Contact Details
- Phone
- +64 3 479 5993
- sharon.ladyman@otago.ac.nz
University Links
- Position
- Senior Research Fellow
- Department
- Department of Anatomy
- Qualifications
- BSc(Hons) PhD
- Research summary
- Neuroendocrinology
Research
Dr Ladyman’s area of expertise is hormone-induced adaptations of the maternal brain.
Her work focuses on understanding the neuro-hormonal circuits that regulate hyperphagia, glucose regulation, suppression of physical activity and thermoregulation during pregnancy and lactation.
She is also interested in understanding how going through pregnancy and lactation influences long term metabolic health. Her research involves using transgenic animal models to understand how the physiological changes of pregnancy and lactation influence neuronal function and behavioural outcomes.
Publications
Clarke, G. S., Vincent, A. D., Ladyman, S. R., Gatford, K. L., & Page, A. J. (2024). Circadian patterns of behaviour change during pregnancy in mice. Journal of Physiology. Advance online publication. doi: 10.1113/JP285553 Journal - Research Article
Clarke, G. S., Li, H., Ladyman, S. R., Young, R. L., Gatford, K. L., & Page, A. J. (2024). Effect of pregnancy on the expression of nutrient-sensors and satiety hormones in mice. Peptides, 172, 171114. doi: 10.1016/j.peptides.2023.171114 Journal - Research Article
Brown, R. S. E., Jacobs, I. M., Khant Aung, Z., Knowles, P. J., Grattan, D. R., & Ladyman, S. R. (2023). High fat diet-induced maternal obesity in mice impairs peripartum maternal behaviour. Journal of Neuroendocrinology. Advance online publication. doi: 10.1111/jne.13350 Journal - Research Article
Garratt, M., Neyt, C., Ladyman, S. R., Pyrski, M., Zufall, F., & Leinders-Zufall, T. (2023). Sensory detection of female olfactory cues as a central regulator of energy metabolism and body weight in male mice. iScience, 26, 106455. doi: 10.1016/j.isci.2023.106455 Journal - Research Article
Hackwell, E. C. R., Ladyman, S. R., Brown, R. S. E., & Grattan, D. R. (2023). Mechanisms of lactation-induced infertility in female mice. Endocrinology. Advance online publication. doi: 10.1210/endocr/bqad049 Journal - Research Article
2024
Journal - Research Article
Clarke, G. S., Vincent, A. D., Ladyman, S. R., Gatford, K. L., & Page, A. J. (2024). Circadian patterns of behaviour change during pregnancy in mice. Journal of Physiology. Advance online publication. doi: 10.1113/JP285553
Clarke, G. S., Li, H., Ladyman, S. R., Young, R. L., Gatford, K. L., & Page, A. J. (2024). Effect of pregnancy on the expression of nutrient-sensors and satiety hormones in mice. Peptides, 172, 171114. doi: 10.1016/j.peptides.2023.171114
2023
Journal - Research Article
Brown, R. S. E., Jacobs, I. M., Khant Aung, Z., Knowles, P. J., Grattan, D. R., & Ladyman, S. R. (2023). High fat diet-induced maternal obesity in mice impairs peripartum maternal behaviour. Journal of Neuroendocrinology. Advance online publication. doi: 10.1111/jne.13350
Garratt, M., Neyt, C., Ladyman, S. R., Pyrski, M., Zufall, F., & Leinders-Zufall, T. (2023). Sensory detection of female olfactory cues as a central regulator of energy metabolism and body weight in male mice. iScience, 26, 106455. doi: 10.1016/j.isci.2023.106455
Hackwell, E. C. R., Ladyman, S. R., Brown, R. S. E., & Grattan, D. R. (2023). Mechanisms of lactation-induced infertility in female mice. Endocrinology. Advance online publication. doi: 10.1210/endocr/bqad049
Swart, J. M., Grattan, D. R., Ladyman, S. R., & Brown, R. S. E. (2023). Pups and prolactin are rewarding to virgin female and pregnant mice. Journal of Neuroendocrinology, 35, e13232. doi: 10.1111/jne.13232
2022
Conference Contribution - Published proceedings: Abstract
