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DSM staff profile

Tim Morgan

PositionResearch Technician
DepartmentDepartment of Women's and Children's Health (Dunedin)
QualificationsMSc
Research summaryClinical Genetics Research Laboratory

Research

I am a Research Technician in Professor Stephen Robertson's Clinical Genetics Group studying the genetic interactions and biochemistry of genes and proteins that are implicated in the cause of malformations in children.

Publications

McKeown, C., Connors, S., Stapleton, R., Morgan, T., Hayes, I., Neas, K., … Markie, D. M., … Robertson, S. P. (2018). A pilot study of exome sequencing in a diverse New Zealand cohort with undiagnosed disorders and cancer. Journal of the Royal Society of New Zealand. Advance online publication. doi: 10.1080/03036758.2018.1464033

Jenkins, Z. A., Macharg, A., Chang, C.-Y., van Kogelenberg, M., Morgan, T., Frentz, S., Wei, W., … Markie, D. M., … Robertson, S. P. (2018). Differential regulation of two FLNA transcripts explains some of the phenotypic heterogeneity in the loss-of-function filaminopathies. Human Mutation, 39(1), 103-113. doi: 10.1002/humu.23355

Bernkopf, M., Hunt, D., Koelling, N., Morgan, T., Collins, A. L., Fairhurst, J., Robertson, S. P., … Goriely, A. (2017). Quantification of transmission risk in a male patient with a FLNB mosaic mutation causing Larsen syndrome: Implications for genetic counselling in post-zygotic mosaicism cases. Human Mutation, 38(10), 1360-1364. doi: 10.1002/humu.23281

Wade, E. M., Jenkins, Z. A., Daniel, P. B., Morgan, T., Addor, M. C., Adés, L. C., … Robertson, S. P. (2017). Autosomal dominant frontometaphyseal dysplasia: Delineation of the clinical phenotype. American Journal of Medical Genetics Part A, 173(7), 1739-1749. doi: 10.1002/ajmg.a.38267

Di Gioia, S. A., Connors, S., Matsunami, N., Cannavino, J., Rose, M. F., Gilette, N. M., … Morgan, T., … Markie, D. M., … Robertson, S. P., … Engle, E. C. (2017). A defect in myoblast fusion underlies Carey-Fineman-Ziter syndrome. Nature Communications, 8, 16077. doi: 10.1038/ncomms16077

Journal - Research Article

McKeown, C., Connors, S., Stapleton, R., Morgan, T., Hayes, I., Neas, K., … Markie, D. M., … Robertson, S. P. (2018). A pilot study of exome sequencing in a diverse New Zealand cohort with undiagnosed disorders and cancer. Journal of the Royal Society of New Zealand. Advance online publication. doi: 10.1080/03036758.2018.1464033

Jenkins, Z. A., Macharg, A., Chang, C.-Y., van Kogelenberg, M., Morgan, T., Frentz, S., Wei, W., … Markie, D. M., … Robertson, S. P. (2018). Differential regulation of two FLNA transcripts explains some of the phenotypic heterogeneity in the loss-of-function filaminopathies. Human Mutation, 39(1), 103-113. doi: 10.1002/humu.23355

Bernkopf, M., Hunt, D., Koelling, N., Morgan, T., Collins, A. L., Fairhurst, J., Robertson, S. P., … Goriely, A. (2017). Quantification of transmission risk in a male patient with a FLNB mosaic mutation causing Larsen syndrome: Implications for genetic counselling in post-zygotic mosaicism cases. Human Mutation, 38(10), 1360-1364. doi: 10.1002/humu.23281

Di Gioia, S. A., Connors, S., Matsunami, N., Cannavino, J., Rose, M. F., Gilette, N. M., … Morgan, T., … Markie, D. M., … Robertson, S. P., … Engle, E. C. (2017). A defect in myoblast fusion underlies Carey-Fineman-Ziter syndrome. Nature Communications, 8, 16077. doi: 10.1038/ncomms16077

Wade, E. M., Jenkins, Z. A., Daniel, P. B., Morgan, T., Addor, M. C., Adés, L. C., … Robertson, S. P. (2017). Autosomal dominant frontometaphyseal dysplasia: Delineation of the clinical phenotype. American Journal of Medical Genetics Part A, 173(7), 1739-1749. doi: 10.1002/ajmg.a.38267

