Contact Details
- Phone
- +64 3 479 7726
- merilyn.hibma@otago.ac.nz
University Links
- Position
- Professor
- Department
- Department of Pathology (Dunedin)
- Qualifications
- BSc MSc PhD(Otago)
- Research summary
- Immune regulation and its contribution to skin pathogenesis
Research
Merilyn is a Professor in the Department of Pathology, Dunedin School of Medicine. She worked for the Imperial Cancer Research Fund in University of Cambridge with Lionel Crawford (FRS), before being awarded an HRC Repatriation Fellowship and returning to the Department of Microbiology and Immunology at the University of Otago. In 2014 she was appointed to the Department of Pathology.
Her research interests include viral regulation of cell function and immunity in the skin, with a particular emphasis on human papillomavirus (HPV) and cancer. HPV causes persistent infections of cutaneous and mucosal skin and is the causal agent of cervical cancer. Although an effective prophylactic vaccine has been developed for the major cancer-causing HPV types, there is a continuing need for better therapeutics for HPV to address the health needs of individuals who are already infected with this high-prevalence virus. Understanding viral regulation of immunity by HPV and developing better immunotherapeutics to treat HPV are the focus of her research.
Publications
Lawton, B., MacDonald, E. J., Storey, F., Stanton, J.-A., Adcock, A., Gibson, M., … King, F., … Watson, H., Bennett, M., Lambert, C. S., Geller, S., Paasi, I., Hibma, M., Sykes, P., Hawkes, D., & Saville, M. (2023). A model for empowering rural solutions for cervical cancer prevention (He Tapu Te Whare Tangata): Protocol for a cluster randomized crossover trial. JMIR Research Protocols, 12, e51643. doi: 10.2196/51643 Journal - Research Other
Saito, M., Rajesh, A., Innes, C., van der Griend, R., Fitzgerald, P., Simcock, B., Sykes, P., & Hibma, M. (2023). The high-risk human papillomavirus type influences the tissue microenvironment in cervical intraepithelial neoplasia grade 2. Viruses, 15, 1953. doi: 10.3390/v15091953 Journal - Research Article
Ticar, V. S., Tschirley, A., Wilson, M., du Plessis, A., & Hibma, M. (2023). Case report: An adverse response to cyclosporin A treatment in BALB/cJ mice. Laboratory Animals. Advance online publication. doi: 10.1177/00236772231177857 Journal - Research Other
Speck, P., Mackenzie, J., Bull, R. A., Slobedman, B., Drummer, H., Fraser, J., … Hibma, M., … Ward, V., … Young, P. (2023). Statement in support of: "Virology under the microscope: A call for rational discourse". mSphere. Advance online publication. doi: 10.1128/msphere.00165-23 Journal - Professional & Other Non-Research Articles
Speck, P., Mackenzie, J., Bull, R. A., Slobedman, B., Drummer, H., Fraser, J., … Hibma, M., … Ward, V., … Young, P. (2023). Statement in support of: "Virology under the microscope: A call for rational discourse". mBio, 14(3). doi: 10.1128/mbio.00815-23 Journal - Professional & Other Non-Research Articles
2023
Journal - Research Article
Saito, M., Rajesh, A., Innes, C., van der Griend, R., Fitzgerald, P., Simcock, B., Sykes, P., & Hibma, M. (2023). The high-risk human papillomavirus type influences the tissue microenvironment in cervical intraepithelial neoplasia grade 2. Viruses, 15, 1953. doi: 10.3390/v15091953
Journal - Research Other
Lawton, B., MacDonald, E. J., Storey, F., Stanton, J.-A., Adcock, A., Gibson, M., … King, F., … Watson, H., Bennett, M., Lambert, C. S., Geller, S., Paasi, I., Hibma, M., Sykes, P., Hawkes, D., & Saville, M. (2023). A model for empowering rural solutions for cervical cancer prevention (He Tapu Te Whare Tangata): Protocol for a cluster randomized crossover trial. JMIR Research Protocols, 12, e51643. doi: 10.2196/51643
Ticar, V. S., Tschirley, A., Wilson, M., du Plessis, A., & Hibma, M. (2023). Case report: An adverse response to cyclosporin A treatment in BALB/cJ mice. Laboratory Animals. Advance online publication. doi: 10.1177/00236772231177857
Speck, P., Mackenzie, J., Bull, R. A., Slobedman, B., Drummer, H., Fraser, J., … Hibma, M., … Ward, V., … Young, P. (2023). Statement in support of: "Virology under the microscope: A call for rational discourse". Journal of Virology. Advance online publication. doi: 10.1128/jvi.00451-23
Gibson-Helm, M., Slater, T., MacDonald, E. J., Stevenson, K., Adcock, A., Geller, S., … Hibma, M., Sykes, P., … Lawton, B. (2023). Te Ara Waiora-Implementing human papillomavirus (HPV) primary testing to prevent cervical cancer in Aotearoa New Zealand: A protocol for a non-inferiority trial. PLoS ONE, 18(3), e0280643. doi: 10.1371/journal.pone.0280643