Young, C. D., Grattan, D. R., & Ladyman, S. (2022). The effect of a Polynesian-specific CREBRF gene variant on pregnancy hormones in a mouse model. In A. Finigan, R. Richards & P. Vakaoti (Eds.), Proceedings of the Pacific Postgraduate Symposium: Pacific Voices XIX. (pp. 39). Dunedin, New Zealand: Pacific Islands Centre, University of Otago. Retrieved from http://hdl.handle.net/10523/16237
Clarke, G. S., Ladyman, S. R., Young, R. L., Gatford, K. L., & Page, A. J. (2022). Circadian variations in food intake during pregnancy in mice. Obesity Reviews, 23(Suppl. 2), (pp. 4-5). doi: 10.1111/obr.13503
Young, C., Grattan, D., & Ladyman, S. (2022). Effect of the Polynesian-specific CREBRF gene variant on lactogenic activity during mouse pregnancy. Proceedings of the joint ESA-SRB-APEG-NZSE Annual Scientific Meeting. 139. Retrieved from https://www.esa-srb-apeg-nzse.org
Ladyman, S. R. (2022). Prolactin modulation of thermoregulatory circuits provides resilience to thermal challenge of pregnancy and lactation. Proceedings of the joint ESA-SRB-APEG-NZSE Annual Scientific Meeting. 223. Retrieved from https://www.esa-srb-apeg-nzse.org
Hackwell, E. C. R., Ladyman, S. R., Brown, R. S. E., Herbison, A. E., & Grattan, D. R. (2022). Prolactin-induced suppression of gonadotrophin secretion during lactation. Proceedings of the joint ESA-SRB-APEG-NZSE Annual Scientific Meeting. 240. Retrieved from https://www.esa-srb-apeg-nzse.org
Gillett, M. L., Grattan, D. R., & Ladyman, S. R. (2022). The role of prolactin in the small intestine during pregnancy and lactation. New Zealand Medical Journal, 135(1557), (pp. 102). Retrieved from https://journal.nzma.org.nz/
Conference Contribution - Verbal presentation and other Conference outputs
Khant Aung, Z., Kado, E., Young, C., Grattan, D. R., & Ladyman, S. R. (2022, August). Protective role of a Polynesian-specific variant of CREBRF gene against gestational diabetes mellitus (GDM): Mouse model. Verbal presentation at the Metabolic & Cardiovascular Disease Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.
Ladyman, S. R. (2022, August-September). Long term impact of pregnancy and lactation on the regulation of energy balance in female mice. Verbal presentation at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Murrell, C. L., Grattan, D. R., & Ladyman, S. R. (2022, August-September). Ghrelin-induced food intake is supressed during pregnancy and restored lactation. Verbal presentation at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Gillett, M. L., Khant Aung, Z., Grattan, D. R., & Ladyman, S. R. (2022, August-September). Prolactin receptors in the epithelial cells of the intestine influence feeding patterns in pregnancy. Verbal presentation at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
2021
Journal - Research Article
Khant Aung, Z., Kokay, I. C., Grattan, D. R., & Ladyman, S. R. (2021). Prolactin-induced adaptation in glucose homeostasis in mouse pregnancy is mediated by the pancreas and not in the forebrain. Frontiers in Endocrinology, 12, 765976. doi: 10.3389/fendo.2021.765976
Ladyman, S. R., Larsen, C. M., Taylor, R. S., Grattan, D. R., & McCowan, L. M. E. (2021). Case–control study of prolactin and placental lactogen in SGA pregnancies. Reproduction & Fertility, 2(4), 244-250. doi: 10.1530/RAF-21-0020
Ladyman, S. R., Carter, K. M., Gillett, M. L., Khant Aung, Z., & Grattan, D. R. (2021). A reduction in voluntary physical activity in early pregnancy in mice is mediated by prolactin. eLIFE, 10, e62260. doi: 10.7554/eLife.62260
Swart, J. M., Grattan, D. R., Ladyman, S. R., & Brown, R. S. E. (2021). Changes in maternal motivation across reproductive states in mice: A role for prolactin receptor activation on GABA neurons. Hormones & Behavior, 135, 105041. doi: 10.1016/j.yhbeh.2021.105041
Ladyman, S. R., & Brooks, V. L. (2021). Central actions of insulin during pregnancy and lactation [Invited review]. Journal of Neuroendocrinology, 33, e12946. doi: 10.1111/jne.12946
Journal - Research Other
