Associate Professor John Leader

2022

Journal - Research Article

Cairns, S. P., Leader, J. P., Higgins, A., & Renaud, J.-M. (2022). The peak force-resting membrane potential relationships of mouse fast- and slow-twitch muscle. American Journal of Physiology: Cell Physiology, 322, C1151-C1165. doi: 10.1152/ajpcell.00401.2021

2021

Journal - Research Other

Jennings, M. J., Molteno, T. C. A., Walker, R. J., Bedford, J. J., Leader, J. P., & Poole, T. (2021). Transmission electron microscopy tilt-series data from in-situ chondrocyte primary cilia [Data descriptor]. Data, 6(11), 118. doi: 10.3390/data6110118

2019

Journal - Research Article

Hurcombe, J. A., Hartley, P., Lay, A. C., Ni, L., Bedford, J. J., Leader, J. P., … Walker, R. J., … Coward, R. J. M. (2019). Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function. Nature Communications, 10, 403. doi: 10.1038/s41467-018-08235-1

Journal - Research Other

Leader, J., Bedford, J., & Walker, R. J. (2019). Drowning in data: Early responses of renal cortical collecting duct cells to lithium. Annals of Translational Medicine, 8(Suppl. 8), S322. doi: 10.21037/atm.2019.09.120

2018

Journal - Research Article

Kalita-De Croft, P., Bedford, J. J., Leader, J. P., & Walker, R. J. (2018). Amiloride modifies the progression of lithium-induced renal interstitial fibrosis. Nephrology, 23(1), 20-30. doi: 10.1111/nep.12929

2016

Journal - Research Article

Marti, H.-P., Jeffs, A., Scherer, A., Leader, J., Leader, C., Bedford, J., & Walker, R. (2016). Renal fibrosis mRNA classifier: Validation in experimental lithium-induced interstitial fibrosis in the rat kidney. PLoS ONE, 11(12), e0168240. doi: 10.1371/journal.pone.0168240

Conference Contribution - Verbal presentation and other Conference outputs

Leader, J., Bedford, J., van der Tholen, L., Weiner, D., & Walker, R. (2016, December). Lithium in the renal cortex. Verbal presentation at the Joint International Meeting of the Renal Scientists of the Australia and New Zealand Society of Nephrology and the Kidney in Health and Disease Network: Translational Medicine: Innovations in Renal Research, Blenheim, New Zealand.

2015

Journal - Research Article

Cairns, S. P., Leader, J. P., Loiselle, D. S., Higgins, A., Lin, W., & Renaud, J.-M. (2015). Extracellular Ca²⁺-induced force restoration in K⁺-depressed skeletal muscle of the mouse involves an elevation of [K⁺]_i: Implications for fatigue. Journal of Applied Physiology, 118(6), 662-674. doi: 10.1152/japplphysiol.00705.2013

2014

Journal - Research Article

Weiner, I. D., Leader, J. P., Bedford, J. J., Verlander, J. W., Ellis, G., Kalita, P., Vos, F., de Jong, S., & Walker, R. J. (2014). Effects of chronic lithium administration on renal acid excretion in humans and rats. Physiological Reports, 2(12), e12242. doi: 10.14814/phy2.12242

2013

Journal - Research Article

Walker, R. J., Leader, J. P., Bedford, J. J., Gobe, G., Davis, G., Vos, F. E., deJong, S., & Schollum, J. B. W. (2013). Chronic interstitial fibrosis in the rat kidney induced by long-term (6-mo) exposure to lithium. American Journal of Physiology: Renal Physiology, 304(3), F300-F307. doi: 10.1152/ajprenal.00182.2012

Conference Contribution - Published proceedings: Abstract

Kalita, P., Bahn, A., Bedford, J., Leader, J., & Walker, R. (2013). Amiloride modifies renal fibrosis induced by long term lithium treatment. Nephrology, 18(Suppl. 1), (pp. 57). doi: 10.1111/nep.12121

Kalita, P., Bahn, A., Bedford, J., Leader, J., & Walker, R. (2013). Long-term modulation of lithium-induced nephrogenic diabetes isipidus by amiloride. Nephrology, 18(Suppl. 1), (pp. 37). doi: 10.1111/nep.12121

Conference Contribution - Poster Presentation (not in published proceedings)

Kalita, P., Bahn, A., Bedford, J., Leader, J., & Walker, R. (2013, September). Long term amiloride therapy attenuates lithium-induced kidney interstitial fibrosis. Poster session presented at the Division of Health Sciences Research Forum: Foundations for Health: Otago Health Research, Christchurch, New Zealand.

