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Paul Pace

Senior Research Fellow

BSc(Hons) (London, UK), PhD (Cambridge, UK)

Email paul.pace@otago.ac.nz
Tel +64 3 364 0898

Research interests

Dr Paul Pace previously worked at Imperial College of Science and Technology in London, before moving to the Laboratory of Molecular Biology in Cambridge, where he obtained his PhD studying DNA repair mechanisms.

His expertise is in molecular biology (cloning, mutagenesis, CRISPR applications), protein biochemistry (protein expression and purification, antibody generation and purification, immunocytochemistry, immunoprecipitation, analytical methods) and cell biology (cell culture, transfection, lentiviral expression). He teaches part of the BBiomedSc(Hons) programme, has supervised two summer students, and currently co-supervises two PhD students.

His current projects include studying the biochemistry of peroxiredoxins, including their roles in cell signalling, including the redox regulation of phosphorylation-dependent cell migration and transformation in cancer.

Publications

Shearer, H., Currie, M., Agnew, H., Trappetti, C., Stull, F., Pace, P., … Hampton, M., … Dickerhof, N. (2023). Sensitising Streptococcus pneumoniae to the immune-derived oxidant hypothiocyanous acid. Free Radical Biology & Medicine, 208(Suppl. 1), 96. doi: 10.1016/j.freeradbiomed.2023.10.110

Meotti, F., de Souza, L. F., Dempsey, B., Silva, R., Pinz, M., Cruz, L., Pace, P., Hampton, M., & Winterbourn, C. (2023). Peroxiredoxin 2 interacts with granule stress proteins in proliferative leukemic myeloid cells. Free Radical Biology & Medicine, 208(Suppl. 1), 38. doi: 10.1016/j.freeradbiomed.2023.10.053

Shearer, H. L., Pace, P. E., Smith, L. M., Fineran, P. C., Matthews, A. J., Camilli, A., Dickerhof, N., & Hampton, M. B. (2023). Identification of Streptococcus pneumoniae genes associated with hypothiocyanous acid tolerance through genome-wide screening. Journal of Bacteriology. Advance online publication. doi: 10.1128/jb.00208-23

Winterbourn, C. C., Peskin, A., Kleffmann, T., Radi, R., & Pace, P. E. (2023). Carbon dioxide/bicarbonate is required for sensitive inactivation of mammalian glyceraldehyde-3-phosphate dehydrogenase by hydrogen peroxide. PNAS, 120(18), e2221047120. doi: 10.1073/pnas.2221047120

Pace, P., & Winterbourn, C. C. (2023). A cautionary note on using phosphatase inhibitors with hydrogen peroxide. Antioxidants & Redox Signaling, 38(4-6), 316-317. doi: 10.1089/ars.2022.0092

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