Associate Professor Beulah Leitch

Contact Details

Phone: 64 3 479 7618
Email: beulah.leitch@otago.ac.nz

University Links

Position

Associate Professor and Director Neuroscience Programme

Department

Department of Anatomy

Qualifications

BSc(Hons) PhD

Research summary

Cellular and molecular neuroscience; neurological disorders

Memberships

2010–present – The Royal Society of New Zealand (MRSNZ)
2007–present – The International Brain Research Organization (IBRO)
1995–present – The Society for Neuroscience USA (SFN)
2007–present – The Federation of European Neuroscience Societies (FENS)
2008–present – The British Neuroscience Association (BNA)
2008–present – The Australian Neuroscience Society (ANS)
2007–present – The Brain Health Research Centre University of Otago (BHRC)
2009–present – The Society for Neuroscience, SFN Otago Chapter

Research

Associate Professor Leitch's research interests are in cellular and molecular neuroscience and focus on the structural and functional development of neurons and their synapses; also changes occurring at synapses during aging and in various brain disorders. Her group is particularly interested in changes that occur at synapses in relation to their synaptic proteins and receptors, as a result of genetic mutations, and how this relates to brain functional abnormalities and diseases, including epilepsy, schizophrenia, autism and ataxia.

A recent focus of the Leitch lab has been into the detection of newly synthesized proteins at synapses and in dendritic locations using high-resolution EM-immunogold techniques. This project is in collaboration with Professor Schuman's Lab, at the Max Planck Institute for Brain Research (MPI-BR), Frankfurt, Germany. The project is based on the novel FUNCAT-PLA and Puro-PLA techniques recently developed in the Schuman laboratory for labelling newly synthesised proteins in cultured neurons. This research will lay the groundwork for studying whether defects in local protein synthesis contributes to synaptic dysfunction underlying various brain disorders such as Alzheimer's disease.

Publications

Hassan, M., Grattan, D. R., & Leitch, B. (2023). Developmental inhibitory changes in the primary somatosensory cortex of the stargazer mouse model of absence epilepsy. Biomolecules, 13, 186. doi: 10.3390/biom13010186 Journal - Research Article

Hassan, M., Adotevi, N. K., & Leitch, B. (2022). Altered GABA_A receptor expression in the primary somatosensory cortex of a mouse model of genetic absence epilepsy. International Journal of Molecular Sciences, 23, 15685. doi: 10.3390/ijms232415685 Journal - Research Article

Leitch, B. (2022). The impact of glutamatergic synapse dysfunction in the corticothalamocortical network on absence seizure generation [Review]. Frontiers in Molecular Neuroscience, 15, 836255. doi: 10.3389/fnmol.2022.836255 Journal - Research Article

Panthi, S., & Leitch, B. (2021). Chemogenetic activation of corticothalamocortical feedforward inhibitory parvalbumin expressing interneurons during absence seizures: An EEG study. Epilepsia, 62(Suppl. 3), (pp. 85-86). doi: 10.1111/epi.17079 Conference Contribution - Published proceedings: Abstract

Panthi, S., Lyons, N. M. A., & Leitch, B. (2021). Impact of dysfunctional feed-forward inhibition on glutamate decarboxylase isoforms and γ-aminobutyric acid transporters. International Journal of Molecular Sciences, 22(14), 7740. doi: 10.3390/ijms22147740 Journal - Research Article

2023

Journal - Research Article

2022

Journal - Research Article

2021

Journal - Research Article

Panthi, S., & Leitch, B. (2021). Chemogenetic activation of feed-forward inhibitory Parvalbumin-expressing interneurons in the cortico-thalamocortical network during absence seizures. Frontiers in Cellular Neuroscience, 15, 688905. doi: 10.3389/fncel.2021.688905

Adotevi, N., Su, A., Peiris, D., Hassan, M., & Leitch, B. (2021). Altered neurotransmitter expression in the corticothalamocortical network of an absence epilepsy model with impaired feedforward inhibition. Neuroscience, 467, 73-80. doi: 10.1016/j.neuroscience.2021.05.024