2012

Conference Contribution - Published proceedings: Abstract

Anagnostopoulou, A., Walker, R., Jeffs, A., Scherer, A., Bedford, J., Leader, J., … Marti, H.-P. (2012). A subset of metzincins and related genes constitutes a marker of solid organ fibrosis across species. Nephrology Dialysis Transplantation, 27(Suppl. 2), (pp. 44). doi: 10.1093/ndt/gfs198

Marti, H. P., Jeffs, A., Scherer, A., Leader, J., Bedford, J., Davis, G., … Walker, R. (2012). Solid organ fibrosis: Evidence for a common pathway across species! Nephrology, 17(Suppl. 2), (pp. 57). doi: 10.1111/j.1440-1797.2012.01632.x

Conference Contribution - Verbal presentation and other Conference outputs

Leader, J., Bedford, J., & Walker, R. (2012, August). Morphological changes in kidneys of rats after long term (six months) exposure to lithium. Verbal presentation at the Translational Nephrology Conference: From Mechanics to Therapeutics, Queenstown, New Zealand.

Kalita, P., Bahn, A., Walker, R., Leader, J., & Bedford, J. (2012, August). Mechanism underlying kidney fibrosis in rats due to prolonged lithium treatment. Verbal presentation at the Translational Nephrology Conference: From Mechanics to Therapeutics, Queenstown, New Zealand.

2011

Journal - Research Article

Cairns, S. P., Leader, J. P., & Loiselle, D. S. (2011). Exacerbated potassium-induced paralysis of mouse soleus muscle at 37°C vis-À-vis 25°C: Implications for fatigue. Pflügers Archiv: European Journal of Physiology, 461(4), 469-479. doi: 10.1007/s00424-011-0927-4

2010

Conference Contribution - Verbal presentation and other Conference outputs

Walker, R., Bedford, J., Davis, G., Gobe, G., Schollum, J., & Leader, J. (2010, August-September). Long term lithium-induced chronic interstitial fibrosis. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Davis, G., Bedford, J., Leader, J., & Walker, R. (2010, November-December). Lithium treated rats have an impaired ability to acidify their urine. Verbal presentation at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.

2008

Journal - Research Article

Bedford, J. J., Weggery, S., Ellis, G., McDonald, F. J., Joyce, P. R., Leader, J. P., & Walker, R. J. (2008). Lithium-induced nephrogenic diabetes insipidus: Renal effects of amiloride. Clinical Journal of the American Society of Nephrology, 3(5), 1324-1331.

Bourke, L., Hodgkinson, I., De Silva, L., & Leader, J. (2008). Chiral photonic film and flake. Optics Express, 16(21), 16889-16894.

Bedford, J. J., Leader, J. P., Jing, R., Walker, L. J., Klein, J. D., Sands, J. M., & Walker, R. J. (2008). Amiloride restores renal medullary osmolytes in lithium-induced nephrogenic diabetes insipidus. American Journal of Physiology: Renal Physiology, 294, F812-F820. doi: 10.1152/ajprenal.00554.2007

Conference Contribution - Verbal presentation and other Conference outputs

Leader, J. (2008, August-September). The effect of long term lithium administration on renal function in the rat. Verbal presentation at the Queenstown Molecular Biology Meetings, Queenstown, New Zealand.

2007

Journal - Research Article

Lowrey, S., De Silva, L., Hodgkinson, I., & Leader, J. (2007). Observation and modeling of polarized light from scarab beetles. Journal of the Optical Society of America A, 24(8), 2418-2425. doi: 10.1364/JOSAA.24.002418

Bedford, J. J., & Leader, J. P. (2007). Organic osmolytes in the developing kidney of the Australian brush-tailed possum, Trichosurus vulpecula. Comparative Biochemistry & Physiology Part A, 147, 1047-1052. doi: 10.1016/j.cbpa.2007.03.015

2006

Journal - Research Article

O'Donnell, M. J., & Leader, J. P. (2006). Changes in fluid secretion rate alter net transepithelial transport of MRP2 and P-glycoprotein substrates in Malpighian tubules of Drosophila melanogaster. Archives of Insect Biochemistry & Physiology, 63, 123-134.

