Dr Nadia Mitchell
| Position | Honorary Research Fellow |
|---|---|
| Department | Department of Radiology (Christchurch) |
| Research summary | Batten disease |
Research
Dr Nadia Mitchell is working on a treatment for Batten disease, a fatal inherited childhood neurodegenerative disorder. She leads preclinical gene therapy trials in two naturally occurring sheep models of the disease. Nadia is supervised by Professor Anthony Butler.
Publications
Murray, S. J., Almuqbel, M. M., Felton, S. A., Palmer, N. J., Myall, D. J., Shoorangiz, R., Palmer, D. N., Melzer, T. R., & Mitchell, N. L. (2023). Progressive MRI brain volume changes in ovine models of CLN5 and CLN6 neuronal ceroid lipofuscinosis. Brain Communications. Advance online publication. doi: 10.1093/braincomms/fcac339
Barry, L. A., Kay, G. W., Mitchell, N. L., Murray, S. J., Jay, N. P., & Palmer, D. N. (2022). Aggregation chimeras provide evidence of in vivo intercellular correction in ovine CLN6 neuronal ceroid lipofuscinosis (Batten disease). PLoS ONE, 17(4), e0261544. doi: 10.1371/journal.pone.0261544
Russell, K. N., Mitchell, N. L., Wellby, M. P., Barrell, G. K., & Palmer, D. N. (2021). Electroretinography data from ovine models of CLN5 and CLN6 neuronal ceroid lipofuscinoses [Data article]. Data in Brief, 37, 107188. doi: 10.1016/j.dib.2021.107188
Murray, S. J., Russell, K. N., Melzer, T. R., Gray, S. J., Heap, S. J., Palmer, D. N., & Mitchell, N. L. (2021). Intravitreal gene therapy protects against retinal dysfunction and degeneration in sheep with CLN5 Batten disease. Experimental Eye Research, 207, 108600. doi: 10.1016/j.exer.2021.108600
Ella, A., Barriére, D. A., Adriaensen, H., Palmer, D. N., Melzer, T. R., Mitchell, N. L., & Keller, M. (2019). The development of brain magnetic resonance approaches in large animal models for preclinical research. Animal Frontiers, 9(3), 44-51. doi: 10.1093/af/vfz024
Murray, S. J., Almuqbel, M. M., Felton, S. A., Palmer, N. J., Myall, D. J., Shoorangiz, R., Palmer, D. N., Melzer, T. R., & Mitchell, N. L. (2023). Progressive MRI brain volume changes in ovine models of CLN5 and CLN6 neuronal ceroid lipofuscinosis. Brain Communications. Advance online publication. doi: 10.1093/braincomms/fcac339
Journal - Research Article
Barry, L. A., Kay, G. W., Mitchell, N. L., Murray, S. J., Jay, N. P., & Palmer, D. N. (2022). Aggregation chimeras provide evidence of in vivo intercellular correction in ovine CLN6 neuronal ceroid lipofuscinosis (Batten disease). PLoS ONE, 17(4), e0261544. doi: 10.1371/journal.pone.0261544
Journal - Research Article
Murray, S. J., Russell, K. N., Melzer, T. R., Gray, S. J., Heap, S. J., Palmer, D. N., & Mitchell, N. L. (2021). Intravitreal gene therapy protects against retinal dysfunction and degeneration in sheep with CLN5 Batten disease. Experimental Eye Research, 207, 108600. doi: 10.1016/j.exer.2021.108600
Journal - Research Article
Ella, A., Barriére, D. A., Adriaensen, H., Palmer, D. N., Melzer, T. R., Mitchell, N. L., & Keller, M. (2019). The development of brain magnetic resonance approaches in large animal models for preclinical research. Animal Frontiers, 9(3), 44-51. doi: 10.1093/af/vfz024
Journal - Research Article
Mitchell, N. L., Russell, K. N., Wellby, M. P., Wicky, H. E., Schoderboeck, L., Barrell, G. K., Melzer, T. R., … Hughes, S. M., & Palmer, D. N. (2018). Longitudinal in vivo monitoring of CNS demonstrates the efficacy of gene therapy in a sheep model of CLN5 Batten disease. Molecular Therapy, 26(10), 2366-2378. doi: 10.1016/j.ymthe.2018.07.015
Journal - Research Article