Clarke, G. S., Gatford, K. L., Young, R. L., Grattan, D. R., Ladyman, S. R., & Page, A. J. (2021). Maternal adaptations to food intake across pregnancy: Central and peripheral mechanisms. Obesity, 29(11), 1813-1824. doi: 10.1002/oby.23224
2020
Chapter in Book - Research
Grattan, D. R., & Ladyman, S. R. (2020). Neurophysiological and cognitive changes in pregnancy. In E. A. P. Steegers, M. J. Cipolla & E. C. Miller (Eds.), Handbook of clinical neurology (Vol. 171): Neurology and pregnancy: Pathophysiology and patient care. (pp. 25-55). Amsterdam, The Netherlands: Elsevier. doi: 10.1016/B978-0-444-64239-4.00002-3
Journal - Research Article
Georgescu, T., Ladyman, S. R., Brown, R. S. E., & Grattan, D. R. (2020). Acute effects of prolactin on hypothalamic prolactin receptor expressing neurones in the mouse. Journal of Neuroendocrinology, 32, e12908. doi: 10.1111/jne.12908
Gustafson, P., Ladyman, S. R., McFadden, S., Larsen, C., Khant Aung, Z., Brown, R. S. E., Bunn, S. J., & Grattan, D. R. (2020). Prolactin receptor-mediated activation of pSTAT5 in the pregnant mouse brain. Journal of Neuroendocrinology, 32, e12901. doi: 10.1111/jne.12901
Barad, Z., Khant Aung, Z., Grattan, D. R., Ladyman, S. R., & Brown, R. S. E. (2020). Impaired prolactin transport into the brain and functional responses to prolactin in aged male mice. Journal of Neuroendocrinology, 32, e12889. doi: 10.1111/jne.12889
Khant Aung, Z., Grattan, D. R., & Ladyman, S. R. (2020). Pregnancy-induced adaptation of central sensitivity to leptin and insulin. Molecular & Cellular Endocrinology, 516, 110933. doi: 10.1016/j.mce.2020.110933
Lopez-Vicchi, F., Ladyman, S. R., Ornstein, A. M., Gustafson, P., Knowles, P., Luque, G. M., Grattan, D. R., & Becu-Villalobos, D. (2020). Chronic high prolactin levels impact on gene expression at discrete hypothalamic nuclei involved in food intake. FASEB Journal, 34, 3902-3914. doi: 10.1096/fj.201902357R
Journal - Research Other
Lopez-Vicchi, F., De Winne, C., Brie, B., Sorianello, E., Ladyman, S. R., & Becu-Villalobos, D. (2020). Metabolic functions of prolactin: Physiological and pathological aspects. Journal of Neuroendocrinology, 32, e12888. doi: 10.1111/jne.12888
Ladyman, S. R., Hackwell, E. C. R., & Brown, R. S. E. (2020). The role of prolactin in co-ordinating fertility and metabolic adaptations during reproduction. Neuropharmacology, 167, 107911. doi: 10.1016/j.neuropharm.2019.107911
Conference Contribution - Published proceedings: Abstract
Swart, J. M., Ladyman, S. R., Grattan, D. R., & Brown, R. S. E. (2020). Identifying a role for lactogenic hormones in maternal motivation. Journal of the Endocrine Society, 4(Suppl. 1), (pp. A1075). doi: 10.1210/jendso/bvaa046.2131
2019
Chapter in Book - Research
Smiley, K. O., Ladyman, S. R., Gustafson, P., Grattan, D. R., & Brown, R. S. E. (2019). Neuroendocrinology and adaptive physiology of maternal care. In L. M. Coolen & D. R. Grattan (Eds.), Neuroendocrine regulation of behavior: Current topics in behavioral neurosciences (Vol. 43). (pp. 161-210). Cham, Switzerland: Springer. doi: 10.1007/7854_2019_122
Journal - Research Article
Gustafson, P., Ladyman, S. R., & Brown, R. S. E. (2019). Suppression of leptin transport into the brain contributes to leptin resistance during pregnancy in the mouse. Endocrinology, 160(4), 880-890. doi: 10.1210/en.2018-01065
Augustine, R. A., Knowles, P. J., Khant Aung, Z., Grattan, D. R., & Ladyman, S. R. (2019). Impaired hypothalamic leptin sensitivity in pseudopregnant rats treated with chronic prolactin to mimic pregnancy. Journal of Neuroendocrinology, 31, e12702. doi: 10.1111/jne.12702
Aquino, N. S. S., Kokay, I. C., Perez, C. T., Ladyman, S. R., Henriques, P. C., Silva, J. F., … Grattan, D. R., & Szawka, R. E. (2019). Kisspeptin stimulation of prolactin secretion requires Kiss1 receptor but not in tuberoinfundibular dopaminergic neurons. Endocrinology, 160(3), 522-533. doi: 10.1210/en.2018-00932
Journal - Research Other
