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Health Science staff profile

 

Dr Rob Weeks

PositionSenior Research Fellow
DepartmentDepartment of Pathology (DSM)
QualificationsPhD
Research summaryCancer genetics

Research

Rob works with Professor Ian Morison. His interest is the control of mammalian gene expression and cancer.

Publications

Gamage, T. K. J. B., Schierding, W., Tsai, P., Ludgate, J. L., Chamley, L. W., Weeks, R. J., Macaulay, E. C., & James, J. L. (2018). Human trophoblasts are primarily distinguished from somatic cells by differences in the pattern rather than the degree of global CpG methylation. Biology Open. Advance online publication. doi: 10.1242/bio.034884

Gamage, T. K. J. B., Schierding, W., Hurley, D., Tsai, P., Ludgate, J. L., Bhoothpur, C., … Weeks, R. J., Macaulay, E. C., & James, J. L. (2018). The role of DNA methylation in human trophoblast differentiation. Epigenetics. Advance online publication. doi: 10.1080/15592294.2018.1549462

Sharp, P. A., Clarkson, R., Hussain, A., Weeks, R. J., & Morison, I. M. (2018). DNA methylation of hepatic iron sensing genes and the regulation of hepcidin expression. PLoS ONE, 13(5), e0197863. doi: 10.1371/journal.pone.0197863

Halliday, B. J., Fukuzawa, R., Markie, D. M., Grundy, R. G., Ludgate, J. L., Black, M. A., … Weeks, R. J., … Morison, I. M. (2018). Germline mutations and somatic inactivation of TRIM28 in Wilms tumour. PLoS Genetics, 14(6), e1007399. doi: 10.1371/journal.pgen.1007399

Chatterjee, A., Macaulay, E. C., Ahn, A., Ludgate, J. L., Stockwell, P. A., Weeks, R. J., Parry, M. F., Foster, T. J., … Eccles, M. R., & Morison, I. M. (2017). Comparative assessment of DNA methylation patterns between reduced representation bisulfite sequencing and Sequenom EpiTyper methylation analysis. Epigenomics, 9(6), 823-832. doi: 10.2217/epi-2016-0176

Journal - Research Article

Gamage, T. K. J. B., Schierding, W., Tsai, P., Ludgate, J. L., Chamley, L. W., Weeks, R. J., Macaulay, E. C., & James, J. L. (2018). Human trophoblasts are primarily distinguished from somatic cells by differences in the pattern rather than the degree of global CpG methylation. Biology Open. Advance online publication. doi: 10.1242/bio.034884

Halliday, B. J., Fukuzawa, R., Markie, D. M., Grundy, R. G., Ludgate, J. L., Black, M. A., … Weeks, R. J., … Morison, I. M. (2018). Germline mutations and somatic inactivation of TRIM28 in Wilms tumour. PLoS Genetics, 14(6), e1007399. doi: 10.1371/journal.pgen.1007399

Sharp, P. A., Clarkson, R., Hussain, A., Weeks, R. J., & Morison, I. M. (2018). DNA methylation of hepatic iron sensing genes and the regulation of hepcidin expression. PLoS ONE, 13(5), e0197863. doi: 10.1371/journal.pone.0197863

Gamage, T. K. J. B., Schierding, W., Hurley, D., Tsai, P., Ludgate, J. L., Bhoothpur, C., … Weeks, R. J., Macaulay, E. C., & James, J. L. (2018). The role of DNA methylation in human trophoblast differentiation. Epigenetics. Advance online publication. doi: 10.1080/15592294.2018.1549462

Chatterjee, A., Macaulay, E. C., Ahn, A., Ludgate, J. L., Stockwell, P. A., Weeks, R. J., Parry, M. F., Foster, T. J., … Eccles, M. R., & Morison, I. M. (2017). Comparative assessment of DNA methylation patterns between reduced representation bisulfite sequencing and Sequenom EpiTyper methylation analysis. Epigenomics, 9(6), 823-832. doi: 10.2217/epi-2016-0176

Weeks, R. J., Ludgate, J. L., LeMée, G., & Morison, I. M. (2016). TESTIN induces rapid death and suppresses proliferation in childhood B acute lymphoblastic leukaemia cells. PLoS ONE, 11(3), e0151341. doi: 10.1371/journal.pone.0151341

