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Contact Details

Phone
64 3 479 9258
Email
anita.dunbier@otago.ac.nz
Position
Associate Professor
Department
Department of Biochemistry
Qualifications
BSc(Hons) PhD
Research summary
Molecular oncology

Research

Research in our laboratory focuses on molecular aspects of cancer with particular emphasis on understanding the genotypic and phenotypic determinants of resistance to endocrine therapy in breast cancer.

Current projects

Investigation of genes involved in breast cancer susceptibility and response to therapy

Breast cancer is the most common malignancy in women, accounting for more than 400,000 deaths per year worldwide. Over three quarters of women diagnosed with breast cancer receive anti-oestrogen therapy. We aim to investigate the role of three newly identified genes in breast cancer. We have found that these genes are turned on in breast cancer at the same time as the oestrogen receptor. They also appear to be involved in the way breast cancers respond to treatment and may contribute to genetic susceptibility to breast cancer. We aim to determine why these genes are turned on together and how they then influence the rate at which cancer cells grow. We will also investigate how these genes influence a woman's risk of breast cancer and the way in which she will respond to treatment. Understanding the role of these genes will help to ensure patients receive the most appropriate treatment and to develop more effective therapies.

How do immune cells help breast cancers to evade therapy?

The majority of breast cancers require the hormone oestrogen to grow. Drugs that act by preventing the production of oestrogen are the most effective treatment currently available for this type of cancer. However, these drugs do not work well for all patients. Our previous research suggests that attracting immune cells to the cancer site may cause the cancer to keep growing during therapy. This project aims to identify which immune cells are recruited to breast cancer cells during treatment and how the cancer cells signal to recruit them to the tumour. This research will help us to identify how breast cancers can evade therapy and to identify potential new drugs which could be used in combination with hormonal therapy to improve breast cancer treatments in the future.

Positions available

Enquires about projects from prospective graduate students and postdoctoral fellows are welcome.

Suitably qualified students, from all countries, are eligible to apply for a University of Otago PhD scholarship (continually assessed) which covers tuition fees and provides a generous emolument for living expenses. If you are interested in this possibility please also make contact with me early on.

Awards

  • Anita Dunbier
    2014, University of Otago Early Career Award for Distinction in Research
  • Anita Dunbier
    2013, OSMS Emerging Researcher Award
    For outstanding research achievement where the awardee has held a PhD for between five and ten years and an appointment at Otago for at least two years.

Publications

McGuinness, C. F., Black, M. A., & Dunbier, A. K. (2023). Restriction site associated DNA sequencing for tumour mutation burden estimation and mutation signature analysis. Cancer Medicine. Advance online publication. doi: 10.1002/cam4.6711

Hazlett, J., Niemi, V., Aiderus, A., Powell, K., Wise, L., Kemp, R., & Dunbier, A. K. (2021). Oestrogen deprivation induces chemokine production and immune cell recruitment in in vitro and in vivo models of oestrogen receptor-positive breast cancer. Breast Cancer Research, 23, 95. doi: 10.1186/s13058-021-01472-1

Wiggins, G. A. R., Black, M. A., Dunbier, A., Morley-Bunker, A. E., kConFab Investigators, Pearson, J. F., & Walker, L. C. (2021). Increased gene expression variability in BRCA1-associated and basal-like breast tumours. Breast Cancer Research & Treatment, 189, 363-375. doi: 10.1007/s10549-021-06328-y

McMillan, H. D., Keeshan, K., Dunbier, A. K., & Mace, P. D. (2021). Structure vs. function of TRIB1: Myeloid neoplasms and beyond. Cancer, 13, 3060. doi: 10.3390/cancers13123060

Wiggins, G. A. R., Black, M. A., Dunbier, A., Merriman, T. R., Pearson, J. F., & Walker, L. C. (2021). Variable expression quantitative trait loci analysis of breast cancer risk variants. Scientific Reports, 11(1), 7192. doi: 10.1038/s41598-021-86690-5

Dunbier, A. K., & Guilford, P. J. (2002). Gastric cancer: Inherited predisposition. In J. R. Bertino (Ed.), Encyclopedia of cancer. (2nd ed.) (pp. 253-258). Academic Press. [Encyclopaedia/Dictionary Entry].

Chapter in Book - Research

Dunbier, A. K., & Guilford, P. J. (2002). Gastric cancer: Inherited predisposition. In S. R. Hamilton & L. A. Aaltonen (Eds.), Encyclopedia of Cancer, Volume 2. (2nd ed.) (pp. 253-258). USA: Elsevier Science.

