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DSM staff profile

Dr Wayne Sutherland

PositionSenior Research Fellow
DepartmentDepartment of Medicine (Dunedin)
QualificationsBSc(Hons) PhD
Research summaryLipoproteins and metabolism

Research

Research has focussed on lipoprotein levels and metabolism and the effects of exercise, diet in health and disease. Transport and metabolism of cholesterol in the blood has been of special interest.

Otago Kidney Research

Publications

Manning, P., Munasinghe, P. E., Bellae Papannarao, J., Gray, A. R., Sutherland, W., & Katare, R. (2019). Acute weight loss restores dysregulated circulating microRNAs in obese individuals. Journal of Clinical Endocrinology & Metabolism, 104(4), 1239-1248. doi: 10.1210/jc.2018-00684

Manning, P. J., Grattan, D., Merriman, T., Manning, T., Williams, S., & Sutherland, W. (2018). Pharmaceutical interventions for weight-loss maintenance: No effect from cabergoline. International Journal of Obesity, 42, 1871-1879. doi: 10.1038/s41366-018-0165-3

Leong, S. L., De Ridder, D., Vanneste, S., Sutherland, W., Ross, S., & Manning, P. (2018). High definition transcranial pink noise stimulation of anterior cingulate cortex on food craving: An explorative study. Appetite, 120, 673-678. doi: 10.1016/j.appet.2017.10.034

De Ridder, D., Manning, P., Leong, S. L., Ross, S., Sutherland, W., Horwath, C., & Vanneste, S. (2016). The brain, obesity and addiction: An EEG neuroimaging study. Scientific Reports, 6, 34122. doi: 10.1038/srep34122

Manning, P. J., Sutherland, W. H. F., Williams, S. M., de Jong, S. A., & Hendry, G. P. (2013). Oral but not intravenous glucose acutely decreases circulating interleukin-6 concentrations in overweight individuals. PLoS ONE, 8(6), e66395. doi: 10.1371/journal.pone.0066395

Nishizawa, M., Sutherland, W., & Nukada, H. (1995). Gosha-jinki-gan treatment in experimental diabetic neuropathy. In N. Hotta, D. A. Greene, J. D. Ward, A. A. F. Sima & A. J. M. Boulton (Eds.), Diabetic Neuropathy: New Concepts and Insights. (pp. 311-313). Amsterdam: Elsevier.

Chapter in Book - Research

Manning, P., Munasinghe, P. E., Bellae Papannarao, J., Gray, A. R., Sutherland, W., & Katare, R. (2019). Acute weight loss restores dysregulated circulating microRNAs in obese individuals. Journal of Clinical Endocrinology & Metabolism, 104(4), 1239-1248. doi: 10.1210/jc.2018-00684

Journal - Research Article

Leong, S. L., De Ridder, D., Vanneste, S., Sutherland, W., Ross, S., & Manning, P. (2018). High definition transcranial pink noise stimulation of anterior cingulate cortex on food craving: An explorative study. Appetite, 120, 673-678. doi: 10.1016/j.appet.2017.10.034

Journal - Research Article

Manning, P. J., Grattan, D., Merriman, T., Manning, T., Williams, S., & Sutherland, W. (2018). Pharmaceutical interventions for weight-loss maintenance: No effect from cabergoline. International Journal of Obesity, 42, 1871-1879. doi: 10.1038/s41366-018-0165-3

Journal - Research Article

De Ridder, D., Manning, P., Leong, S. L., Ross, S., Sutherland, W., Horwath, C., & Vanneste, S. (2016). The brain, obesity and addiction: An EEG neuroimaging study. Scientific Reports, 6, 34122. doi: 10.1038/srep34122

Journal - Research Article

Manning, P. J., Sutherland, W. H. F., Williams, S. M., de Jong, S. A., & Hendry, G. P. (2013). Oral but not intravenous glucose acutely decreases circulating interleukin-6 concentrations in overweight individuals. PLoS ONE, 8(6), e66395. doi: 10.1371/journal.pone.0066395

