Mr Rob Weeks
Position | Senior Research Fellow |
---|---|
Department | Department of Pathology (Dunedin) |
Qualifications | BSc(Hons)(Liv J Moores) |
Research summary | Cancer genetics |
Research
Rob works with Professor Ian Morison. His interest is the control of mammalian gene expression and cancer.
Publications
Smith, J., Day, R. C., & Weeks, R. J. (2022). Next-generation bisulfite sequencing for targeted DNA methylation analysis. In J. Horsfield & J. Marsman (Eds.), Chromatin: Methods and protocols: Methods in molecular biology (Vol. 2458). (pp. 47-62). New York, NY: Springer. doi: 10.1007/978-1-0716-2140-0_3
Smith, J., Banerjee, R., Weeks, R. J., & Chatterjee, A. (2022). Editing of DNA methylation patterns using CRISPR-based tools. In J. Horsfield & J. Marsman (Eds.), Chromatin: Methods and protocols: Methods in molecular biology (Vol. 2458). (pp. 63-74). New York, NY: Springer. doi: 10.1007/978-1-0716-2140-0_4
Banerjee, R., Smith, J., Eccles, M. R., Weeks, R. J., & Chatterjee, A. (2022). Epigenetic basis and targeting of cancer metastasis. Trends in Cancer, 8(3), 226-241. doi: 10.1016/j.trecan.2021.11.008
Smith, J., Banerjee, R., Waly, R., Urbano, A., Gimenez, G., Day, R., Eccles, M. R., Weeks, R. J., & Chatterjee, A. (2021). Locus-specific DNA methylation editing in melanoma cell lines using a CRISPR-based system. Cancers, 13, 5433. doi: 10.3390/cancers13215433
Ludgate, J. L., Weeks, R. J., & Morison, I. M. (2021). Aberrant immunoglobulin kappa locus rearrangement in a patient with CARD11-related B cell lymphocytosis. Journal of Clinical Immunology. Advance online publication. doi: 10.1007/s10875-021-01114-3
Smith, J., Banerjee, R., Weeks, R. J., & Chatterjee, A. (2022). Editing of DNA methylation patterns using CRISPR-based tools. In J. Horsfield & J. Marsman (Eds.), Chromatin: Methods and protocols: Methods in molecular biology (Vol. 2458). (pp. 63-74). New York, NY: Springer. doi: 10.1007/978-1-0716-2140-0_4
Chapter in Book - Research
Smith, J., Day, R. C., & Weeks, R. J. (2022). Next-generation bisulfite sequencing for targeted DNA methylation analysis. In J. Horsfield & J. Marsman (Eds.), Chromatin: Methods and protocols: Methods in molecular biology (Vol. 2458). (pp. 47-62). New York, NY: Springer. doi: 10.1007/978-1-0716-2140-0_3
Chapter in Book - Research
Almomani, S. N., Alsaleh, A. A., Weeks, R. J., Chatterjee, A., Day, R. C., Honda, I., … Fukuzawa, R., Slatter, T. L., Hung, N. A., Devenish, C., Morison, I. M., & Macaulay, E. C. (2021). Identification and validation of DNA methylation changes in pre-eclampsia. Placenta, 110, 16-23. doi: 10.1016/j.placenta.2021.05.005
Journal - Research Article
Mayyas, I. M., Weeks, R. J., Day, R. C., Magrath, H. E., O’Connor, K. M., Kardailsky, O., Hore, T. A., Hampton, M. B., & Morison, I. M. (2021). Hairpin-bisulfite sequencing of cells exposed to decitabine documents the process of DNA demethylation. Epigenetics, 16(11), 1251-1259. doi: 10.1080/15592294.2020.1861169
Journal - Research Article
Smith, J., Banerjee, R., Waly, R., Urbano, A., Gimenez, G., Day, R., Eccles, M. R., Weeks, R. J., & Chatterjee, A. (2021). Locus-specific DNA methylation editing in melanoma cell lines using a CRISPR-based system. Cancers, 13, 5433. doi: 10.3390/cancers13215433
Journal - Research Article
Weeks, R. J., Ludgate, J. L., Le Mée, G., Khanal, R., Mehta, S., Williams, G., Slatter, T. L., Braithwaite, A. W., & Morison, I. M. (2020). Silencing of Testin expression is a frequent event in spontaneous lymphomas from Trp53-mutant mice. Scientific Reports, 10, 16255. doi: 10.1038/s41598-020-73229-3
