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Health Sciences profile

Professor Stephen Brennan

PositionClinical Professor
DepartmentDepartment of Pathology and Biomedical Science (Christchurch)
QualificationsBSc(Hons), PhD(Massey), FRSNZ
Research summaryMolecular Pathology

Research

Principal research interest is elaborating the interrelationships between protein structure, function, and disease. Both genetic (mutation) and acquired (post-translational) modification of a proteins structure can affect its function and induce disease. Have a specific interest in mutations and disease mechanisms associated with:
  • The haemoglobinopathies and thalassaemias
  • a1 antitrypsin deficiency and liver cirrhosis / emphysema.
  • Antithrombin mutation and deep vein thrombosis / pulmonary embolism.
  • Apolipoprotein mutation and hyperlipidemia.
  • Albumin mutation and familial hyperthyroxemia.
  • Dysfibrinogenaemia and bleeding, thrombosis and renal amyloidosis
  • Hypo-and afibrinogenaemia and its association with bleeding and liver cirrhosis.

Publications

Turner, R., Brennan, S. O., Ashby, L. V., Dickerhof, N., Hamzah, M. R., Pearson, J. F., Stamp, L. K., & Kettle, A. J. (2018). Conjugation of urate-derived electrophiles to proteins during normal metabolism and inflammation. Journal of Biological Chemistry, 293(51), 19886-19898. doi: 10.1074/jbc.RA118.005237

Brennan, S. O., & Laurie, A. D. (2018). Mutation of the -RPVR- propeptide motif at C-terminal of the Aα chain is associated with decreased fibrinogen expression. Thrombosis & Haemostasis, 118(1), 207-209. doi: 10.1160/th17-08-0578

Marchi, R., Linares, M., Rojas, H., Ruiz-Saez, A., Meyer, M., Casini, A., & Brennan, S. O. (2017). A novel fibrinogen mutation: FGA g. 3057 C > T (p. Arg104 > Cys) impairs fibrinogen secretion. BMC Hematology, 17, 22. doi: 10.1186/s12878-017-0086-8

Brennan, S. O., & Laurie, A. D. (2017). Hypofibrinogenaemia associated with novel Aα126Val→Asp mutation in the fibrinogen coiled coil. Thrombosis & Haemostasis, 117(10), 2000-2002. doi: 10.1160/TH17-04-0270

Pullon, B. M., & Brennan, S. O. (2017). Two familial cases of Hb Tyne confirm instability as cause of low expression. Thalassemia Reports, 7(1), 6504. doi: 10.4081/thal.2017.6504

Ledgerwood, E. C., & Brennan, S. (1995). Furin. In A. Haeberli (Ed.), Human Protein Data: 3rd Instalment. VCH: Weinheim and New York.

Chapter in Book - Research

Turner, R., Brennan, S. O., Ashby, L. V., Dickerhof, N., Hamzah, M. R., Pearson, J. F., Stamp, L. K., & Kettle, A. J. (2018). Conjugation of urate-derived electrophiles to proteins during normal metabolism and inflammation. Journal of Biological Chemistry, 293(51), 19886-19898. doi: 10.1074/jbc.RA118.005237

Journal - Research Article

Marchi, R., Linares, M., Rojas, H., Ruiz-Saez, A., Meyer, M., Casini, A., & Brennan, S. O. (2017). A novel fibrinogen mutation: FGA g. 3057 C > T (p. Arg104 > Cys) impairs fibrinogen secretion. BMC Hematology, 17, 22. doi: 10.1186/s12878-017-0086-8

Journal - Research Article

Brennan, S. O., & MacKay, R. (2016). Acquired and congenital fast albumin bands; Insights from electrospray TOF analysis of whole plasma into drug binding and albumin recycling. Clinical Biochemistry, 49, 180-182. doi: 10.1016/j.clinbiochem.2015.09.013

Journal - Research Article

Brennan, S. O., Laurie, A. D., & Bell, J.-A. (2016). Novel FGB mutation Bβ240Cys→Arg confirms importance of the Bβ211-240 disulphide for plasma expression of fibrinogen. Thrombosis Research, 147, 94-96. doi: 10.1016/j.thromres.2016.09.031

Journal - Research Article

Brennan, S. O., Potter, H. C., & Hanss, M. (2016). Bisalbuminaemia due to novel mutation at a critical residue involved in recycling; Albumin Lyon (510His → Arg). Clinical Biochemistry, 49(7-8), 544-547. doi: 10.1016/j.clinbiochem.2016.01.008

Journal - Research Article

Brennan, S. O., Potter, H. C., Sheen, C. R., & George, P. M. (2016). Unique albumin with two silent substitutions (540Thr → Ala and 546Ala → Ser): Insights into how albumin is recycled. Clinica Chimica Acta, 457, 125-129. doi: 10.1016/j.cca.2016.04.014

