1161/jaha.115.002603
Journal - Research Article
Williams, M. J. A., Harding, S. A., Devlin, G., Nunn, C., El-Jack, S., Scott, T., … on behalf of the ANZACS-QI Investigators, including Matsis, P., Smyth, D., Blake, J., Elliott, J., Lainchbury, J., Bridgman, P., Troughton, R., Wilkins, G., Green, B., Edmond, J., & Milburn, K. (2016). National variation in coronary angiography rates and timing after an acute coronary syndrome in New Zealand (ANZACS-QI 6). New Zealand Medical Journal, 129(1428), 65-77. Retrieved from https://www.nzma.org.nz/journal
Journal - Research Article
Bussey, C. T., Hughes, G., Saxena, P., Galvin, I. F., Bunton, R. W., Noye, M. K., Coffey, S., Williams, M. J. A., Baldi, J. C., Jones, P. P., & Lamberts, R. R. (2015). Chamber-specific changes in calcium-handling proteins in the type 2 diabetic human heart with preserved ejection fraction. International Journal of Cardiology, 193, 53-55. doi: 10.1016/j.ijcard.2015.05.053
Journal - Research Article
Coffey, S., Williams, M. J. A., Phillips, L. V., & Jones, G. T. (2015). Circulating microRNA profiling needs further refinement before clinical use in patients with aortic stenosis. Journal of the American Heart Association, 4(8), e002150. doi: 10.1161/jaha.115.002150
Journal - Research Article
Ellis, C., Hammett, C., Ranasinghe, I., French, J., Briffa, T., Devlin, G., Elliott, J., … Williams, M., Troughton, R., … on behalf of Bi-National Acute Coronary Syndromes (ACS) 'SNAPSHOT' Audit Group. (2015). Comparison of the management and in-hospital outcomes of acute coronary syndrome patients in Australia and New Zealand: Results from the binational SNAPSHOT acute coronary syndrome 2012 audit. Internal Medicine Journal, 45(5), 497-509. doi: 10.1111/imj.12739
Journal - Research Article
Horwood, H., Williams, M. J. A., & Mandic, S. (2015). Examining motivations and barriers for attending maintenance community-based cardiac rehabilitation using the Health-Belief Model. Heart, Lung & Circulation, 24, 980-987. doi: 10.1016/j.hlc.2015.03.023
Journal - Research Article
Majeed, K., Hamer, A. W., White, S. C., Pegg, T. J., Wilkins, G. T., Williams, S. M., … Williams, M. J. A. (2015). Prevalence of abdominal aortic aneurysm in patients referred for transthoracic echocardiography. Internal Medicine Journal, 45(1), 32-39. doi: 10.1111/imj.12592
Journal - Research Article
Mandic, S., Body, D., Barclay, L., Walker, R., Nye, E. R., Grace, S. L., & Williams, M. J. A. (2015). Community-based cardiac rehabilitation maintenance programs: Use and effects. Heart, Lung & Circulation, 24, 710-718. doi: 10.1016/j.hlc.2015.01.014
Journal - Research Article
Sharma, M., Von Zychlinski-Kleffmann, A., Porteous, C. M., Jones, G. T., Williams, M. J. A., & McCormick, S. P. A. (2015). Lipoprotein (a) upregulates ABCA1 in liver cells via scavenger receptor-B1 through its oxidized phospholipids. Journal of Lipid Research, 56, 1318-1328. doi: 10.1194/jlr.M056150
Journal - Research Article
Theodore, R. F., Broadbent, J., Nagin, D., Ambler, A., Hogan, S., Ramrakha, S., … Williams, M. J. A., Harrington, H., Moffitt, T. E., … Milne, B., & Poulton, R. (2015). Childhood to early-midlife systolic blood pressure trajectories: Early-life predictors, effect modifiers, and adult cardiovascular outcomes. Hypertension, 66, 1108-1115. doi: 10.1161/HYPERTENSIONAHA.115.05831
Journal - Research Article
Coffey, S., Cox, B., & Williams, M. J. A. (2014). Lack of progress in valvular heart disease in the pre—transcatheter aortic valve replacement era: Increasing deaths and minimal change in mortality rate over the past three decades. American Heart Journal, 167(4), 562-567. doi: 10.1016/j.ahj.2013.12.030
Journal - Research Article
Coffey, S., Cox, B., & Williams, M. J. A. (2014). The prevalence, incidence, progression, and risks of aortic valve sclerosis: A systematic review and meta-analysis. JACC, 63(25), 2852-2861. doi: 10.1016/j.jacc.2014.04.018
