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Health Science staff profile

 

Jackie Ludgate

PositionAssistant Research Fellow
DepartmentDepartment of Pathology (DSM)
QualificationsBSc(Hons)
Research summaryGenetic/Epigenetic origins of childhood leukaemia

Research

Providing laboratory support to a wide range of research projects undertaken in the Epigenetics Group.

  • Investigating candidate genes for involvement in childhood acute lymphoblastic leukaemia
  • Using a range of methods including: transgenic mice, yeast two-hybrid, methylation (epigenetic) analysis

Publications

Gamage, T. K. J. B., Schierding, W., Tsai, P., Ludgate, J. L., Chamley, L. W., Weeks, R. J., Macaulay, E. C., & James, J. L. (2018). Human trophoblasts are primarily distinguished from somatic cells by differences in the pattern rather than the degree of global CpG methylation. Biology Open. Advance online publication. doi: 10.1242/bio.034884

Gamage, T. K. J. B., Schierding, W., Hurley, D., Tsai, P., Ludgate, J. L., Bhoothpur, C., … Weeks, R. J., Macaulay, E. C., & James, J. L. (2018). The role of DNA methylation in human trophoblast differentiation. Epigenetics. Advance online publication. doi: 10.1080/15592294.2018.1549462

Halliday, B. J., Fukuzawa, R., Markie, D. M., Grundy, R. G., Ludgate, J. L., Black, M. A., … Weeks, R. J., … Morison, I. M. (2018). Germline mutations and somatic inactivation of TRIM28 in Wilms tumour. PLoS Genetics, 14(6), e1007399. doi: 10.1371/journal.pgen.1007399

Chatterjee, A., Macaulay, E. C., Ahn, A., Ludgate, J. L., Stockwell, P. A., Weeks, R. J., Parry, M. F., Foster, T. J., … Eccles, M. R., & Morison, I. M. (2017). Comparative assessment of DNA methylation patterns between reduced representation bisulfite sequencing and Sequenom EpiTyper methylation analysis. Epigenomics, 9(6), 823-832. doi: 10.2217/epi-2016-0176

Ludgate, J. L., Wright, J., Stockwell, P. A., Morison, I. M., Eccles, M. R., & Chatterjee, A. (2017). A streamlined method for analysing genome-wide DNA methylation patterns from low amounts of FFPE DNA. BMC Medical Genomics, 10, 54. doi: 10.1186/s12920-017-0290-1

Journal - Research Article

Gamage, T. K. J. B., Schierding, W., Tsai, P., Ludgate, J. L., Chamley, L. W., Weeks, R. J., Macaulay, E. C., & James, J. L. (2018). Human trophoblasts are primarily distinguished from somatic cells by differences in the pattern rather than the degree of global CpG methylation. Biology Open. Advance online publication. doi: 10.1242/bio.034884

Halliday, B. J., Fukuzawa, R., Markie, D. M., Grundy, R. G., Ludgate, J. L., Black, M. A., … Weeks, R. J., … Morison, I. M. (2018). Germline mutations and somatic inactivation of TRIM28 in Wilms tumour. PLoS Genetics, 14(6), e1007399. doi: 10.1371/journal.pgen.1007399

Gamage, T. K. J. B., Schierding, W., Hurley, D., Tsai, P., Ludgate, J. L., Bhoothpur, C., … Weeks, R. J., Macaulay, E. C., & James, J. L. (2018). The role of DNA methylation in human trophoblast differentiation. Epigenetics. Advance online publication. doi: 10.1080/15592294.2018.1549462

Chatterjee, A., Macaulay, E. C., Ahn, A., Ludgate, J. L., Stockwell, P. A., Weeks, R. J., Parry, M. F., Foster, T. J., … Eccles, M. R., & Morison, I. M. (2017). Comparative assessment of DNA methylation patterns between reduced representation bisulfite sequencing and Sequenom EpiTyper methylation analysis. Epigenomics, 9(6), 823-832. doi: 10.2217/epi-2016-0176

Ludgate, J. L., Wright, J., Stockwell, P. A., Morison, I. M., Eccles, M. R., & Chatterjee, A. (2017). A streamlined method for analysing genome-wide DNA methylation patterns from low amounts of FFPE DNA. BMC Medical Genomics, 10, 54. doi: 10.1186/s12920-017-0290-1

Weeks, R. J., Ludgate, J. L., LeMée, G., & Morison, I. M. (2016). TESTIN induces rapid death and suppresses proliferation in childhood B acute lymphoblastic leukaemia cells. PLoS ONE, 11(3), e0151341. doi: 10.1371/journal.pone.0151341

Ludgate, J. L., Le Mée, G., Fukuzawa, R., Rodger, E. J., Weeks, R. J., Reeve, A. E., & Morison, I. M. (2013). Global demethylation in loss of imprinting subtype of Wilms tumor. Genes Chromosomes & Cancer, 52(2), 174-184. doi: 10.1002/gcc.22017

Oliver, V. F., Miles, H. L., Cutfield, W. S., Hofman, P. L., Ludgate, J. L., & Morison, I. M. (2012). Defects in imprinting and genome-wide DNA methylation are not common in the in vitro fertilization population. Fertility & Sterility, 97(1), 147-153.e7. doi: 10.1016/j.fertnstert.2011.10.027

Miller, J. C., Thomson, C. D., Williams, S. M., van Havre, N., Wilkins, G. T., Morison, I. M., Ludgate, J. L., & Skeaff, C. M. (2012). Influence of the glutathione peroxidase 1 Pro200Leu polymorphism on the response of glutathione peroxidase activity to selenium supplementation: A randomized controlled trial. American Journal of Clinical Nutrition, 96, 923-931. doi: 10.3945/ajcn.112.043125

Hare, J. R., Holmes, K. M., Wilson, J. L., & Cree, A. (2009). Modelling exposure to selected temperature during pregnancy: The limitations of squamate viviparity in a cool-climate environment. Biological Journal of the Linnean Society, 96(3), 541-552. doi: 10.1111/j.1095-8312.2008.01151.x

Wilson, J., & Cree, A. (2003). Extended gestation with late-autumn births in a cool-climate viviparous gecko from southern New Zealand (Reptilia: Naultinus gemmeus). Austral Ecology, 28, 339-348.

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Journal - Research Other

Wilson, J. L., & Morison, I. M. (2005). No evidence for preferential maternal origin of duplicated chromosome 14 in hyperdiploid ALL. Blood, 105(4), 1837-1838. doi: 10.1182/blood-2004-09-3804

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