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Dr Jaydee Cabral

Senior Lecturer

PhD (ODU/EVMS), BS/MA (College of William & Mary)

dr jaydee cabral image 2019

Contact

Tel +64 3 479 3048 Ext 3048
Email jaydee.cabral@otago.ac.nz
Location Room 1.20, Mellor Building

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About

In her role as Senior Lecturer, Jaydee is responsible for contributing to Applied Science and Bioengineering papers.  As an experienced chemist and biomedical engineer she played a key role in the development and commercialization of a post-surgical, FDA approved medical hydrogel, Chitogel™. Dr. Cabral’s research expertise includes the synthesis, physicochemical characterization, and in vitro/in vivo biocompatibility of medical hydrogels and biomaterials; as well as 3D bioprinting, tissue engineering, and regenerative medicine. She is the principal investigator on an HRC Explorer grant and a Lottery Health Research grant to 3D biofabricate regenerate, vascularized living dressings for the treatment of chronic wounds. She has received funding from a variety of external and internal funding agencies for the purchase of the only GeSiM 3.1 3D Bioscaffolder in New Zealand. She has published in high impact factor multidisciplinary journals and been invited to speak at both national and international conferences. She collaborates with national and international researchers, clinicians, and industry partners.

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Teaching

Contributor to:

  • APPS201 Applied Science: Properties & Applications
  • BIOE 401 Research Methods
  • BIOE 402 Regenerative Medicine & Stem Cells
  • BIOE 403 Bioengineering Design
  • BIOE 404 Medical Device & Technology
  • BIOE 480/495 Master’s Thesis Preparation

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Research

Research Interests

  •  Hydrogels
  • Biomaterials
  • Wound healing
  • Regenerative medicine
  • Tissue Engineering
  • Vascularization

Research Projects

Dr Jaydee Cabral is the Principal Investigator of an HRC Explorer funded project entitled, “Developing the holy grail of bioprinting: vascularization”. The goal of this project was to 3D bioprint regenerative, vascularized tissue engineered constructs for the treatment of chronic wounds. We are currently investigating the protection of commercially valuable Intellectual Property in relation to this project. She is also the Principal Investigator of a Lottery Health Research funded project entitled,” The right tissue for the right patient at the right time: in vitro proof of concept”. The aim is to construct a 3D bioprinted, biodegradable, biocompatible living dressing that will promote the healing diabetic foot ulcers. These projects are in collaboration with Departments of Microbiology & Immunology, Chemistry, Pathology, and Surgical Sciences here at Otago.

Other projects include a MedTech CoRE BRNZ funded project to develop drug delivery methods to the inner ear for the treatment of hearing loss. This is in collaboration with researchers from the Department of Physiology, University of Auckland, and Callaghan Innovation.

Postgraduate Supervision

Current students

Mina Rajabi (PhD) 3D printing of chitosan-based scaffolds for bone tissue engineering.

Jamie Kok Me-Lein (PhD) In vitro study on chitosan nanoparticles as carrier of seaweed extracts against atopic dermatitis.

Caitlin Berry-Kilgour (MSc) Assessment of a bioactive gel in mouse models of skin wounds.

Minami Yoshida (MSc) Invertebral disc tissue engineering: An investigation of scaffolds with 3D printing and melt-electrowriting.

Previous students

Eve Hewitt (MSc Bioengineering) Development of 3D bioprinted scaffolds for soft tissue regeneration.

Claudio Intini (MSc) Biocompatibility of 3D printed chitosan scaffolds.

Maggie Chan (MSc Microbiology & Immunology) The importance of free aldehyde groups in the efficacy of a chitosan/dextran-based surgical hydrogel.

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Publications

Aziz, M. A., Cabral, J. D., Brooks, H. J. L., Moratti, S. C., & Hanton, L. R. (2012). Antimicrobial properties of a chitosan dextran-based hydrogel for surgical use. Antimicrobial Agents & Chemotherapy, 56(1), 280-287. doi: 10.1128/aac.05463-11

Ghosh, S., Cabral, J. D., Hanton, L. R., & Moratti, S. C. (2016). Strong poly(ethylene oxide) based gel adhesives via oxime cross-linking. Acta Biomaterialia, 29, 206-214. doi: 10.1016/j.actbio.2015.10.018

Cabral, J. D., Roxburgh, M., Shi, Z., Liu, L., McConnell, M., Williams, G., … Hanton, L. R., Simpson, J., Moratti, S. C., Robinson, B. H., … Robinson, S. (2014). Synthesis, physiochemical characterization, and biocompatibility of a chitosan/dextran-based hydrogel for postsurgical adhesion prevention. Journal of Materials Science: Materials in Medicine, 25(12), 2743-2756. doi: 10.1007/s10856-014-5292-3

Aziz, M. A., Cabral, J. D., Brooks, H. J. L., McConnell, M. A., Fitzpatrick, C., Hanton, L. R., & Moratti, S. C. (2015). In vitro biocompatibility and cellular interactions of a chitosan/dextran-based hydrogel for postsurgical adhesion prevention. Journal of Biomedical Materials Research Part B, 103(2), 332-341. doi: 10.1002/jbm.b.33206

Cabral, J. D., McConnell, M. A., Fitzpatrick, C., Mros, S., Williams, G., Wormald, P. J., Moratti, S. C., & Hanton, L. R. (2015). Characterization of the in vivo host response to a bi-labeled chitosan-dextran based hydrogel for postsurgical adhesion prevention. Journal of Biomedical Materials Research Part A, 103(8), 2611-2620. doi: 10.1002/jbm.a.35395

Journal - Research Article

Ghosh, S., Cabral, J. D., Hanton, L. R., & Moratti, S. C. (2016). Strong poly(ethylene oxide) based gel adhesives via oxime cross-linking. Acta Biomaterialia, 29, 206-214. doi: 10.1016/j.actbio.2015.10.018

Cabral, J. D., McConnell, M. A., Fitzpatrick, C., Mros, S., Williams, G., Wormald, P. J., Moratti, S. C., & Hanton, L. R. (2015). Characterization of the in vivo host response to a bi-labeled chitosan-dextran based hydrogel for postsurgical adhesion prevention. Journal of Biomedical Materials Research Part A, 103(8), 2611-2620. doi: 10.1002/jbm.a.35395

Aziz, M. A., Cabral, J. D., Brooks, H. J. L., McConnell, M. A., Fitzpatrick, C., Hanton, L. R., & Moratti, S. C. (2015). In vitro biocompatibility and cellular interactions of a chitosan/dextran-based hydrogel for postsurgical adhesion prevention. Journal of Biomedical Materials Research Part B, 103(2), 332-341. doi: 10.1002/jbm.b.33206

Cabral, J. D., Roxburgh, M., Shi, Z., Liu, L., McConnell, M., Williams, G., … Hanton, L. R., Simpson, J., Moratti, S. C., Robinson, B. H., … Robinson, S. (2014). Synthesis, physiochemical characterization, and biocompatibility of a chitosan/dextran-based hydrogel for postsurgical adhesion prevention. Journal of Materials Science: Materials in Medicine, 25(12), 2743-2756. doi: 10.1007/s10856-014-5292-3

Aziz, M. A., Cabral, J. D., Brooks, H. J. L., Moratti, S. C., & Hanton, L. R. (2012). Antimicrobial properties of a chitosan dextran-based hydrogel for surgical use. Antimicrobial Agents & Chemotherapy, 56(1), 280-287. doi: 10.1128/aac.05463-11

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