Associate Professor Mark Thompson-Fawcett
| Position | Associate Professor and Head of Department of Surgical Sciences |
|---|---|
| Department | Department of Surgical Sciences (Dunedin) |
| Qualifications | MB ChB(Auck) MD FRACS |
| Research summary | Ileal pouch microbiota and pouchitis, functional bowel disorders, colorectal cancer, student assessment |
| Teaching |
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| Memberships |
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| Clinical |
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Research
My research is interests are linked to my activity as a colorectal surgeon clinician and clinical teacher.
Ileal pouch research: In collaboration with the Department of Microbiology and Immunology, this has involved detailed analysis of stool from patients with and without pouchitis, and pouches created for FAP. DNA techniques were used to study the microbiota. Currently, we are embarking on a clinical trial to explore the use of a specially developed probiotic to observe its effects on pouch inflammation. In addition to this, we are developing a set of DNA stool analysis tools to identify potentially adverse profiles of bacteria in the stool that may increase pouch inflammation and cause pouchitis.
I lead a Functional Bowel Disorder Clinic with Clinical Nurse Specialists and we have are currently setting up a new programme to build on a previous small RCT looking at treatment of bowel control.
I contribute to the Colorectal Translation Research Group that has a number projects on colorectal cancer and inflammatory bowel disease underway. In addition, we have completed and have a number of ongoing projects into the outcomes of colorectal surgery in Otago.
As a clinical teacher I have an interest in the assessment of undergraduate and postgraduate students in the area of clinical skills using OSCEs, working with the faculty, and recently as a member of the Clinical Examination Committee of the RACS.
Publications
Fischer, J., Dobbs, B., Dixon, L., Eglinton, T. W., Wakeman, C. J., Frizelle, F. A., on behalf of the New Zealand Malignant Polyp Study (NZ MAPS) Group, including Thompson-Fawcett, M. (2017). Management of malignant colorectal polyps in New Zealand. ANZ Journal of Surgery, 87(5), 350-355. doi: 10.1111/ans.13502
Tiong, J., Gray, A., Jackson, C., Thompson-Fawcett, M., & Schultz, M. (2017). Audit of the association between length of time spent on diagnostic work-up and tumour stage in patients with symptomatic colon cancer. ANZ Journal of Surgery, 87(3), 138-142. doi: 10.1111/ans.12804
Teloken, P. E., Spilsbury, K., Platell, C., BCCA Operations Committee, including Thompson-Fawcett, M. (2016). Analysis of mortality in colorectal surgery in the Bi-National Colorectal Cancer Audit. ANZ Journal of Surgery, 86(6), 454-458. doi: 10.1111/ans.13523
Hunter, R. A., Moore, J., BCCA Operations Committee, including Thompson-Fawcett, M. (2016). Evolution of the Bi-National Colorectal Cancer Audit: History, governance and future directions. ANZ Journal of Surgery, 86(6), 431-432. doi: 10.1111/ans.13593
Schultz, M., Lai, C. C., Lindstrom, A. L., Stein, K., Donaldson, G., Thompson-Fawcett, M., & Butt, A. G. (2015). Aggravation of established colitis in specific pathogen-free IL-10 knockout mice by restraint stress is not mediated by increased colonic permeability. Journal of Crohn's & Colitis, 9(9), 754-762. doi: 10.1093/ecco-jcc/jjv098
Chapter in Book - Research
Thompson-Fawcett, M. W. (2003). Pouchitis and pouch dysfunction. In J. Satsangi, L. R. Sutherland, J. F. Colombel, C. Fiocchi, R. Lofberg, J. H. Pemberton & P. Rutgeerts (Eds.), Inflammatory bowel diseases. (pp. 567-584). Edinburgh: Churchill Livingstone.
Thompson-Fawcett, M. W., & Mortensen, N. J. (2001). Crohn's disease. In R. K. S. Phillips (Ed.), Volume IV Colorectal Surgery - A Companion to Specialist Surgical Practice. (2nd Edition). (pp. 207-251). London: W B Saunders Co Ltd.
Thompson-Fawcett, M. W., & McLeod, R. (2000). Recurrent Crohn's disease: Factors influencing and prophylaxis. In J. Corson & R. C. N. Williamson (Eds.), Surgery. London: Mosby International Ltd.