Journal - Research Article
Francois, M. E., Baldi, J. C., Manning, P. J., Lucas, S. J. E., Hawley, J. A., Williams, M. J. A., & Cotter, J. D. (2014). ‘Exercise snacks’ before meals: A novel strategy to improve glycaemic control in individuals with insulin resistance. Diabetologia, 57(7), 1437-1445. doi: 10.1007/s00125-014-3244-6
Journal - Research Article
Jin, C., Phillips, L. V., Williams, M. J. A., van Rij, A. M., & Jones, G. T. (2014). Plasma heat shock protein 27 is associated with coronary artery disease, abdominal aortic aneurysm and peripheral artery disease. SpringerPlus, 3, 635. doi: 10.1186/2193-1801-3-635
Journal - Research Article
Kader, T., Porteous, C. M., Williams, M. J. A., Gieseg, S. P., & McCormick, S. P. A. (2014). Ribose-cysteine increases glutathione-based antioxidant status and reduces LDL in human lipoprotein(a) mice. Atherosclerosis, 237(2), 725-733. doi: 10.1016/j.atherosclerosis.2014.10.101
Journal - Research Article
Lamberts, R. R., Lingam, S. J., Wang, H.-Y., Bollen, I. A. E., Hughes, G., Galvin, I. F., Bunton, R. W., Bahn, A., Katare, R., Baldi, J. C., Williams, M. J. A., Saxena, P., Coffey, S., & Jones, P. P. (2014). Impaired relaxation despite upregulated calcium-handling protein atrial myocardium from type 2 diabetic patients with preserved ejection fraction. Cardiovascular Diabetology, 13, 72. doi: 10.1186/1475-2840-13-72
Journal - Research Article
Moore, A., Shindikar, A., Fomison-Nurse, I., Riu, F., Munasinghe, P. E., Parshu Ram, T., Saxena, P., Coffey, S., Bunton, R. W., Galvin, I. F., Williams, M. J. A., … Katare, R. (2014). Rapid onset of cardiomyopathy in STZ-induced female diabetic mice involves the downregulation of pro-survival Pim-1. Cardiovascular Diabetology, 13, 68. doi: 10.1186/1475-2840-13-68
Journal - Research Article
von Zychilinski, A., Williams, M., McCormick, S., & Kleffmann, T. (2014). Absolute quantification of apolipoproteins and associated proteins on human plasma lipoproteins. Journal of Proteomics, 106, 181-190. doi: 10.1016/j.jprot.2014.04.030
Journal - Research Article
Chu, J. W., Jones, G. T., Tarr, G. P., Phillips, L. V., Wilkins, G. T., van Rij, A. M., & Williams, M. J. A. (2013). Plasma active matrix metalloproteinase 9 and indices of diastolic function in patients with preserved systolic function. International Journal of Cardiology, 167(4), 1242-1246. doi: 10.1016/j.ijcard.2012.03.147
Journal - Research Article
Ellis, C., Gamble, G., Devlin, G., Elliott, J., Hamer, A., Williams, M., Matsis, P., Troughton, R., … for the New Zealand Acute Coronary Syndromes (NZACS) 'SNAPSHOT' Audit Group. (2013). The management of acute coronary syndrome patients across New Zealand in 2012: Results of a third comprehensive nationwide audit and observations of current interventional care. New Zealand Medical Journal, 126(1387). Retrieved from http://www.nzma.org.nz/journal
Journal - Research Article
Jones, G. T., Bown, M. J., Gretarsdottir, S., Romaine, S. P. R., Helgadottir, A., Yu, G., … Jin, C., … Phillips, L. V., Williams, M. J. A., Topless, R., Merriman, T. R., … Lewis, D. R., … van Rij, A. M. (2013). A sequence variant associated with sortilin-1 (SORT1) on 1p13.3 is independently associated with abdominal aortic aneurysm. Human Molecular Genetics, 22(14), 2941-2947. doi: 10.1093/hmg/ddt141
Journal - Research Article
Mandic, S., Hodge, C., Stevens, E., Walker, R., Nye, E. R., Body, D., Barclay, L., & Williams, M. J. A. (2013). Effects of community-based cardiac rehabilitation on body composition and physical function in individuals with stable coronary artery disease: 1.6-year followup. BioMed Research International, 2013, 903604. doi: 10.1155/2013/903604
Journal - Research Article
