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DSM staff profile

Associate Professor John Leader

PositionAssociate Professor
DepartmentDepartment of Medicine (Dunedin)
QualificationsBA(Hons)(Cantab) PhD(Bristol)
Research summaryRenal Physiology

Research

Physiology and pathophysiology of water balance, renal function Cryobiology, chironomidae - systematic

Otago Kidney Research

Publications

Leader, J., Bedford, J., & Walker, R. J. (2019). Drowning in data: Early responses of renal cortical collecting duct cells to lithium. Annals of Translational Medicine, 8(Suppl. 8), S322. doi: 10.21037/atm.2019.09.120

Hurcombe, J. A., Hartley, P., Lay, A. C., Ni, L., Bedford, J. J., Leader, J. P., … Walker, R. J., … Coward, R. J. M. (2019). Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function. Nature Communications, 10, 403. doi: 10.1038/s41467-018-08235-1

Kalita-De Croft, P., Bedford, J. J., Leader, J. P., & Walker, R. J. (2018). Amiloride modifies the progression of lithium-induced renal interstitial fibrosis. Nephrology, 23(1), 20-30. doi: 10.1111/nep.12929

Marti, H.-P., Jeffs, A., Scherer, A., Leader, J., Leader, C., Bedford, J., & Walker, R. (2016). Renal fibrosis mRNA classifier: Validation in experimental lithium-induced interstitial fibrosis in the rat kidney. PLoS ONE, 11(12), e0168240. doi: 10.1371/journal.pone.0168240

Cairns, S. P., Leader, J. P., Loiselle, D. S., Higgins, A., Lin, W., & Renaud, J.-M. (2015). Extracellular Ca2+-induced force restoration in K+-depressed skeletal muscle of the mouse involves an elevation of [K+]i: Implications for fatigue. Journal of Applied Physiology, 118(6), 662-674. doi: 10.1152/japplphysiol.00705.2013

Leader, J. P., & Neufeld, D. (2001). Haemolymph physiology. In L. H. Field (Ed.), Biology of Wetas, King Crickets and their Allies. (pp. 509-517). Oxon, UK: CAB International.

Chapter in Book - Research

Hurcombe, J. A., Hartley, P., Lay, A. C., Ni, L., Bedford, J. J., Leader, J. P., … Walker, R. J., … Coward, R. J. M. (2019). Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function. Nature Communications, 10, 403. doi: 10.1038/s41467-018-08235-1

Journal - Research Article

Kalita-De Croft, P., Bedford, J. J., Leader, J. P., & Walker, R. J. (2018). Amiloride modifies the progression of lithium-induced renal interstitial fibrosis. Nephrology, 23(1), 20-30. doi: 10.1111/nep.12929

Journal - Research Article

Marti, H.-P., Jeffs, A., Scherer, A., Leader, J., Leader, C., Bedford, J., & Walker, R. (2016). Renal fibrosis mRNA classifier: Validation in experimental lithium-induced interstitial fibrosis in the rat kidney. PLoS ONE, 11(12), e0168240. doi: 10.1371/journal.pone.0168240

Journal - Research Article

Cairns, S. P., Leader, J. P., Loiselle, D. S., Higgins, A., Lin, W., & Renaud, J.-M. (2015). Extracellular Ca2+-induced force restoration in K+-depressed skeletal muscle of the mouse involves an elevation of [K+]i: Implications for fatigue. Journal of Applied Physiology, 118(6), 662-674. doi: 10.1152/japplphysiol.00705.2013

Journal - Research Article

Weiner, I. D., Leader, J. P., Bedford, J. J., Verlander, J. W., Ellis, G., Kalita, P., Vos, F., de Jong, S., & Walker, R. J. (2014). Effects of chronic lithium administration on renal acid excretion in humans and rats. Physiological Reports, 2(12), e12242. doi: 10.14814/phy2.12242

Journal - Research Article

Walker, R. J., Leader, J. P., Bedford, J. J., Gobe, G., Davis, G., Vos, F. E., deJong, S., & Schollum, J. B. W. (2013). Chronic interstitial fibrosis in the rat kidney induced by long-term (6-mo) exposure to lithium. American Journal of Physiology: Renal Physiology, 304(3), F300-F307. doi: 10.1152/ajprenal.00182.2012

