Associate Professor Philip Sheard

Sayer, R. J., Bray, J. J., Mills, R. G., & Sheard, P. W. (1999). Introduction to the Nervous System. In J. J. Bray, P. A. Cragg, A. D. C. Macknight & R. G. Mills (Eds.), Lecture Notes on Human Physiology. (pp. 39-64). London: Blackwell Science.

Chapter in Book - Research

Lal, N. N., Cornwall, J., & Sheard, P. W. (2023). Use of a novel technique to assess impact of age-related denervation on mouse soleus muscle function. Biogerontology. Advance online publication. doi: 10.1007/s10522-023-10021-6

Journal - Research Article

Peeters, W. M., Gram, M., Dias, G. J., Vissers, M. C. M., Hampton, M. B., Dickerhof, N., Bekhit, A. E., … Bayer, S., … Sheard, P. W., Danielson, K. M., … Cornwall, J., & Rowlands, D. S. (2023). Changes to insulin sensitivity in glucose clearance systems and redox following dietary supplementation with a novel cysteine-rich protein: A pilot randomized controlled trial in humans with type-2 diabetes. Redox Biology, 67, 102918. doi: 10.1016/j.redox.2023.102918

Journal - Research Article

Redmond, A. K., Davies, T. M., Schofield, M. R., & Sheard, P. W. (2023). New tools for the investigation of muscle fiber-type spatial distributions across histological sections. Skeletal Muscle, 13, 7. doi: 10.1186/s13395-023-00316-0

Journal - Research Article

Lal, N. N., Cornwall, J., & Sheard, P. W. (2021). Age-related structural changes show that loss of fibers is not a significant contributor to muscle atrophy in old mice. Experimental Gerontology, 156, 111618. doi: 10.1016/j.exger.2021.111618

Journal - Research Article

Gillon, A., Steel, C., Cornwall, J., & Sheard, P. (2020). Increased nuclear permeability is a driver for age-related motoneuron loss. GeroScience, 42, 833-847. doi: 10.1007/s11357-020-00155-7

Journal - Research Article

Davies, T. M., Schofield, M. R., Cornwall, J., & Sheard, P. W. (2019). Modelling multilevel spatial behaviour in binary-mark muscle fibre configurations. Annals of Applied Statistics, 13(3), 1329-1347. doi: 10.1214/18-AOAS1214

Journal - Research Article

Gillon, A., Nielsen, K., Steel, C., Cornwall, J., & Sheard, P. (2018). Exercise attenuates age-associated changes in motoneuron number, nucleocytoplasmic transport proteins and neuromuscular health. GeroScience, 40, 177-192. doi: 10.1007/s11357-018-0020-4

Journal - Research Article

Nielsen, K. B., Lal, N. N., & Sheard, P. W. (2018). Age-related remodelling of the myotendinous junction in the mouse soleus muscle. Experimental Gerontology, 104, 52-59. doi: 10.1016/j.exger.2018.01.021

Journal - Research Article

Tan, C. L., Sheard, P. W., & Jasoni, C. L. (2018). Developing neurites from mouse basal forebrain gonadotropin-releasing hormone neurons use Sonic hedgehog to modulate their growth. International Journal of Developmental Neuroscience, 68, 89-97. doi: 10.1016/j.ijdevneu.2018.05.005

Journal - Research Article

Hennebry, A., Oldham, J., Shavlakadze, T., Grounds, M. D., Sheard, P., Fiorotto, M. L., … McMahon, C. D. (2017). IGF1 stimulates greater muscle hypertrophy in the absence of myostatin in male mice. Journal of Endocrinology, 234(2), 187-200. doi: 10.1530/joe-17-0032

Journal - Research Article

Cornwall, J., Farrell, S. F., & Sheard, P. W. (2016). Fibre types of human suboccipital muscles. European Journal of Anatomy, 20(1), 31-36.

Journal - Research Article

White, Z., Terrill, J., White, R. B., McMahon, C., Sheard, P., Grounds, M. D., & Shavlakadze, T. (2016). Voluntary resistance wheel exercise from mid-life prevents sarcopenia and increases markers of mitochondrial function and autophagy in muscles of old male and female C57BL/6J mice. Skeletal Muscle, 6(1), 45. doi: 10.1186/s13395-016-0117-3

Journal - Research Article

Gillon, A., & Sheard, P. (2015). Elderly mouse skeletal muscle fibres have a diminished capacity to upregulate NCAM production in response to denervation. Biogerontology, 16(6), 811-823. doi: 10.1007/s10522-015-9608-6

Journal - Research Article

Lal, N., & Sheard, P. (2015). Dying myofibers in elderly mouse skeletal muscles are characterized by the appearance of dystrophin-encircled vacuoles. Biogerontology, 16, 443-459. doi: 10.1007/s10522-015-9565-0