Russell, K. N., Mitchell, N. L., Anderson, N. G., Bunt, C. R., Wellby, M. P., Melzer, T. R., … Palmer, D. N. (2018). Computed tomography provides enhanced techniques for longitudinal monitoring of progressive intracranial volume loss associated with regional neurodegeneration in ovine neuronal ceroid lipofuscinoses. Brain & Behavior, 8, e01096. doi: 10.1002/brb3.1096
Journal - Research Article
Best, H. L., Neverman, N. J., Wicky, H. E., Mitchell, N. L., Leitch, B., & Hughes, S. M. (2017). Characterisation of early changes in ovine CLN5 and CLN6 Batten disease neural cultures for the rapid screening of therapeutics. Neurobiology of Disease, 100, 62-74. doi: 10.1016/j.nbd.2017.01.001
Journal - Research Article
Perentos, N., Martins, A. Q., Cumming, R. J. M., Mitchell, N. L., Palmer, D. N., Sawiak, S. J., & Morton, A. J. (2016). An EEG investigation of sleep homeostasis in healthy and CLN5 Batten disease affected sheep. Journal of Neuroscience, 36(31), 8238-8249. doi: 10.1523/JNEUROSCI.4295-15.2016
Journal - Research Article
Amorim, I. S., Mitchell, N. L., Palmer, D. N., Sawiak, S. J., Mason, R., Wishart, T. M., & Gillingwater, T. H. (2015). Molecular neuropathology of the synapse in sheep with CLN5 Batten disease. Brain & Behavior, 5(11), e00401. doi: 10.1002/brb3.401
Journal - Research Article
Palmer, D. N., Neverman, N. J., Chen, J. Z., Chang, C.-T., Houweling, P. J., Barry, L. A., … Hughes, S. M., & Mitchell, N. L. (2015). Recent studies of ovine neuronal ceroid lipofuscinoses from BARN, the Batten Animal Research Network. Biochimica et Biophysica Acta: Molecular Basis of Disease, 1852(10, Part B), 2279-2286. doi: 10.1016/j.bbadis.2015.06.013
Journal - Research Article
Perentos, N., Martins, A. Q., Watson, T. C., Bartsch, U., Mitchell, N. L., Palmer, D. N., … Morton, A. J. (2015). Translational neurophysiology in sheep: Measuring sleep and neurological dysfunction in CLN5 Batten disease affected sheep. Brain, 138(4), 862-874. doi: 10.1093/brain/awv026
Journal - Research Article
Sawiak, S. J., Perumal, S. R., Rudiger, S. R., Matthews, L., Mitchell, N. L., McLaughlin, C. J., … Palmer, D. N., … Morton, A. J. (2015). Rapid and progressive regional brain atrophy in CLN6 Batten disease affected sheep measured with longitudinal magnetic resonance imaging. PLoS ONE, 10(7), e0132331. doi: 10.1371/journal.pone.0132331
Journal - Research Article
Hughes, S. M., Hope, K. M., Xu, J. B., Mitchell, N. L., & Palmer, D. N. (2014). Inhibition of storage pathology in prenatal CLN5-deficient sheep neural cultures by lentiviral gene therapy. Neurobiology of Disease, 62, 543-550. doi: 10.1016/j.nbd.2013.11.011
Journal - Research Article
Linterman, K. S., Palmer, D. N., Kay, G. W., Barry, L. A., Mitchell, N. L., McFarlane, R. G., Black, M. A., … Hughes, S. M. (2011). Lentiviral-mediated gene transfer to the sheep brain: Implications for gene therapy in Batten disease. Human Gene Therapy, 22(8), 1011-1020. doi: 10.1089/hum.2011.026
Journal - Research Article
Russell, K. N., Mitchell, N. L., Wellby, M. P., Barrell, G. K., & Palmer, D. N. (2021). Electroretinography data from ovine models of CLN5 and CLN6 neuronal ceroid lipofuscinoses [Data article]. Data in Brief, 37, 107188. doi: 10.1016/j.dib.2021.107188
Journal - Research Other
Almuqbel, M. M., Leeper, G., Palmer, D. N., Mitchell, N. L., Russell, K. N., Keenan, R. J., & Melzer, T. (2018). Practical implications of motion correction with motion insensitive radial k-space acquisitions in MRI. British Journal of Radiology, 91(1087), 20170593. doi: 10.1259/bjr.20170593
Journal - Research Other