Thompson-Fawcett, M. W., & Mortensen, N. J. (1997). Crohns disease. In Volume IV Colorectal Surgery - a Companion to Specialist Surgical Practice. (pp. 179-216). London: W B Saunders Co Ltd.
Chapter in Book - Other
Thompson-Fawcett, M. W. (2003). Clinical presentation: Faecal incontinence [Contribution to chapter 15: Common complaints]. In V. O'Connor & G. Kovacs (Eds.), Obstetrics, gynaecology, and women's health. (pp. 551-553). Cambridge University Press.
Journal - Research Article
Fischer, J., Dobbs, B., Dixon, L., Eglinton, T. W., Wakeman, C. J., Frizelle, F. A., on behalf of the New Zealand Malignant Polyp Study (NZ MAPS) Group, including Thompson-Fawcett, M. (2017). Management of malignant colorectal polyps in New Zealand. ANZ Journal of Surgery, 87(5), 350-355. doi: 10.1111/ans.13502
Tiong, J., Gray, A., Jackson, C., Thompson-Fawcett, M., & Schultz, M. (2017). Audit of the association between length of time spent on diagnostic work-up and tumour stage in patients with symptomatic colon cancer. ANZ Journal of Surgery, 87(3), 138-142. doi: 10.1111/ans.12804
Teloken, P. E., Spilsbury, K., Platell, C., BCCA Operations Committee, including Thompson-Fawcett, M. (2016). Analysis of mortality in colorectal surgery in the Bi-National Colorectal Cancer Audit. ANZ Journal of Surgery, 86(6), 454-458. doi: 10.1111/ans.13523
Schultz, M., Lai, C. C., Lindstrom, A. L., Stein, K., Donaldson, G., Thompson-Fawcett, M., & Butt, A. G. (2015). Aggravation of established colitis in specific pathogen-free IL-10 knockout mice by restraint stress is not mediated by increased colonic permeability. Journal of Crohn's & Colitis, 9(9), 754-762. doi: 10.1093/ecco-jcc/jjv098
Owens, K. H., Murphy, P. G. M., Medlicott, N. J., Kennedy, J., Zacharias, M., Curran, N., Sreebhavan, S., Thompson-Fawcett, M., & Reith, D. M. (2014). Population pharmacokinetics of intravenous acetaminophen and its metabolites in major surgical patients. Journal of Pharmacokinetics & Pharmacodynamics, 41(3), 211-221. doi: 10.1007/s10928-014-9358-0
Goonerante, D., Gray, C., Lim, M., Dixon, L., Dobbs, B., Wakeman, C., Frizelle, F., for the Colorectal Lung Metastases Research Group (CRLMRG), including Thompson-Fawcett, M., Ho, C., & Dennett, E. (2013). Survival outcome in New Zealand after resection of colorectal cancer lung metastases. ANZ Journal of Surgery, 83(12), 959-962. doi: 10.1111/ans.12012
Tweed, M. J., Thompson-Fawcett, M., & Wilkinson, T. J. (2013). Decision-making bias in assessment: The effect of aggregating objective information and anecdote. Medical Teacher, 35(10), 832-837. doi: 10.3109/0142159x.2013.803062
Tweed, M., Thompson-Fawcett, M., Schwartz, P., & Wilkinson, T. J. (2013). Determining measures of insight and foresight from responses to multiple choice questions. Medical Teacher, 35(2), 127-133. doi: 10.3109/0142159x.2012.733834
Tannock, G. W., Lawley, B., Munro, K., Lay, C., Taylor, C., Daynes, C., … Thompson-Fawcett, M. (2012). Comprehensive analysis of the bacterial content of stool from patients with chronic pouchitis, normal pouches, or familial adenomatous polyposis pouches. Inflammatory Bowel Diseases, 18(5), 925-934. doi: 10.1002/ibd.21936
Richards, C. H., Campbell, V., Ho, C., Hayes, J., Elliot, T., & Thompson-Fawcett, M. (2012). Smoking is a major risk factor for anastomotic leak in patients undergoing low anterior resection. Colorectal Disease, 14(5), 628-633. doi: 10.1111/j.1463-1318.2011.02718.x
Owens, K. H., Medlicott, N. J., Zacharias, M., Chary, S., Thompson-Fawcett, M., & Reith, D. M. (2012). The pharmacokinetic profile of intravenous paracetamol in adult patients undergoing major abdominal surgery. Therapeutic Drug Monitoring, 34(6), 713-721. doi: 10.1097/FTD.0b013e31826a70ea
Yassaie, O., Thompson-Fawcett, M., & Rossaak, J. (2012). Management of sigmoid volvulus: Is early surgery justifiable? ANZ Journal of Surgery, 83(1-2), 74-78. doi: 10.1111/j.1445-2197.2012.06182.x
Pollard, M. F., Thompson-Fawcett, M. W., & Stringer, M. D. (2012). The human ileocaecal junction: Anatomical evidence of a sphincter. Surgical & Radiologic Anatomy, 34(1), 21-29. doi: 10.1007/s00276-011-0865-z
Tweed, M. J., Thompson-Fawcett, M., Schwartz, P., & Wilkinson, T. J. (2012). A confidence and safety approach to multiple-choice question scoring. Focus on Health Professional Education, 13(3), 84-92.