Chapter in Book - Research

McGuinness, C. F., Black, M. A., & Dunbier, A. K. (2023). Restriction site associated DNA sequencing for tumour mutation burden estimation and mutation signature analysis. Cancer Medicine. Advance online publication. doi: 10.1002/cam4.6711

Journal - Research Article

Hazlett, J., Niemi, V., Aiderus, A., Powell, K., Wise, L., Kemp, R., & Dunbier, A. K. (2021). Oestrogen deprivation induces chemokine production and immune cell recruitment in in vitro and in vivo models of oestrogen receptor-positive breast cancer. Breast Cancer Research, 23, 95. doi: 10.1186/s13058-021-01472-1

Journal - Research Article

Wiggins, G. A. R., Black, M. A., Dunbier, A., Merriman, T. R., Pearson, J. F., & Walker, L. C. (2021). Variable expression quantitative trait loci analysis of breast cancer risk variants. Scientific Reports, 11(1), 7192. doi: 10.1038/s41598-021-86690-5

Journal - Research Article

Wiggins, G. A. R., Black, M. A., Dunbier, A., Morley-Bunker, A. E., kConFab Investigators, Pearson, J. F., & Walker, L. C. (2021). Increased gene expression variability in BRCA1-associated and basal-like breast tumours. Breast Cancer Research & Treatment, 189, 363-375. doi: 10.1007/s10549-021-06328-y

Journal - Research Article

Aiderus, A., Black, M. A., & Dunbier, A. K. (2018). Fatty acid oxidation is associated with proliferation and prognosis in breast and other cancers. BMC Cancer, 18, 805. doi: 10.1186/s12885-018-4626-9

Journal - Research Article

Jamieson, S. A., Ruan, Z., Burgess, A. E., Curry, J. R., McMillan, H. D., Brewster, J. L., Dunbier, A. K., … Mace, P. D. (2018). Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1. Science Signaling, 11(549), eaau0597. doi: 10.1126/scisignal.aau0597

Journal - Research Article

Prat, A., Lluch, A., Turnbull, A. K., Dunbier, A. K., Calvo, L., Albanell, J., … Alba, E. (2017). A PAM50-based chemoendocrine score for hormone receptor-positive breast cancer with an intermediate risk of relapse. Clinical Cancer Research, 23(12). doi: 10.1158/1078-0432.ccr-16-2092

Journal - Research Article

López-Knowles, E., Wilkerson, P. M., Ribas, R., Anderson, H., Mackay, A., Ghazoui, Z., … Dunbier, A. K., … Dowsett, M. (2015). Integrative analyses identify modulators of response to neoadjuvant aromatase inhibitors in patients with early breast cancer. Breast Cancer Research, 17, 35. doi: 10.1186/s13058-015-0532-0

Journal - Research Article

Turnbull, A. K., Arthur, L. M., Renshaw, L., Larionov, A. A., Kay, C., Dunbier, A. K., … Dixon, J. M. (2015). Accurate prediction and validation of response to endocrine therapy in breast cancer. Journal of Clinical Oncology, 33(20), 2270-2278. doi: 10.1200/jco.2014.57.8963

Journal - Research Article

Gao, Q., Patani, N., Dunbier, A. K., Ghazoui, Z., Zvelebil, M., Martin, L.-A., & Dowsett, M. (2014). Effect of aromatase inhibition on functional gene modules in estrogen receptor–positive breast cancer and their relationship with antiproliferative response. Clinical Cancer Research, 20(9), 2485-2494. doi: 10.1158/1078-0432.CCR-13-2602

Journal - Research Article

Patani, N., Dunbier, A. K., Anderson, H., Ghazoui, Z., Ribas, R., Anderson, E., … Dowsett, M. (2014). Differences in the transcriptional response to fulvestrant and estrogen deprivation in ER-positive breast cancer. Clinical Cancer Research, 20(15), 3962-3973. doi: 10.1158/1078-0432.ccr-13-1378

Journal - Research Article

Ribas, R., Ghazoui, Z., Gao, Q., Pancholi, S., Rani, A., Dunbier, A., … Martin, L.-A. (2014). Identification of chemokine receptors as potential modulators of endocrine resistance in oestrogen receptor–positive breast cancers. Breast Cancer Research, 16, 447. doi: 10.1186/s13058-014-0447-1

Journal - Research Article

Dowsett, M., Sestak, I., Lopez-Knowles, E., Sidhu, K., Dunbier, A. K., Cowens, J. W., … Cuzick, J. (2013). Comparison of PAM50 risk of recurrence score with Oncotype DX and IHC4 for predicting risk of distant recurrence after endocrine therapy. Journal of Clinical Oncology, 31(22), 2783-2790. doi: 10.1200/jco.2012.46.1558