Hibma, M. H. (2023). Silencing genes in the vaginal mucosa by topical application of a cholesterol-modified siRNA to inhibit HIV transmission. Journal of the European Academy of Dermatology & Venereology, 37(3), 467-468. doi: 10.1111/jdv.18877
Journal - Professional & Other Non-Research Articles
Speck, P., Mackenzie, J., Bull, R. A., Slobedman, B., Drummer, H., Fraser, J., … Hibma, M., … Ward, V., … Young, P. (2023). Statement in support of: "Virology under the microscope: A call for rational discourse". mSphere. Advance online publication. doi: 10.1128/msphere.00165-23
Speck, P., Mackenzie, J., Bull, R. A., Slobedman, B., Drummer, H., Fraser, J., … Hibma, M., … Ward, V., … Young, P. (2023). Statement in support of: "Virology under the microscope: A call for rational discourse". mBio, 14(3). doi: 10.1128/mbio.00815-23
2022
Journal - Research Article
Aziz, M. A., Seo, B., Hussaini, H. M., Hibma, M., & Rich, A. M. (2022). Comparing two methods for the isolation of exosomes. Journal of Nucleic Acids, 8648373. doi: 10.1155/2022/8648373
Rajesh, A., Saito, M., Morrin, H., Tschirley, A., Simcock, J., Currie, M., & Hibma, M. (2022). Characterisation of the immune microenvironment of cutaneous squamous cell carcinoma in immunosuppression. Experimental Dermatology, 31, 1720-1728. doi: 10.1111/exd.14650
Saito, M., Rajesh, A., Innes, C., van der Griend, R., Fitzgerald, P., Simcock, B., Sykes, P., & Hibma, M. (2022). Blimp-1 is a prognostic indicator for progression of cervical intraepithelial neoplasia grade 2. Journal of Cancer Research & Clinical Oncology, 148, 1991-2002. doi: 10.1007/s00432-022-03993-4
Sykes, P. H., Simcock, B. J., Innes, C. R., Harker, D., Williman, J. A., Whitehead, M., van der Griend, R. A., … Hibma, M., … Petrich, S., … Sadler, L. (2022). Predicting regression of cervical intraepithelial neoplasia grade 2 in women under 25 years. American Journal of Obstetrics & Gynecology, 226, 222.e1-222.e13. doi: 10.1016/j.ajog.2021.09.009
Journal - Research Other
Hibma, M. (2022). Special Issue: HPV and HPV Vaccines. Viruses, 14, 274. doi: 10.3390/v14020274
Conference Contribution - Verbal presentation and other Conference outputs
Saito, M., Rajesh, A., Innes, C., van der Griend, R., Fitzgerald, P., Simcock, B., Sykes, P., & Hibma, M. (2022, August). The immune microenvironment in progression and regression of cervical intraepithelial neoplasia grade 2. Verbal presentation at the Cancer Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.
Other Research Output
Hibma, M. (2022, September). Human papillomavirus and cervical cancer: A translational research success story. University of Otago, Dunedin, New Zealand. [Inaugural Professorial Lecture].
2021
Journal - Research Article
Tschirley, A. M., Stockwell, P. A., Rodger, E. J., Eltherington, O., Morison, I. M., Christensen, N., Chatterjee, A., & Hibma, M. (2021). The mouse papillomavirus epigenetic signature is characterised by DNA hypermethylation after lesion regression. Viruses, 13, 2045. doi: 10.3390/v13102045
Mohd Zawawi, W. F. A. W., Hibma, M. H., Salim, M. I., & Jemon, K. (2021). Hyperthermia by near infrared radiation induced immune cells activation and infiltration in breast tumor. Scientific Reports, 11(1), 10278. doi: 10.1038/s41598-021-89740-0
MacDonald, E. J., Geller, S., Sibanda, N., Stevenson, K., Denmead, L., Adcock, A., Cram, F., Hibma, M., & Lawton, B. (2021). Reaching under-screened/never-screened indigenous peoples with human papilloma virus self-testing: A community-based cluster randomised controlled trial. Australian & New Zealand Journal of Obstetrics & Gynaecology, 61, 135-141. doi: 10.1111/ajo.13285
Journal - Research Other
Rajesh, A., Stuart, G., Real, N., Tschirley, A., Ahn, J., Wise, L., & Hibma, M. (2021). Skin antigen presenting cells and wound healing: New knowledge gained and challenges encountered using mouse depletion models. Immunology, 163, 98-104. doi: 10.1111/imm.13311
Conference Contribution - Published proceedings: Abstract
Ticar, V., Nair, B., Wilson, M., & Hibma, M. (2021). Microparticles produced from human papillomavirus type 16 E6 and E7 expressing keratinocytes regulate antigen-presentation by Langerhans cells. New Zealand Medical Journal, 134(1537), (pp. 104-105). Retrieved from https://www.nzma.org.nz/journal
Aziz, M. A., Seo, B., Hussaini, H. M., & Hibma, M. (2021). An in vitro examination of OSCC-derived exosomes. Oral Surgery, Oral Medicine, Oral Pathology & Oral Radiology, 132(1), (pp. e8). doi: 10.1016/j.oooo.2021.03.044
Conference Contribution - Verbal presentation and other Conference outputs
Cheetham, K., Wilson, J., Crabtree, I., Howell, T., Pullon, S., Dar, O., & Hibma, M. (2021, November). Vision for the Dunedin Hospital Interprofessional Learning Centre. Panel discussion at the Interprofessional Education for Interprofessional Practice Seminar, Dunedin, New Zealand.