Morton, J. E. V., Frentz, S., Morgan, T., Sutherland-Smith, A. J., & Robertson, S. P. (2016). Biallelic mutations in CYP26B1: A differential diagnosis for Pfeiffer and Antley–Bixler syndromes. American Journal of Medical Genetics Part A, 170(10), 2706-2710. doi: 10.1002/ajmg.a.37804

Wade, E. M., Daniel, P. B., Jenkins, Z. A., McInerney-Leo, A., Leo, P., Morgan, T., … Markie, D. M., & Robertson, S. P. (2016). Mutations in MAP3K7 that alter the activity of the TAK1 signaling complex cause frontometaphyseal dysplasia. American Journal of Human Genetics, 99(2), 392-406. doi: 10.1016/j.ajhg.2016.05.024

van Kogelenberg, M., Clark, A. R., Jenkins, Z., Morgan, T., Anandan, A., Sawyer, G. M., … Robertson, S. P. (2015). Diverse phenotypic consequences of mutations affecting the C-terminus of FLNA. Journal of Molecular Medicine, 93(7), 773-782. doi: 10.1007/s00109-015-1261-7

Bunn, K. J., Daniel, P., Rösken, H. S., O'Neill, A. C., Cameron-Christie, S. R., Morgan, T., … Markie, D. M., & Robertson, S. P. (2015). Mutations in DVL1 cause an osteosclerotic form of Robinow syndrome. American Journal of Human Genetics, 96(4), 623-630. doi: 10.1016/j.ajhg.2015.02.010

Gray, M. J., van Kogelenberg, M., Beddow, R., Morgan, T., Wordsworth, P., Shears, D. J., Robertson, S. P., & Hurst, J. A. (2014). A new acro-osteolysis syndrome caused by duplications including PTHLH. Journal of Human Genetics, 59, 484-487. doi: 10.1038/jhg.2014.58

Reinstein, E., Frentz, S., Morgan, T., García-Miñaúr, S., Leventer, R. J., McGillivray, G., … Robertson, S. P. (2013). Vascular and connective tissue anomalies associated with X-linked periventricular heterotopia due to mutations in Filamin A. European Journal of Human Genetics, 21(5), 494-502. doi: 10.1038/ejhg.2012.209

Cappello, S., Gray, M. J., Badouel, C., Lange, S., Einsiedler, M., Srour, M., … Jenkins, Z. A., Morgan, T., Preitner, N., … Black, M. A., Markie, D., … Robertson, S. P. (2013). Mutations in genes encoding the cadherin receptor-ligand pair DCHS1 and FAT4 disrupt cerebral cortical development. Nature Genetics, 45(11), 1300-1308. doi: 10.1038/ng.2765

Holman, S. K., Morgan, T., Baujat, G., Cormier-Daire, V., Cho, T.-J., Lees, M., … Robertson, S. P. (2013). Osteopathia striata congenita with cranial sclerosis and intellectual disability due to contiguous gene deletions involving the WTX locus. Clinical Genetics, 83(3), 251-256. doi: 10.1111/j.1399-0004.2012.01905.x

Daniel, P. B., Morgan, T., Alanay, Y., Bijlsma, E., Cho, T.-J., Cole, T., … Robertson, S. P. (2012). Disease-associated mutations in the actin-binding domain of filamin B cause cytoplasmic focal accumulations correlating with disease severity. Human Mutation, 33(4), 665-673. doi: 10.1002/humu.22012

Tsutsumi, S., Maekawa, A., Obata, M., Morgan, T., Robertson, S. P., & Kurachi, H. (2012). A case of boomerang dysplasia with a novel causative mutation in filamin B: Identification of typical imaging: Findings on ultrasonography and 3D-CT imaging. Fetal Diagnosis & Therapy, 32, 216-220. doi: 10.1159/000335687

Holman, S. K., Daniel, P., Jenkins, Z. A., Herron, R. L., Morgan, T., Savarirayan, R., … Robertson, S. P. (2011). The male phenotype in osteopathia striata congenita with cranial sclerosis. American Journal of Medical Genetics Part A, 155(10), 2397-2408. doi: 10.1002/ajmg.a.34178

Skidmore, D. L., Chitayat, D., Morgan, T., Hinek, A., Fischer, B., Dimopoulou, A., … Robertson, S. P. (2011). Further expansion of the phenotypic spectrum associated with mutations in ALDH18A1, encoding Δ1-pyrroline-5-carboxylate synthase (P5CS). American Journal of Medical Genetics Part A, 155(8), 1848-1856. doi: 10.1002/ajmg.a.34057