Journal - Research Article
Gamage, T. K. J. B., Schierding, W., Hurley, D., Tsai, P., Ludgate, J. L., Bhoothpur, C., … Weeks, R. J., Macaulay, E. C., & James, J. L. (2018). The role of DNA methylation in human trophoblast differentiation. Epigenetics, 13(12), 1154-1173. doi: 10.1080/15592294.2018.1549462
Journal - Research Article
Gamage, T. K. J. B., Schierding, W., Tsai, P., Ludgate, J. L., Chamley, L. W., Weeks, R. J., Macaulay, E. C., & James, J. L. (2018). Human trophoblasts are primarily distinguished from somatic cells by differences in the pattern rather than the degree of global CpG methylation. Biology Open, 7, bio034884. doi: 10.1242/bio.034884
Journal - Research Article
Halliday, B. J., Fukuzawa, R., Markie, D. M., Grundy, R. G., Ludgate, J. L., Black, M. A., … Weeks, R. J., … Morison, I. M. (2018). Germline mutations and somatic inactivation of TRIM28 in Wilms tumour. PLoS Genetics, 14(6), e1007399. doi: 10.1371/journal.pgen.1007399
Journal - Research Article
Sharp, P. A., Clarkson, R., Hussain, A., Weeks, R. J., & Morison, I. M. (2018). DNA methylation of hepatic iron sensing genes and the regulation of hepcidin expression. PLoS ONE, 13(5), e0197863. doi: 10.1371/journal.pone.0197863
Journal - Research Article
Chatterjee, A., Macaulay, E. C., Ahn, A., Ludgate, J. L., Stockwell, P. A., Weeks, R. J., Parry, M. F., Foster, T. J., … Eccles, M. R., & Morison, I. M. (2017). Comparative assessment of DNA methylation patterns between reduced representation bisulfite sequencing and Sequenom EpiTyper methylation analysis. Epigenomics, 9(6), 823-832. doi: 10.2217/epi-2016-0176
Journal - Research Article
Weeks, R. J., Ludgate, J. L., LeMée, G., & Morison, I. M. (2016). TESTIN induces rapid death and suppresses proliferation in childhood B acute lymphoblastic leukaemia cells. PLoS ONE, 11(3), e0151341. doi: 10.1371/journal.pone.0151341
Journal - Research Article
Chatterjee, A., Stockwell, P. A., Rodger, E. J., Duncan, E. J., Parry, M. F., Weeks, R. J., & Morison, I. M. (2015). Genome-wide DNA methylation map of human neutrophils reveals widespread inter-individual epigenetic variation. Scientific Reports, 5, 17328. doi: 10.1038/srep17328
Journal - Research Article
Ludgate, J. L., Le Mée, G., Fukuzawa, R., Rodger, E. J., Weeks, R. J., Reeve, A. E., & Morison, I. M. (2013). Global demethylation in loss of imprinting subtype of Wilms tumor. Genes Chromosomes & Cancer, 52(2), 174-184. doi: 10.1002/gcc.22017
Journal - Research Article
Chatterjee, A., Rodger, E. J., Stockwell, P. A., Weeks, R. J., & Morison, I. M. (2012). Technical considerations for reduced representation bisulfite sequencing with multiplexed libraries. Journal of Biomedicine & Biotechnology, 2012, 741542. doi: 10.1155/2012/741542
Journal - Research Article
Macaulay, E. C., Weeks, R. J., Andrews, S., & Morison, I. M. (2011). Hypomethylation of functional retrotransposon-derived genes in the human placenta. Mammalian Genome, 22, 722-735. doi: 10.1007/s00335-011-9355-1
Journal - Research Article
Weeks, R. J., Kees, U. R., Song, S., & Morison, I. M. (2010). Silencing of TESTIN by dense biallelic promoter methylation is the most common molecular event in childhood acute lymphoblastic leukaemia. Molecular Cancer, 9, 163. doi: 10.1186/1476-4598-9-163
Journal - Research Article