Journal - Research Article

Manning, P. J., Sutherland, W. H. F., Williams, S. M., Walker, R. J., Berry, E. A., De Jong, S. A., & Ryalls, A. R. (2013). The effect of lipoic acid and vitamin E therapies in individuals with the metabolic syndrome. Nutrition, Metabolism & Cardiovascular Diseases, 23(6), 543-549. doi: 10.1016/j.numecd.2011.11.006

Journal - Research Article

Manning, P. J., De Jong, S. A., Ryalls, A. R., & Sutherland, W. H. F. (2012). Paraoxonase 1 activity in chylomicrons and VLDL: The effect of type 2 diabetes and meals rich in saturated fat and oleic acid. Lipids, 47(3), 259-267. doi: 10.1007/s11745-011-3640-3

Journal - Research Article

Todd, A. S., MacGinley, R. J., Schollum, J. B. W., Williams, S. M., Sutherland, W. H. F., Mann, J. I., & Walker, R. J. (2012). Dietary sodium loading in normotensive healthy volunteers does not increase arterial vascular reactivity or blood pressure. Nephrology, 17(3), 249-256. doi: 10.1111/j.1440-1797.2011.01550.x

Journal - Research Article

Vos, F. E., Manning, P. J., Sutherland, W. H. F., Schollum, J. B., & Walker, R. J. (2011). Anti-inflammatory effect of an insulin infusion in patients on maintenance haemodialysis: A randomized controlled pilot study. Nephrology, 16(1), 68-75. doi: 10.1111/j.1440-1797.2010.01329.x

Journal - Research Article

Sutherland, W. H. F., de Jong, S. A., Hessian, P. A., & Williams, M. J. A. (2010). Ingestion of native and thermally oxidized polyunsaturated fats acutely increases circulating numbers of endothelial microparticles. Metabolism, 59(3), 446-453. doi: 10.1016/j.metabol.2009.07.033

Journal - Research Article

Taylor, R. W., Brooking, L., Williams, S. M., Manning, P. J., Sutherland, W. H., Coppell, K. J., Tipene-Leach, D., Dale, K. S., McAuley, K. A., & Mann, J. I. (2010). Body mass index and waist circumference cutoffs to define obesity in indigenous New Zealanders. American Journal of Clinical Nutrition, 92, 390-397. doi: 10.3945/ajcn.2010.29317

Journal - Research Article

Todd, A. S., MacGinley, R. J., Schollum, J. B. W., Johnson, R. J., Williams, S. M., Sutherland, W. H. F., Mann, J. I., & Walker, R. J. (2010). Dietary salt loading impairs arterial vascular reactivity. American Journal of Clinical Nutrition, 91(3), 557-564. doi: 10.3945/ajcn.2009.28645

Journal - Research Article

Yoga, R., Theis, J.-C., Walton, M., & Sutherland, W. (2009). Interleukin-6 as an early marker for fat embolism. Journal of Orthopaedic Surgery & Research, 4. doi: 10.1186/1749-799X-4-18

Journal - Research Article

Manning, P. J., Sutherland, W. H. F., McGrath, M. M., de Jong, S. A., Walker, R. J., & Williams, M. J. A. (2008). Postprandial cytokine concentrations and meal composition in obese and lean women. Obesity, 16(9), 2046-2052. doi: 10.1038/oby.2008.334

Journal - Research Article

Manning, P. J., Sutherland, W. H. F., Walker, R. J., de Jong, S. A., & Berry, E. A. (2008). The effect of glucose ingestion on inflammation and oxidative stress in obese individuals. Metabolism, 57, 1345-1349.

Journal - Research Article

Manning, P. J., Sutherland, W. H. F., Walker, R. J., Williams, S. M., de Jong, S. A., & Berry, E. A. (2008). The effect of rosiglitazone on oxidative stress and insulin resistance in overweight individuals. Diabetes Research & Clinical Practice, 81, 209-215.