Conference Contribution - Published proceedings: Abstract

Lyons, N., Panthi, S., & Leitch, B. (2021). Upregulation of GAD65 in somatosensory cortex of stargazer absence epileptic mice. New Zealand Medical Journal, 134(1537), (pp. 118). Retrieved from https://www.nzma.org.nz/journal

Panthi, S., & Leitch, B. (2021). An investigation into dysfunctional feed-forward inhibition within the cortico-thalamocortical network on absence seizure generation. New Zealand Medical Journal, 134(1537), (pp. 110-111). Retrieved from https://www.nzma.org.nz/journal

2019

Journal - Research Article

Panthi, S., & Leitch, B. (2019). The impact of silencing feed-forward parvalbumin-expressing inhibitory interneurons in the cortico-thalamocortical network on seizure generation and behaviour. Neurobiology of Disease, 132, 104610. doi: 10.1016/j.nbd.2019.104610

Hafner, A.-S., Donlin-Asp, P. G., Leitch, B., Herzog, E., & Schuman, E. M. (2019). Local protein synthesis is a ubiquitous feature of neuronal pre- and postsynaptic compartments. Science, 364(6441), eaau3644. doi: 10.1126/science.aau3644

Adotevi, N. K., & Leitch, B. (2019). Cortical expression of AMPA receptors during postnatal development in a genetic model of absence epilepsy. International Journal of Developmental Neuroscience, 73, 19-25. doi: 10.1016/j.ijdevneu.2018.12.006

Conference Contribution - Published proceedings: Abstract

Leitch, B., & Adotevi, N. (2019). Development of dysfunctional feed-forward inhibition in the thalamo-cortical network of a mouse model of absence epilepsy. Brain & Neuroscience Advances, 3, PS015. doi: 10.1177/2398212819855490

Panthi, S., & Leitch, B. (2019). Using DREADD technology to interrogate dysfunctional feed-foward inhibition within cortico-thalamo-cortical microcircuits to investigate absence seizure generation and altered behaviour. Proceedings of the 39th Australasian Neuroscience Society (ANS) Annual Scientific Meeting. 11562. Retrieved from https://www.ans.org.au

Leitch, B., & Panthi, S. (2019). The impact of loss of feed-forward inhibition in the thalamo-cortical network of a mouse model of absence epilepsy. Epilepsia, 60(Suppl. 2), (pp. 45). doi: 10.1111/epi.16336

2018

Conference Contribution - Published proceedings: Abstract

Hassan, M., Adotevi, N. K., & Leitch, B. (2018). GABAergic changes in the somatosensory cortext of the stargazer mouse model of absence epilepsy. Proceedings of the 38th Australasian Neuroscience Society (ANS) Annual Scientific Meeting. 9316. Retrieved from https://www.ans.org.au

Panthi, S., & Leitch, B. (2018). Investigating mechanisms underlying absence epilepsy using DREADD technology to silence microcircuits within the cortico-thalamic-cortical network. Proceedings of the Society for Neuroscience 48th Annual Meeting. 039.21/F7. SfN. Retrieved from https://www.sfn.org/

2017

Journal - Research Article

Adotevi, N. K., & Leitch, B. (2017). Synaptic changes in AMPA receptor subunit expression in cortical parvalbumin interneurons in the stargazer model of absence epilepsy. Frontiers in Molecular Neuroscience, 10, 434. doi: 10.3389/fnmol.2017.00434

Seo, S., & Leitch, B. (2017). Postnatal expression of thalamic GABA_A receptor subunits in the stargazer mouse model of absence epilepsy. NeuroReport, 28(18), 1255-1260. doi: 10.1097/wnr.0000000000000909

Barad, Z., Grattan, D. R., & Leitch, B. (2017). NMDA receptor expression in the thalamus of the stargazer model of absence epilepsy. Scientific Reports, 7, 42926. doi: 10.1038/srep42926

Best, H. L., Neverman, N. J., Wicky, H. E., Mitchell, N. L., Leitch, B., & Hughes, S. M. (2017). Characterisation of early changes in ovine CLN5 and CLN6 Batten disease neural cultures for the rapid screening of therapeutics. Neurobiology of Disease, 100, 62-74. doi: 10.1016/j.nbd.2017.01.001