2020
Chapter in Book - Research
Rajesh, A., & Hibma, M. (2020). Novel concepts: Langerhans cells in the tumour microenvironment. In A. Birbrair (Ed.), Tumor microenvironment: Hematopoietic cells, part B: Advances in experimental medicine and biology (Vol. 1273). (pp. 147-158). Cham, Switzerland: Springer. doi: 10.1007/978-3-030-49270-0_8
Journal - Research Article
Rajesh, A., Stuart, G., Real, N., Ahn, J., Tschirley, A., Wise, L., & Hibma, M. (2020). Depletion of langerin+ cells enhances cutaneous wound healing. Immunology, 160, 366-381. doi: 10.1111/imm.13202
Dempster-Rivett, K., Innes, C. R., Simcock, B. J., Harker, D., Williman, J. A., Van Der Griend, R. A., Whitehead, M., Hibma, M., … Petrich, S., Faherty, J., … Sykes, P. H. (2020). Evaluation of guidelines for observational management of cervical intraepithelial neoplasia 2 in young women. American Journal of Obstetrics & Gynecology, 223, 408.e1-408.e11. doi: 10.1016/j.ajog.2020.02.029
Journal - Research Other
Lawton, B., Heffernan, M., Wurtak, G., Steben, M., Lhaki, P., Cram, F., … Hibma, M., Adcock, A., … Garland, S. M. (2020). IPVS Policy Statement addressing the burden of HPV disease for Indigenous peoples. Papillomavirus Research, 9, 100191. doi: 10.1016/j.pvr.2019.100191
Conference Contribution - Published proceedings: Abstract
Ticar, V., Nair, B., Tschirley, A., & Hibma, M. (2020). Increased major histocompatibility complex class I expression on Langerhans cells following microparticle co-culture. New Zealand Medical Journal, 133(1518), (pp. 96). Retrieved from https://www.nzma.org.nz/journal
2019
Journal - Research Article
Adcock, A., Cram, F., Lawton, B., Geller, S., Hibma, M., Sykes, P., … Hart, S. (2019). Acceptability of self-taken vaginal HPV sample for cervical screening among an under-screened Indigenous population. Australian & New Zealand Journal of Obstetrics & Gynaecology, 59, 301-307. doi: 10.1111/ajo.12933
Journal - Research Other
Rajesh, A., Wise, L., & Hibma, M. (2019). The role of Langerhans cells in pathologies of the skin. Immunology & Cell Biology, 97(8), 700-713. doi: 10.1111/imcb.12253
Conference Contribution - Published proceedings: Abstract
Budhwani, M., McLellan, A., Kleffmann, T., & Hibma, M. (2019). Extracellular vesicles released from human papillomavirus type 16 E7 keratinocytes suppress antigen presenting cell activation and antigen-specific T cell proliferation. European Journal of Immunology, 49(Suppl. 2), (pp. 7-8). doi: 10.1002/eji.201970200
Rajesh, A., Stuart, G. S., Real, N., Tschirley, A., Wise, L., & Hibma, M. (2019). Novel suppressive role of Langerhans cells in wound healing. European Journal of Immunology, 49(Suppl. 2), (pp. 22-23). doi: 10.1002/eji.201970200
Conference Contribution - Verbal presentation and other Conference outputs
Hibma, M. (2019, August-September). Evaluating immune modulation of dendritic cells by extracellular vesicles shed from human papillomavirus type 16-E7 expressing keratinocytes. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2018
Journal - Research Article
Innes, C. R., Sykes, P. H., Harker, D., Williman, J. A., Van der Griend, R. A., Whitehead, M., Hibma, M., … Petrich, S., Faherty, J., … Simcock, B. J. (2018). Changes in human papillomavirus genotypes associated with cervical intraepithelial neoplasia grade 2 lesions in a cohort of young women (2013–2016). Papillomavirus Research, 6, 77-82. doi: 10.1016/j.pvr.2018.10.010
Zhang, J., Burn, C., Young, K., Wilson, M., Ly, K., Budhwani, M., Tschirley, A., Braithwaite, A., Baird, M., & Hibma, M. (2018). Microparticles produced by human papillomavirus type 16 E7-expressing cells impair antigen presenting cell function and the cytotoxic T cell response. Scientific Reports, 8, 2373. doi: 10.1038/s41598-018-20779-2
Conference Contribution - Published proceedings: Abstract
Hibma, M., Zhang, T., Gimenez, G., Ly, K., Burn, C., Young, K., Wilson, M., … Tschirley, A., Braithwaite, A., & Baird, M. (2018). Human papillomavirus regulation of Langerhans cell function in the skin. European Journal of Immunology, 48(Suppl. 1), (pp. 96-97). doi: 10.1002/eji.201871000
Conference Contribution - Poster Presentation (not in published proceedings)
Sharma, I., Wilson, M., Nair, B., Gimenez, G., Hunter, F., Young, S., & Hibma, M. (2018, September). Mechanisms of HPV suppression of antigen presenting cells. Poster session presented at the Otago Spotlight Symposium on Infectious Disease, Wellington, New Zealand.
Rajesh, A., Jones, N., Stuart, G., Cunliffe, H., Wise, L., & Hibma, M. (2018, September). Investigating the role of Langerhans cells during wound healing. Poster session presented at the Otago Spotlight Symposium on Infectious Disease, Wellington, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Rajesh, A., Stuart, G., Real, N., Ahn, J., Tschirley, A., Hibma, M., & Wise, L. (2018, August). Depletion of Langerin/CD207+ cells accelerated wound healing. Verbal presentation at the Queenstown Molecular Biology (QMB) and Australasian Society for Immunology New Zealand Branch (ASI-NZ) Joint Meeting, Queenstown, New Zealand.
2017
Conference Contribution - Verbal presentation and other Conference outputs
Rajesh, A., Cunliffe, H., Wise, L., & Hibma, M. (2017, July). Role of Langerhans cells in wound healing. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand.
Tschirley, A. M., Currie, M. J., Simcock, J. W., & Hibma, M. H. (2017, July). Mapping the contribution of β-human papillomaviruses to aggressive cutaneous squamous cell carcinoma. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand.
