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Health Science staff profile

 

Dr Cushla McKinney

PositionResearch Fellow
DepartmentDepartment of Pathology (DSM)
QualificationsPhD, MBHL
Research summaryComplex disease genetics

Research

Cushla has been working on the genetics of complex disease for the past few years, focusing on the role of copy number variation on susceptibility to rheumatoid arthritis.

Publications

Fatima, T., McKinney, C., Major, T. J., Stamp, L. K., Dalbeth, N., Iverson, C., Merriman, T. R., & Miner, J. N. (2018). The relationship between ferritin and urate levels and risk of gout. Arthritis Research & Therapy, 20, 179. doi: 10.1186/s13075-018-1668-y

Rasheed, H., McKinney, C., Stamp, L. K., Dalbeth, N., Topless, R. K., Day, R., … Merriman, T. R. (2016). The toll-like receptor 4 (TLR4) variant rs2149356 and risk of gout in European and Polynesian sample sets. PLoS ONE, 11(1), e0147939. doi: 10.1371/journal.pone.0147939

Mathew, S. F., Crowe-McAuliffe, C., Graves, R., Cardno, T. S., McKinney, C., Poole, E. S., & Tate, W. P. (2015). The highly conserved codon following the Slippery Sequence Supports -1 frameshift efficiency at the HIV-1 frameshift site. PLoS ONE, 10(3), e0122176. doi: 10.1371/journal.pone.0122176

McKinney, C., Stamp, L. K., Dalbeth, N., Topless, R. K., Day, R. O., Kannangara, D. R. W., … Merriman, T. R. (2015). Multiplicative interaction of functional inflammasome genetic variants in determining the risk of gout. Arthritis Research & Therapy, 17, 288. doi: 10.1186/s13075-015-0802-3

McKinney, C. (2015). Is resistance (n)ever futile? A response to "Futility in chronic anorexia nervosa: A concept whose time has not yet come" by Cynthia Geppert. American Journal of Bioethics, 15(7), 53-54. doi: 10.1080/15265161.2015.1042991

Chapter in Book - Research

Merriman, T. R., & McKinney, C. (2013). An update on the genetic causes of hyperuricemia and gout. In N. Dalbeth, F. Perez-Ruiz & N. Schlesinger (Eds.), Gout. (pp. 54-69). London, UK: Future Medicine. doi: 10.2217/ebo.12.256

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Journal - Research Article

Fatima, T., McKinney, C., Major, T. J., Stamp, L. K., Dalbeth, N., Iverson, C., Merriman, T. R., & Miner, J. N. (2018). The relationship between ferritin and urate levels and risk of gout. Arthritis Research & Therapy, 20, 179. doi: 10.1186/s13075-018-1668-y

Rasheed, H., McKinney, C., Stamp, L. K., Dalbeth, N., Topless, R. K., Day, R., … Merriman, T. R. (2016). The toll-like receptor 4 (TLR4) variant rs2149356 and risk of gout in European and Polynesian sample sets. PLoS ONE, 11(1), e0147939. doi: 10.1371/journal.pone.0147939

Mathew, S. F., Crowe-McAuliffe, C., Graves, R., Cardno, T. S., McKinney, C., Poole, E. S., & Tate, W. P. (2015). The highly conserved codon following the Slippery Sequence Supports -1 frameshift efficiency at the HIV-1 frameshift site. PLoS ONE, 10(3), e0122176. doi: 10.1371/journal.pone.0122176

McKinney, C., Stamp, L. K., Dalbeth, N., Topless, R. K., Day, R. O., Kannangara, D. R. W., … Merriman, T. R. (2015). Multiplicative interaction of functional inflammasome genetic variants in determining the risk of gout. Arthritis Research & Therapy, 17, 288. doi: 10.1186/s13075-015-0802-3

Teruel, M., McKinney, C., Balsa, A., Pascual-Salcedo, D., Rodriguez-Rodriguez, L., Ortiz, A. M., … Merriman, T., … Martin, J. (2013). Association of CD247 polymorphisms with rheumatoid arthritis: A replication study and a meta-analysis. PLoS ONE, 8(7), e68295. doi: 10.1371/journal.pone.0068295

McKinney, C., Broen, J. C. A., Vonk, M. C., Beretta, L., Hesselstrand, R., Hunzelmann, N., … Merriman, T. R. (2012). Evidence that deletion at FCGR3B is a risk factor for systemic sclerosis. Genes & Immunity, 13(6), 458-460. doi: 10.1038/gene.2012.15