Journal - Research Article

Dunbier, A. K., Ghazoui, Z., Anderson, H., Salter, J., Nerurkar, A., Osin, P., … Dowsett, M. (2013). Molecular profiling of aromatase inhibitor-treated post-menopausal breast tumors identifies immune-related correlates of resistance. Clinical Cancer Research, 19(10), 2775-2786. doi: 10.1158/1078-0432.ccr-12-1000

Journal - Research Article

Sgroi, D. C., Sestak, I., Cuzick, J., Zhang, Y., Schnabel, C. A., Schroeder, B., … Dunbier, A., … Dowsett, M. (2013). Prediction of late distant recurrence in patients with oestrogen-receptor-positive breast cancer: A prospective comparison of the breast-cancer index (BCI) assay, 21-gene recurrence score, and IHC4 in the TransATAC study population. Lancet Oncology, 14, 1067-1076. doi: 10.1016/S1470-2045(13)70387-5

Journal - Research Article

Weigel, M. T., Ghazoui, Z., Dunbier, A. K., Pancholi, S., Dowsett, M., & Martin, L.-A. (2012). Preclinical and clinical studies of estrogen deprivation support the PDGF/Abl pathway as a novel therapeutic target for overcoming endocrine resistance in breast cancer. Breast Cancer Research, 14(3), R78. doi: 10.1186/bcr3191

Journal - Research Article

Dowsett, M., Smith, I., Robertson, J., Robison, L., Pinhel, I., Johnson, L., … Dunbier, A., … Bliss, J. (2011). Endocrine therapy, new biologicals, and new study designs for presurgical studies in breast cancer. Journal of the National Cancer Institute Monographs, 43, 120-123. doi: 10.1093/jncimonographs/lgr034

Journal - Research Article

Dunbier, A. K., Anderson, H., Ghazoui, Z., Lopez-Knowles, E., Pancholi, S., Ribas, R., … Dowsett, M. (2011). ESR1 is co-expressed with closely adjacent uncharacterised genes spanning a breast cancer susceptibility locus at 6q25.1. PLoS Genetics, 7(4), e1001382. doi: 10.1371/journal.pgen.1001382

Journal - Research Article

Dunbier, A. K., Anderson, H., Ghazoui, Z., Salter, J., Parker, J. S., Perou, C. M., … Dowsett, M. (2011). Association between breast cancer subtypes and response to neoadjuvant anastrozole. Steroids, 76(8), 736-740. doi: 10.1016/j.steroids.2011.02.025

Journal - Research Article

Dunbier, A. K., Martin, L.-A., & Dowsett, M. (2011). New and translational perspectives of oestrogen deprivation in breast cancer. Molecular & Cellular Endocrinology, 340(2), 137-141. doi: 10.1016/j.mce.2010.12.034

Journal - Research Article

Ghazoui, Z., Buffa, F. M., Dunbier, A. K., Anderson, H., Dexter, T., Detre, S., … Dowsett, M. (2011). Close and stable relationship between proliferation and a hypoxia metagene in aromatase inhibitor-treated ER-positive breast cancer. Clinical Cancer Research, 17(9), 3005-3012. doi: 10.1158/1078-0432.ccr-10-1704

Journal - Research Article

Lønning, P. E., Haynes, B. P., Straume, A. H., Dunbier, A., Helle, H., Knappskog, S., & Dowsett, M. (2011). Recent data on intratumor estrogens in breast cancer. Steroids, 76(8), 786-791. doi: 10.1016/j.steroids.2011.02.040

Journal - Research Article

Lønning, P. E., Haynes, B. P., Straume, A. H., Dunbier, A., Helle, H., Knappskog, S., & Dowsett, M. (2011). Exploring breast cancer estrogen disposition: The basis for endocrine manipulation. Clinical Cancer Research, 17(15), 4948-4958. doi: 10.1158/1078-0432.ccr-11-0043

Journal - Research Article

Martin, L.-A., Ghazoui, Z., Weigel, M. T., Pancholi, S., Dunbier, A., Johnston, S., & Dowsett, M. (2011). An in vitro model showing adaptation to long-term oestrogen deprivation highlights the clinical potential for targeting kinase pathways in combination with aromatase inhibition. Steroids, 76, 772-776. doi: 10.1016/j.steroids.2011.02.035

Journal - Research Article

Miller, T. W., Balko, J. M., Fox, E. M., Ghazoui, Z., Dunbier, A., Anderson, H., … Arteaga, C. L. (2011). ERα-dependent E2F transcription can mediate resistance to estrogen deprivation in human breast cancer. Cancer Discovery, 1, 338-351. doi: 10.1158/2159-8290.CD-11-0101