Journal - Research Article

Kerr, P. G., Sutherland, W. H. F., de Jong, S., Vaithalingham, I., Williams, S. M., & Walker, R. J. (2007). The impact of standard high-flux polysulfone versus novel high-flux polysulfone dialysis membranes on inflammatory markers: A randomized, single-blinded, controlled clinical trial. American Journal of Kidney Diseases, 49(4), 533-539. doi: 10.1053/j.ajkd.2006.12.019

Journal - Research Article

Sutherland, W. H. F., de Jong, S. A., & Walker, R. J. (2007). Effect of dietary cholesterol and fat on cell cholesterol transfer to postprandial plasma in hyperlipidemic men. Lipids, 42, 901-911. doi: 10.1007/s11745-007-3101-1

Journal - Research Article

Sutherland, W. H. F., Manning, P. J., Walker, R. J., de Jong, S. A., Ryalls, A. R., & Berry, E. A. (2007). Vitamin E supplementation and plasma 8-isoprostane and adiponectin in overweight subjects. Obesity, 15(2), 386-391. doi: 10.1038/oby.2007.546

Journal - Research Article

Sutherland, W. H. F., Williams, M. J. A., de Jong, S. A., & McCormick, M. P. (2007). Ingestion of moderately thermally oxidized polyunsaturated fat decreases serum resistance to oxidation in men with coronary artery disease. Nutrition Research, 27, 265-272. doi: 10.1016/j.nutres.2006.12.014

Journal - Research Article

Sutherland, W. H., Williams, M. J., & de Jong, S. A. (2007). Plasma protein lipofuscin-like fluorophores in men with coronary artery disease treated with statins. Archives of Medical Research, 38, 757-763.

Journal - Research Article

Aitken, W. A. E., Chisholm, A. W.-A. H., Duncan, A. W., Harper, M. J., Humphries, S. E., Mann, J. I., Skeaff, C. M., Sutherland, W. H. F., Wallace, A. J., & Williams, S. M. (2006). Variation in the cholesteryl ester transfer protein (CETP) gene does not influence individual plasma cholesterol response to changes in the nature of dietary fat. Nutrition, Metabolism & Cardiovascular Diseases, 16(5), 353-363. doi: 10.1016/j.numecd.2005.06.007

Journal - Research Article

Sutherland, W. H. F., de Jong, S. A., & Walker, R. J. (2005). Hypochlorous acid and 3,4-dihydroxyphenylalanine increase the formation of serum protein lipofuscin-like fluorophores in vitro. Renal Failure, 27, 239-246.

Journal - Research Article

Williams, M. J., Sutherland, W. H., McCormick, M. P., Yeoman, D. J., & de Jong, S. A. (2005). Aged garlic extract improves endothelial function in men with coronary artery disease. Phytotherapy Research, 19(4), 314-319.

Journal - Research Article

Manning, P. J., Sutherland, W. H., Hendry, G., de Jong, S. A., McGrath, M., & Williams, S. M. (2004). Changes in circulating postprandial proinflammatory cytokine concentrations in diet-controlled type 2 diabetes and the effect of ingested fat. Diabetes Care, 27(10), 2509-2511.

Journal - Research Article

Manning, P. J., Sutherland, W. H., Walker, R. J., Williams, S. M., de Jong, S. A., Ryalls, A. R., & Berry, E. A. (2004). Effect of high-dose vitamin E on insulin resistance and associated parameters in overweight subjects. Diabetes Care, 27(9), 2166-2171.

Journal - Research Article

Sutherland, W. H. F., de Jong, S. A., & Walker, R. J. (2004). Hypochlorous acid and low serum paraoxonase activity in haemodialysis patients: An in vitro study. Nephrology Dialysis Transplantation, 19(1), 75-82.

Journal - Research Article

Walker, R. J., Sutherland, W. H., & De Jong, S. A. (2004). Effect of changing from a cellulose acetate to a polysulphone dialysis membrane on protein oxidation and inflammation markers. Clinical Nephrology, 61(3), 198-206. doi: 10.5414/CNP61198

Journal - Research Article

Whelan, A. P., Sutherland, W. H. F., McCormick, M. P., Yeoman, D. J., de Jong, S. A., & Williams, M. J. A. (2004). Effects of white and red wine on endothelial function in subjects with coronary artery disease. Internal Medicine Journal, 34, 224-228.

Journal - Research Article

Williams, M. J. A., Sutherland, W. H. F., Whelan, A. P., McCormick, M. P., & de Jong, S. A. (2004). Acute effect of drinking red and white wines on circulating levels of inflammation-sensitive molecules in men with coronary artery disease. Metabolism, 53(3), 318-323.