Conference Contribution - Published proceedings: Abstract

Leader, J., Jing, R., Walker, R., & Bedford, J. (2006). The effect of amiloride in lithium-induced nephrogenic diabetes insipidus in rats. FASEB Journal, 20(5), 754.17, (pp. A1222). [Abstract]

Jing, R., Bedford, J., Walker, R., & Leader, J. (2006). Correction of the urine concentrating defect in rats with lithium-induced nephrogenic diabetes insipidus by amiloride. Journal of the American Society of Nephrology. 17, (pp. 537A). [Abstract]

Bedford, J. J., Yang, B. S., Walker, R. J., & Leader, J. P. (2006). Upregulation of the taurine transporter, TAUT, in the renal medulla of thirsted rats. FASEB Journal, 20(5), 754.16, (pp. A1221). [Abstract]

2005

Journal - Research Article

Leader, J. P., & O'Donnell, M. J. (2005). Transepithelial transport of fluorescent p-glycoprotein and MRP2 substrates by insect Malpighian tubules: Confocal microscopic analysis of secreted fluid droplets. Journal of Experimental Biology, 208, 4363-4376.

Samuelsson, L. M., Bedford, J. J., Smith, R. A. J., & Leader, J. P. (2005). A comparison of the counteracting effects of glycine betaine and TMAO on the activity of RNase A in aqueous urea solution. Comparative Biochemistry & Physiology Part A, 141, 22-28.

Every, S. G., Leader, J. P., Molteno, A. C., Bevin, T. H., & Sanderson, G. (2005). Ultraviolet photography of the in vivo human cornea unmasks the Hudson-Stähli line and physiologic vortex patterns. Investigative Ophthalmology & Visual Science, 46(10), 3616-3622.

De Silva, L., Hodgkinson, I., Murray, P., Wu, Q. H., Arnold, M., Leader, J., & McNaughton, A. (2005). Natural and nanoengineered chiral reflectors: Structural color of manuka beetles and titania coatings. Electromagnetics, 25(5), 391-408. doi: 10.1080/02726340590957399

Walker, R. J., Weggery, S., Bedford, J. J., McDonald, F. J., Ellis, G., & Leader, J. P. (2005). Lithium-induced reduction in urinary concentrating ability and urinary aquaporin 2 (AQP2) excretion in healthy volunteers. Kidney International, 67, 291-294.

Conference Contribution - Published proceedings: Abstract

Bedford, J. J., Jing, R., Walker, R. J., & Leader, J. P. (2005). The effect of amiloride on aquaporins 1-4 in rats with lithium-induced nephrogenic diabetes insipidus. Proceedings of the Cell Volume Control in Health and Disease Conference. (pp. 77). Copenhagen, Denmark. [Abstract]

Jing, Y., Bedford, J. J., Walker, R. J., & Leader, J. P. (2005). The effect of amiloride on lithium-induced nephrogenic diabetes insipidus in rats. Proceedings of the Medical Sciences Congress. (pp. 39). [Abstract]

Conference Contribution - Poster Presentation (not in published proceedings)

Groenewegen, L. G., Cotter, J. D., Rehrer, N. J., Clarkson, A. N., Harrison, J. C., Sammut, I. A., & Leader, J. P. (2005, December). Intermittent high intensity exercise and the expression of water channels in rat skeletal muscle. Poster session presented at the Medical Sciences Congress: The joint meeting of New Zealand Biomedical and Medical Societies, Queenstown, New Zealand.

Yang, S. S., Bedford, J. J., & Leader, J. P. (2005, December). Abundance of osmolytes and osmolyte transporter distribution in the thirsting rat kidney. Poster session presented at the Medical Sciences Congress, Queenstown, New Zealand.

2004

Conference Contribution - Published proceedings: Full paper

Hodgkinson, I. J., De Silva, L., Murray, P., Wu, Q. h., Arnold, M. D., & Leader, J. P. (2004). Modeling optical reflectance from chiral micro-mirrors embedded in manuka beetles. In A. Lakhtakia & S. A. Maksimenko (Eds.), Proceedings of the Society of Photo-Optical Instrumentation Engineers: Nanomodelling. 5509, (pp. 15-23). Bellingham, WA: SPIE. [Full Paper]

Conference Contribution - Published proceedings: Abstract

Walker, R., Bedford, J., MacDonald, F., Weggery, S., & Leader, J. (2004). Lithium induced reducation of urinary aquaporin (AQP2) excretion and urinary concentrating ability in normal human volunteers. Proceedings of the 40th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology. (pp. A33). Adelaide, Australia: ANZSN. [Abstract]

2003

Journal - Research Article

Al-Dameh, A. O., Bedford, J. J., Leader, J. P., & Walker, R. J. (2003). Urinary aquaporin-2 levels in healthy volunteers. Nephrology, 8, 139-141.