Conference Contribution - Published proceedings: Abstract

Adotevi, N. K., & Leitch, B. (2017). Changes in synaptic expression of glutamatergic AMPA receptors in cortical inhibitory interneurons in a mouse model of absence epilepsy. Epilepsia, 58(Suppl. 5), (pp. S25-S26). doi: 10.1111/epi.13944

Conference Contribution - Edited volume of conference proceedings

Leitch, B. (Ed.). (2017). Proceedings of the 35th International Australasian Winter Conference on Brain Research. AWCBR. 68p. Retrieved from http://www.otago.ac.nz/awcbr/index.html

2016

Chapter in Book - Research

Lee, K., Goodman, L., Fourie, C., Schenk, S., Leitch, B., & Montgomery, J. M. (2016). AMPA receptors as therapeutic targets for neurological disorders. In R. Donev (Ed.), Advances in Protein Chemistry & Structural Biology (Vol. 103). (pp. 203-261). Elsevier. doi: 10.1016/bs.apcsb.2015.10.004

Journal - Research Article

Adotevi, N. K., & Leitch, B. (2016). Alterations in AMPA receptor subunit expression in cortical inhibitory interneurons in the epileptic stargazer mutant mouse. Neuroscience, 339, 124-138. doi: 10.1016/j.neuroscience.2016.09.052

Jing, Y., Liu, P., & Leitch, B. (2016). Region-specific changes in presynaptic agmatine and glutamate levels in the aged rat brain. Neuroscience, 312, 10-18. doi: 10.1016/j.neuroscience.2015.11.002

Conference Contribution - Published proceedings: Abstract

Adotevi, N. K., & Leitch, B. (2016). Altered AMPA receptor expression in cortical inhibitory interneurons of the epileptic stargazer mutant mouse. Proceedings of the Australasian Neuroscience Society (ANS) Annual Scientific Meeting. Retrieved from https://www.ans.org.au

Conference Contribution - Edited volume of conference proceedings

Leitch, B. (Ed.). (2016). Proceedings of the 34th International Australasian Winter Conference on Brain Research. AWCBR. 74p. Retrieved from http://www.otago.ac.nz/awcbr

2015

Journal - Research Article

Seo, S., & Leitch, B. (2015). Synaptic changes in GABA_A receptor expression in the thalamus of the Stargazer mouse model of absence epilepsy. Neuroscience, 306, 28-38. doi: 10.1016/j.neuroscience.2015.08.021

Conference Contribution - Edited volume of conference proceedings

Leitch, B. (Ed.). (2015). Proceedings of the 33rd International Australasian Winter Conference on Brain Research. AWCBR. 77p. Retrieved from http://www.otago.ac.nz/awcbr

2014

Journal - Research Article

Seo, S., & Leitch, B. (2014). Altered thalamic GABA_A -receptor subunit expression in the stargazer mouse model of absence epilepsy. Epilepsia, 55(2), 224-232. doi: 10.1111/epi.12500

Trotman, M., Barad, Z., Guévremont, D., Williams, J., & Leitch, B. (2014). Changes in the GRIP 1&2 scaffolding proteins in the cerebellum of the ataxic stargazer mouse. Brain Research, 1546, 53-62. doi: 10.1016/j.brainres.2013.12.027

Conference Contribution - Published proceedings: Abstract

Barad, Z., & Leitch, B. (2014). Altered NMDAR subunit composition in the thalamus of a mouse model of absence epilepsy. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 32nd International Australasian Winter Conference on Brain Research. 32, (pp. 68). AWCBR. Retrieved from https://web.psy.otago.ac.nz/awcbr/proceedings.html

Adotevi, N., & Leitch, B. (2014). Cortical changes in AMPA receptor expression in the stargazer mouse model of absence epilepsy. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 32nd International Australasian Winter Conference on Brain Research. 32, (pp. 67). AWCBR. Retrieved from https://web.psy.otago.ac.nz/awcbr/proceedings.html

