Contact Details
University Links
- Position
- Postdoctoral Fellow
- Department
- Department of Surgical Sciences (Dunedin)
- Research summary
- Cardiovascular disease genetics
Research
My research is on understanding the mechanism by which genetic variants contribute to cardiovascular diseases. Numerous genetic variants that are associated with a range of cardiovascular diseases have been identified, however, many of these are located in non-coding DNA and have no assignable target gene. I aim to investigate which genes are affected by these genetic variants, and how the variants regulate the expression of these genes.
?Research areas:
?- Gene regulation
- Cardiovascular diseases
- 3D chromatin interactions
- Zebrafish as an animal model ?
Publications
Horsfield, J., & Marsman, J. (Eds.). (2022). Chromatin: Methods and protocols: Methods in molecular biology (Vol. 2458). New York, NY: Springer, 379p. doi: 10.1007/978-1-0716-2140-0
Marsman, J., Day, R. C., & Gimenez, G. (2022). Circular chromosome conformation capture sequencing (4C-Seq ) in primary adherent cells. In J. Horsfield & J. Marsman (Eds.), Chromatin: Methods and protocols: Methods in molecular biology (Vol. 2458). (pp. 301-320). New York, NY: Springer. doi: 10.1007/978-1-0716-2140-0_16
Thomas, A. L., Marsman, J., Antony, J., Schierding, W., O'Sullivan, J. M., & Horsfield, J. A. (2021). Transcriptional regulation of RUNX1: An informatics analysis. Gene, 12(8), 1175. doi: 10.3390/genes12081175
Jones, G. T., Marsman, J., Bhat, B., Phillips, V. L., Chatterjee, A., Rodger, E. J., Williams, M. J. A., van Rij, A. M., & McCormick, S. P. A. (2020). DNA methylation profiling identifies a high effect genetic variant for lipoprotein(a) levels. Epigenetics, 15(9), 949-958. doi: 10.1080/15592294.2020.1739797
Marsman, J., Gimenez, G., Day, R. C., Horsfield, J. A., & Jones, G. T. (2020). A non-coding genetic variant associated with abdominal aortic aneurysm alters ERG gene regulation. Human Molecular Genetics, 29(4), 554-565. doi: 10.1093/hmg/ddz256
Horsfield, J., & Marsman, J. (Eds.). (2022). Chromatin: Methods and protocols: Methods in molecular biology (Vol. 2458). New York, NY: Springer, 379p. doi: 10.1007/978-1-0716-2140-0
Edited Book - Research
Marsman, J., Day, R. C., & Gimenez, G. (2022). Circular chromosome conformation capture sequencing (4C-Seq ) in primary adherent cells. In J. Horsfield & J. Marsman (Eds.), Chromatin: Methods and protocols: Methods in molecular biology (Vol. 2458). (pp. 301-320). New York, NY: Springer. doi: 10.1007/978-1-0716-2140-0_16
Chapter in Book - Research
Thomas, A. L., Marsman, J., Antony, J., Schierding, W., O'Sullivan, J. M., & Horsfield, J. A. (2021). Transcriptional regulation of RUNX1: An informatics analysis. Gene, 12(8), 1175. doi: 10.3390/genes12081175
Journal - Research Article
Jones, G. T., Marsman, J., Bhat, B., Phillips, V. L., Chatterjee, A., Rodger, E. J., Williams, M. J. A., van Rij, A. M., & McCormick, S. P. A. (2020). DNA methylation profiling identifies a high effect genetic variant for lipoprotein(a) levels. Epigenetics, 15(9), 949-958. doi: 10.1080/15592294.2020.1739797
Journal - Research Article
Marsman, J., Gimenez, G., Day, R. C., Horsfield, J. A., & Jones, G. T. (2020). A non-coding genetic variant associated with abdominal aortic aneurysm alters ERG gene regulation. Human Molecular Genetics, 29(4), 554-565. doi: 10.1093/hmg/ddz256
Journal - Research Article
Jones, G. T., Marsman, J., Pardo, L. M., Nijsten, T., De Maeseneer, M., Phillips, V., Lynch-Sutherland, C., Horsfield, J., Krysa, J., & van Rij, A. M. (2019). A variant of the castor zinc finger 1 (CASZ1) gene is differentially associated with the clinical classification of chronic venous disease. Scientific Reports, 9, 14011. doi: 10.1038/s41598-019-50586-2
Journal - Research Article
Leask, M., Dowdle, A., Salvesen, H., Topless, R., Fadason, T., Wei, W., … Marsman, J., Antony, J., … Merriman, T. R., & Horsfield, J. A. (2019). Functional urate-associated genetic variants influence expression of lincRNAs LINC01229 and MAFTRR. Frontiers in Genetics, 9, 733. doi: 10.3389/fgene.2018.00733
Journal - Research Article
Marsman, J., Thomas, A., Osato, M., O'Sullivan, J. M., & Horsfield, J. A. (2017). A DNA contact map for the mouse Runx1 gene identifies novel haematopoietic enhancers. Scientific Reports, 7, 13347. doi: 10.1038/s41598-017-13748-8
Journal - Research Article
Voets, E., Marsman, J., Demmers, J., Beijersbergen, R., & Wolthuis, R. (2015). The lethal response to Cdk1 inhibition depends on sister chromatid alignment errors generated by KIF4 and isoform 1 of PRC1. Scientific Reports, 5, 14798. doi: 10.1038/srep14798
Journal - Research Article
Leeke, B., Marsman, J., O'Sullivan, J. M., & Horsfield, J. A. (2014). Cohesin mutations in myeloid malignancies: Underlying mechanisms. Experimental Hematology & Oncology, 3, 13. doi: 10.1186/2162-3619-3-13
Journal - Research Article
Marsman, J., O'Neill, A. C., Kao, B. R.-Y., Rhodes, J. M., Meier, M., Antony, J., Mönnich, M., & Horsfield, J. A. (2014). Cohesin and CTCF differentially regulate spatiotemporal runx1 expression during zebrafish development. Biochimica et Biophysica Acta: Gene Regulatory Mechanisms, 1839(1), 50-61. doi: 10.1016/j.bbagrm.2013.11.007
Journal - Research Article
Marsman, J., & Horsfield, J. A. (2012). Long distance relationships: Enhancer-promoter communication and dynamic gene transcription. Biochimica et Biophysica Acta: Gene Regulatory Mechanisms, 1819(11-12), 1217-1227. doi: 10.1016/j.bbagrm.2012.10.008
Journal - Research Article