Ladyman, S. R. (2019). Anticipating future demands: Hormone-induced transcriptional programming in the maternal pancreas during pregnancy. Endocrinology, 160(5), 1164-1165. doi: 10.1210/en.2019-00243
Conference Contribution - Poster Presentation (not in published proceedings)
Khant Aung, Z., Jacobs, I., Grattan, D. R., Brown, R. S. E., & Ladyman, S. R. (2019, August-September). Peripartum prolactin and growth hormone concentrations in diet-induced obese mice. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Hackwell, E. C. R., Brown, R. S. E., Ladyman, S. R., & Grattan, D. R. (2019, August-September). Prolactin action on kisspeptin neurons is required for maintaining lactational infertility. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Ladyman, S. R., & Grattan, D. R. (2019, September). Contribution of central prolactin receptors to changes in energy homeostasis during pregnancy and lactation. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Swart, J. M., Ladyman, S. R., Grattan, D. R., & Brown, R. S. E. (2019, September). The effect of reproductive experience on maternal motivation. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Georgescu, T., Ladyman, S. R., Brown, R. S. E., & Grattan, D. R. (2019, August-September). Investigating the acute effects of prolactin upon hypothalamic prolactin-receptor expressing neurons. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2018
Journal - Research Article
McEwen, H. J. L., Cognard, E., Ladyman, S. R., Khant-Aung, Z., Tups, A., Shepherd, P. R., & Grattan, D. R. (2018). Feeding and GLP-1 receptor activation stabilize beta-catenin in specific hypothalamic nuclei in male rats. Journal of Neuroendocrinology, 30(6), e12607, 1-10. doi: 10.1111/jne.12607
Ladyman, S. R., Carter, K. M., & Grattan, D. R. (2018). Energy homeostasis and running wheel activity during pregnancy in the mouse. Physiology & Behavior, 194, 83-94. doi: 10.1016/j.physbeh.2018.05.002
Ladyman, S. R., Khant Aung, Z., & Grattan, D. R. (2018). Impact of pregnancy and lactation on the long-term regulation of energy balance in female mice. Endocrinology, 159(6), 2324-2336. doi: 10.1210/en.2018-00057
Conference Contribution - Published proceedings: Abstract
Ladyman, S. R., Khant Aung, Z., & Grattan, D. R. (2018). Pregnancy-induced adaptations in glucose homeostasis in the mouse requires prolactin receptor expression in the pancreas but not the brain. Endocrine Reviews, 39(2), MON-150. [Abstract]
Lopez-Vicchi, F., Ladyman, S. R., Ornstein, A. M., Luque, G. M., Grattan, D. R., & Becu-Villalobus, D. (2018). Leptin insensitivity and nuclei-specific altered gene expression in hypothalamus of trransgenic mice with chronic hyperprolactinemia. Endocrine Reviews, 39(2), SAT-623-LB. [Abstract]
Khant Aung, Z., Grattan, D., & Ladyman, S. R. (2018). Long-term consequences of reproductive experience on metabolic homeostasis in mothers. Proceedings of the 9th International Congress of Neuroendocrinology (ICN). (pp. 214). Retrieved from http://www.icn2018.org/
Ladyman, S., Carter, K. M., & Grattan, D. (2018). Prolactin drives the decreases in voluntary physical activity in early pregnancy. Proceedings of the 9th International Congress of Neuroendocrinology (ICN). (pp. 173). Retrieved from http://www.icn2018.org/
Gustafson, P., Ladyman, S. R., Grattan, D., & Brown, R. S. E. (2018). Changing dynamics of prolactin and leptin transport into the brain during pregnancy and with aging. Proceedings of the 9th International Congress of Neuroendocrinology (ICN). (pp. 124). Retrieved from http://www.icn2018.org/
Conference Contribution - Poster Presentation (not in published proceedings)
Hackwell, E. C. R., Ladyman, S. R., Brown, R. S. E., & Grattan, D. R. (2018, November). Central prolactin action is required for maintaining lactational diestrus in mice. Poster session presented at the Women’s Wellbeing Symposium, Dunedin, New Zealand.