Seo, S., & Leitch, B. (2014). Region-specific changes in GABA_AR subunits in the thalamus of an animal model of absence epilepsy. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 32nd International Australasian Winter Conference on Brain Research. 32, (pp. 30). AWCBR. Retrieved from https://web.psy.otago.ac.nz/awcbr/proceedings.html

Conference Contribution - Edited volume of conference proceedings

Leitch, B., & Shemmell, J. (Eds.). (2014). Proceedings of the 32nd International Australasian Winter Conference on Brain Research, 32. AWCBR. 86p. Retrieved from https://web.psy.otago.ac.nz/awcbr/proceedings.html

2013

Conference Contribution - Published proceedings: Abstract

Trotman, M., Barad, Z., & Leitch, B. (2013). GRIP-ping changes in synaptic protein interactions in Stargazers. Proceedings of the Australasian Neuroscience Society (ANS) Annual Meeting. (pp. 145). Retrieved from http://www.ans.org.au/

Seo, S., Barad, Z., & Leitch, B. (2013). Alteration of GABA-A receptor status subunits expression within the thalamus of Stargazer mouse model of absence epilepsy. Proceedings of the Australasian Neuroscience Society (ANS) Annual Meeting. (pp. 144). Retrieved from http://www.ans.org.au/

Seo, S., & Leitch, B. (2013). Altered GABAA receptor subunit expression at thalamocortical synapses in an animal model of absence epilepsy. Journal of the Neurological Sciences, 333(Suppl. 1), (pp. e33-e34). doi: 10.1016/j.jns.2013.07.125

Leitch, B., Shevtsova, O., & Arbuthnott, G. (2013). Absence seizures arising from a mutation that causes selective loss of AMPA receptors within thalamocortical networks. Journal of the Neurological Sciences, 333(Suppl. 1), (pp. e51). doi: 10.1016/j.jns.2013.07.183

Conference Contribution - Edited volume of conference proceedings

Leitch, B., & Shemmell, J. (Eds.). (2013). Proceedings of the 31st International Australasian Winter Conference on Brain Research, 31. AWCBR. 80p. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2013copy.html

Conference Contribution - Poster Presentation (not in published proceedings)

Trotman, M., Barad, Z., & Leitch, B. (2013, September). GRIPping changes in synaptic protein interactions in Stargazer mutants. Poster session presented at the Division of Health Sciences Research Forum: Foundations for Health: Otago Health Research, Christchurch, New Zealand.

2012

Journal - Research Article

Barad, Z., Shevtsova, O., Arbuthnott, G. W., & Leitch, B. (2012). Selective loss of AMPA receptors at corticothalamic synapses in the epileptic stargazer mouse. Neuroscience, 217, 19-31. doi: 10.1016/j.neuroscience.2012.05.011

Shevtsova, O., & Leitch, B. (2012). Selective loss of AMPA receptor subunits at inhibitory neuron synapses in the cerebellum of the ataxic stargazer mouse. Brain Research, 1427, 54-64. doi: 10.1016/j.brainres.2011.10.022

Conference Contribution - Published proceedings: Abstract

Leitch, B., Trotman, M., Barad, Z., Guevremont, D., & Williams, J. (2012). Changes in GRIP expression at cerebellar synapses in the ataxic Stargazer mutant mouse. FENS Abstracts. 7, 011.06. Retrieved from http://fens2012.meetingxpert.net/FENS_331/poster_31521/program.aspx/anchor385

Barad, Z., Shevtsova, O., Arbuthnott, G., & Leitch, B. (2012). Selective loss of AMPA receptor subunits in the reticular thalamic nucleus of the epileptic stargazer mouse. Proceedings of the Australian Neuroscience Society (ANS) Annual Scientific Meeting. (pp. 96). Retrieved from http://www.ans.org.au/ans-annual-conference/

Conference Contribution - Edited volume of conference proceedings

Leitch, B., & Shemmell, J. (Eds.). (2012). Proceedings of the 30th International Australasian Winter Conference on Brain Research, 30. AWCBR. 78p. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2012.html

Conference Contribution - Poster Presentation (not in published proceedings)

Trotman, M., Barad, Z., & Leitch, B. (2012, September). Gripping changes in synaptic protein interactions in stargazer mutants. Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.

