|Department||Department of Pathology (Dunedin)|
|Research summary||Investigating mechanisms of invasion in triple negative breast cancer|
Joshua is pursuing a PhD in the Molecular Oncology Group, supervised by Dr Heather Cunliffe. His research is investigating the driving mechanisms behind the invasive and metastatic behaviour of Triple Negative Breast Cancer (TNBC).
TNBC is a highly aggressive subtype of breast cancer diagnosed in 10–25% of patients. As TNBCs do not express clinically significant levels of the estrogen receptor (ER), the progesterone receptor (PgR) and human epidermal growth factor 2 receptor (HER2), treatments that target and disrupt these receptors are not useful for this subtype, leaving no established options for systemic therapy other than chemotherapy. Prognosis will remain poor for patients with TNBC until effective targeted therapies are defined.