Dr Adriana Saraiva
Contact Details
University Links
- Position
- Teaching Fellow
- Department
- Department of Pathology (Dunedin)
- Qualifications
- PhD in Cell Biology
- Research summary
- Brain tumour subtypes, Glioblastoma and Meningioma
- Teaching
- Histopathology. Current Teaching Fellow at the Pathology Department, giving support to the Medical Laboratory Science Programme (second and third year)
- Clinical
- Inflammation, tumorigenesis, cellular trafficking, metastasis, intracellular signalling, genomics, epigenetics.
Research
Brain tumour is a solid mass of cells characterised by an abnormal and uncontrolled growth pattern. Depending on the cell origin, the tumour is classified as primary (starting in the brain) or secondary / metastatic. The brain metastases corresponds to cancer cells that escaped from its original locus (other part of the body), migrated, installed, infiltrated and now grows in the intracranial area.
One in 4 patients with cancer may develop brain metastases. It has, typically, more aggressive outcomes with poor prognoses, requiring a quick and precise medical decision. The understanding of tumour subtypes is fundamental for an accurate diagnosis and to estimated prognosis and two find the an effective therapeutic approach.
Glioblastoma is an aggressive and devastating brain cancer which median survival is only 15 months. Some tumours in the brain may be largely benign, having slow growth. The most common type is called Meningioma, which make up 30% of central nervous system tumours (incidence 6 per 100,000) and is 2.8 times more frequent in Māori. Twenty percent of patients have atypical lesions (WHO grade II) and have an unpredictable outcome, making them difficult to clinically management. A more accurate means to predict outcome for those with atypical meningiomas exists based on new molecular based technologies. These methods provide a better understanding of how tumours with similar morphology can behave differently to a treatment.
Meningioma and Glioblastoma project: The DNA methylation-base classification for meningioma has distinct ability to subtype brain tumours and better predict longer-term overall survival compared to the current morphology based WHO grade (p= 0.0096). This system has been designed with clinical practice in mind, with a pipeline for data analysis and subtype assignment. This project will adapt the molecular classification system for use in FFPE samples in New Zealand. The project will also determine if the subtypes are also relevant for Māori patients or if modified subtypes are required. This project is in collaboration with Dunedin and Hamilton hospitals.
Publications
Boix De Jesus, A. N., Taha, A., Wang, D., Mehta, P. M., Mehta, S., Reily-Bell, A., Polwatta Lekamlage, S., Machado Saraiva, A., Tahmeedzaman, T., … Royds, J., Braithwaite, A., Hung, N., & Slatter, T. L. (2023). Increased expression of the Δ133p53ß isoform enhances brain metastasis. International Journal of Molecular Sciences, 24, 1267. doi: 10.3390/ijms24021267
Alves e Silva, M. R. M., da Fonseca Pacheco, C. M., Fernandes Moreira Madeira, M., Machado Saraiva, A., Alves de Freitas, E., Marcolan Valverde, T., … Aparecida da Silva, T. (2019). Effect of the extract and constituents from Hancornia speciosa fruits in osteoclasts. Planta Medica International Open, 6, e7-e14. doi: 10.1055/a-0829-0454
Mayra da Silva, J., Moreira dos Santos, T. P., Machado Saraiva, A., Fernandes de Oliveira, A. L., Pompermaier Garlet, G., Carvalho Batista, A., … Aparecida da Silva, T. (2019). Role of atypical chemokine receptor ACKR2 in experimental oral squamous cell carcinogenesis. Cytokine, 118, 160-167. doi: 10.1016/j.cyto.2018.03.001