Journal - Research Article

Thaung, H. P. A., Baldi, J. C., Wang, H.-Y., Hughes, G., Cook, R. F., Bussey, C. T., Sheard, P. W., Bahn, A., Jones, P. P., Schwenke, D. O., & Lamberts, R. R. (2015). Increased efferent cardiac sympathetic nerve activity and defective intrinsic heart rate regulation in type 2 diabetes. Diabetes, 64(8), 2944-2956. doi: 10.2337/db14-0955

Journal - Research Article

Hellyer, S. D., Selwood, A. I., van Ginkel, R., Munday, R., Sheard, P., Miles, C. O., … Kerr, D. S. (2014). In vitro labelling of muscle type nicotinic receptors using a fluorophore-conjugated pinnatoxin F derivative. Toxicon, 87, 17-25. doi: 10.1016/j.toxicon.2014.05.013

Journal - Research Article

McMahon, C. D., Chai, R., Radley-Crabb, H. G., Watson, T., Matthews, K. G., Sheard, P. W., … Shavlakadze, T. (2014). Lifelong exercise and locally produced insulin-like growth factor-1 (IGF-1) have a modest influence on reducing age-related muscle wasting in mice. Scandinavian Journal of Medicine & Science in Sports, 24(6), e423-e435. doi: 10.1111/sms.12200

Journal - Research Article

Rowlands, D. S., Page, R. A., Sukala, W. R., Giri, M., Ghimbovschi, S. D., Hayat, I., … Leikis, M., Sheard, P. W., Wakefield, St. J., … Krebs, J., … Hoffman, E. P. (2014). Multi-omic integrated networks connect DNA methylation and miRNA with skeletal muscle plasticity to chronic exercise in Type 2 diabetic obesity. Physiological Genomics, 46(20), 747-765. doi: 10.1152/physiolgenomics.00024.2014

Journal - Research Article

Davies, T. M., Cornwall, J., & Sheard, P. W. (2013). Modelling dichotomously marked muscle fibre configurations. Statistics in Medicine, 32(24), 4240-4258. doi: 10.1002/sim.5806

Journal - Research Article

Sheard, P. W., & Anderson, R. D. (2012). Age-related loss of muscle fibres is highly variable amongst mouse skeletal muscles. Biogerontology, 13(2), 157-167. doi: 10.1007/s10522-011-9365-0

Journal - Research Article

Sheard, P. W., Bewick, G. S., Woolley, A. G., Shaw, J., Fisher, L., Fong, S. W., & Duxson, M. J. (2010). Investigation of neuromuscular abnormalities in neurotrophin-3-deficient mice. European Journal of Neuroscience, 31(1), 29-41. doi: 10.1111/j.1460-9568.2009.07032.x

Journal - Research Article

Woolley, A. G., Tait, K. J., Hurren, B. J., Fisher, L., Sheard, P. W., & Duxson, M. J. (2008). Developmental loss of NT-3 in vivo results in reduced levels of myelin-specific proteins, a reduced extent of myelination and increased apoptosis of Schwann cells. GLIA, 56(3), 306-317. doi: 10.1002/glia.20614

Journal - Research Article

Li, C., Stanton, J.-A. L., Robertson, T. M., Suttie, J. M., Sheard, P. W., Harris, A. J., & Clark, D. E. (2007). Nerve growth factor mRNA expression in the regenerating antler tip of red deer (Cervus elaphus). PLoS ONE, 2(1), e148. Retrieved from http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0000148

Journal - Research Article

Homer, C., Knight, D. A., Hananeia, L., Sheard, P., Risk, J., Lasham, A., Royds, J. A., & Braithwaite, A. W. (2005). Y-box factor YB1 controls p53 apoptotic function. Oncogene, 24, 8314-8325. Retrieved from http://www.nature.com/onc/journal/v24/n56/abs/1208998a.html

Journal - Research Article

Sun, C.-K., Zhang, X.-Y., Sheard, P. W., Mabuchi, A., & Wheatley, A. M. (2005). Change in mitochondrial membrane potential is the key mechanism in early warm hepatic ischemia-reperfusion injury. Microvascular Research, 70, 102-110.

Journal - Research Article

Woolley, A. G., Sheard, P. W., & Duxson, M. J. (2005). Neurotrophin-3 null mutant mice display a postnatal motor neuropathy. European Journal of Neuroscience, 21, 2100-2110.

Journal - Research Article

Mabuchi, A., Mullaney, I., Sheard, P. W., Hessian, P. A., Mallard, B. L., Tawadrous, M. N., … Wheatley, A. M. (2004). Role of hepatic stellate cell/hepatocyte interaction and activation of hepatic stellate cells in the early phase of liver regeneration in the rat. Journal of Hepatology, 40, 910-916.

Journal - Research Article

Mabuchi, A., Mullaney, I., Sheard, P., Hessian, P., Zimmermann, A., Senoo, H., & Wheatley, A. M. (2004). Role of hepatic stellate cells in the early phase of liver regeneration in rat: Formation of tight adhesion to parenchymal cells. Comparative Hepatology, 3(Suppl. 1), S29.

