Free radicals and antioxidants
A strength of the Centre is its research on the biological chemistry of free radicals and antioxidants.
This fundamental research provides a solid platform for our other research projects.
- Free radical toxicity and the biological reactions of superoxide
- Thiols as antioxidants and regulators of cell signalling pathways
- Biochemistry and cell biology of peroxiredoxins
- Physiological and pathological actions of mammalian peroxidases
- Redox regulation of mitochondrial function and cell death
- Effects of hypochlorous acid on protein structure and cell function
- Radical-radical reactions of superoxide: a potential route to toxicity
- Thiol chemistry and specificity in redox signalling
- Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling
- Peroxiredoxin 2 and peroxide metabolism in the erythrocyte
We have a well-established program investigating the roles of free radicals and white blood cells in infection and inflammation.
We apply fundamental scientific knowledge to develop diagnostic and treatment options for inflammatory diseases.
Inflammatory diseases include heart disease, arthritis, neurodegenerative disease, cystic fibrosis, inflammatory bowel disease, gout and infectious disease.
Active areas of research
- Mechanisms of bacterial killing by neutrophils
- Regulation of cell death/apoptosis in inflammatory cells
- The biological chemistry of chlorine bleach
- The enzymology of mammalian peroxidases
- Enzyme inhibitors and redox-active drugs
- Novel biomarkers for measuring the level of oxidative stress in inflammatory pathologies that can be adopted into routine clinical use
- Assessing the efficacy of antioxidants, food extracts, and redox active pharmaceuticals as anti-inflammatory compounds
- Ascorbate-dependent vasopressor synthesis: a rationale for vitamin C administration in severe sepsis and septic shock?
- Redox reactions and microbial killing in the neutrophil phagosome
- Inside the neutrophil phagosome: oxidants, myeloperoxidase, and bacterial killing
- Myeloperoxidase: a front-line defender against phagocytosed microorganisms
- Biomarkers of myeloperoxidase-derived hypochlorous acid
- The role of oxidants and vitamin C on neutrophil apoptosis and clearance
We carry out research into the roles of free radicals in the development of cancer.
We investigate how the antioxidant systems of cancer cells might be manipulated to increase their susceptibility to treatment.
- White blood cells in the promotion and progression of cancer
- Vitamin C in preventing and treating cancer
- Oxidative stress during the death of cancer cells
- Anti-cancer properties of compounds that target the antioxidant systems of cancer cells
- Biomarkers to measure the effectiveness of anti-cancer compounds
- Regulation of the 2-oxoglutarate-dependent dioxygenases and implications for cancer
- Biological targets of isothiocyanates
Nutrients and optimal health
We are investigating the roles that specific micronutrients and phytochemicals play in the promotion and maintenance of optimal health.
We are particularly interested in studying vitamin C, carotenoids, flavonoids and isothiocyanates.
We carry out in vitro (cell culture) and in vivo (human) intervention studies to investigate the mechanisms and effects of these micronutrients and phytochemicals in promoting human health.
- Bioavailability and optimal intakes of vitamin C derived from supplements and food-sources
- Bioavailability and formulation of vegetable isothiocyanates for optimal uptake
- Role of vitamin C and isothiocyanates in white blood cell function and immunity
- Role of vitamin C and phytochemicals in cardiovascular and metabolic health
- Role of micronutrients in psychological wellbeing