Dias Corrêa, J., Machado Saraiva, A., Martins Queiroz-Junior, C., Fernandes Moreira Madeira, M., Duarte, P. M., Martins Teixeira, M., … Aparecida da Silva, T. (2016). Arthritis-induced alveolar bone loss is associated with changes in the composition of oral microbiota. Anaerobe, 39, 91-96. doi: 10.1016/j.anaerobe.2016.03.006
Elias Marques, P., Gustavo Oliveira, A., Vaz Pereira, R., Araújo David, B., Ferreira Gomides, L., Machado Saraiva, A., … Batista Menezes, G. (2015). Hepatic DNA deposition drives drug-induced liver injury and inflammation in mice. Hepatology, 61(1), 348-360. doi: 10.1002/hep.27216
Boix De Jesus, A. N., Taha, A., Wang, D., Mehta, P. M., Mehta, S., Reily-Bell, A., Polwatta Lekamlage, S., Machado Saraiva, A., Tahmeedzaman, T., … Royds, J., Braithwaite, A., Hung, N., & Slatter, T. L. (2023). Increased expression of the Δ133p53ß isoform enhances brain metastasis. International Journal of Molecular Sciences, 24, 1267. doi: 10.3390/ijms24021267
Journal - Research Article
Alves e Silva, M. R. M., da Fonseca Pacheco, C. M., Fernandes Moreira Madeira, M., Machado Saraiva, A., Alves de Freitas, E., Marcolan Valverde, T., … Aparecida da Silva, T. (2019). Effect of the extract and constituents from Hancornia speciosa fruits in osteoclasts. Planta Medica International Open, 6, e7-e14. doi: 10.1055/a-0829-0454
Journal - Research Article
Mayra da Silva, J., Moreira dos Santos, T. P., Machado Saraiva, A., Fernandes de Oliveira, A. L., Pompermaier Garlet, G., Carvalho Batista, A., … Aparecida da Silva, T. (2019). Role of atypical chemokine receptor ACKR2 in experimental oral squamous cell carcinogenesis. Cytokine, 118, 160-167. doi: 10.1016/j.cyto.2018.03.001
Journal - Research Article
Dias Corrêa, J., Machado Saraiva, A., Martins Queiroz-Junior, C., Fernandes Moreira Madeira, M., Duarte, P. M., Martins Teixeira, M., … Aparecida da Silva, T. (2016). Arthritis-induced alveolar bone loss is associated with changes in the composition of oral microbiota. Anaerobe, 39, 91-96. doi: 10.1016/j.anaerobe.2016.03.006
Journal - Research Article
Elias Marques, P., Gustavo Oliveira, A., Vaz Pereira, R., Araújo David, B., Ferreira Gomides, L., Machado Saraiva, A., … Batista Menezes, G. (2015). Hepatic DNA deposition drives drug-induced liver injury and inflammation in mice. Hepatology, 61(1), 348-360. doi: 10.1002/hep.27216
Journal - Research Article
de Faria Amormino, S. A., Arão, T. C., Machado Saraiva, A., Santiago Gomez, R., Ornelas Dutra, W., Eustáquio da Costa, J., … Rocha Moreira, P. (2013). Hypermethylation and low transcription of TLR2 gene in chronic periodontitis. Human Immunology, 74(9), 1231-1236. doi: 10.1016/j.humimm.2013.04.037
Journal - Research Article
e Silva, M. R. M. A., Moreira, P. R., da Costa, G. C., Saraiva, A. M., de Souza, P. E. A., Amormino, S. A. F., … Dutra, W. O. (2013). Association of CD28 and CTLA-4 gene polymorphisms with aggressive periodontitis in Brazilians. Oral Diseases, 19, 568-576. doi: 10.1111/odi.12036
Journal - Research Article
Machado Saraiva, A., Alves e Silva, M. R. M., de Fátima Correia Silva, J., Eustáquio da Costa, J., Gollob, K. J., Ornelas Dutra, W., & Rocha Moreira, P. (2013). Evaluation of IL17A expression and of IL17A, IL17F and IL23R gene polymorphisms in Brazilian individuals with periodontitis. Human Immunology, 74(2), 207-214. doi: 10.1016/j.humimm.2012.10.026
Journal - Research Article
Machado Saraiva, A., de Fátima Correia Silva, J., Alves e Silva, M. R. M., Eustáquio da Costa, J., Gollob, K. J., Rocha Moreira, P., & Ornelas Dutra, W. (2013). Transcription factor STAT1 gene polymorphism is associated with the development of severe forms of periodontal disease [Short communication]. Inflammation Research, 62(6), 551-554. doi: 10.1007/s00011-013-0622-3
Journal - Research Other