Hibma, M., Zhang, J., Baird, M., & Braithwaite, A. (2017, July). Evaluating immune modulation of Langerhans cells by microparticles shed from human papillomavirus type 16-E7 expressing keratinocyctes. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand.
2016
Journal - Research Article
Jemon, K., Leong, C.-M., Ly, K., Young, S. L., McLellan, A. D., & Hibma, M. H. (2016). Suppression of the CD8 T cell response by human papillomavirus type 16 E7 occurs in Langerhans cell-depleted mice. Scientific Reports, 6, 34789. doi: 10.1038/srep34789
Journal - Research Other
Sykes, P., Innes, C., Harker, D., Whitehead, M., van der Griend, R., Lawton, B., Hibma, M., … Petrich, S., Faherty, J., Bergzoll, C., … Parker, C., Sadler, L., & Simcock, B. (2016). Observational management of CIN 2 in young women: A prospective multicenter trial. Journal of Lower Genital Tract Disease, 20(4), 343-347. doi: 10.1097/lgt.0000000000000244
Conference Contribution - Published proceedings: Abstract
Zhang, T., Burn, C., Ly, K., Young, K., Wilson, M., Braithwaite, A., Baird, M., & Hibma, M. (2016). Immune modulation of Langerhans cells by microparticles from human papillomavirus type 16 E7 expressing keratinocytes. European Journal of Immunology, 46(Suppl. 1), (pp. 890-891). doi: 10.1002/eji.201670200
Saito, M., Budhwani, M., Coffey, K., Sykes, P., & Hibma, M. (2016). Immunological markers of persistence & regression in cervical intraepithelial neoplasia grade 2 in women under 25. European Journal of Immunology, 46(Suppl. 1), (pp. 217-218). doi: 10.1002/eji.201670200
Budhwani, M., Jemon, K., Ly, K., & Hibma, M. (2016). Effects of human papilloma virus oncoprotein E7 on antigen presentation and potential involvement of keratinocyte exosomes. European Journal of Immunology, 46(Suppl. 1), (pp. 96). doi: 10.1002/eji.201670200
Saul, D., Rawle, C., Hibma, M., Lawton, B., & Stanton, J.-A. L. (2016). PDQeX: Reliable nucleic acid extraction for in-field and at the point-of-care applications. Proceedings of the Otago Global Health Institute (OGHI) 9th Annual Conference. (pp. 17). Retrieved from http://dnmeds.otago.ac.nz/departments/psm/research/international_hlth/conference/
2015
Journal - Research Article
Warif, N. M. A., Stoitzner, P., Leggatt, G. R., Mattarollo, S. R., Frazer, I. H., & Hibma, M. H. (2015). Langerhans cell homeostasis and activation Is altered in hyperplastic human papillomavirus type 16 E7 expressing epidermis. PLoS ONE, 10(5), e0127155. doi: 10.1371/journal.pone.0127155
Conference Contribution - Published proceedings: Abstract
Saul, D., Hibma, M., Lawton, B., Rawle, C., & Stanton, J.-A. L. (2015). New technology to enable reliable nucleic acid sample preparation in low resource settings. Proceedings of the 8th Annual Otago International Health Research Network (OIHRN) Conference. (pp. 2). Retrieved from http://dnmeds.otago.ac.nz/departments/psm/research/international_hlth
Conference Contribution - Verbal presentation and other Conference outputs
Hibma, M. (2015, July). Evaluating the immune modulating effects of microparticles from human papillomavirus type 16-E7 expressing keratinocytes on Langerhans cells. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Auckland, New Zealand.
2013
Journal - Research Article
Jemon, K., Young, V., Wilson, M., McKee, S., Ward, V., Baird, M., Young, S., & Hibma, M. (2013). An enhanced heterologous virus-like particle for human papillomavirus type 16 tumour immunotherapy. PLoS ONE, 8(6), e66866. doi: 10.1371/journal.pone.0066866
Conference Contribution - Published proceedings: Abstract
Budhwani, M., Nadwa, K., & Hibma, M. (2013). A lentivirus-based system to study the effects of HPV16 E7 on antigen presentation in vivo. Proceedings of the 43rd Australasian Society for Immunology (ASI) Annual Scientific Meeting. (pp. 170). Retrieved from http://www.asi2013.org/
Bell, G., Budhwani, M., Highton, A., Hibma, M., & Kemp, R. (2013). Construction of a melanoma cell line for orthotopic models of cancer. Proceedings of the 43rd Australasian Society for Immunology (ASI) Annual Scientific Meeting. (pp. 132). Retrieved from http://www.asi2013.org/
Warif, N. M. A., Stoitzner, P., Leggatt, G. R., Mattarollo, S. R., Frazer, I. H., & Hibma, M. (2013). Langerhans cell homeostasis and activation is altered in epidermis expressing human papillomavirus type 16 E7. Proceedings of the 43rd Australasian Society for Immunology (ASI) Annual Scientific Meeting. (pp. 55-56). Retrieved from http://www.asi2013.org/