Carter, K. M., Grattan, D. R., & Ladyman, S. R. (2018, November). Prolactin acutely influences running wheel activity but not ambulatory activity in female mice. Poster session presented at the Women’s Wellbeing Symposium, Dunedin, New Zealand.
Jacobs, I., Brown, R. S. E., Grattan, D. R., & Ladyman, S. R. (2018, November). Are impairments in prolactin signalling in the brain of obese mice associated with deficits in maternal care? Poster session presented at the Women’s Wellbeing Symposium, Dunedin, New Zealand.
Ladyman, S. R., & Grattan, D. R. (2018, November). Pregnancy and lactation lead to long term changes in body weight and small intestine length in female mice. Poster session presented at the Women’s Wellbeing Symposium, Dunedin, New Zealand.
Carter, K. M., Grattan, D. R., & Ladyman, S. R. (2018, August). Prolactin acutely influences running wheel activity but not ambulatory activity in female mice. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Khant Aung, Z., Ladyman, S. R., & Grattan, D. R. (2018, August). Central prolactin receptor activation contributes to the hyperphagia of lactation. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Khant Aung, Z., Ladyman, S. R., & Grattan, D. R. (2018, November). Central prolactin receptor activition contributes to the hyperphagia of lactation. Poster session presented at the Women’s Wellbeing Symposium, Dunedin, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Tawngdee, Y., Grattan, D. R., Ladyman, S. R., & Brown, R. S. E. (2018, August). The role of prolactin in reward aspects of maternal behaviour. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Jacobs, I., Brown, R. S. E., Grattan, D. R., & Ladyman, S. R. (2018, August). Are impairments in prolactin signaling in the brain of obese mice associated with deficits in maternal care? Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Hackwell, E. C. R., Ladyman, S. R., Brown, R. S. E., & Grattan, D. R. (2018, August). Central prolactin action is required for maintaining lactational diestrus in mice. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
2017
Journal - Research Article
Ladyman, S. R., & Grattan, D. R. (2017). Region-specific suppression of hypothalamic responses to insulin to adapt to elevated maternal insulin secretion during pregnancy. Endocrinology, 158(12), 4257-4269. doi: 10.1210/en.2017-00600
Brown, R. S. E., Aoki, M., Ladyman, S. R., Phillipps, H. R., Wyatt, A., Boehm, U., & Grattan, D. R. (2017). Prolactin action in the medial preoptic area is necessary for postpartum maternal nursing behavior. PNAS, 114(40), 10779-10784. doi: 10.1073/pnas.1708025114
Ladyman, S. R., MacLeod, M. A., Khant Aung, Z., Knowles, P., Phillipps, H. R., Brown, R. S. E., & Grattan, D. R. (2017). Prolactin receptors in Rip-cre cells, but not in AgRP neurons, are involved in energy homeostasis. Journal of Neuroendocrinology, 29(10), e12474. doi: 10.1111/jne.12474
Tups, A., Benzler, J., Sergi, D., Ladyman, S. R., & Williams, L. M. (2017). Central regulation of glucose homeostasis. Comprehensive Physiology, 7(2), 741-764. doi: 10.1002/cphy.c160015
Augustine, R. A., Ladyman, S. R., Bouwer, G. T., Alyousif, Y., Sapsford, T. J., Scott, V., Kokay, I. C., Grattan, D. R., & Brown, C. H. (2017). Prolactin regulation of oxytocin neurone activity in pregnancy and lactation. Journal of Physiology, 595(11), 3591-3605. doi: 10.1113/jp273712
Conference Contribution - Published proceedings: Abstract
Carter, K. M., Grattan, D. R., & Ladyman, S. R. (2017). Prolactin acutely influences running wheel activity but not ambulatory activity in female mice. Proceedings of the Australasian Neuroscience Society 37th Annual Scientific Meeting. Retrieved from http://ans2017.aomevents.com.au