2011

Journal - Research Article

Seo, S., Liu, P., & Leitch, B. (2011). Spatial learning-induced accumulation of agmatine and glutamate at hippocampal CA1 synaptic terminals. Neuroscience, 129, 28-36. doi: 10.1016/j.neuroscience.2011.07.007

Leitch, B., Shevtsova, O., Reusck, K., Bergin, D. H., & Liu, P. (2011). Spatial learning-induced increase in agmatine levels at hippocampal CA1 synapses. Synapse, 65(2), 146-153. doi: 10.1002/syn.20828

Conference Contribution - Published proceedings: Abstract

Jing, Y., Liu, P., & Leitch, B. (2011). Regional specific changes of agmatine level in the presynaptic terminals in the aged rat brain. In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 5.8. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html

Shevtsova, O., & Leitch, B. (2011). Selective loss of AMPA receptor subunits at cerebellar synapses in the stargazer mouse. Proceedings of the Australian Neuroscience Society (ANS) Annual Scientific Meeting. (pp. 135). Retrieved from http://www.ans.org.au/uploads/documents/2011%20Docs/conference%20abstracts/ANS%202011%20Poster%20Abstracts.pdf

Seo, S., Liu, P., & Leitch, B. (2011). Learning-induced changes at glutamatergic and agmatinergic synapses in the hippocampal CA1 region. Proceedings of the Australian Neuroscience Society (ANS) Annual Scientific Meeting. (pp. 43). Retrieved from http://www.ans.org.au/uploads/documents/2011%20Docs/conference%20abstracts/ANS%202011%20Oral%20Abstracts.pdf

Shevtsova, O., & Leitch, B. (2011). Loss of AMPA receptor GluA4 subunits at corticothalamic synapses in the reticular thalamic nucleus of the epileptic stargazer mouse. Proceedings of the 8th International Brain Research Organization (IBRO) World Congress of Neuroscience. Retrieved from http://www.abstractstosubmit.com/ibro2011/abstracts/

Leitch, B., & Shevtsova, O. (2011). Reduction in AMPA receptor GluA4 subunit expression at synapses in inhibitory but not excitatory thalamic neurons of the epileptic stargazer mouse. Proceedings of the 8th International Brain Research Organization (IBRO) World Congress of Neuroscience. Retrieved from http://www.abstractstosubmit.com/ibro2011/abstracts/

Conference Contribution - Edited volume of conference proceedings

Leitch, B. (Ed.). (2011). Proceedings of the 29th International Australasian Winter Conference on Brain Research, 29. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html

Conference Contribution - Verbal presentation and other Conference outputs

Leitch, B. (2011, July). Seizures and stargazers: Is there anything to get excited about? Verbal presentation at the Brain Health Research Centre Conference, Dunedin, New Zealand.

2010

Conference Contribution - Published proceedings: Abstract

Leitch, B., Shevtsova, O., Reusck, K., Bergin, D. H., & Liu, P. (2010). Spatial learning-induced increase in agmatine levels at hippocampal CA1 synapses. Proceedings of the 30th Annual Meeting of the Australian Neuroscience Society, in conjunction with the 50th Anniversary Meeting of the Australian Physiological Society (ANS/AuPS). (pp. 175). Retrieved from http://www.sallyjayconferences.com.au/sydney2010/abstracts.html

Seo, S., Shevtsova, O., Liu, P., & Leitch, B. (2010). Co-localization of L-glutamate and agmatine in the hippocampal CA1 synaptic terminals in rats. In B. Leitch (Ed.), Proceedings of the 28th International Australasian Winter Conference on Brain Research. 28, (pp. 37). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2010.htm

Conference Contribution - Edited volume of conference proceedings

Leitch, B. (Ed.). (2010). Proceedings of the 28th International Australasian Winter Conference on Brain Research, 28. AWCBR. 43p. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2010.htm

2009

Chapter in Book - Research

Leitch, B., & Pitman, R. M. (2009). Neuromodulation of mechanosensory input to the insect CNS. In A. Kamkin & I. Kiseleva (Eds.), Mechanosensitivity of the nervous system (Vol. 2). (pp. 145-170). Amsterdam: Springer.