Budhwani, M., & Hibma, M. (2013). A lentivirus-based system to study the effects of HPV16 E7 on antigen presentation in vivo. Proceedings of the Australasian Virology Society (AVS) Meeting. Retrieved from http://www.avs.org.au/scientific-program/
Ahn, J., Wise, L., Real, N., Stuart, G., & Hibma, M. (2013). Inhibitory role of Langerhans cells (LCs) during cutaneous wound healing. New Zealand Medical Journal, 126(1386). Retrieved from http://www.nzma.org.nz/journal
2012
Journal - Research Article
Hibma, M. H. (2012). The immune response to papillomavirus during infection persistence and regression. Open Virology Journal, 6(Suppl. 2), 241-248. doi: 10.2174/1874357901206010241
D'Costa, Z. J., Jolly, C., Androphy, E. J., Mercer, A., Matthews, C. M., & Hibma, M. H. (2012). Transcriptional repression of E-cadherin by human papillomavirus type 16 E6. PLoS ONE, 7(11), e48954. doi: 10.1371/journal.pone.0048954
Rose, S. B., Lawton, B. A., Lanumata, T. S., Hibma, M., & Baker, M. G. (2012). Predictors of intent to vaccinate against HPV/cervical cancer: A multi-ethnic survey of 769 parents in New Zealand. New Zealand Medical Journal, 125(1350). Retrieved from http://www.nzma.org.nz/journal
Dutton, S., Fleming, S. B., Ueda, N., Heath, D. D., Hibma, M. H., & Mercer, A. A. (2012). Delivery of Echinococcus granulosus antigen EG95 to mice and sheep using recombinant vaccinia virus. Parasite Immunology, 34(6), 312-317. doi: 10.1111/j.1365-3024.2012.01360.x
D'Costa, Z. J., Leong, C.-M., Shields, J., Matthews, C., & Hibma, M. H. (2012). Screening of drugs to counteract human papillomavirus 16 E6 repression of E-cadherin expression. Investigational New Drugs, 30(6), 2236-2251. doi: 10.1007/s10637-012-9803-0
Conference Contribution - Published proceedings: Abstract
Jemon, K., Young, V., Wilson, M., McKee, S., Ward, V., Baird, M., Young, S., & Hibma, M. (2012). An enhanced heterologous virus-like particle for human papillomavirus type 16 tumour immunotherapy. Proceedings of the Virus-Like Particle & Nano-Particle Vaccines (VLPNPV) International Conference. [CD-ROM] [Abstract]
Conference Contribution - Verbal presentation and other Conference outputs
Hibma, M. (2012, June). Human papillomavirus type 16 e7 regulation of antigen presentation in the skin. Verbal presentation at the New Zealand Australasian Society for Immunology (NZ ASI) Branch Meeting, Dunedin, New Zealand.
2011
Conference Contribution - Published proceedings: Abstract
Burn, C., & Hibma, M. (2011). Microparticles and antigen sampling by Langerhans cells during human papillomavirus infection. New Zealand Medical Journal, 124(1346). Retrieved from http://journal.nzma.org.nz/journal/124-1346/4980/content.pdf
Flanagan, L., Sykes, P., Miller, A., & Hibma, M. (2011). Antigen presenting cells in the human papillomavirus-induced tumour microenvironment. New Zealand Medical Journal, 124(1346). Retrieved from http://journal.nzma.org.nz/journal/124-1346/4980/content.pdf
D'Costa, Z., Matthews, C., Mercer, A., Wise, L., & Hibma, M. (2011). Human papillomavirus type 16 E6 regulates E-cadherin in a DNA methyltransferase-dependent manner. New Zealand Medical Journal, 124(1344). Retrieved from http://journal.nzma.org.nz/journal/124-1344/4919/content.pdf
Burn, C., Leong, J., & Hibma, M. (2011). Human papillomavirus virus-like particles and their potential as gene delivery vectors in the skin. New Zealand Medical Journal. 124(1335). Retrieved from http://www.nzma.org.nz/journal/124-1335/4693/content.pdf
Conference Contribution - Poster Presentation (not in published proceedings)
D'Costa, Z., Yajid, A., Matthews, C., Raj, K., & Hibma, M. (2011, July). Methylation-dependent transcriptional repression of E-cadherin by human papillomavirus 16 E6. Poster session presented at the International Centre for Genetic Engineering and Biotechnology (ICGEB) DNA Tumour Virus Meeting, Trieste, Italy.
Conference Contribution - Verbal presentation and other Conference outputs
D'Costa, Z., Yajid, A., Matthews, C., & Hibma, M. (2011, December). Methylation-dependent transcriptional repression of E-cadherin by human papillomavirus type 16 E6. Verbal presentation at the 6th Australasian Virology Society Meeting (AVS), Kingscliff, Australia.
2010
Journal - Research Article
Rose, S. B., Lawton, B. A., Lanumata, T., Hibma, M., & Baker, M. G. (2010). HPV/cervical cancer vaccination: Parental preferences on age, place and information needs. Journal of Primary Health Care, 2(3), 190-198.
