Dr Braeden Donaldson
Contact Details
- Phone
- 64 3 470 3455
- braeden.donaldson@otago.ac.nz
University Links
- Position
- Professional Practice Fellow
- Department
- Department of Pathology (Dunedin)
- Qualifications
- BMLSc, PGDipMLSc
- Research summary
- The development of immunotherapeutic vaccines as novel cancer therapies
- Teaching
My teaching commitments include roles in pathology, medical laboratory science, medicine, and several other health sciences courses.
- Memberships
- Member, Australasian Society of Immunology
- Member, Australasian Virology Society
- Alumnus, Fulbright Scholarship Program
- Clinical
Interests in current clinical therapies for cancer, and novel advancements in drug development, surgical intervention procedures, and patient management and care.
Research
Under the supervision of Associate Professor Sarah Young and Professor Vernon Ward, I have been using rabbit haemorrhagic disease virus (RHDV) virus-like particles (VLP) as a vaccine scaffold for the chemical conjugation and recombinant insertion of tumour-associated antigens (TAAs). These vaccines have previously proven effective at inducing potent anti-tumour immune responses in murine models of melanoma, lung cancer, and colorectal cancer. We are currently adapting this vaccine for prostate cancer and breast cancer, in addition to developing the vaccine for use in human clinical trials.
Publications
Campbell, K., Young, V. L., Donaldson, B. C., Woodall, M. J., Shields, N. J., Walker, G. F., Ward, V. K., & Young, S. L. (2021). Delivering two tumour antigens survivin and mucin-1 on virus-like particles enhances anti-tumour immune responses. Vaccines, 9(5), 463. doi: 10.3390/vaccines9050463 Journal - Research Article
Kramer, K., Donaldson, B., Young, V. L., Walker, G. F., Ward, V. K., & Young, S. L. (2018). Delivering tumour antigens survivin and mucin-1 on virus-like particles for breast cancer immunotherapy. Proceedings of the 41st Annual San Antonio Breast Cancer Symposium (SABCS). P4-06-20. Retrieved from https://www.sabcs.org/ Conference Contribution - Published proceedings: Abstract
Donaldson, B., Lateef, Z., Walker, G. F., Young, S. L., & Ward, V. K. (2018). Virus-like particle vaccines: Immunology and formulation for clinical translation. Expert Review of Vaccines, 17(9), 833-849. doi: 10.1080/14760584.2018.1516552 Journal - Research Other
Kramer, K., Donaldson, B., Young, V. L., Walker, G. F., Ward, V. K., & Young, S. L. (2018). Delivering tumour antigens survivin and mucin-1 on virus-like particles for breast cancer immunotherapy. Proceedings of the New Zealand Society for Oncology (NZSO) Conference. Retrieved from http://www.nzsoncology.org.nz/ Conference Contribution - Published proceedings: Abstract
Kramer, K., Donaldson, B., Young, V. L., Walker, G. F., & Young, S. L. (2017). Co-delivery of survivin and mucin-1 on virus-like particles for breast cancer. In A. Blackman, L. Gillman, C. Oliver & D. Dantzic (Eds.), Proceedings of the Inaugural New Zealand Breast Cancer Symposium (NZBCS): United for a Cure through Research. (pp. 96). Auckland, New Zealand: Auckland University of Technology. [Abstract] Conference Contribution - Published proceedings: Abstract