Journal - Research Article

Leitch, B., Szostek, A., Lin, R., & Shevtsova, O. (2009). Subcellular distribution of L-type calcium channel subtypes in rat hippocampal neurons. Neuroscience, 164(2), 641-657. doi: 10.1016/j.neuroscience.2009.08.006

Leitch, B., Shevtsova, O., Guévremont, D., & Williams, J. (2009). Loss of calcium channels in the cerebellum of the ataxic and epileptic stargazer mutant mouse. Brain Research, 1279, 156-167. doi: 10.1016/j.brainres.2009.04.051

Leitch, B., Shevtsova, O., & Kerr, J. R. (2009). Selective reduction in synaptic proteins involved in vesicle docking and signalling at synapses in the ataxic mutant mouse Stargazer. Journal of Comparative Neurology, 512(1), 52-73. doi: 10.1002/cne.21890

Conference Contribution - Published proceedings: Abstract

Leitch, B., Szostek, A., Lin, R., & Shevtsova, O. (2009). Subcellular distribution of L-type calcium channel subtypes in rodent hippocampal neurons. In R. Napper (Ed.), Proceedings of the 27th International Australasian Winter Conference on Brain Research. 27, (pp. 36). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2009.htm

Shevtsova, O., Guévremont, D., Williams, J. M., & Leitch, B. (2009). Alteration in calcium channel expression at cerebellar synapses in the ataxic and epileptic stargazer mutant mouse. In R. Napper (Ed.), Proceedings of the 27th International Australasian Winter Conference on Brain Research. 27, (pp. 36). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2009.htm

2008

Conference Contribution - Published proceedings: Abstract

Shevtsova, O., & Leitch, B. (2008). Selective reduction in synaptic proteins involved in vesicle docking and signalling at synapses in the ataxic mutant mouse Stargazer. In J. G. Anson (Ed.), Proceedings of the 26th International Australasian Winter Conference on Brain Research. 26, (pp. 69). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2008Abstracts.pdf

Leitch, B., Shevtsova, O., Guévremont, D., & Williams, J. M. (2008). Synaptic changes in cerebellar neurons of an ataxic mouse. In J. G. Anson (Ed.), Proceedings of the 26th International Australasian Winter Conference on Brain Research. 26, (pp. 29). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2008Abstracts.pdf

2007

Journal - Research Article

Richardson, C. A., & Leitch, B. (2007). Identification of the neurotransmitters involved in modulation of transmitter release from the central terminals of the locust wing hinge stretch receptor. Journal of Comparative Neurology, 502, 794-809. doi: 10.1002/cne.21323

Conference Contribution - Published proceedings: Abstract

Leitch, B., Kerr, J. R., Kirkesola, T., & Stensland, H. (2007). Stargazin mutation causes a selective reduction in synaptic proteins and impairs synaptic vesicle docking. Proceedings of the Society for Neuroscience 37th Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/viewer/SearchResults.asp

2005

Journal - Research Article

Richardson, C. A., & Leitch, B. (2005). Phenotype of cerebellar glutamatergic neurons is altered in stargazer mutant mice lacking brain-derived neurotrophic factor mRNA expressions. Journal of Comparative Neurology, 481, 145-159. doi: 10.1002/cne.20386

2004

Conference Contribution - Poster Presentation (not in published proceedings)

Leitch, B., & Richardson, C. A. (2004, October). Identification of the neurotransmitteres involved in modulation of transmitter release from the central terminals of the locust wing hinge stretch receptors. Poster session presented at the Proceedings of the Society for Neuroscience 34th Annual Meeting, San Diego, CA, USA.