Chen-Xu, M., Topless, R., McKinney, C., Merriman, M. E., Phipps-Green, A., Dalbeth, N., … Harrison, A. A., Highton, J., … van Rij, A., Jones, G. T., … Stamp, L. K., … Merriman, T. R. (2012). Replication of association of the interleukin 23 receptor rs1343151 variant with rheumatoid arthritis in Caucasian sample sets. Annals of the Rheumatic Diseases, 71(1), 155-157. doi: 10.1136/annrheumdis-2011-200591

McKinney, C., & Merriman, T. R. (2012). Meta-analysis confirms a role for deletion in FCGR3B in autoimmune phenotypes. Human Molecular Genetics, 21(10), 2370-2376. doi: 10.1093/hmg/dds039

Hook, S. M., Phipps-Green, A. J., Faiz, F., McNoe, L., McKinney, C., Hollis-Moffatt, J. E., & Merriman, T. R. (2011). Smad2: A candidate gene for the murine autoimmune diabetes locus Idd21.1. Journal of Clinical Endocrinology & Metabolism, 96(12), E2072-E2077. doi: 10.1210/jc.2011-0463

Bentley, R. W., Pearson, J., Gearry, R. B., Barclay, M. L., McKinney, C., Merriman, T. R., & Roberts, R. L. (2010). Association of higher DEFB4 genomic copy number with Crohn's disease. American Journal of Gastroenterology, 105(2), 354-359. doi: 10.1038/ajg.2009.582

McKinney, C., Fanciulli, M., Merriman, M. E., Phipps-Green, A., Alizadeh, B. Z., Koeleman, B. P. C., … Harrison, A. A., Highton, J., … Stamp, L. K., … Merriman, T. R. (2010). Association of variation in Fcγ receptor 3B gene copy number with rheumatoid arthritis in Caucasian samples. Annals of the Rheumatic Diseases, 69, 1711-1716. doi: 10.1136/ard.2009.123588

Nasri, S., More, H., Graziano, F., Ruzzo, A., Wilson, E., Dunbier, A., McKinney, C., Merriman, T., Guilford, P., … Humar, B. (2008). A novel diffuse gastric cancer susceptibility variant in E-cadherin (CDH1) intron 2: A case control study in an Italian population. BMC Cancer, 8, 138. doi: 10.1186/1471-2407-8-138

McKinney, C., Merriman, M. E., Chapman, P. T., Gow, P. J., Harrison, A. A., Highton, J., … O'Donnell, J. L., … Stamp, L. K., Willis, J., … Merriman, T. R. (2008). Evidence for an influence of chemokine ligand 3-like 1 (CCL3L1) gene copy number on susceptibility to rheumatoid arthritis. Annals of the Rheumatic Diseases, 67, 409-413. doi: 10.1136/ard.2007.075028

Gil, M., McKinney, C., Lee, M. K., Eells, J. B., Phyillaier, M. A., & Nikodem, V. M. (2007). Regulation of GTP cyclohydrolase I expression by orphan receptor Nurr1 in cell culture and in vivo. Journal of Neurochemistry, 101, 142-150.

McKinney, C., & Merriman, T. R. (2007). The human genome and understanding of common disease: Present and future technologies. Cellular & Molecular Life Sciences, 64(7-8), 961-978.

Irvine, J., Horsfield, J. A., McKinney, C. Z., & Tate, W. P. (1998). A novel strategy to interfere with human immunodeficiency virus type 1 propagation. New Zealand Medical Journal, 111, 222-224.

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Journal - Research Other

McKinney, C. (2015). Is resistance (n)ever futile? A response to "Futility in chronic anorexia nervosa: A concept whose time has not yet come" by Cynthia Geppert. American Journal of Bioethics, 15(7), 53-54. doi: 10.1080/15265161.2015.1042991

Phipps-Green, A., McKinney, C., Rossol, M., Merriman, M. E., Topless, R., Hollis-Moffatt, J. E., Wan Taib, W. R., … Harrison, A. A., Highton, J., … Stamp, L. K., … Merriman, T. R. (2011). Analysis of association of DNASE2 promoter variation with rheumatoid arthritis in European Caucasians [Letter]. Annals of the Rheumatic Diseases, 70(8), 1512-1514. doi: 10.1136/ard.2010.138727

McKinney, C. (2010). [Review of the book Artscience: Creativity in the post-Google generation]. Junctures, 13, 93-94.

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