Journal - Research Article

Paul, A. C., Sheard, P. W., & Duxson, M. J. (2004). Development of a mammalian series-fibered muscle. Anatomical Record Part A, 278A, 571-578. doi: 10.1002/ar.a.20020

Journal - Research Article

Maclennan, K. M., Zheng, Y., Sheard, P. W., Williams, S. M., Darlington, C. L., & Smith, P. F. (2003). Adrenalectomy-induced cell death in the dentate gyrus: Further characterisation using TUNEL and effects of the Ginkgo biloba extract, EGb 761 and ginkgolide B. Hippocampus, 13, 212-225.

Journal - Research Article

Zhang, Y.-F., Homer, C., Edwards, S. J., Hananeia, L., Lasham, A., Royds, J., Sheard, P., & Braithwaite, A. W. (2003). Nuclear localization of Y-box factor YB1 requires wild-type p53. Oncogene, 22, 2782-2794. doi: 10.1038/sj.onc.1206357

Journal - Research Article

Paul, A. C., Sheard, P. W., Kaufman, S. J., & Duxson, M. J. (2002). Localization of α7 integrins and dystrophin suggests potential for both lateral and longitudinal transmission of tension in large mammalian muscles. Cell & Tissue Research, 308, 255-265.

Journal - Research Article

Sheard, P. W., Musaad, K., & Duxson, M. J. (2002). Distribution of neurotrophin receptors in the mouse neuromuscular system. International Journal of Developmental Biology, 46, 569-575.

Journal - Research Article

Sheard, P. W., Paul, A., & Duxson, M. J. (2002). Intramuscular force transmission. Advances in Experimental Medicine & Biology, 508, 495-499.

Journal - Research Article

Scarlett, J. L., Sheard, P. W., Hughes, G., Ledgerwood, E. C., Ku, H.-H., & Murphy, M. P. (2000). Changes in mitochondrial membrane potential during staurosporine-induced apoptosis in Jurkat cells. FEBS Letters, 475, 267-272.

Journal - Research Article

Sheard, P. W. (2000). Tension delivery from short fibers in long muscles. Exercise & Sport Sciences Reviews, 28(2), 51-56.

Journal - Research Article

Young, M., Paul, A., Rodda, J., Duxson, M. J., & Sheard, P. W. (2000). Examination of intrafascicular muscle fiber terminations: Implications for tension delivery in series-fibered muscles. Journal of Morphology, 245, 130-145.

Journal - Research Article

James, A. M., Sheard, P. W., Wei, Y.-H., & Murphy, M. P. (1999). Decreased ATP synthesis is phenotypically expressed during increased energy demand in fibroblasts containing mitochondrial tRNA mutations: Implications for neurodegenerative and mitochondrial DNA diseases. European Journal of Biochemistry, 259, 462-469.

Journal - Research Article

Sheard, P. W., McHannigan, P., & Duxson, M. J. (1999). Single and paired motor unit performance in skeletal muscles: Comparison between simple and series-fibred muscles from the rat and the guinea pig. Basic & Applied Myology, 9(2), 79-87.

Journal - Research Article

Woolley, A., Sheard, P. W., Dodds, K. G., & Duxson, M. J. (1999). Alpha motoneurons are present in normal numbers but with reduced soma size in neurotrophin-3 knockout mice. Neuroscience Letters, 272, 107-110.

Journal - Research Article

Porteous, W. K., James, A. M., Sheard, P. W., Porteous, C., Packer, M., Hyslop, S. J., Melton, J. V., … Murphy, M. P. (1998). Bioenergetic consequences of accumulating the common 4977-bp mitochondrial DNA deletion. European Journal of Biochemistry, 257, 192-201.

Journal - Research Article

Beazley, L. D., Sheard, P. W., Tennant, M., Starac, D., & Dunlop, S. A. (1997). Optic nerve regenerates but does not restore topographic projections in the lizard Ctenophorus ornatus. Journal of Comparative Neurology, 377(1), 105-120.

Journal - Research Article

Sheard, P. W., & Duxson, M. J. (1997). The transient existence of "en passant" nerve terminals in normal embryonic rat skeletal muscle. Developmental Brain Research, 98(2), 259-264. doi: 10.1016/S0165-3806(96)00184-8

Journal - Research Article

Sheard, P. W., Oettli, H. E., Johnson, A. J., & Duxson, M. J. (1997). Variations in oxidative enzyme type profiles among prenatal rat lumbar motoneurons. Developmental Brain Research, 103(1), 67-75. doi: 10.1016/S0165-3806(97)00118-1

Journal - Research Article

Sheard, P. W., & Duxson, M. J. (1996). Composition of newly forming motor units in prenatal rat intercostal muscle. Developmental Dynamics, 205, 196-212.

Journal - Research Article

Duxson, M. J., & Sheard, P. W. (1995). Formation of new myotubes occurs exclusively at the multiple innervation zones of an embryonic large muscle. Developmental Dynamics, 204, 391-405.

Journal - Research Article