Accessibility Skip to Global Navigation Skip to Local Navigation Skip to Content Skip to Search Skip to Site Map Menu

Health Science staff profile

 

Amy Dowdle

PositionPhD student
DepartmentDepartment of Pathology (DSM)
QualificationsBBiomedSc(Hons) BBiomedSc(Hons)
Research summaryInsights into genome activation from nuclear structure

Research

After completing my honours with Associate Professor Julia Horsfield in 2015, I moved away from gout genetics – the subject of my honours thesis – into an entirely different field of research to begin my PhD study. The topic of my PhD is developmental genetics; specifically, I aim to gain novel insights into genome activation from studying nuclear structure. I hypothesise that formation of a three-dimensional, transcriptionally-competent genome is the trigger for genome activation following conception of a zygote. This project requires imaging zebrafish embryos at various stages to map the changes in nuclear structure, in conjunction with a HiC experiment to capture interactions occurring throughout early development.

Publications

Leask, M., Dowdle, A., Salvesen, H., Topless, R., Fadason, T., Wei, W., … Marsman, J., … Merriman, T. R., & Horsfield, J. A. (2019). Functional urate-associated genetic variants influence expression of lincRNAs LINC01229 and MAFTRR. Frontiers in Genetics, 9, 733. doi: 10.3389/fgene.2018.00733

Meier, M., Grant, J., Dowdle, A., Thomas, A., Gerton, J., Collas, P., … Horsfield, J. A. (2018). Cohesin facilitates zygotic genome activation in zebrafish. Development, 145, dev156521. doi: 10.1242/dev.156521

Journal - Research Article

Leask, M., Dowdle, A., Salvesen, H., Topless, R., Fadason, T., Wei, W., … Marsman, J., … Merriman, T. R., & Horsfield, J. A. (2019). Functional urate-associated genetic variants influence expression of lincRNAs LINC01229 and MAFTRR. Frontiers in Genetics, 9, 733. doi: 10.3389/fgene.2018.00733

Meier, M., Grant, J., Dowdle, A., Thomas, A., Gerton, J., Collas, P., … Horsfield, J. A. (2018). Cohesin facilitates zygotic genome activation in zebrafish. Development, 145, dev156521. doi: 10.1242/dev.156521

More publications...