Fukuzawa, R., Anaka, M. R., Weeks, R. J., Morison, I. M., & Reeve, A. E. (2009). Canonical WNT signalling determines lineage specificity in Wilms tumour. Oncogene, 28(8), 1063-1075. doi: 10.1038/onc.2008.455
Journal - Research Article
Zou, D., Yoon, H.-S., Perez, D., Weeks, R. J., Guilford, P., & Humar, B. (2009). Epigenetic silencing in non-neoplastic epithelia identifies E-cadherin (CDH1) as a target for chemoprevention of lobular neoplasia. Journal of Pathology, 218(2), 265-272. doi: 10.1002/path.2541
Journal - Research Article
Morison, I. M., Cramer Bordé, E. M., Cheesman, E. J., Cheong, P. L., Holyoake, A. J., Fichelson, S., Weeks, R. J., Lo, A., Davies, S. M. K., Wilbanks, S. M., Fagerlund, R. D., Ludgate, M. W., da Silva Tatley, F. M., Coker, M. S. A., Bockett, N. A., Hughes, G., Pippig, D. A., Smith, M. P., … Ledgerwood, E. C. (2008). A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia. Nature Genetics, 40(4), 387-389. doi: 10.1038/ng.103
Journal - Research Article
Hall, G. D., Smith, B., Weeks, R. J., Selby, P. J., Southgate, J., & Chester, J. D. (2006). Novel urothelium specific gene expression identified by differential display reverse transcriptase-polymerase chain reaction. Journal of Urology, 175, 337-342.
Journal - Research Article
Weeks, R. J., & Morison, I. M. (2006). Detailed methylation analysis of CpG islands on human chromosome region 9p21. Genes Chromosomes & Cancer, 45(4), 357-364.
Journal - Research Article
Hall, G. D., Weeks, R. J., Olsburgh, J., Southgate, J., Knowles, M. A., Selby, P. J., & Chester, J. D. (2005). Transcriptional control of the human urothelial-specific gene, uroplakin Ia. Biochimica et Biophysica Acta: Gene Structure & Expression, 1729, 126-134.
Journal - Research Article
Olsburgh, J., Harnden, P., Weeks, R., Smith, B., Joyce, A., Hall, G., … Southgate, J. (2003). Uroplakin gene expression in normal human tissues and locally advanced bladder cancer. Journal of Pathology, 199(1), 41-49.
Journal - Research Article
Olsburgh, J., Weeks, R., Selby, P., & Southgate, J. (2002). Human uroplakin lb gene structure and promoter analysis. Biochimica et Biophysica Acta: Gene Structure & Expression, 1576, 163-170.
Journal - Research Article
Elder, R. H., Jansen, J. G., Weeks, R., Willington, M. A., Deans, B., Watson, A. J., & ... (1998). Alkylpurine-DNA-N-glycosylase knockout mice show increased susceptibility to induction of mutations by methyl methanesulfonate. Molecular & Cellular Biology, 18(10), 5828-5837.
Journal - Research Article
Banerjee, R., Smith, J., Eccles, M. R., Weeks, R. J., & Chatterjee, A. (2022). Epigenetic basis and targeting of cancer metastasis. Trends in Cancer, 8(3), 226-241. doi: 10.1016/j.trecan.2021.11.008
Journal - Research Other
Ludgate, J. L., Weeks, R. J., & Morison, I. M. (2021). Aberrant immunoglobulin kappa locus rearrangement in a patient with CARD11-related B cell lymphocytosis. Journal of Clinical Immunology. Advance online publication. doi: 10.1007/s10875-021-01114-3
Journal - Research Other
Smith, J., Sen, S., Weeks, R. J., Eccles, M. R., & Chatterjee, A. (2020). Promoter DNA hypermethylation and paradoxical gene activation. Trends in Cancer, 6(5), 392-406. doi: 10.1016/j.trecan.2020.02.007
Journal - Research Other
Urbano, A., Smith, J., Weeks, R. J., & Chatterjee, A. (2019). Gene-specific targeting of DNA methylation in the mammalian genome. Cancers, 11(10), 1515. doi: 10.3390/cancers11101515
Journal - Research Other