Lord, I., Page, B., Thorn, M., & Thompson-Fawcett, M. (2011). Laparoscopic cholecystectomy through the umbilicus—minimal access surgery gets more minimal. New Zealand Medical Journal, 124(1341). Retrieved from http://journal.nzma.org.nz/journal/124-1341/4841/content.pdf
Michelsen, H. B., Thompson-Fawcett, M., Lundby, L., Krogh, K., Laurberg, S., & Buntzen, S. (2010). Six years of experience with sacral nerve stimulation for fecal incontinence. Diseases of the Colon & Rectum, 53(4), 414-421. doi: 10.1007/DCR.0b013e3181ca7dc2
Jaye, C., Egan, T., Smith-Han, K., & Thompson-Fawcett, M. (2009). Teaching and learning in the hospital ward. New Zealand Medical Journal, 122(1304). Retrieved from http://journal.nzma.org.nz/journal/122-1304/3820/content.pdf
Yan, S.-L., & Thompson-Fawcett, M. (2009). NOTES: New dimension of minimally invasive surgery. ANZ Journal of Surgery, 79(5), 337-343. doi: 10.1111/j.1445-2197.2009.04885.x
Wakeman, C. J., Dobbs, B. R., Frizelle, F. A., Bissett, I. P., Dennett, E. R., Hill, A. G., & Thompson-Fawcett, M. W. (2008). The impact of splenectomy on outcome after resection for colorectal cancer: A multicenter, nested, paired cohort study. Diseases of the Colon & Rectum, 51, 213-217. doi: 10.1007/s10350-007-9139-6
Büchler, M. W., Seiler, C. M., Monson, J. R. T., Flamant, Y., Thompson-Fawcett, M. W., Byrne, M. M., & Mortensen, E. R. (2008). Clinical trial: Alvimopan for the management of post-operative ileus after abdominal surgery: Results of an international randomized, double-blind, multicentre, placebo-controlled clinical study. Alimentary Pharmacology & Therapeutics, 28, 312-325. doi: 10.1111/j.1365-2036.2008.03696.x
Rudland, J., Wilkinson, T., Smith-Han, K., & Thompson-Fawcett, M. (2008). ″You can do it late at night or in the morning. You can do it at home, I did it with my flatmate.″ The educational impact of an OSCE. Medical Teacher, 30, 206-211. doi: 10.1080/01421590701851312
Anjomshoaa, A., Lin, Y.-H., Black, M. A., McCall, J. L., Humar, B., Song, S., Fukuzawa, R., Yoon, H.-S., … van Rij, A., Thompson-Fawcett, M., & Reeve, A. E. (2008). Reduced expression of a gene proliferation signature is associated with enhanced malignancy in colon cancer. British Journal of Cancer, 99, 966-973. doi: 10.1038/sj.bjc.6604560
Richter, K. K., Schmidt, C., Thompson-Fawcett, M., Settmacher, U., & Altendorf-Hofmann, A. (2008). Long-term follow-up in 54 surgically treated patients with gastrointestinal stromal tumours. Langenbeck's Archives of Surgery, 393(6), 949-955. doi: 10.1007/s00423-008-0318-2
Lauti, M., Scott, D., & Thompson-Fawcett, M. W. (2008). Fibre supplementation in addition to loperamide for faecal incontinence in adults: A randomized trial. Colorectal Disease, 10, 553-562. doi: 10.1111/j.1463-1318.2007.01439.x
Thompson-Fawcett, M. W., McC Mortensen, N. J., Jewel, D. P., & Warren, B. F. (2007). Use of a monoclonal antibody to sucrase-isomaltase for evaluation of the columnar cuff after stapled restorative proctocolectomy. Diseases of the Colon & Rectum, 50(9), 1428-1435.