Conference Contribution - Poster Presentation (not in published proceedings)
Khant Aung, Z., Ladyman, S. R., & Grattan, D. R. (2017, September). Pregnancy-induced adaptations in glucose homeostasis in the mouse requires prolactin receptor expression in the pancreas but not the brain. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Carter, K., Grattan, D. R., & Ladyman, S. R. (2017, September). Prolactin-induced suppression of acute running wheel activity in female mice. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2016
Journal - Research Article
Ladyman, S. R., & Grattan, D. R. (2016). Central effects of leptin on glucose homeostasis are modified during pregnancy in the rat. Journal of Neuroendocrinology, 28(10). doi: 10.1111/jne.12431
Brown, R. S. E., Kokay, I. C., Phillipps, H. R., Yip, S. H., Gustafson, P., Wyatt, A., Larsen, C. M., Knowles, P., Ladyman, S. R., LeTissier, P., & Grattan, D. R. (2016). Conditional deletion of the prolactin receptor reveals functional subpopulations of dopamine neurons in the arcuate nucleus of the hypothalamus. Journal of Neuroscience, 36(35), 9173-9185. doi: 10.1523/jneurosci.1471-16.2016
Ladyman, S. R., Augustine, R. A., Scherf, E., Phillipps, H. R., Brown, C. H., & Grattan, D. R. (2016). Attenuated hypothalamic responses to α-melanocyte stimulating hormone during pregnancy in the rat. Journal of Physiology, 594(4), 1087-1101. doi: 10.1113/jp271605
Brown, R. S. E., Wyatt, A. K., Herbison, R. E., Knowles, P. J., Ladyman, S. R., Binart, N., … Grattan, D. R. (2016). Prolactin transport into mouse brain is independent of prolactin receptor. FASEB Journal, 30(2), 1002-1010. doi: 10.1096/fj.15-276519
Conference Contribution - Published proceedings: Abstract
Grattan, D. R., McEwen, H., Ladyman, S., & Shepherd, P. (2016). Feeding and GLP-1 receptor activation stabilize β-catenin in specific hypothalamic nuclei in male rats. Proceedings of the Society for Neuroscience 46th Annual Meeting. 731.21/CCC15. SfN. Retrieved from https://www.sfn.org/
Brown, R. S. E., Kokay, I. C., Phillipps, H. R., Gustafson, P. E., Khant Aung, Z., Ladyman, S. R., & Grattan, D. R. (2016). Conditional deletion of prolactin receptor gene reveals remarkable redundancy in feedback regulation of tuberoinfundibular dopamine neurons by prolactin. Endocrine Reviews, 37(2, Suppl.), FRI-504. Retrieved from http://press.endocrine.org/series/endo-meetings
Conference Contribution - Poster Presentation (not in published proceedings)
Khant Aung, Z., Grattan, D. R., & Ladyman, S. R. (2016, August). Impaired pregnancy-induced changes to glucose homeostasis in mice lacking prolactin receptors in the pancreas. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Kaplish, M., Ladyman, S. R., & Grattan, D. R. (2016, August). The effect of pregnancy-induced adaptations on glucagon like-peptide-1 receptor activation-induced stabilisation of beta-catenin in hypothalamic neurons in female rats. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.
MacLeod, M. A., Ladyman, S. R., & Grattan, D. R. (2016, August). The effect of prolactin on AgRP neurons in the arcuate nucleus. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.
Carter, K., Rizwan, M., Ladyman, S. R., & Grattan, D. R. (2016, August). Feeding-induced regulation of Wnt/beta catenin signaling in the mouse hypothalamus. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.
Brown, R. S. E., Kokay, I. C., Phillipps, H. R., Yip, S. H., Gustafson, P., Wyatt, A., Larsen, C. M., Knowles, P., Ladyman, S. R., … Grattan, D. R. (2016, August). Conditional deletion of the prolactin receptor reveals functional subpopulations of dopamine neurons in the arcuate nucleus of the hypothalamus. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.
