Dr Kunyu Li
|Department||Department of Pathology (Dunedin)|
|Research summary||Immunotherapies and immunoregulation in chronic diseases|
|Teaching||Chemical Pathology for 200 and 300 Level MEL course|
I am an immunologist with a strong background in translational research in cancer immunotherapies, particularly cellular therapy for solid cancers.
My current research primarily focuses on Immunoregulation by both intrinsic and extrinsic factors in Chronic conditions, and how dysregulation of immune response could lead to tissue pathology. Cancer and autoimmune diseases are both chronic diseases that share common characteristics of dysregulation of immune responses to self-derived antigens. The finding of my previous research suggests that immune dysregulation in both cases could be closely linked. Thereby studying one could guide us to solve the problems or answer the questions of the other.
I am currently leading research projects in understanding tumour resistance to adoptive T-cell therapy (ACT), overcoming the limitation of ACT through genetic modification of tumour-reactive T cells, and immunoregulation by D133p53 isoform in the development and progression of inflammatory bowel disease (IBD).
I also have a longstanding interest in using Traditional Chinese Medicine to enhance immunity and treat chronic inflammation. I am currently setting up collaborations with TCM researchers in China.
- DSM Dean’s Bequest Grant
- New Zealand Lottery Health Research Grant
- HRC Explorer Grant
Research projects available for postgraduate students
- The role of D133p53 isoform in IBD
- Understanding how tumour resistance to ACT arises
- ACT using genetically modified T cells in solid cancer
Li, K., Donaldson, B., Young, V., Ward, V., Jackson, C., Baird, M., & Young, S. (2017). Adoptive cell therapy with CD4+ T helper 1 cells and CD8+ cytotoxic T cells enhances complete rejection of an established tumour, leading to generation of endogenous memory responses to non-targeted tumour epitopes. Clinical & Translational Immunology, 6(10), e160. doi: 10.1038/cti.2017.37
Li, K., Baird, M., Yang, J., Jackson, C., Ronchese, F., & Young, S. (2016). Conditions for the generation of cytotoxic CD4+ Th cells that enhance CD8+ CTL-mediated tumor regression. Clinical & Translational Immunology, 5(8), e95. doi: 10.1038/cti.2016.46
Li, K., Peers-Adams, A., Win, S. J., Scullion, S., Wilson, M., Young, V. L., Jennings, P., Ward, V. K., Baird, M. A., & Young, S. L. (2013). Antigen incorporated in virus-like particles is delivered to specific dendritic cell subsets that induce an effective antitumor immune response in vivo. Journal of Immunotherapy, 36(1), 11-19. doi: 10.1097/CJI.0b013e3182787f5e
Tang, R., Li, K., Wilson, M., Both, G. W., Taylor, J. A., & Young, S. L. (2012). Potent antietumor immunity in mice induced by vaccination with an ovine Atadenovirus vector. Journal of Immunotherapy, 35(1), 32-41. doi: 10.1097/CJI.0b013e318238a115