Mandic, S., Walker, R., Stevens, E., Nye, E. R., Body, D., Barclay, L., & Williams, M. J. A. (2013). Estimating exercise capacity from walking tests in elderly individuals with stable coronary artery disease. Disability & Rehabilitation, 35(22), 1853-1858. doi: 10.3109/09638288.2012.759629
Journal - Research Article
Murrell, C. J., Cotter, J. D., Thomas, K. N., Lucas, S. J. E., Williams, M. J. A., & Ainslie, P. N. (2013). Cerebral blood flow and cerebrovascular reactivity at rest and during sub-maximal exercise: Effect of age and 12-week exercise training. Age, 35(3), 905-920. doi: 10.1007/s11357-012-9414-x
Journal - Research Article
Sorrenson, B., Suetani, R. J., Williams, M. J. A., Bickley, V. M., George, P. M., Jones, G. T., & McCormick, S. P. A. (2013). Functional rescue of mutant ABCA1 proteins by sodium 4-phenylbutyrate. Journal of Lipid Research, 54, 55-62. doi: 10.1194/jlr.M027193
Journal - Research Article
Tarr, G. P., Williams, M. J. A., Wilkins, G. T., Chen, V. H. T., Phillips, L. V., van Rij, A. M., & Jones, G. T. (2013). Intra-individual changes of active matrix metalloproteinase-9 are associated with clinical in-stent restenosis of bare metal stents. Cardiology, 124(1), 28-35. doi: 10.1159/000345591
Journal - Research Article
Nadarasa, K., & Williams, M. J. A. (2012). Single high oral dose amiodarone for cardioversion of recent onset atrial fibrillation. Heart, Lung & Circulation, 21(8), 444-448. doi: 10.1016/j.hlc.2012.03.015
Journal - Research Article
Nadarasa, K., Robertson, M. C., Wong, C.-K., Green, B. K. W., Chen, V. H. T., Wilkins, G. T., & Williams, M. J. A. (2012). Rapid cycle change to predominantly radial access coronary angiography and percutaneous coronary intervention: Effect on vascular access site complications. Catheterization & Cardiovascular Interventions, 79(4), 589-594. doi: 10.1002/ccd.23120
Journal - Research Article
Murrell, C. J., Cotter, J. D., George, K., Shave, R., Wilson, L., Thomas, K., Williams, M. J. A., & Ainslie, P. N. (2011). Cardiorespiratory and cerebrovascular responses to head-up tilt II: Influence of age, training status and acute exercise. Experimental Gerontology, 46(1), 1-8. doi: 10.1016/j.exger.2010.06.004
Journal - Research Article
Murrell, C. J., Cotter, J. D., George, K., Shave, R., Wilson, L., Thomas, K., Williams, M. J. A., & Ainslie, P. N. (2011). Syncope is unrelated to supine and postural hypotension following prolonged exercise. European Journal of Applied Physiology, 111(3), 469-476. doi: 10.1007/s00421-010-1671-8
Journal - Research Article
Murrell, C. J., Cotter, J. D., George, K., Shave, R., Wilson, L., Thomas, K., Williams, M. J. A., & Ainslie, P. N. (2011). Cardiorespiratory and cerebrovascular responses to head-up tilt I: Influence of age and training status. Experimental Gerontology, 46(1), 9-17. doi: 10.1016/j.exger.2010.06.005
Journal - Research Article
Sorrenson, B., Suetani, R. J., Bickley, V. M., George, P. M., Williams, M. J. A., Scott, R. S., & McCormick, S. P. A. (2011). An ABCA1 truncation shows no dominant negative effect in a familial hypoalphalipoproteinemia pedigree with three ABCA1 mutations. Biochemical & Biophysical Research Communications, 409(3), 400-405. doi: 10.1016/j.bbrc.2011.05.006
Journal - Research Article
Suetani, R. J., Sorrenson, B., Tyndall, J. D. A., Williams, M. J. A., & McCormick, S. P. A. (2011). Homology modeling and functional testing of an ABCA1 mutation causing Tangier disease. Atherosclerosis, 218(2), 404-410. doi: 10.1016/j.atherosclerosis.2011.06.019
Journal - Research Article
Tarr, G. P., Williams, M. J. A., Phillips, L. V., van Rij, A. M., & Jones, G. T. (2011). Pro-MMP-9/TIMP-1 ratio correlates poorly with a direct assessment of MMP-9 activity. Clinical Biochemistry, 44(17-18), 1480-1482. doi: 10.1016/j.clinbiochem.2011.09.019
Journal - Research Article
