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Health Science staff profile

 

Dr Karen Knapp

PositionPostdoctoral Fellow
DepartmentDepartment of Pathology (DSM)
Research summaryGenetic disorders, cancer

Research

She completed her PhD in the research group of Professor Norbert Sträter at Leipzig University, Germany (2010), carrying out research involving the biochemical and structural characterization of a cancer drug target (CD73). She went on to carry out postdoctoral research within the Biochemistry Department, at the University of Otago (2010-2013), involving the structural characterisation of viral and host protein complexes, followed by further postdoctoral research at the North West Cancer Research Institute, Bangor University, UK (2013-2015), investigating DNA repair mechanisms and their role in cancer. In 2016 Karen joined the Bicknell Lab as a postdoctoral research fellow, and is carrying out research which focuses on identifying and characterising novel DNA replication components, in which mutations cause the rare Mendelian disorder Meier-Gorlin syndrome (MGS).

Publications

Knapp, K., Zebisch, M., Pippel, J., El-Tayeb, A., Müller, C. E., & Sträter, N. (2012). Crystal structure of the human ecto-5′-nucleotidase (CD73): Insights into the regulation of purinergic signaling. Structure, 20(12), 2161-2173. doi: 10.1016/j.str.2012.10.001

Couñago, R. M., Knapp, K. M., Nakatani, Y., Fleming, S. B., Corbett, M., Wise, L. M., Mercer, A. A., & Krause, K. L. (2015). Structures of orf virus chemokine binding protein in complex with host chemokines reveal clues to broad binding specificity. Structure, 23(7), 1199-1213. doi: 10.1016/j.str.2015.04.023

Villahermosa, D., Knapp, K., & Fleck, O. (2017). A mutated dph3 gene causes sensitivity of Schizosaccharomyces pombe cells to cytotoxic agents. Current Genetics, 63(6), 1081-1091. doi: 10.1007/s00294-017-0711-x

Villahermosa, D., Christensen, O., Knapp, K., & Fleck, O. (2017). Schizosaccharomyces pombe MutSα and MutLα maintain stability of tetra-nucleotide repeats and Msh3 of hepta-nucleotide repeats. Genes Genomes Genetics, 7(5), 1463-1473. doi: 10.1534/g3.117.040816

Journal - Research Article

Villahermosa, D., Knapp, K., & Fleck, O. (2017). A mutated dph3 gene causes sensitivity of Schizosaccharomyces pombe cells to cytotoxic agents. Current Genetics, 63(6), 1081-1091. doi: 10.1007/s00294-017-0711-x

Villahermosa, D., Christensen, O., Knapp, K., & Fleck, O. (2017). Schizosaccharomyces pombe MutSα and MutLα maintain stability of tetra-nucleotide repeats and Msh3 of hepta-nucleotide repeats. Genes Genomes Genetics, 7(5), 1463-1473. doi: 10.1534/g3.117.040816

Couñago, R. M., Knapp, K. M., Nakatani, Y., Fleming, S. B., Corbett, M., Wise, L. M., Mercer, A. A., & Krause, K. L. (2015). Structures of orf virus chemokine binding protein in complex with host chemokines reveal clues to broad binding specificity. Structure, 23(7), 1199-1213. doi: 10.1016/j.str.2015.04.023

Knapp, K., Zebisch, M., Pippel, J., El-Tayeb, A., Müller, C. E., & Sträter, N. (2012). Crystal structure of the human ecto-5′-nucleotidase (CD73): Insights into the regulation of purinergic signaling. Structure, 20(12), 2161-2173. doi: 10.1016/j.str.2012.10.001

More publications...