Journal - Research Article

Manning, P. J., Sutherland, W. H. F., Allum, A. R., de Jong, S. A., & Jones, S. (2003). HRT does not improve urinary albumen excretion in postmenopausal diabetic women. Diabetes Research & Clinical Practice, 60(1), 33-39.

Journal - Research Article

Sutherland, W. H. F., Gieseg, S. P., Walker, R. J., de Jong, S. A., Firth, C. A., & Scott, N. (2003). Serum protein-bound 3,4-dihydroxyphenylalanine and related products of protein oxidation and chronic hemodialysis. Renal Failure, 25(6), 997-1009.

Journal - Research Article

Manning, P. J., Sutherland, W. H. F., Allum, A. R., de Jong, S. A., & Jones, S. D. (2002). The effect of hormone replacement therapy on inflammation-sensitive proteins in post-menopausal women with Type 2 diabetes. Diabetic Medicine, 19(10), 847-852. doi: 10.1046/j.1464-5491.2002.00808.x

Journal - Research Article

Sutherland, W. H. F., de Jong, S. A., Walker, R. J., & Williams, S. M. (2002). Release of cholesterol from cell membranes to postprandial plasma from mildly hypercholesterolemic subjects: The effect of meals rich in olive and safflower oils. Metabolism, 51(10), 1306-1312.

Journal - Research Article

Sutherland, W. H. F., De Jong, S. A., Walker, R. J., Williams, M. J. A., Skeaff, C. M., Duncan, A., & Harper, M. J. (2002). Effect of meals rich in heated olive and safflower oils on oxidation of postprandial serum in healthy men. Atherosclerosis, 160, 195-203.

Journal - Research Article

Sutherland, W. H. F., de Jong, S. A., Walker, R. J., Williams, M. J. A., Skeaff, C. M., Duncan, A., & Harper, M. J. (2002). Effect of meals rich in heated olive and safflower oils on oxidation of postprandial serum in healthy men. Atherosclerosis, 160, 195-203.

Journal - Research Article

Sutherland, W. H. F., Walker, R. J., De Jong, S. A., & Williams, S. M. (2002). Release of cholesterol from cell membranes to postprandial plasma from mildly hypercholesterolemic subjects: the effect of meals rich in olive and safflower oils. Metabolism, 51(10), 1306-1312.

Journal - Research Article

Manning, P. J., Allum, A., Jones, S., Sutherland, W. H. F., & Williams, S. M. (2001). The effect of hormone replacement therapy on cardiovascular risk factors in type 2 diabetes: A randomised controlled trial. Archives of Internal Medicine, 161, 1772-1776.

Journal - Research Article

Sutherland, W. H., Manning, P. J., de Jong, S. A., Allum, A. R., Jones, S. D., & Williams, S. M. (2001). Hormone replacement therapy increases serum paraoxonase arylesterase activity in diabetic postmenopausal women. Metabolism, 50, 319-324.

Journal - Research Article

Walker, R. J., Lewis-Barned, N. J., Sutherland, W. H. F., Goulding, A., Edwards, E. A., de Jong, S. A., Gold, E. J., & Walker, H. (2001). The effects of sequential combined oral 17β-estradiol-Norethisterone acetate on insulin sensitivity and body composition in healthy postmenopausal women: A randomized single blind placebo-controlled study. Menopause, 8, 27-32.

Journal - Research Article

Wallace, A. J., Sutherland, W. H. F., Mann, J., & Williams, S. M. (2001). The effect of meals rich in thermally stressed olive and safflower oils on postprandial serum paraoxanase activity in patients with diabetes. European Journal of Clinical Nutrition, 55, 951-958.

Journal - Research Article

Williams, M. J. A., Sutherland, W. H. F., McCormick, M., de Jong, S. A., McDonald, J. R., & Walker, R. J. (2001). Vitamin C improves endothelial dysfunction in renal allograft recipients. Nephrology Dialysis Transplantation, 16, 1251-1255.

Journal - Research Article

Williams, M. J. A., Sutherland, W. H. F., McCormick, M., Yeoman, D., de Jong, S. A., & Walker, R. J. (2001). Normal endothelial function after meals rich in olive or safflower oil previously used for deep frying. Nutrition, Metabolism & Cardiovascular Diseases, 11, 147-152.

