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Health Science staff profile

 

Dr Silke Neumann

PositionResearch Fellow
DepartmentDepartment of Pathology (DSM)
QualificationsBPharm PhD
Research summaryCancer research and stroke immunology/immune therapy

Research

My research focuses on understanding the role of inflammation in disease progression (cancer and stroke), and how it shapes immune responses. I am particularly insterested in innate immune cells that play an important role in initiating and driving inflammatory processes, which in turn impair therapeutic success (cancer) and wound repair (stroke).

In the stroke project I have studied the temporal profile of immune cells that enter the brain post-stroke to understand when and in what ways these cells can be manipulated to inhibit inflammation and improve stroke recovery. A primary focus on my work has been the use of neurotransmitters or drugs that act like neurotransmitters to dampen the inflammatory processes.

Another aspect of my research is the development of a protocol for immunotherapy that will entail priming immune cells to selectively recognise and destroy cancer cells while sparing healthy cells. Furthermore, we are interested in deciphering the role of the immunoproteasome, a key component that enables antigen-presentation in the interplay between cancer and immune cells.

Elucidating the role of particular immune cell populations and soluble pro-inflammatory factors in the cancer and stroke microenvironment requires the use of multiple techniques. These techniques encompass cell-based assays, flow cytometric analysis and methods to assess the significance of immune cell populations, and the contribution of each to inflammation.

Publications

Clarkson, A. N., Boothman-Burrell, L., Dósa, Z., Nagaraja, R. Y., Jin, L., Parker, K., … Neumann, S., Gowing, E. K., … Chebib, M. (2018). The flavonoid, 2'-methoxy-6-methylflavone, affords neuroprotection following focal cerebral ischaemia. Journal of Cerebral Blood Flow & Metabolism. Advance online publication. doi: 10.1177/0271678x18755628

Evans, M. A., Lim, R., Kim, H. A., Chu, H. X., Gardiner-Mann, C. V., Taylor, K. W. E., … Neumann, S., … Gowing, E. K., … Clarkson, A. N., … Broughton, B. R. S. (2018). Acute or delayed systemic administration of human amnion epithelial cells improves outcomes in experimental stroke. Stroke, 49(3), 700-709. doi: 10.1161/strokeaha.117.019136

Grant, M. L., Shields, N., Neumann, S., Kramer, K., Bonato, A., Jackson, C., Baird, M. A., & Young, S. L. (2017). Combining dendritic cells and B cells for presentation of oxidised tumour antigens to CD8+ T cells. Clinical & Translational Immunology, 6(7), e149. doi: 10.1038/cti.2017.28

Neumann, S., Shirley, S. A., Kemp, R. A., & Hook, S. M. (2016). Improved antitumor activity of a therapeutic melanoma vaccine through the use of the dual COX-2/5-LO inhibitor licofelone. Frontiers in Immunology, 7(537), 537. doi: 10.3389/fimmu.2016.00537

Neumann, S., Young, K., Compton, B., Anderson, R., Painter, G., & Hook, S. (2015). Synthetic TRP2 long-peptide and α-galactosylceramide formulated into cationic liposomes elicit CD8+ T-cell responses and prevent tumour progression. Vaccine, 33, 5838-5844. doi: 10.1016/j.vaccine.2015.08.083

Journal - Research Article

Clarkson, A. N., Boothman-Burrell, L., Dósa, Z., Nagaraja, R. Y., Jin, L., Parker, K., … Neumann, S., Gowing, E. K., … Chebib, M. (2018). The flavonoid, 2'-methoxy-6-methylflavone, affords neuroprotection following focal cerebral ischaemia. Journal of Cerebral Blood Flow & Metabolism. Advance online publication. doi: 10.1177/0271678x18755628

Evans, M. A., Lim, R., Kim, H. A., Chu, H. X., Gardiner-Mann, C. V., Taylor, K. W. E., … Neumann, S., … Gowing, E. K., … Clarkson, A. N., … Broughton, B. R. S. (2018). Acute or delayed systemic administration of human amnion epithelial cells improves outcomes in experimental stroke. Stroke, 49(3), 700-709. doi: 10.1161/strokeaha.117.019136

Grant, M. L., Shields, N., Neumann, S., Kramer, K., Bonato, A., Jackson, C., Baird, M. A., & Young, S. L. (2017). Combining dendritic cells and B cells for presentation of oxidised tumour antigens to CD8+ T cells. Clinical & Translational Immunology, 6(7), e149. doi: 10.1038/cti.2017.28

Neumann, S., Shirley, S. A., Kemp, R. A., & Hook, S. M. (2016). Improved antitumor activity of a therapeutic melanoma vaccine through the use of the dual COX-2/5-LO inhibitor licofelone. Frontiers in Immunology, 7(537), 537. doi: 10.3389/fimmu.2016.00537

Neumann, S., Young, K., Compton, B., Anderson, R., Painter, G., & Hook, S. (2015). Synthetic TRP2 long-peptide and α-galactosylceramide formulated into cationic liposomes elicit CD8+ T-cell responses and prevent tumour progression. Vaccine, 33, 5838-5844. doi: 10.1016/j.vaccine.2015.08.083

Neumann, S., Shields, N. J., Balle, T., Chebib, M., & Clarkson, A. N. (2015). Innate immunity and inflammation post-stroke: An α7-nicotinic agonist perspective. International Journal of Molecular Sciences, 16(12), 29029-29046. doi: 10.3390/ijms161226141

Neumann, S., Burkert, K., Kemp, R., Rades, T., Dunbar, P. R., & Hook, S. (2014). Activation of the NLRP3 inflammasome is not a feature of all particulate vaccine adjuvants. Immunology & Cell Biology, 92, 535-542. doi: 10.1038/icb.2014.21

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