Journal - Research Article

Cairns, S. P., Leader, J. P., & Loiselle, D. S. (2011). Exacerbated potassium-induced paralysis of mouse soleus muscle at 37°C vis-À-vis 25°C: Implications for fatigue. Pflügers Archiv: European Journal of Physiology, 461(4), 469-479. doi: 10.1007/s00424-011-0927-4

Journal - Research Article

Bedford, J. J., Leader, J. P., Jing, R., Walker, L. J., Klein, J. D., Sands, J. M., & Walker, R. J. (2008). Amiloride restores renal medullary osmolytes in lithium-induced nephrogenic diabetes insipidus. American Journal of Physiology: Renal Physiology, 294, F812-F820. doi: 10.1152/ajprenal.00554.2007

Journal - Research Article

Bedford, J. J., Weggery, S., Ellis, G., McDonald, F. J., Joyce, P. R., Leader, J. P., & Walker, R. J. (2008). Lithium-induced nephrogenic diabetes insipidus: Renal effects of amiloride. Clinical Journal of the American Society of Nephrology, 3(5), 1324-1331.

Journal - Research Article

Bourke, L., Hodgkinson, I., De Silva, L., & Leader, J. (2008). Chiral photonic film and flake. Optics Express, 16(21), 16889-16894.

Journal - Research Article

Bedford, J. J., & Leader, J. P. (2007). Organic osmolytes in the developing kidney of the Australian brush-tailed possum, Trichosurus vulpecula. Comparative Biochemistry & Physiology Part A, 147, 1047-1052. doi: 10.1016/j.cbpa.2007.03.015

Journal - Research Article

Lowrey, S., De Silva, L., Hodgkinson, I., & Leader, J. (2007). Observation and modeling of polarized light from scarab beetles. Journal of the Optical Society of America A, 24(8), 2418-2425. doi: 10.1364/JOSAA.24.002418

Journal - Research Article

O'Donnell, M. J., & Leader, J. P. (2006). Changes in fluid secretion rate alter net transepithelial transport of MRP2 and P-glycoprotein substrates in Malpighian tubules of Drosophila melanogaster. Archives of Insect Biochemistry & Physiology, 63, 123-134.

Journal - Research Article

De Silva, L., Hodgkinson, I., Murray, P., Wu, Q. H., Arnold, M., Leader, J., & McNaughton, A. (2005). Natural and nanoengineered chiral reflectors: Structural color of manuka beetles and titania coatings. Electromagnetics, 25(5), 391-408. doi: 10.1080/02726340590957399

Journal - Research Article

Every, S. G., Leader, J. P., Molteno, A. C., Bevin, T. H., & Sanderson, G. (2005). Ultraviolet photography of the in vivo human cornea unmasks the Hudson-Stähli line and physiologic vortex patterns. Investigative Ophthalmology & Visual Science, 46(10), 3616-3622.

Journal - Research Article

Leader, J. P., & O'Donnell, M. J. (2005). Transepithelial transport of fluorescent p-glycoprotein and MRP2 substrates by insect Malpighian tubules: Confocal microscopic analysis of secreted fluid droplets. Journal of Experimental Biology, 208, 4363-4376.

Journal - Research Article

Samuelsson, L. M., Bedford, J. J., Smith, R. A. J., & Leader, J. P. (2005). A comparison of the counteracting effects of glycine betaine and TMAO on the activity of RNase A in aqueous urea solution. Comparative Biochemistry & Physiology Part A, 141, 22-28.

Journal - Research Article

Walker, R. J., Weggery, S., Bedford, J. J., McDonald, F. J., Ellis, G., & Leader, J. P. (2005). Lithium-induced reduction in urinary concentrating ability and urinary aquaporin 2 (AQP2) excretion in healthy volunteers. Kidney International, 67, 291-294.

Journal - Research Article

Al-Dameh, A. O., Bedford, J. J., Leader, J. P., & Walker, R. J. (2003). Urinary aquaporin-2 levels in healthy volunteers. Nephrology, 8, 139-141.

Journal - Research Article

Bedford, J. J., Leader, J. P., & Walker, R. J. (2003). Aquaporin expression in normal human kidney and in renal disease. Journal of the American Society of Nephrology, 14, 2581-2587.