Leong, C.-M., Doorbar, J., Nindl, I., Yoon, H.-S., & Hibma, M. H. (2010). Deregulation of E-cadherin by human papillomavirus is not confined to high-risk, cancer-causing types. British Journal of Dermatology, 163(6), 1253-1263. doi: 10.1111/j.1365-2133.2010.09968.x
Leong, C. M., Doorbar, J., Nindl, I., Yoon, H.-S., & Hibma, M. H. (2010). Loss of epidermal Langerhans cells occurs in human papillomavirus α, γ, and μ but not β genus infections. Journal of Investigative Dermatology, 130(2), 472-480. doi: 10.1038/jid.2009.266
Conference Contribution - Published proceedings: Abstract
D'Costa, Z., Matthews, C., & Hibma, M. (2010). Transcriptional regulation of E-cadherin by HPV16 E6. Proceedings of the 26th International Papillomavirus (HPV) Conference & Clinical and Public Health Workshops. Retrieved from http://hpv2010.org/abstractsearch/
Leong, C. M., Doorbar, J., Nindl, I., Yoon, H.-S., & Hibma, M. (2010). Human papillomavirus associated loss of E-cadherin expression is conserved across all but the β genera. Proceedings of the 26th International Papillomavirus (HPV) Conference & Clinical and Public Health Workshops. Retrieved from http://hpv2010.org/abstractsearch/
2009
Journal - Research Article
Westphal, D., Ledgerwood, E. C., Tyndall, J. D. A., Hibma, M. H., Ueda, N., Fleming, S. B., & Mercer, A. A. (2009). The orf virus inhibitor of apoptosis functions in a Bcl-2-like manner, binding and neutralizing a set of BH3-only proteins and active Bax. Apoptosis, 14(11), 1317-1330. doi: 10.1007/s10495-009-0403-1
Hibma, M. H., Real, N. C., Wiles, A., Dobson-Le, D., Dix, B. R., Wynford-Thomas, D., Braithwaite, A. W., & Royds, J. A. (2009). Increased apoptosis and reduced replication efficiency of the E3 region-modified dl309 adenovirus in cancer cells. Virus Research, 145(1), 112-120. doi: 10.1016/j.virusres.2009.06.016
Conference Contribution - Published proceedings: Abstract
Wong, Y. K., & Hibma, M. (2009). Human papillomavirus type 16 E6 protein regulates cellular β-catenin and glycogen synthase kinase-3β. New Zealand Medical Journal. 122(1295). Retrieved from http://journal.nzma.org.nz/journal/122-1295/3623/content.pdf
Conference Contribution - Verbal presentation and other Conference outputs
Hibma, M., Leong, J., Doorbar, J., & Yoon, H.-S. (2009, May). Regulation of Langerhans cell number across HPV genera. Verbal presentation at the 25th International Papillomavirus Conference, Malmö, Sweden.
2008
Journal - Research Article
Heinemann, L., Woodfield, L., Amer, M., & Hibma, M. (2008). Effective induction of type 1 helper IgG2a and cytotoxic T-cell responses in mice following immunization with human papillomavirus type 16 E2 in MF59. Viral Immunology, 21(2), 225-233. doi: 10.1089/vim.2007.0101
Conference Contribution - Poster Presentation (not in published proceedings)
D'Costa, Z., & Hibma, M. (2008, November). Human papillomavirus type 16 E6 protein regulates cell surface E-cadherin expression. Poster session presented at the Virology Theme Meeting, Dunedin, New Zealand.
D'Costa, Z., & Hibma, M. (2008, August-September). Human papillomavirus type 16 E6 protein regulates cell surface E-cadherin expression. Poster session presented at the Queestown Molecular Biology Meetings, Queenstown, New Zealand.
Chin, M., & Hibma, M. (2008, November). Degradation of cellular β-catenin by the human papillomavirus type 16 E6 oncoprotein. Poster session presented at the Virology Theme Meeting, Dunedin, New Zealand.
Chin, M., & Hibma, M. (2008, August-September). Degradation of cellular β-catenin by the human papillomavirus type 16 E6 oncoprotein. Poster session presented at the Queenstown Molecular Biology Meetings, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Hibma, M., Dillon, S., Sasagawa, T., Heinemann, L., Woodfield, L., Crawford, A., … Prestidge, J., Inder, M., Jerram, J., & Mercer, A. (2008, June). Resolution of cervical dysplasia is associated with T-cell proliferative responses to human papillomavirus type 16 E2. Verbal presentation at the Australian Society for Immunology New Zealand Branch Meeting, Wellington, New Zealand.
Leong, C.-M., Doorbar, J., Yoon, H.-S., Mercer, A., & Hibma, M. (2008, November). Human papillomavirus regulation of Langerhans cell density occurs in types from the α, μ and γ genera but not in types from the β genus. Verbal presentation at the Virology Theme Meeting, Dunedin, New Zealand.
Hibma, M. H., & et al (2008, November). Resolution of cervical dysplasia is associated with T-cell proliferative responses to human papillomavirus type 16 E2. Verbal presentation at the Otago International Health Research Network Conference, Dunedin, New Zealand.
2007
Journal - Research Article
Westphal, D., Ledgerwood, E. C., Hibma, M. H., Fleming, S. B., Whelan, E. M., & Mercer, A. A. (2007). A novel Bcl-2-like inhibitor of apoptosis is encoded by the parapoxvirus orf virus. Journal of Virology, 81(13), 7178-7188.
Dillon, S., Sasagawa, T., Crawford, A., Prestidge, J., Inder, M. K., Jerram, J., Mercer, A. A., & Hibma, M. (2007). Resolution of cervical dysplasia is associated with T-cell proliferative responses to human papillomavirus type 16 E2. Journal of General Virology, 88, 803-813.
Journal - Research Other
Leong, C. M., Hibma, M., & Tarbotton, J. (2007). Self-applied treatment of persistent plantar wart with 5% imiquimod cream [Letter]. New Zealand Medical Journal, 120(1259). Retrieved from http://journal.nzma.org.nz/journal/120-1259/2668/content.pdf
Conference Contribution - Verbal presentation and other Conference outputs
Hibma, M. (2007, April). Human papillomavirus regulation of cell adhesion: A potential immunotherapeutic target? Verbal presentation at the Webster Centre for Molecular Research in Infectious Diseases Symposium, Dunedin, New Zealand.
Leong, C.-M., Matthews, K., Doorbar, J., & Hibma, M. (2007, May). Human papilloma virus E6 protein reduction of cell surface E-cadherin is not limited to high-risk types. Verbal presentation at the New Zealand Society for Oncology Conference, Dunedin, New Zealand.