Bedford, J. J., Leader, J. P., & Walker, R. J. (2003). Aquaporin expression in normal human kidney and in renal disease. Journal of the American Society of Nephrology, 14, 2581-2587.

Conference Contribution - Published proceedings: Abstract

Walker, R. J., Bedford, J. J., & Leader, J. P. (2003). Lithium induced reducation of urinary aquaporin (AQP2) excretion and urinary concentrating ability in normal human volunteers. Journal of American Society of Nephrology. 14, (pp. 750A). [Abstract]

Leader, J. P., Bedford, J. J., & Walker, R. J. (2003). Sidedness of expression of AQP1 in mIMCD cells. Proceedings of the Experimental Biology Late-Breaking. [Abstract]

Bedford, J. J., Leader, J. P., & Walker, R. J. (2003). Glomerulart endothelium shows increased expression of AQP1 in renal disease. Proceedings of the Experimental Biology Late-Breaking. [Abstract]

2002

Journal - Research Article

Bedford, J. J., Schofield, J. C., Yancey, P. H., & Leader, J. P. (2002). The effects of hypoosmotic infusion on the composition of renal tissue of the Australian brush-tailed possum Trichosurus vulpecula. Comparative Biochemistry & Physiology Part B, 132, 645-652.

Bedford, J. J., Burg, M. B., Peters, E., Smith, R. A. J., & Leader, J. P. (2002). Putative osmolytes in the kidney of the Australian brush-tailed possum, Trichosurus vulpecula. Comparative Biochemistry & Physiology Part B, 132, 635-644.

Conference Contribution - Published proceedings: Abstract

Leader, J. P., Bedford, J. J., & Neufeld, D. S. (2002). Tolerance to freezing if the malpighian tubules of the New Zealand weta. Proceedings of the Experimental Biology Late-Breaking. [Abstract]

Short-Rollo, J., & Leader, J. P. (2002). Aquaporin-1 is expressed in cultured IMCD cells in response to external hypertonic shock. New Zealand Medical Journal, 115(1159), (pp. 1-10). [Abstract]

Leader, J. P., Bedford, J. J., & Neufeld, D. (2002). Tolerance to freezing of the Malpighian tubules of the New Zealand weta, Hemideina maori. Experimental Biology. (pp. LB49). New Orleans: Federation of American Society for Experimental Biology. [Abstract]

Walker, R. J., Bedford, J. J., & Leader, J. P. (2002). Aquaporin expression in renal disease. Journal of the American Society of Nephrology. 13, (pp. 472A). [Abstract]

2001

Chapter in Book - Research

Leader, J. P., & Neufeld, D. (2001). Haemolymph physiology. In L. H. Field (Ed.), Biology of Wetas, King Crickets and their Allies. (pp. 509-517). Oxon, UK: CAB International.

Journal - Research Article

Bedford, J. J., Stanton, J.-A. L., & Leader, J. P. (2001). A taurine transporter isolated from rat cardiac muscle. Advances in Experimental Medicine & Biology, 483, 523-534.

Conference Contribution - Published proceedings: Abstract

Leader, J. P., Bedford, J. J., & Neufeld, D. (2001). Cell volume regulation in the malpighian tubules of the freezing-tolerant New Zealand montane weta, Hemideina. Proceedings of the Molecuar Mechanism in Cell Volume Regulation. [Abstract]

Palmer, H. R., Bedford, J. J., Leader, J. P., Smith, R. A. J., & Gao, Z. (2001). Understanding counteracting osmolytes: An investigation based on nuclear magnetic resonance spectroscopy. Proceedings of the Molecuar Mechanism in Cell Volume Regulation. [Abstract]

2000

Journal - Research Article

Leader, J. P., & Bedford, J. J. (2000). What happens to an insect when it freezes and does it matter? New Zealand Science Monthly, 11(7), 6-8.

Palmer, H. R., Bedford, J. J., Leader, J. P., & Smith, R. A. J. (2000). ³¹P and ¹H NMR studies of the effect of the counteracting osmolyte trimethylamine-N-oxide on interactions of urea with ribonuclease A. Journal of Biological Chemistry, 275, 27708-27711.