Laue, K., Pogoda, H.-M., Daniel, P. B., van Haeringen, A., Alanay, Y., von Ameln, S., … Morgan, T., Gray, M. J., … Robertson, S. P. (2011). Craniosynostosis and multiple skeletal anomalies in humans and zebrafish result from a defect in the localized degradation of retinoic acid. American Journal of Human Genetics, 89(5), 595-606. doi: 10.1016/j.ajhg.2011.09.015

Kapur, R. P., Robertson, S. P., Hannibal, M. C., Finn, L. S., Morgan, T., van Kogelenberg, M., & Loren, D. J. (2010). Diffuse abnormal layering of small intestinal smooth muscle is present in patients with FLNA mutations and X-linked intestinal pseudo-obstruction. American Journal of Surgical Pathology, 34(10), 1528-1543. doi: 10.1097/PAS.0b013e3181f0ae47

Jenkins, Z. A., van Kogelenberg, M., Morgan, T., Jeffs, A., Fukuzawa, R., Pearl, E., … Robertson, S. P. (2009). Germline mutations in WTX cause a sclerosing skeletal dysplasia but do not predispose to tumorigenesis. Nature Genetics, 41(1), 95-100. doi: 10.1038/ng.270

van Roij, M. H. H., Mizumoto, S., Yamada, S., Morgan, T., Tan-Sindhunata, M. B., Meijers-Heijboer, H., … Markie, D., … Robertson, S. P. (2008). Spondyloepiphyseal dysplasia, Omani type: Further definition of the phenotype. American Journal of Medical Genetics Part A, 146A(18), 2376-2384. doi: 10.1002/ajmg.a.32482

Robertson, S. P., Thompson, S., Morgan, T., Holder-Espinasse, M., Martinot-Duquenoy, V., Wilkie, A. O. M., & Manouvrier-Hanu, S. (2006). Postzygotic mutation and germline mosaicism in the otopalatodigital syndrome spectrum disorders. European Journal of Human Genetics, 14, 549-554.

Robertson, S. P., Jenkins, Z. A., Morgan, T., Adès, L., Aftimos, S., Boute, O., … Krakow, D. (2006). Frontometaphyseal Dysplasia: Mutations in FLNA and phenotypic diversity. American Journal of Medical Genetics Part A, 140A, 1726-1736. doi: 10.1002/ajmg.a.31322

Bicknell, L. S., Morgan, T., Bonafé, L., Wessels, M. W., Bialer, M. G., Willems, P. J., … Robertson, S. P. (2005). Mutations in FLNB cause boomerang dysplasia. Journal of Medical Genetics, 42(7), e43. doi: 10.1136/jmg.2004.029967

Sheen, V. L., Jansen, A., Chen, M. H., Parrini, E., Morgan, T., . . ., Robertson, S., & et al (2005). Filamin A mutations cause periventricular heterotopia with Ehlers-Danlos syndrome. Neurology, 64, 254-262.

Krakow, D., Robertson, S. P., King, L. M., Morgan, T., & et al (2004). Mutations in the gene encoding filamin B disrupt vertebral segmentation, joint formation and skeletogenesis. Nature Genetics, 36(4), 405-410.

Morgan, T. R., Shand, J. A., Clarke, S. M., & Eaton-Rye, J. J. (1998). Specific requirements for cytochrome c-550 and the manganese-stabilizing protein in photoautotrophic strains of Synechocystis sp. PCC 6803 with mutations in the domain Gly-351 to Thr-436 of the chlorophyll-binding protein CP47. Biochemistry, 37(41), 14437-14449.

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Journal - Research Other

Bertola, D., Passos-Bueno, M. R., Pereira, A., Kim, C., Morgan, T., & Robertson, S. P. (2015). Recurrence of frontometaphyseal dysplasia in two sisters with a mutation in FLNA and an atypical paternal phenotype: Insights into genotype—phenotype correlation. American Journal of Medical Genetics Part A, 167(5), 1161-1164. doi: 10.1002/ajmg.a.36981

de Athayde Costa, L. S., Pegler, S. P., Lellis, R. F., Krebs, V. L. J., Robertson, S., Morgan, T., … Kim, C. A. (2015). Menkes disease: Importance of diagnosis with molecular analysis in the neonatal period. Revista da Associaçāo Médica Brasileira, 61(5), 407-410. doi: 10.1590/1806-9282.61.05.407

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