Leong, C. M., Doorbar, J., Yoon, H.-S., Mercer, A., & Hibma, M. (2007, November). Human papillomavirus E6 regulation of Langerhans Cell density via E-cadherin is conserved in types from the A, C and E supergenera but not in types 5 and 8 from the B supergenus. Verbal presentation at the 24th International Papillomavirus Conference and Clinical Workshop, Beijing, China.
Wiles, A., Hibma, M., Russell, A., Braithwaite, A., & Royds, J. A. (2007, December). Factors affecting efficiency of Onco-viral therapy involving the adenovirus ONYX-015. Verbal presentation at the 4th Australian Virology Group Meeting, Fraser Island, Australia.
2006
Journal - Research Article
Royds, J. A., Hibma, M., Dix, B. R., Hananeia, L., Russell, I. A., Wiles, A., … Braithwaite, A. W. (2006). p53 promotes adenoviral replication and increases late viral gene expression. Oncogene, 25, 1509-1520.
Conference Contribution - Verbal presentation and other Conference outputs
Leong, C. M., Matthews, K., Doorbar, J., & Hibma, M. (2006, January). Human papillomavirus type 16 E6 protein reduces cell surface E-cadherin: A mechanism for viral immune evasion. Verbal presentation at the Keystone Symposia: Determinants of Host Resistance, Susceptibility or Immunopathology to Pathogens: Integrating Knowledge from Experimental Models to Human Disease, Keystone, CO.
Leong, C. M., & Hibma, M. (2006, February). Human papillomavirus E6 regulation of E-cadherin is associated with the ability of the virus to persist in the host and is independent of P53 degradation. Verbal presentation at the New Zealand Chapter of the Controlled Release Society 8th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand.
Leong, C. M., Doorbar, J., & Hibma, M. (2006, December). Human papillomavirus type 16 E6 protein reduces cell surface E-cadherin: A mechanism for viral immune evasion. Verbal presentation at the Australasian Society for Immunology Conference, Auckland, New Zealand.
2005
Journal - Research Article
Leong, C.-M., & Hibma, M. H. (2005). A flow cytometry-based assay for the measurement of protein regulation of E-cadherin-mediated adhesion. Journal of Immunological Methods, 302, 116-124.
Conference Contribution - Published proceedings: Abstract
Shields, J., & Hibma, M. (2005). The constitutive expression of HPV16 E6 in HCT116 cells leads to a reduction in E-cadherin levels that cannot be counteracted by chemicals Indole-3-carbinol or Tamoxifen. New Zealand Medical Journal, 118(1225). Retrieved from http://journal.nzma.org.nz/journal/118-1225/1740/content.pdf
Conference Contribution - Verbal presentation and other Conference outputs
Westphal, D., Ledgerwood, E. C., Whelan, E. M., Fleming, S. B., Hibma, M. H., & Mercer, A. A. (2005, November). Characterisation of a novel inhibitor of apoptosis expressed by orf virus. Verbal presentation at the SBMB New Zealand and the NZMS Conference: Celebrating 50 years of Microbial Interactions, Dunedin, New Zealand.
Leong, C.-M., Banks, L., & Hibma, M. (2005, July). Human papillomavirus E6 regulation of E-cadherin is associated with the ability of the virus to persist in the host and is independent of P53 degradation. Verbal presentation at the Cancer Research UK: DNA Tumour Virus Meeting, Cambridge, England.
Dillon, S., Sasagawa, T., Crawford, A., Prestidge, J., Inder, M., Jerram, J., & Hibma, M. (2005, July). Resolution of cervical dysplasia is associated with T cell proliferative responses to human papillomavirus type 16 E2. Verbal presentation at the Cancer Research UK: DNA Tumour Virus Meeting, Cambridge, England.
2004
Journal - Research Article
Heinemann, L., Dillon, S., Crawford, A., Bäckström, B. T., & Hibma, M. H. (2004). Flow cytometric quantitation of the protective efficacy of dendritic cell based vaccines in a human papillomavirus type 16 murine challenge model. Journal of Virological Methods, 117, 9-18.
Conference Contribution - Poster Presentation (not in published proceedings)
Tong, S., Inglis, E., Nooijen, A., Wynford-Thomas, D., Braithwaite, A., & Hibma, M. (2004, February). Evasion of host immunity by human papillomavirus mediated Fas (CD95) down-regulation. Poster session presented at the 21st International Papillomavirus Conference and Clinical Workshop, Mexico City.
Conference Contribution - Verbal presentation and other Conference outputs
Leong, C. M., Matthews, K., Baxter, L., Inglis, E., & Hibma, M. (2004, February). Human papillomavirus type 16 E6 protein reduces cell surface E-cadherin: A mechanism for viral immune evasion. Verbal presentation at the 21st International Papillomavirus Conference and Clinical Workshop, Mexico City.
Mercer, A., Whelan, E., Westphal, D., Hibma, M., Fleming, S., & Ledgerwood, E. (2004, September). Inhibition of apoptosis by orf virus: Contribution of a unique, mitochondrial targeted factor. Verbal presentation at the XVth International Poxvirus and Iridovirus Conference, Oxford, England.
2003
Journal - Research Article
Middleton, K., Peh, W., Southern, S., Griffin, H., Sotlar, K., Nakahara, T., … Hibma, M. H., … Doorbar, J. (2003). Organization of human papillomavirus productive cycle during neoplastic progression provides a basis for selection of diagnostic markers. Journal of Virology, 77(19), 10186-10201.