2014
Journal - Research Article
Ladyman, S., & Woodside, B. (2014). Food restriction during lactation suppresses Kiss1 mRNA expression and kisspeptin-stimulated LH release in rats. Reproduction, 147, 743-751. doi: 10.1530/rep-13-0426
2013
Journal - Research Article
Ladyman, S. R., & Grattan, D. R. (2013). JAK-STAT and feeding. JAK-STAT, 2(2), e23675. doi: 10.4161/jkst.23675
Phillipps, H. R., Ladyman, S. R., & Grattan, D. R. (2013). Maintained expression of genes associated with metabolism in the ventromedial hypothalamic nucleus despite development of leptin resistance during pregnancy in the rat. Physiological Reports, 1(6), e00162. doi: 10.1002/phy2.162
Conference Contribution - Published proceedings: Abstract
McEwen, H. J. L., Cognard, E., Ladyman, S. R., Shepherd, P. R., & Grattan, D. R. (2013). Regulation of beta-catenin by GLP-1 in the hypothalamus. Endocrine Reviews, 34(3, Suppl.), SAT-825. Retrieved from http://press.endocrine.org/series/endo-meetings
2012
Journal - Research Article
Ladyman, S. R., Fieldwick, D. M., & Grattan, D. R. (2012). Suppression of leptin-induced hypothalamic JAK/STAT signaling and feeding response during pregnancy in the mouse. Reproduction, 144(1), 83-90. doi: 10.1530/rep-12-0112
Conference Contribution - Published proceedings: Abstract
McEwen, H. J. L., Smith, G. C., Ladyman, S. R., Grattan, D. R., & Shepherd, P. R. (2012). Phosphorylation of Akt by antipsychotic drugs is induced indirectly through dysregulation of glucose homeostasis. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 30th International Australasian Winter Conference on Brain Research. 30, (pp. 64). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2012.html
2011
Journal - Research Article
Ladyman, S. R., Sapsford, T. J., & Grattan, D. R. (2011). Loss of acute satiety response to cholecystokinin in pregnant rats. Journal of Neuroendocrinology, 23(11), 1091-1098. doi: 10.1111/j.1365-2826.2011.02191.x
Conference Contribution - Published proceedings: Abstract
McEwen, H. J. L., Ladyman, S. R., Cognard, E., Shepherd, P. R., & Grattan, D. R. (2011). Activation of the Wnt signalling pathway in the hypothalamus by metabolic parameters and its potential: Possible involvement in the glucose homeostasis? In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 5.25. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html
Scherf, E., Ladyman, S., & Grattan, D. (2011). Patterns of α-MSH-induces neuronal activation in the pregnant rat brain. New Zealand Medical Journal, 124(1335). Retrieved from http://www.nzma.org.nz/journal/124-1335/4693/content.pdf
Conference Contribution - Verbal presentation and other Conference outputs
Scherf, E. M., Ladyman, S. R., & Grattan, D. R. (2011, August). Patterns of α-MSH-induced neuronal activation in the pregnant rat brain. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Ladyman, S. R., & Grattan, D. R. (2011, August). Pregnancy-induced adaptations in the neuroendocrine networks controlling metabolism. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
2010
Journal - Research Article
Ladyman, S. R., Augustine, R. A., & Grattan, D. R. (2010). Hormone interactions regulating energy balance during pregnancy. Journal of Neuroendocrinology, 22, 805-817. doi: 10.1111/j.1365-2826.2010.02017.x
Conference Contribution - Published proceedings: Abstract
Ladyman, S. R., & Grattan, D. R. (2010). Leptin resistance during pregnancy is associated with a loss of the satiety response to cholecystokinin. Proceedings of the Society for Neuroscience 40th Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/Plan/SSResults.aspx
Conference Contribution - Poster Presentation (not in published proceedings)
Fieldwick, D. M., Ladyman, S. R., & Grattan, D. R. (2010, November-December). Suppression of leptin induced pSTAT3 in the hypothalamus of pregnant mice. Poster session presented at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Ladyman, S. R., & Grattan, D. R. (2010, November-December). Development of hypothalamic insulin resistance during pregnancy. Verbal presentation at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.