Lin, Y.-H., Friederichs, J., Black, M. A., Mages, J., Rosenberg, R., Guilford, P. J., Phillips, V., Thompson-Fawcett, M., … van Rij, A., Yoon, H.-S., McCall, J. L., … Reeve, A. E. (2007). Multiple gene expression classifiers from different array platforms predict poor prognosis of colorectal cancer. Clinical Cancer Research, 13(2), 498-507. doi: 10.1158/1078-0432.CCR-05-2734
Thompson-Fawcett, M. W. (2003). Pouches and stomas. Medicine, 31(2), 83-87.
Wilkinson, T. J., Frampton, C. M., Thompson-Fawcett, M. W., & Egan, A. G. (2003). Objectivity in objective structured clinical examinations: Checklists are no substitute for examiner commitment. Academic Medicine, 78(2), 219-223.
Connolly, A. C., Frizelle, F. A., Keating, J. P., Lynch, A. C., Parry, B. R., Thompson-Fawcett, M. W., & Robertson, G. M. (2002). Review of developments in colorectal surgery in New Zealand. New Zealand Medical Journal, 115(1155), 262-265.
Thompson-Fawcett, M. W., Redston, M., Marcus, V., Cohen, Z., & McLeod, R. (2001). Risk of dysplasia in long-term ileal pouches and pouches with chronic pouchitis. Gastroenterology, 121, 275-281.
Thompson-Fawcett, M. W., Redston, M., Marcus, V., Cohen, Z., & McLeod, R. (2001). Adenomatous polyps develop commonly in the ileal pouch of patients with familial adenomatous polyposis. Diseases of the Colon & Rectum, 44, 347-353.
Thompson-Fawcett, M. W., Richard, C., O'Connor, B., Cohen, Z., & McLeod, R. (2000). Quality of life is excellent after a pelvic pouch for colitis associated neoplasia. Diseases of the Colon & Rectum, 43(11), 1497-1502.
Thompson-Fawcett, M. W., Warren, B. F., & Mortensen, N. J. (2000). Aneuploidy and columnar cuff surveillance after a stapled ileal pouch anal anastomosis in ulcerative colitis. Diseases of the Colon & Rectum, 43, 408-413.
Bailey, C., Thompson-Fawcett, M. W., Kettlewell, M., Garrard, C., & Mortensen, N. J. (2000). Laparostomy for serious intra abdominal infection complicating colorectal surgery. Diseases of the Colon & Rectum, 43, 25-30.
Thompson-Fawcett, M. W., Warren, B. F., & Mortensen, N. J. (1999). Cuffitis and inflammatory changes in the columnar cuff, anal transitional zone and ileal reservoir after stapled pouch anal anastomosis. Diseases of the Colon & Rectum, 42, 348-355.
Thompson-Fawcett, M. W., Cook, T. C., Bagrie, R. J., & Mortensen, N. J. (1998). What patients think of day-surgery proctology. British Journal of Surgery, 85, 1388.
Thompson-Fawcett, M. W., Warren, B. F., & Mortensen, N. J. (1998). A new look at the anal transitional zone: with reference to the columnar cuff and restorative proctocolectomy. British Journal of Surgery, 85, 1517-1521.
Thompson-Fawcett, M. W., Moon, M., Hands, L., & Collin, J. (1998). The significance of donor leg distal runoff in femoro-femoral bypass grafting. Australian & New Zealand Journal of Surgery, 68, 493-497.
Journal - Research Other
Hunter, R. A., Moore, J., BCCA Operations Committee, including Thompson-Fawcett, M. (2016). Evolution of the Bi-National Colorectal Cancer Audit: History, governance and future directions. ANZ Journal of Surgery, 86(6), 431-432. doi: 10.1111/ans.13593