Matthews, K. E., Leong, C. M., Baxter, L., Inglis, E., Yun, K., Bäckström, B. T., … Hibma, M. H. (2003). Depletion of Langerhans cells in human papillomavirus type 16-infected skin is associated with E6-mediated down regulation of E-cadherin. Journal of Virology, 77(15), 8378-8385. doi: 10.1128/JVI.77.15.8378-8385.2003
Conference Contribution - Verbal presentation and other Conference outputs
Hibma, M., Leong, C. M., Matthews, K., Inglis, E., & Baxter, L. (2003, December). Human papillomavirus type 16 E6 protein reduces cell surface E-cadherin: A mechanism for viral immune evasion. Verbal presentation at the 2nd Australian Virology Group Meeting, Fraser Island, Australia.
Leong, C. M., Matthews, K., Baxter, L., Inglis, E., & Hibma, M. (2003, November). Human papillomavirus type 16 E6 protein reduces cell surface E-cadherin: A mechanism for viral immune evasion. Verbal presentation at the 5th Peter MacCallum Cancer Centre Symposium, Melbourne, Australia.
2002
Journal - Research Article
Edwards, S. J., Dix, B. R., Myers, C. J., Dobson-Le, D., Huschtscha, L., Hibma, M., Royds, J., & Braithwaite, A. W. (2002). Evidence that replication of the antitumor adenovirus ONYX-015 is not controlled by the p53 and p14ARF tumor suppressor genes. Journal of Virology, 76(24), 12483-12490. doi: 10.1128/JVI.76.24.12483-12490.2002
Heinemann, B. L., Dillon, S. M., & Hibma, M. H. (2002). Immunisation with bone marrow-derived dendritic cells presenting HPV-16 E2 protects mice from virus challenge. New Zealand Medical Journal, 115(1159). Retrieved from http://www.nzma.org.nz/journal/115-1159
Conference Contribution - Verbal presentation and other Conference outputs
Tong, S., Inglis, E., Nooijen, A., Wynford-Thomas, D., & Hibma, M. H. (2002). Evasion of host immunity by human papillomavirus mediated Fas (CD95) down-regulation. Verbal presentation at the 32nd Annual Scientific Meeting of the Australasian Society for Immunology, Australia.
2001
Journal - Research Article
Hibma, M., & Braithwaite, A. (2001). Viruses to the rescue: p53-based therapies in the fight against cancer. New Zealand Medical Journal, 114(1133), 266-269.
Conference Contribution - Published proceedings: Abstract
Wiles, A., Hibma, M. H., Wynford-Thomas, D., Royds, J. A., & Braithwaite, A. (2001). p53 co-operates with adenovirus early protein E1b 55k to induce cell death. Lorne Conference. [Abstract]
Royds, J. A., Hibma, M. H., Wiles, A., Jales, L., Wynford-Thomas, D., & Braithwaite, A. (2001). Adenovirus early proten -E1b 55k, p53 and cell death. Lorne Conference. [Abstract]
Conference Contribution - Verbal presentation and other Conference outputs
Hibma, M. H., Wiles, A., Jales, L., Wynford-Thomas, D., & Braithwaite, A. (2001). The influence of p53 and E1b55k on cell cycle following adenovirus type 5 infection. Verbal presentation at the DNA Tumour Virus Meeting, UK.
2000
Conference Contribution - Poster Presentation (not in published proceedings)
Dillon, S., Amer, M., & Hibma, M. (2000). Detection and characterisation of immune responses in women infected with human papillomavirus type 16. Poster session presented at the 18th International Papillomavirus Conference, Barcelona.
Matthews, K., Jales, L., Doorbar, J., & Hibma, M. (2000). The effects of HPV16 early genes on the expression of cellular e-cadherin. Poster session presented at the 18th International Papillomavirus Conference, Barcelona.
1999
Conference Contribution - Verbal presentation and other Conference outputs
Hibma, M. H., Amer, M., & Heinemann, B. L. (1999). Immune responses to the HPV16 early protein E2. Verbal presentation at the 18th International Papillomavirus Meeting
1998
Journal - Research Article
Housawi, F. M., Roberts, G. M., Gilray, J. A., Pow, I., Reid, H. W., Nettleton, P. F., … Hibma, M. H., & Mercer, A. A. (1998). The reactivity of monoclonal antibodies against orf virus with other parapoxviruses and the identification of a 39 kDa immunodominant protein. Archives of Virology, 143(12), 2289-2303.
Conference Contribution - Verbal presentation and other Conference outputs
Hibma, M. H., Amer, M., Heinemann, B. L., & Van Nest, G. (1998). Immune responses to the HPV16 early protein E2. Verbal presentation at the Australasian Society for Immunology 28th Annual Conference, Australia.
1997
Journal - Research Article
Zatsepina, O., Braspenning, J., Robberson, D., Hajibagheri, M., Blight, K., Ely, S., Hibma, M., … Tommasino, M. (1997). The human papillomavirus type 16 E7 protein is associated with the nucleolus in mammalian and yeast cells. Oncogene, 14(10), 1137-1145.
Stellato, G., Paavonen, J., Nieminen, P., Hibma, M., Vilja, P., & Lehtinen, M. (1997). Diagnostic phase antibody response to the human papillomavirus type 16 E2 protein is associated with successful treatment of genital HPV lesions with systemic interferon α-2b. Clinical & Diagnostic Virology, 7(3), 167-172.
Conference Contribution - Verbal presentation and other Conference outputs
Hibma, M. H. (1997). Immune responses to the HPV16 early protein E2. Verbal presentation at the Vaccines 2000 Workshop, Australia.