Journal - Research Article

Bedford, J. J., Burg, M. B., Peters, E., Smith, R. A. J., & Leader, J. P. (2002). Putative osmolytes in the kidney of the Australian brush-tailed possum, Trichosurus vulpecula. Comparative Biochemistry & Physiology Part B, 132, 635-644.

Journal - Research Article

Bedford, J. J., Schofield, J. C., Yancey, P. H., & Leader, J. P. (2002). The effects of hypoosmotic infusion on the composition of renal tissue of the Australian brush-tailed possum Trichosurus vulpecula. Comparative Biochemistry & Physiology Part B, 132, 645-652.

Journal - Research Article

Bedford, J. J., Stanton, J.-A. L., & Leader, J. P. (2001). A taurine transporter isolated from rat cardiac muscle. Advances in Experimental Medicine & Biology, 483, 523-534.

Journal - Research Article

Leader, J. P., & Bedford, J. J. (2000). What happens to an insect when it freezes and does it matter? New Zealand Science Monthly, 11(7), 6-8.

Journal - Research Article

Palmer, H. R., Bedford, J. J., Leader, J. P., & Smith, R. A. J. (2000). 31P and 1H NMR studies of the effect of the counteracting osmolyte trimethylamine-N-oxide on interactions of urea with ribonuclease A. Journal of Biological Chemistry, 275, 27708-27711.

Journal - Research Article

Bedford, J. J., Harper, J. L., Leader, J. P., & Smith, R. A. J. (1998). Identification and measurement of methylamines in elasmobranch tissues using proton nuclear magnetic resonance (1H-NMR) spectroscopy. Journal of Comparative Physiology B, 168(2), 123-131.

Journal - Research Article

Bedford, J. J., Harper, J. L., Leader, J. P., Yancey, P. H., & Smith, R. A. J. (1998). Betaine is the principal counteracting osmolyte in tissues of the elephant fish, Callorhincus millii (Elasmobranchii, Holocephali). Comparative Biochemistry & Physiology Part B, 119(3), 521-526.

Journal - Research Article

Biyouki, M. A. A., Smith, R. A. J., Bedford, J. J., & Leader, J. P. (1998). Hydroxymethylation and carbamoylation of di- and tetramethylpyridines using radical (Minisci) reactions. Synthetic Communications, 28, 3817-3825.

Journal - Research Article

Kovbasnjuk, O., Leader, J. P., Weinstein, A. M., & Spring, K. R. (1998). Water does not flow across the tight junctions of MDCK cell epithelium. PNAS, 95, 6526-6530.

Journal - Research Article

Neufeld, D., & Leader, J. P. (1998). Cold inhibition of cell volume regulation during the freezing of insect Malpighian tubules. Journal of Experimental Biology, 201, 2195-2204.

Journal - Research Article

Neufeld, D., & Leader, J. P. (1998). Electrochemical characteristics of ion secretion in Malpighian tubules of the New Zealand alpine weta (Hemideina maori). Journal of Insect Physiology, 44, 39-48.

Journal - Research Article

Neufeld, D., & Leader, J. P. (1998). Freezing survival by isolated Malpighian tubules of the New Zealand alpine weta, Hemideina maori. Journal of Experimental Biology, 201, 227-236.

Journal - Research Article

Harper, J. L., Smith, R. A. J., Bedford, J. J., & Leader, J. P. (1997). Synthesis, acidity and 19F-NMR characteristics of 1-substituted fluoroimidazoles with potential application as probes for intracellular pH determination. Tetrahedron, 53(24), 8211-8224.

Journal - Research Article

Wilson, P. W., & Leader, J. P. (1995). Stabilization of supercooled fluids by thermal hysteresis proteins. Biophysical Journal, 68(5), 2098-2107. doi: 10.1016/S0006-3495(95)80389-9

Journal - Research Article

Leader, J., Bedford, J., & Walker, R. J. (2019). Drowning in data: Early responses of renal cortical collecting duct cells to lithium. Annals of Translational Medicine, 8(Suppl. 8), S322. doi: 10.21037/atm.2019.09.120

Journal - Research Other

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