Conference Contribution - Published proceedings: Abstract

Bedford, J. J., Stanton, J.-A. L., & Leader, J. P. (2000). Expression and properties of a taurine transporter from rat heart. Federation of American Societies for Experimental Biology Journal. 14(4), (pp. A99). [Abstract]

Leader, J. P., Palmer, H. R., & Smith, R. A. J. (2000). NMR investigations of the effects of trimethylamine oxide on the structure abd function of ribonuclease A. Federation of American Societies for Experimental Biology Journal. 14(4), (pp. A99). [Abstract]

Pepper, B. M., Rehrer, N., & Leader, J. P. (2000). The effect of oral glycerol on human athletic performance. Federation of American Societies for Experimental Biology Journal. 14(4), (pp. A616). [Abstract]

1999

Conference Contribution - Published proceedings: Abstract

Bedford, J. J., & Leader, J. P. (1999). Osmolytes in the developing kidney of the Australian brush-tailed possum, Trichosurus vulpecula. Federation of American Societies for Experimental Biology Journal. 13(348.10). [Abstract]

Wilson, P. W., Neufeld, D. S., & Leader, J. P. (1999). Freezing damage to the Malpighian tubules of the montane weta. International Congress of Cryobiology. (140P). [Abstract]

Leader, J. P., Harper, J. L., Biyouki, M. A. A., Bedford, J. J., & Smith, R. A. J. (1999). Organo-fluorine compunds for the determination of intracellular pH using NMR spectroscopy. Experimental Biology Journal. 13(348.09). [Abstract]

1998

Journal - Research Article

Biyouki, M. A. A., Smith, R. A. J., Bedford, J. J., & Leader, J. P. (1998). Hydroxymethylation and carbamoylation of di- and tetramethylpyridines using radical (Minisci) reactions. Synthetic Communications, 28, 3817-3825.

Bedford, J. J., Harper, J. L., Leader, J. P., & Smith, R. A. J. (1998). Identification and measurement of methylamines in elasmobranch tissues using proton nuclear magnetic resonance (¹H-NMR) spectroscopy. Journal of Comparative Physiology B, 168(2), 123-131.

Neufeld, D., & Leader, J. P. (1998). Electrochemical characteristics of ion secretion in Malpighian tubules of the New Zealand alpine weta (Hemideina maori). Journal of Insect Physiology, 44, 39-48.

Neufeld, D., & Leader, J. P. (1998). Freezing survival by isolated Malpighian tubules of the New Zealand alpine weta, Hemideina maori. Journal of Experimental Biology, 201, 227-236.

Neufeld, D., & Leader, J. P. (1998). Cold inhibition of cell volume regulation during the freezing of insect Malpighian tubules. Journal of Experimental Biology, 201, 2195-2204.

Kovbasnjuk, O., Leader, J. P., Weinstein, A. M., & Spring, K. R. (1998). Water does not flow across the tight junctions of MDCK cell epithelium. PNAS, 95, 6526-6530.

Bedford, J. J., Harper, J. L., Leader, J. P., Yancey, P. H., & Smith, R. A. J. (1998). Betaine is the principal counteracting osmolyte in tissues of the elephant fish, Callorhincus millii (Elasmobranchii, Holocephali). Comparative Biochemistry & Physiology Part B, 119(3), 521-526.

1997

Journal - Research Article

Harper, J. L., Smith, R. A. J., Bedford, J. J., & Leader, J. P. (1997). Synthesis, acidity and ¹⁹F-NMR characteristics of 1-substituted fluoroimidazoles with potential application as probes for intracellular pH determination. Tetrahedron, 53(24), 8211-8224.

Conference Contribution - Published proceedings: Abstract

Leader, J. P., & Bedford, J. J. (1997). Osmolytes in the developing kidney of the Australian brush-tailed possum, Trichosurus vulpecula. Proceedings of the International Congress of Physiology. (pp. P025.09). [Abstract]

Leader, J. P., & Bedford, J. J. (1997). Osmolytes in the developing kidney of the Australian brush-tailed possum, Trichosurus vulpecula. Proceedings of the University of Otago Medical School Research Society. (pp. 15). [Abstract]

Bedford, J. J., Leader, J. P., & Walker, R. J. (1997). Glomerular endothelium shows increased expression of AQP1 in renal disease. Federation of American Soceities for Experimental Biology Journal. (pp. 17). [Abstract]

1995

Journal - Research Article

Wilson, P. W., & Leader, J. P. (1995). Stabilization of supercooled fluids by thermal hysteresis proteins. Biophysical Journal, 68(5), 2098-2107. doi: 10.1016/S0006-3495(95)80389-9