2009
Journal - Research Article
Ladyman, S. R., & Woodside, B. (2009). Regulation of maternal food intake and mother-pup interactions by the Y5 receptor. Physiology & Behavior, 97, 91-97. doi: 10.1016/j.physbeh.2009.02.008
Ladyman, S. R., Tups, A., Augustine, R. A., Swahn-Azavedo, A., Kokay, I. C., & Grattan, D. R. (2009). Loss of hypothalamic response to leptin during pregnancy associated with development of melanocortin resistance. Journal of Neuroendocrinology, 21(5), 449-456. doi: 10.1111/j.1365-2826.2009.01862.x
2008
Chapter in Book - Research
Woodside, B., Augustine, R. A., Ladyman, S. R., Naef, L., & Grattan, D. R. (2008). Role of prolactin in the metabolic adaptations to pregnancy and lactation. In R. S. Bridges (Ed.), Neurobiology of the parental brain. (pp. 249-267). London: Academic Press.
Journal - Research Article
Augustine, R. A., Ladyman, S. R., & Grattan, D. R. (2008). From feeding one to feeding many: Hormone-induced changes in bodyweight homeostasis during pregnancy (Symposium report). Journal of Physiology, 586(2), 387-397. doi: 10.1113/jphysiol.2007.146316
Journal - Research Other
Ladyman, S. R. (2008). Leptin resistance during pregnancy in the rat. Journal of Neuroendocrinology, 20(269), 269-277. doi: 10.1111/j.1365-2826.2007.01628.x
2007
Journal - Research Article
Grattan, D. R., Ladyman, S. R., & Augustine, R. A. (2007). Hormonal induction of leptin resistance during pregnancy. Physiology & Behavior, 91, 366-374.
2006
Conference Contribution - Published proceedings: Abstract
Augustine, R. A., Ladyman, S. R., Swahn Azavedo, A. M., Kokay, I. C., & Grattan, D. R. (2006). Pregnancy-induced leptin resistance involves a loss of appetite suppression by alpha-melanocyte stimulating hormone. Endocrine Journal. 53(Suppl.), (pp. 100). [Abstract]
2005
Journal - Research Article
Ladyman, S. R., & Grattan, D. R. (2005). Suppression of leptin receptor messenger ribonucleic acid and leptin responsiveness in the ventromedial nucleus of the hypothalamus during pregnancy in the rat. Endocrinology, 146(9), 3868-3874.
2004
Journal - Research Article
Ladyman, S. R., & Grattan, D. R. (2004). Region-specific reduction in leptin-induced phosphorylation of signal transducer and activator of transcription-3 (STAT3) in the rat hypothalamus is associated with leptin resistance during pregnancy. Endocrinology, 145(8), 3704-3711.
Conference Contribution - Published proceedings: Abstract
Ladyman, S. R., & Grattan, D. R. (2004). Leptin-induced phosphorylation of STAT3 in alpha-MSH neurons is maintained during pregnancy in the rat. Proceedings of the Society for Neuroscience Abstracts. (893.21). Retrieved from http://sfn.scholarone.com/itin2004/index.html
2003
Journal - Research Article
Augustine, R. A., Kokay, I. C., Andrews, Z. B., Ladyman, S. R., & Grattan, D. R. (2003). Quantitation of prolactin receptor mRNA in the maternal rat brain during pregnancy and lactation. Journal of Molecular Endocrinology, 31, 221-232.
Todd, B. J., Ladyman, S. R., & Grattan, D. R. (2003). Suppression of pulsatile luteinizing hormone secretion but not luteinizing hormone surge in leptin resistant obese Zucker rats. Journal of Neuroendocrinology, 15, 61-68.
Conference Contribution - Published proceedings: Abstract
Ladyman, S. R., & Grattan, D. R. (2003). Exogenous leptin does not suppress appetite in pregnant rats. Proceedings of the 33rd Annual Meeting of the Society for Neuroscience. Washington, DC: Society for Neuroscience. Retrieved from http://sfn.scholarone.com/itin2003
Ladyman, S. R., & Grattan, D. R. (2003). Effect of intracerebroventricular leptin administration on food intake in pregnant and cycling rats. Proceedings of the Endocrine Society of Australia. 46(185), (pp. 203-204). [Abstract]
2000
Conference Contribution - Published proceedings: Abstract
Todd, B. J., Ladyman, S. R., Davis, G., & Grattan, D. R. (2000). Characterisation of luteinising hormone secretion in the female obese Zucker rat. Proceedings of the University of Otago Medical School. 78, (pp. 29). [Abstract]