Journal - Research Article

King, R. I., & Brennan, S. O. (2016). Direct analysis of VLDL by TOF-MS allows rapid definition of Apo E genotypes and facilitates characterisation of post translational changes. Clinica Chimica Acta, 457, 54-58. doi: 10.1016/j.cca.2016.03.021

Journal - Research Article

Aung, N. N., Kennedy, H., Faed, J. M., & Brennan, S. O. (2015). Novel heterozygous Bbeta (c.1311T>A) mutation (Fibrinogen St Kilda) associated with recurrent pregnancy loss. Pathology, 47(6), 583-585. doi: 10.1097/pat.0000000000000307

Journal - Research Article

Brennan, S. O. (2015). Variation of fibrinogen oligosaccharide structure in the acute phase response: Possible haemorrhagic implications. Biochimica et Biophysica Acta: Clinical, 3, 221-226. doi: 10.1016/j.bbacli.2015.02.007

Journal - Research Article

Brennan, S. O., Laurie, A. D., Mo, A., & Grigg, A. (2015). Novel fibrinogen mutations (Aα17Gly→Cys and Aα381Ser→Phe) occurring with a 312Thr→Ala polymorphism: Allelic phase assigned by direct mass measurement. Blood Coagulation & Fibrinolysis, 26(8), 882-886. doi: 10.1097/mbc.0000000000000316

Journal - Research Article

Brennan, S. O., Laurie, A., & Smith, M. (2015). Novel FGG variant (γ339C→S) confirms importance of the γ326–339 disulphide bond for plasma expression of newly synthesised fibrinogen. Thrombosis & Haemostasis, 113(4), 903-905. doi: 10.1160/TH14-10-0849

Journal - Research Article

Brennan, S. O., Rollo, C., & Potter, H. C. (2015). Novel silent albumin variant (191Ala → Thr) detected by TOF MS of whole plasma. Clinica Chimica Acta, 440, 40-43. doi: 10.1016/j.cca.2014.11.003

Journal - Research Article

Lankes, U., Brennan, S. O., Walmsley, T. A., & George, P. M. (2015). Relative quantification of albumin and fibrinogen modifications by liquid chromatography tandem mass spectrometry in the diagnosis and monitoring of acute pancreatitis. Journal of Chromatography B, 988, 121-126. doi: 10.1016/j.jchromb.2015.02.013

Journal - Research Article

Brennan, S. O., & Laurie, A. (2014). Functionally compromised FGG variant (γ320Asp→Glu) expressed at low level in plasma fibrinogen. Thrombosis Research, 134, 744-746. doi: 10.1016/j.thromres.2014.06.030

Journal - Research Article

Brennan, S. O., Mangos, H., & Faed, J. M. (2014). Benign FGB (148Lys→Asn, and 448Arg→Lys), and novel causative y211Tyr→His mutation distinguished by time of flight mass spectrometry in a family with hypofibrinogenaemia. Thrombosis & Haemostasis, 111(4), 679-684. doi: 10.1160/TH13-08-0657

Journal - Research Article

Brennan, S. O., Povall, A., & Lankes, U. (2014). Hb Ashburton [β12(A9)Thr → Pro; HBB: C.37A > C], a novel, mildly unstable variant and the first substitution identified at codon 12. Hemoglobin, 38(2), 79-83. doi: 10.3109/03630269.2013.879065

Journal - Research Article

Galanakis, D. K., Neerman-Arbez, M., Brennan, S., Rafailovich, M., Hyder, L., Travlou, O., … Scharrer, I. (2014). Thromboelastographic phenotypes of fibrinogen and its variants: Clinical and non-clinical implications. Thrombosis Research, 133(6), 1115-1123. doi: 10.1016/j.thromres.2014.03.026

Journal - Research Article

Shen, Y.-M., Trang, V., Sarode, R., & Brennan, S. (2014). Fibrinogen Dusart presenting as recurrent thromboses in the hepatic portal system. Blood Coagulation & Fibrinolysis, 25(4), 392-394. doi: 10.1097/mbc.0000000000000045

Journal - Research Article

Brennan, S. O., & Chan, T. (2013). Hb Papanui [α99(G8)Lys→Arg; HBA2: c.299A>G]: A novel silent substitution interfering in Hb A1c determination. Hemoglobin, 37(6), 589-592. doi: 10.3109/03630269.2013.809734

Journal - Research Article

Brennan, S. O., & Chitlur, M. (2013). Hypodysfibrinogenaemia and thrombosis in association with a new fibrinogen γ chain with two mutations (γ114Tyr→His, and γ320Asp deleted). Thrombosis & Haemostasis, 109(6), 1180-1182. doi: 10.1160/TH13-01-0068