Journal - Research Article

Lewis-Barned, N. J., Sutherland, W. H. F., Walker, R. J., de Jong, S. A., Walker, H. L., Edwards, E. A., Markham, V. H., & Goulding, A. (2000). Plasma cholesterol ester fatty acid composition, insulin sensitivity, the menopause and hormone replacement therapy. Journal of Endocrinology, 165, 649-655.

Journal - Research Article

Upritchard, J., Sutherland, W. H. F., & Mann, J. (2000). Effect of supplementation with tomato juice, vitamin E, and vitamin C on LDL oxidation and products of inflammatory activity in type 2 diabetes. Diabetes Care, 23, 733-738.

Journal - Research Article

Wallace, A. J., Humphries, S. E., Fisher, R. M., Mann, J., Chisholm, A., & Sutherland, W. H. F. (2000). Genetic factors associated with response of LDL subfractions to change in the nature of dietary fat. Atherosclerosis, 149, 387-394.

Journal - Research Article

Wallace, A. J., Mann, J. I., Sutherland, W. H. F., Williams, S., Chisholm, A., Skeaff, C. M., … Humphries, S. E. (2000). Variants in the cholesterol ester transfer protein and lipoprotein lipase genes are predictors of plasma cholesterol response to dietary change. Atherosclerosis, 152(2), 327-336. doi: 10.1016/S0021-9150(99)00490-6

Journal - Research Article

Lewis-Barned, N. J., Sutherland, W. H. F., Walker, R. J., Walker, H. L., de Jong, S. A., Edwards, E. A., & Markham, V. H. (1999). Plasma cholesteryl esterification and transfer, the menopause and hormone replacement therapy in women. Journal of Clinical Endocrinology & Metabolism, 84, 3534-3538.

Journal - Research Article

Sutherland, W. H. F., Walker, R. J., de Jong, S. A., & Upritchard, J. E. (1999). Supplementation with tomato juice increases plasma lycopene but does not alter susceptibility to oxidation of low density lipoproteins from renal transplant recipients. Clinical Nephrology, 52, 30-36.

Journal - Research Article

Sutherland, W. H. F., Walker, R. J., de Jong, S. A., van Rij, A. M., Phillips, L. V., & Walker, H. (1999). Reduced postprandial serum paraoxonase activity after a meal rich in used cooking fat. Arteriosclerosis, Thrombosis, & Vascular Biology, 19, 1340-1347.

Journal - Research Article

Sutherland, W. H. F., Williams, M. J. A., Nye, E. R., Restieaux, N. J., de Jong, S. A., & Walker, H. (1999). Associations of plasma noncholesterol sterol levels with severity of coronary artery disease. Nutrition, Metabolism & Cardiovascular Diseases, 8, 386-391.

Journal - Research Article

Upritchard, J. E., & Sutherland, W. H. F. (1999). Oxidation of heparin-treated low density lipoprotein by peroxidases. Atherosclerosis, 146, 211-219.

Journal - Research Article

Wallace, A. J., Mann, J., Sutherland, W. H. F., Williams, S. M., Chisholm, A., & Skeaff, C. M. (1999). Variation in plasma cholesterol response to dietary change. Nutrition, Metabolism & Cardiovascular Diseases, 9, 176-183.

Journal - Research Article

Williams, M. J., Sutherland, W. H. F., McCormick, M. P., de Jong, S. A., Walker, R. J., & Wilkins, G. T. (1999). Impaired endothelial function after a meal rich in used cooking fat. JACC, 33, 1050-1055.

Journal - Research Article

Chisholm, A., Mann, J., Skeaff, M., Frampton, C., Sutherland, W., Duncan, A., & Tiszavari, S. (1998). A diet rich in walnuts favourably influences plasma fatty acid profile in moderately hyperlipidaemic subjects. European Journal of Clinical Nutrition, 52, 12-16.

Journal - Research Article

Cox, C. M., Sutherland, W., Mann, J., de Jong, S., Chisholm, A., & Skeaff, M. (1998). Effects of dietary coconut oil, butter and safflower oil on plasma lipids, lipoproteins and lathosterol levels. European Journal of Clinical Nutrition, 52, 650-654.