Chatterjee, A., Stockwell, P. A., Rodger, E. J., Duncan, E. J., Parry, M. F., Weeks, R. J., & Morison, I. M. (2015). Genome-wide DNA methylation map of human neutrophils reveals widespread inter-individual epigenetic variation. Scientific Reports, 5, 17328. doi: 10.1038/srep17328

Ludgate, J. L., Le Mée, G., Fukuzawa, R., Rodger, E. J., Weeks, R. J., Reeve, A. E., & Morison, I. M. (2013). Global demethylation in loss of imprinting subtype of Wilms tumor. Genes Chromosomes & Cancer, 52(2), 174-184. doi: 10.1002/gcc.22017

Chatterjee, A., Rodger, E. J., Stockwell, P. A., Weeks, R. J., & Morison, I. M. (2012). Technical considerations for reduced representation bisulfite sequencing with multiplexed libraries. Journal of Biomedicine & Biotechnology, 2012, 741542. doi: 10.1155/2012/741542

Macaulay, E. C., Weeks, R. J., Andrews, S., & Morison, I. M. (2011). Hypomethylation of functional retrotransposon-derived genes in the human placenta. Mammalian Genome, 22, 722-735. doi: 10.1007/s00335-011-9355-1

Weeks, R. J., Kees, U. R., Song, S., & Morison, I. M. (2010). Silencing of TESTIN by dense biallelic promoter methylation is the most common molecular event in childhood acute lymphoblastic leukaemia. Molecular Cancer, 9, 163. doi: 10.1186/1476-4598-9-163

Fukuzawa, R., Anaka, M. R., Weeks, R. J., Morison, I. M., & Reeve, A. E. (2009). Canonical WNT signalling determines lineage specificity in Wilms tumour. Oncogene, 28(8), 1063-1075. doi: 10.1038/onc.2008.455

Zou, D., Yoon, H.-S., Perez, D., Weeks, R. J., Guilford, P., & Humar, B. (2009). Epigenetic silencing in non-neoplastic epithelia identifies E-cadherin (CDH1) as a target for chemoprevention of lobular neoplasia. Journal of Pathology, 218(2), 265-272. doi: 10.1002/path.2541

Morison, I. M., Cramer Bordé, E. M., Cheesman, E. J., Cheong, P. L., Holyoake, A. J., Fichelson, S., Weeks, R. J., Lo, A., Davies, S. M. K., Wilbanks, S. M., Fagerlund, R. D., Ludgate, M. W., da Silva Tatley, F. M., Coker, M. S. A., Bockett, N. A., Hughes, G., Pippig, D. A., Smith, M. P., … Ledgerwood, E. C. (2008). A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia. Nature Genetics, 40(4), 387-389. doi: 10.1038/ng.103

Hall, G. D., Smith, B., Weeks, R. J., Selby, P. J., Southgate, J., & Chester, J. D. (2006). Novel urothelium specific gene expression identified by differential display reverse transcriptase-polymerase chain reaction. Journal of Urology, 175, 337-342.

Weeks, R. J., & Morison, I. M. (2006). Detailed methylation analysis of CpG islands on human chromosome region 9p21. Genes Chromosomes & Cancer, 45(4), 357-364.

Hall, G. D., Weeks, R. J., Olsburgh, J., Southgate, J., Knowles, M. A., Selby, P. J., & Chester, J. D. (2005). Transcriptional control of the human urothelial-specific gene, uroplakin Ia. Biochimica et Biophysica Acta: Gene Structure & Expression, 1729, 126-134.

Olsburgh, J., Harnden, P., Weeks, R., Smith, B., Joyce, A., Hall, G., … Southgate, J. (2003). Uroplakin gene expression in normal human tissues and locally advanced bladder cancer. Journal of Pathology, 199(1), 41-49.

Olsburgh, J., Weeks, R., Selby, P., & Southgate, J. (2002). Human uroplakin lb gene structure and promoter analysis. Biochimica et Biophysica Acta: Gene Structure & Expression, 1576, 163-170.

Elder, R. H., Jansen, J. G., Weeks, R., Willington, M. A., Deans, B., Watson, A. J., & ... (1998). Alkylpurine-DNA-N-glycosylase knockout mice show increased susceptibility to induction of mutations by methyl methanesulfonate. Molecular & Cellular Biology, 18(10), 5828-5837.

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