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Health Sciences profile

Dr Judith Marsman

PositionPostdoctoral Fellow
DepartmentDepartment of Surgical Sciences (Dunedin)
Research summaryCardiovascular disease genetics

Research

My research is on understanding the mechanism by which genetic variants contribute to cardiovascular diseases. Numerous genetic variants that are associated with a range of cardiovascular diseases have been identified, however, many of these are located in non-coding DNA and have no assignable target gene. I aim to investigate which genes are affected by these genetic variants, and how the variants regulate the expression of these genes.

Publications

Thomas, A. L., Marsman, J., Antony, J., Schierding, W., O'Sullivan, J. M., & Horsfield, J. A. (2021). Transcriptional regulation of RUNX1: An informatics analysis. Gene, 12(8), 1175. doi: 10.3390/genes12081175

Jones, G. T., Marsman, J., Bhat, B., Phillips, V. L., Chatterjee, A., Rodger, E. J., Williams, M. J. A., van Rij, A. M., & McCormick, S. P. A. (2020). DNA methylation profiling identifies a high effect genetic variant for lipoprotein(a) levels. Epigenetics, 15(9), 949-958. doi: 10.1080/15592294.2020.1739797

Marsman, J., Gimenez, G., Day, R. C., Horsfield, J. A., & Jones, G. T. (2020). A non-coding genetic variant associated with abdominal aortic aneurysm alters ERG gene regulation. Human Molecular Genetics, 29(4), 554-565. doi: 10.1093/hmg/ddz256

Jones, G. T., Marsman, J., Pardo, L. M., Nijsten, T., De Maeseneer, M., Phillips, V., Lynch-Sutherland, C., Horsfield, J., Krysa, J., & van Rij, A. M. (2019). A variant of the castor zinc finger 1 (CASZ1) gene is differentially associated with the clinical classification of chronic venous disease. Scientific Reports, 9, 14011. doi: 10.1038/s41598-019-50586-2

Leask, M., Dowdle, A., Salvesen, H., Topless, R., Fadason, T., Wei, W., … Marsman, J., Antony, J., … Merriman, T. R., & Horsfield, J. A. (2019). Functional urate-associated genetic variants influence expression of lincRNAs LINC01229 and MAFTRR. Frontiers in Genetics, 9, 733. doi: 10.3389/fgene.2018.00733

Thomas, A. L., Marsman, J., Antony, J., Schierding, W., O'Sullivan, J. M., & Horsfield, J. A. (2021). Transcriptional regulation of RUNX1: An informatics analysis. Gene, 12(8), 1175. doi: 10.3390/genes12081175

Journal - Research Article

Jones, G. T., Marsman, J., Bhat, B., Phillips, V. L., Chatterjee, A., Rodger, E. J., Williams, M. J. A., van Rij, A. M., & McCormick, S. P. A. (2020). DNA methylation profiling identifies a high effect genetic variant for lipoprotein(a) levels. Epigenetics, 15(9), 949-958. doi: 10.1080/15592294.2020.1739797

Journal - Research Article

Marsman, J., Gimenez, G., Day, R. C., Horsfield, J. A., & Jones, G. T. (2020). A non-coding genetic variant associated with abdominal aortic aneurysm alters ERG gene regulation. Human Molecular Genetics, 29(4), 554-565. doi: 10.1093/hmg/ddz256

Journal - Research Article

Jones, G. T., Marsman, J., Pardo, L. M., Nijsten, T., De Maeseneer, M., Phillips, V., Lynch-Sutherland, C., Horsfield, J., Krysa, J., & van Rij, A. M. (2019). A variant of the castor zinc finger 1 (CASZ1) gene is differentially associated with the clinical classification of chronic venous disease. Scientific Reports, 9, 14011. doi: 10.1038/s41598-019-50586-2

Journal - Research Article

Leask, M., Dowdle, A., Salvesen, H., Topless, R., Fadason, T., Wei, W., … Marsman, J., Antony, J., … Merriman, T. R., & Horsfield, J. A. (2019). Functional urate-associated genetic variants influence expression of lincRNAs LINC01229 and MAFTRR. Frontiers in Genetics, 9, 733. doi: 10.3389/fgene.2018.00733

Journal - Research Article

Marsman, J., Thomas, A., Osato, M., O'Sullivan, J. M., & Horsfield, J. A. (2017). A DNA contact map for the mouse Runx1 gene identifies novel haematopoietic enhancers. Scientific Reports, 7, 13347. doi: 10.1038/s41598-017-13748-8

Journal - Research Article

Voets, E., Marsman, J., Demmers, J., Beijersbergen, R., & Wolthuis, R. (2015). The lethal response to Cdk1 inhibition depends on sister chromatid alignment errors generated by KIF4 and isoform 1 of PRC1. Scientific Reports, 5, 14798. doi: 10.1038/srep14798

Journal - Research Article

Leeke, B., Marsman, J., O'Sullivan, J. M., & Horsfield, J. A. (2014). Cohesin mutations in myeloid malignancies: Underlying mechanisms. Experimental Hematology & Oncology, 3, 13. doi: 10.1186/2162-3619-3-13

Journal - Research Article

Marsman, J., O'Neill, A. C., Kao, B. R.-Y., Rhodes, J. M., Meier, M., Antony, J., Mönnich, M., & Horsfield, J. A. (2014). Cohesin and CTCF differentially regulate spatiotemporal runx1 expression during zebrafish development. Biochimica et Biophysica Acta: Gene Regulatory Mechanisms, 1839(1), 50-61. doi: 10.1016/j.bbagrm.2013.11.007

Journal - Research Article

Marsman, J., & Horsfield, J. A. (2012). Long distance relationships: Enhancer-promoter communication and dynamic gene transcription. Biochimica et Biophysica Acta: Gene Regulatory Mechanisms, 1819(11-12), 1217-1227. doi: 10.1016/j.bbagrm.2012.10.008

Journal - Research Article

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