Journal - Research Article

Miller, T. W., Balko, J. M., Ghazoui, Z., Dunbier, A., Anderson, H., Dowsett, M., … Arteaga, C. L. (2011). A gene expression signature from human breast cancer cells with acquired hormone independence identifies MYC as a mediator of antiestrogen resistance. Clinical Cancer Research, 17(7), 2024-2034. doi: 10.1158/1078-0432.ccr-10-2567

Journal - Research Article

Dowsett, M., Cuzick, J., Wale, C., Forbes, J., Mallon, E. A., Salter, J., … Dunbier, A., … Shak, S. (2010). Prediction of risk of distant recurrence using the 21-gene recurrence score in node-negative and node-positive postmenopausal patients with breast cancer treated with anastrozole or tamoxifen: A TransATAC study. Journal of Clinical Oncology, 28(11), 1829-1834. doi: 10.1200/JCO.2009.24.4798

Journal - Research Article

Dunbier, A. K., Anderson, H., Ghazoui, Z., Folkerd, E. J., A’Hern, R., Crowder, R. J., … Dowsett, M. (2010). Relationship between plasma estradiol levels and estrogen-responsive gene expression in estrogen receptor-positive breast cancer in postmenopausal women. Journal of Clinical Oncology, 28(7), 1161-1167. doi: 10.1200/JCO.2009.23.9616

Journal - Research Article

Dowsett, M., & Dunbier, A. K. (2008). Emerging biomarkers and new understanding of traditional markers in personalized therapy for breast cancer. Clinical Cancer Research, 14(24), 8019-8026. doi: 10.1158/1078-0432.ccr-08-0974

Journal - Research Article

Humar, B., McNoe, L., Dunbier, A., Heathcott, R., Braithwaite, A. W., & Reeve, A. E. (2008). Heterogeneous gene expression changes in colorectal cancer cells share the WNT pathway in response to growth suppression by APHS-mediated COX-2 inhibition. Biologics, 2(2), 329-337.

Journal - Research Article

Kendall, A., Anderson, H., Dunbier, A. K., Mackay, A., Dexter, T., Urruticoechea, A., … Dowsett, M. (2008). Impact of estrogen deprivation on gene expression profiles of normal postmenopausal breast tissue in vivo. Cancer Epidemiology, Biomarkers & Prevention, 17(4), 855-863. doi: 10.1158/1055-9965.epi-07-2718

Journal - Research Article

Nasri, S., More, H., Graziano, F., Ruzzo, A., Wilson, E., Dunbier, A., McKinney, C., Merriman, T., Guilford, P., … Humar, B. (2008). A novel diffuse gastric cancer susceptibility variant in E-cadherin (CDH1) intron 2: A case control study in an Italian population. BMC Cancer, 8, 138. doi: 10.1186/1471-2407-8-138

Journal - Research Article

Humar, B., Fukuzawa, R., Blair, V., Dunbier, A., More, H., Charlton, A., … Reeve, A. E., … Guilford, P. (2007). Destabilized adhesion in the gastric proliferative zone and c-Src kinase activation mark the development of early diffuse gastric cancer. Cancer Research, 67(6), 2480-2489. doi: 10.1158/0008-5472.CAN-06-3021

Journal - Research Article

da Silva Tatley, F. M., Aldwell, F., Dunbier, A. K., & Guilford, P. J. (2003). N-terminal E-cadherin peptides act as decoy receptors for Listeria monocytogenes. Infection & Immunity, 71(3), 1580-1583.

Journal - Research Article

Dunbier, A. K., & Guilford, P. J. (2001). Hereditary diffuse gastric cancer. Advances in Cancer Research, 83, 55-65.

Journal - Research Article

Grady, W. M., Willis, J., Guilford, P. J., Dunbier, A. K., Toro, T. T., Lynch, H., … Markowitz, S. D. (2000). Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer. Nature Genetics, 26, 16-17.

Journal - Research Article

McMillan, H. D., Keeshan, K., Dunbier, A. K., & Mace, P. D. (2021). Structure vs. function of TRIB1: Myeloid neoplasms and beyond. Cancer, 13, 3060. doi: 10.3390/cancers13123060

Journal - Research Other

Dunbier, A. K., Hong, Y., Masri, S., Brown, K. A., Sabnis, G. J., & Palomares, M. R. (2010). Progress in aromatase research and identification of key future directions. Journal of Steroid Biochemistry & Molecular Biology, 118(4-5), 311-315. doi: 10.1016/j.jsbmb.2009.09.005

Journal - Research Other

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