2003

Journal - Research Article

Leitch, B., Judge, S., & Pitman, R. M. (2003). Octopaminergic modulation of synaptic transmission between an identified sensory afferent and flight motoneuron in the locust. Journal of Comparative Neurology, 462, 55-70. doi: 10.1002/cne.10698

Conference Contribution - Poster Presentation (not in published proceedings)

Richardson, C. A., & Leitch, B. (2003, April). Glutamate immunoreactiveity is severely reduced in the cerebellar cells of stargazer mutant mice which show a specific deficit in BDNF MRNA expression. Poster session presented at the Proceedings of the 17th National Meeting of the British Neuroscience Association, Harrogate, UK.

Conference Contribution - Verbal presentation and other Conference outputs

Pitman, R. M., & Leitch, B. (2003, March). Modulation of cholinegic events in insect neurons. Verbal presentation at the Society for Experimental Biology Annual Main Meeting, Southhampton, UK.

2002

Journal - Research Article

Richardson, C. A., & Leitch, B. (2002). Cerebellar Golgi, Purkinje, and basket cells have reduced γ-aminobutyric acid immunoreactivity in stargazer mutant mice. Journal of Comparative Neurology, 453, 85-99. doi: 10.1002/cne.10406

Conference Contribution - Poster Presentation (not in published proceedings)

Richardson, C., & Leitch, B. (2002, July). Cerebellar cells in stargazer mutant mice have reduced levels of GABA and glutamate immunoreactivity. Poster session presented at the Proceedings of the 3rd Forum of European Neuroscience, Paris, France.

2000

Journal - Research Article

Down, R. E., Ford, L., Woodhouse, S. D., Raemaekers, R. J. M., Leitch, B., Gatehouse, J. A., & Gatehouse, A. M. R. (2000). Snowdrop lectin (GNA) has no acute toxic effects on a beneficial insect predator, the 2-spot ladybird (Adalia bipunctata L.). Journal of Insect Physiology, 46, 379-391. doi: 10.1016/s0022-1910(99)00121-3

Conference Contribution - Published proceedings: Abstract

Judge, S., & Leitch, B. (2000). Octopaminergic modulation of the central cholinergic neurons in an identified locust sensory pathway. Journal of Physiology. 523(Suppl. S), (pp. 273P-274P). doi: 10.1111/j.1469-7793.2000.tb00226.x

1999

Journal - Research Article

Judge, S., & Leitch, B. (1999). Modulation of transmitter release from the locust forewing stretch receptor neuron by GABAergic interneurons activated via muscarinic receptors. Journal of Neurobiology, 40(3), 420-431.

Judge, S., & Leitch, B. (1999). GABA immunoreactivity in processes presynaptic to the locust wing stretch receptor neuron. Journal of Comparative Neurology, 407(1), 103-114.

1998

Conference Contribution - Published proceedings: Abstract

Judge, S. J., & Leitch, B. (1998). Modulation of transmitter release from a locust (Locusta migratoria) sensory afferent by muscarinic and GABA receptors. Journal of Physiology, 513(Suppl.), (pp. 101P-102P). doi: 10.1111/j.1469-7793.1998.tb00100.x

1996

Journal - Research Article

Laurent, G., Wehr, M., MacLeod, K., Stopfer, M., Leitch, B., & Davidowitz, H. (1996). Dynamic encoding of odors with oscillating neuronal assemblies in the locust brain. Biological Bulletin, 191(1), 70-75. doi: 10.2307/1543064

Leitch, B., & Laurent, G. (1996). GABAergic synapses in the antennal lobe and mushroom body of the locust olfactory system. Journal of Comparative Neurology, 372(4), 487-514. doi: 10.1002/(SICI)1096-9861(19960902)372:4<487::AID-CNE1>3.0.CO;2-0

1995

Journal - Research Article

Leitch, B., Shepherd, D., & Laurent, G. (1995). Morphogenesis of the branching pattern of a group of spiking local interneurons in relation to the organization of embryonic sensory neuropils in locust. Philosophical Transactions of the Royal Society B, 349, 433-447. doi: 10.1098/rstb.1995.0128

Watkins, B. L., Leitch, B., Burrows, M., & Knowles, B. H. (1995). Localization of a nicotinic acetylcholine receptor-like antigen in the thoracic nervous system of embryonic locusts, Schistocerca gregaria. Journal of Comparative Neurology, 351(1), 134-144. doi: 10.1002/cne.903510112