Journal - Research Article

Sutherland, W. H. F., Restieaux, N. J., Nye, E. R., Williams, M. J. A., de Jong, S. A., Robertson, M. C., & Walker, H. (1998). IDL composition and angiographically determined progression of atherosclerotic lesions during simvastin therapy. Arteriosclerosis, Thrombosis, & Vascular Biology, 18, 577-583.

Journal - Research Article

Sutherland, W. H., Walker, H. L., & Ball, M. J. (1998). Cholesteryl ester transfer during posprandial lipemia: the effect of the type of fat in the meal. Nutrition, Metabolism & Cardiovascular Diseases, 8(1), 13-20.

Journal - Research Article

Manning, P. J., Sutherland, W. H. F., & Mann, J. (1997). Hyperchylomicronaemia might have resolved anyway. British Medical Journal, 314, 65.

Journal - Research Article

Manning, P. J., Sutherland, W. H. F., & Mann, J. (1997). Late diagnosis of diabetic ketoacidosis and underlying disease influence response to treatment. British Medical Journal, 314, 63.

Journal - Research Article

Sutherland, W. H., Ball, M. J., & Walker, H. (1997). The effect of increased egg consumption on plasma cholesteryl ester transfer activity in healthy subjects. European Journal of Clinical Nutrition, 51(3), 172-176.

Journal - Research Article

Walker, R. J., Sutherland, W. H. F., Walker, H. L., MacMahon, S., & Robson, R. A. (1997). Effect of treatment with simvastatin on serum cholesteryl ester transfer in patients on dialysis. Nephrology Dialysis Transplantation, 12(1), 87-92. doi: 10.1093/ndt/12.1.87

Journal - Research Article

Chisholm, A., Mann, J., Sutherland, W., Duncan, A., Skeaff, M., & Frampton, C. (1996). Effect on lipoprotein profile of replacing butter with margarine in a low fat diet: Randomised crossover study with hypercholesterolaemic subjects. British Medical Journal, 312(7036), 931-934. doi: 10.1136/bmj.312.7036.931

Journal - Research Article

Cox, C. M., Sutherland, W. H., Ball, M. J., & Mann, J. (1996). Response of plasma lathosterol concentration to change in the quality of dietary fat in men and women. European Journal of Clinical Nutrition, 50, 358-363.

Journal - Research Article

Humphries, S. E., Talmud, P. J., Cox, C. M., Sutherland, W. H., & Mann, J. (1996). Genetic factors affecting the consistency and magnitude of changes in plasma cholesterol in response to dietary challenge. QJM, 89, 671-680.

Journal - Research Article

Cox, C. M., Mann, J., Sutherland, W. H., & Ball, M. J. (1995). Individual variation in plasma cholesterol response to dietary saturated fat. British Medical Journal, 311, 1260-1264.

Journal - Research Article

Nishizawa, M., Sutherland, W. H., & Nukada, H. (1995). Gosha-jinki-gan (herbal medicine) in streptozocin-induced diabetic neuropathy. Journal of the Neurological Sciences, 132, 177-181.

Journal - Research Article

Sanderson, K. J., van Rij, A. M., Wade, C. R., & Sutherland, W. H. (1995). Lipid peroxidation of circulating low density lipoproteins with age, smoking and in peripheral vascular disease. Atherosclerosis, 118, 45-51.

Journal - Research Article

Sanderson, K. J., van Rij, A. M., Wade, C. R., & Sutherland, W. H. F. (1995). Lipid peroxidation of circulating low density lipoproteins with age, smoking and in peripheral vascular disease. Atherosclerosis, 118, 45-51.

Journal - Research Article

Sutherland, W. H. F., Shilton, M. E., Nye, E. R., Gillies, M. E., Bakini, I., & Robertson, M. C. (1995). Urban/rural differences in red blood cell fatty acid composition, plasma lipids and diet in Melanesian Fijians. European Journal of Clinical Nutrition, 49, 233-241.

Journal - Research Article

Manning, P. J., Sutherland, W. H. F., & Walker, R. J. (2005). Effect of high-dose vitamin E on insulin resistance and associated parameters in overweight subjects [Response to Vale]. Diabetes Care, 28(1), 230-231.

Journal - Research Other

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