Tarr, G. P., Williams, M. J. A., Phillips, L. V., van Rij, A. M., & Jones, G. T. (2011). Seasonal variation and stability of matrix metalloproteinase-9 activity and tissue inhibitor of matrix metalloproteinase-1 with storage at -80 oC. Clinical Biochemistry, 44(16), 1346-1348. doi: 10.1016/j.clinbiochem.2011.08.1139
Journal - Research Article
von Zychlinski, A., Kleffmann, T., Williams, M. J. A., & McCormick, S. P. (2011). Proteomics of Lipoprotein(a) identifies a protein complement associated with response to wounding. Journal of Proteomics, 74, 2881-2891. doi: 10.1016/j.jprot.2011.07.008
Journal - Research Article
Ellis, C., Devlin, G., Elliott, J., Matsis, P., Williams, M., Gamble, G., … Richards, M., … for the New Zealand Acute Coronary Syndromes (NZACS) Audit Group. (2010). ACS patients in New Zealand experience significant delays to access cardiac investigations and revascularisation treatment especially when admitted to non-interventional centres: Results of the second comprehensive national audit of ACS patients. New Zealand Medical Journal, 123(1319). Retrieved from http://journal.nzma.org.nz/journal/123-1319/4237/content.pdf
Journal - Research Article
Ellis, C., Gamble, G., Hamer, A., Williams, M., Matsis, P., Elliott, J., … Richards, M., … for the New Zealand Acute Coronary Syndromes (NZACS) Audit Group. (2010). Patients admitted with an acute coronary syndrome in New Zealand in 2007: Results of a second comprehensive nationwide audit and a comparison with the first audit from 2002. New Zealand Medical Journal, 123(1319). Retrieved from http://journal.nzma.org.nz/journal/123-1319/4235/content.pdf
Journal - Research Article
Gretarsdottir, S., Baas, A. F., Thorleifsson, G., Holm, H., den Heijer, M., de Vries, J.-P. P. M., … van Rij, A. M., Williams, M. J. A., … Jones, G. T., … Stefansson, K. (2010). Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm. Nature Genetics, 42(8), 692-697. doi: 10.1038/ng.622
Journal - Research Article
Stewart, R. A. H., Kerr, A. J., Whalley, G. A., Legget, M. E., Zeng, I., Williams, M. J. A., Lainchbury, J., … Richards, M. A., … for the New Zealand Heart Valve Study Investigators. (2010). Left ventricular systolic and diastolic function assessed by tissue Doppler imaging and outcome in asymptomatic aortic stenosis. European Heart Journal, 31(18), 2216-2222. doi: 10.1093/eurheartj/ehq159
Journal - Research Article
Sutherland, W. H. F., de Jong, S. A., Hessian, P. A., & Williams, M. J. A. (2010). Ingestion of native and thermally oxidized polyunsaturated fats acutely increases circulating numbers of endothelial microparticles. Metabolism, 59(3), 446-453. doi: 10.1016/j.metabol.2009.07.033
Journal - Research Article
Thomas, K. N., Galvin, S. D., Williams, M. J. A., Willie, C. K., & Ainslie, P. N. (2010). Identical pattern of cerebral hypoperfusion during different types of syncope. Journal of Human Hypertension, 24(7), 458-466. doi: 10.1038/jhh.2009.93
Journal - Research Article
Gudbjartsson, D. F., Bjornsdottir, U. S., Halapi, E., Helgadottir, A., Sulem, P., Jonsdottir, G. M., … Williams, M. J. A., van Rij, A. M., Jones, G. T., … Stefansson, K. (2009). Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nature Genetics, 41(3), 342-347. doi: 10.1038/ng.323
Journal - Research Article
Jones, G. T., Tarr, G. P., Phillips, L. V., Wilkins, G. T., van Rij, A. M., & Williams, M. J. A. (2009). Active matrix metalloproteinases 3 and 9 are independently associated with coronary artery in-stent restenosis. Atherosclerosis, 207(2), 603-607. doi: 10.1016/j.atherosclerosis.2009.05.036
Journal - Research Article
Murrell, C. J., Cotter, J. D., George, K. P., Shave, R., Wilson, L. C., Thomas, K. N., Williams, M. J. A., … Ainslie, P. N. (2009). Influence of age on syncope following prolonged exercise: Differential responses but similar orthostatic intolerance. Journal of Physiology, 587(24), 5959-5969. doi: 10.1113/jphysiol.2009.179549
Journal - Research Article