Leitch, B., & Pitman, R. M. (1995). Modulation of transmitter release from the terminals of the locust wing stretch receptor neuron by muscarinic antagonists. Journal of Neurobiology, 28(4), 455-464. doi: 10.1002/neu.480280406

1993

Journal - Research Article

Watson, A. H., Burrows, M., & Leitch, B. (1993). GABA-immunoreactivity in processes presynaptic to the terminals of afferents from a locust leg proprioceptor. Journal of Neurocytology, 22(7), 547-557. doi: 10.1007/BF01189042

Leitch, B., Watkins, B. L., & Burrows, M. (1993). Distribution of acetylcholine receptors in the central nervous system of adult locusts. Journal of Comparative Neurology, 334(1), 47-58. doi: 10.1002/cne.903340104

Leitch, B., & Laurent, G. (1993). Distribution of GABAergic synaptic terminals on the dendrites of locust spiking local interneurones. Journal of Comparative Neurology, 337(3), 461-470. doi: 10.1002/cne.903370309

1992

Journal - Research Article

Leitch, B., Pitman, R. M., Heitler, W. J., & Cobb, J. L. (1992). Structural and functional post-embryonic development of a non-rectifying electrical synapse in the crayfish. Journal of Neurocytology, 21(2), 120-128. doi: 10.1007/BF01189010

Leitch, B., Laurent, G., & Shepherd, D. (1992). Embryonic development of synapses on spiking local interneurones in locust. Journal of Comparative Neurology, 324(2), 213-236. doi: 10.1002/cne.903240206

Leitch, B., Heitler, W. J., Pitman, R. M., & Cobb, J. L. (1992). Two classes of vesicles are present and change in relative proportion during post-embryonic development of rectifying electrical synapses in the crayfish. Journal of Comparative Neurology, 321(2), 267-276. doi: 10.1002/cne.903210207

Leitch, B. (1992). Ultrastructure of electrical synapses: Review. Electron Microscopy Reviews, 5(2), 311-339. doi: 10.1016/0892-0354(92)90014-h

1991

Journal - Research Article

Heitler, W. J., Pitman, R. M., Cobb, J. L., & Leitch, B. (1991). Postembryonic development of rectifying electrical synapses in crayfish: Physiology. Journal of Neurocytology, 20(2), 109-123. doi: 10.1007/BF01279615

1990

Journal - Research Article

Leitch, B., & Probert, A. J. (1990). Schistosoma haematobium: The effect of Astiban on the cell composition and ultrastructure of the vitelline gland and the ultrastructure of the tegument and gastrodermis. Journal of Helminthology, 64(1), 65-69. doi: 10.1017/s0022149x00011901

Leitch, B., Heitler, W. J., Cobb, J. L., & Pitman, R. M. (1990). Anti-GABA antibodies label a subpopulation of chemical synapses which modulate an electrical synapse in crayfish. Journal of Neurocytology, 19(6), 929-936. doi: 10.1007/BF01186820

Leitch, B., & Finbow, M. E. (1990). The gap junction-like form of a vacuolar proton channel component appears not to be an artifact of isolation: An immunocytochemical localization study. Experimental Cell Research, 190(2), 218-226. doi: 10.1016/0014-4827(90)90189-h

1989

Journal - Research Article

Leitch, B., Cobb, J. L., Heitler, W. J., & Pitman, R. M. (1989). Post-embryonic development of rectifying electrical synapses in the crayfish: Ultrastructure. Journal of Neurocytology, 18(6), 749-761. doi: 10.1007/BF01187228

1984

Journal - Research Article

Leitch, B., & Probert, A. J. (1984). Schistosoma haematobium: Amoscanate and adult worm ultrastructure. Experimental Parasitology, 58(3), 278-289. doi: 10.1016/0014-4894(84)90045-6

Leitch, B., Probert, A. J., & Runham, N. W. (1984). The ultrastructure of the tegument of adult Schistosoma haematobium. Parasitology, 89 (Pt. 1), 71-78. doi: 10.1017/s003118200000114