Journal - Research Article

Brennan, S. O., Zebeljan, D., & Ho, L. L. (2013). Thrombosis in association with a novel substitution (γ346Gly→Val) at an absolutely conserved site in the fibrinogen γ chain. Thrombosis & Haemostasis, 109(4), 757-758. doi: 10.1160/th12-11-0832

Journal - Research Article

Marchi, R., Brennan, S., Meyer, M., Rojas, H., Kanzler, D., De Agrela, M., & Ruiz-Saez, A. (2013). A novel mutation in the FGB: c.1105C>T turns the codon for amino acid Bβ Q339 into a stop codon causing hypofibrinogenemia. Blood Cells, Molecules & Diseases, 50(3), 177-181. doi: 10.1016/j.bcmd.2012.11.010

Journal - Research Article

Andersen, J. T., Dalhus, B., Cameron, J., Daba, M. B., Plumridge, A., Evans, L., Brennan, S. O., … Sandlie, I. (2012). Structure-based mutagenesis reveals the albumin-binding site of the neonatal Fc receptor. Nature Communications, 3, 610. doi: 10.1038/ncomms1607

Journal - Research Article

Brennan, S. O., Chan, T., & Duncan, J. (2012). Novel α2 gene deletion (c.349_359 del GAGTTCACCCC) identified in association with the -α3.7 deletion. Hemoglobin, 36(1), 93-97. doi: 10.3109/03630269.2011.637592

Journal - Research Article

Brennan, S. O., King, R. I., & Florkowski, C. M. (2012). β37Trp→Cys mutation leads to multiple new hemoglobin species in red cells. Clinical Biochemistry, 45, 259-263. doi: 10.1016/j.clinbiochem.2011.12.001

Journal - Research Article

Brennan, S. O., Pullon, B., Owen, M. C., & Brittain, T. (2012). Novel hemoglobin mutation (α127Lys→Glu) increases oxygen affinity and has a minor effect on haptoglobin binding. Clinical Biochemistry, 45(18). doi: 10.1016/j.clinbiochem.2012.08.021

Journal - Research Article

Cheah, C. Y., Brennan, S. O., Kennedy, H., Januszewicz, E. H., Maxwell, E., & Burbury, K. (2012). Fibrinogen Melbourne: A novel congenital hypodysfibrinogenemia caused by [gamma]326Cys-Phe in the fibrinogen [gamma] chain, presenting as massive splanchnic venous thrombosis. Blood Coagulation & Fibrinolysis, 23(6), 563-565. doi: 10.1097/MBC.0b013e328354a23b

Journal - Research Article

Ireland, R. D., Brennan, S. O., Gerrard, J. A., Walmsley, T. A., George, P. M., & King, R. I. (2012). A mass-spectroscopic method for measuring des-Leu albumin: A novel marker for chronic pancreatitis. Clinical Biochemistry, 45(18), 1664-1668. doi: 10.1016/j.clinbiochem.2012.08.017

Journal - Research Article

Brennan, S. O., & Roncolato, F. (2011). Novel fibrinogen (Bβ401Gly→Val) presents as dys- or hypodysfibrinogenaemia due to alterations in sialic acid content. Thrombosis & Haemostasis, 106(3), 551-553. doi: 10.1160/TH11-05-0287

Journal - Research Article

Brennan, S. O., Oliver, J., & Davis, R. L. (2011). Adjacent substitutions (γ352Gly→Cys and 353Thr→Pro) in fibrinogen Ilam cause diminished γ chain expression. Thrombosis & Haemostasis, 105, 379-381. doi: 10.1160/TH10-09-0619

Journal - Research Article

Brennan, S. O., & Chan, T. (2010). Hb Perpignan [β136(H14)GLY→Ser], a silent variant associated with normal hematology. Hemoglobin, 34(2), 157-160. doi: 10.3109/03630261003677221

Journal - Research Article

Brennan, S. O., & Davis, R. L. (2010). Substitution (γ335Trp→Arg) in fibrinogen Fremantle causes diminished γ chain expression and increased sialic acid content. Thrombosis & Haemostasis, 104(6), 1274-1276. doi: 10.1160/TH10-04-0252

Journal - Research Article

Brennan, S. O., Davis, R. L., & Chitlur, M. (2010). New fibrinogen substitution (γSer313Arg) causes diminished γ chain expression and hypodysfibrinogenaemia. Thrombosis & Haemostasis, 103(2), 478-479. doi: 10.1160/TH09-07-0459

Journal - Research Article

Brennan, S. O., Davis, R. L., Conard, K., Savo, A., & Furuya, K. N. (2010). Novel fibrinogen mutation γ314Thr → Pro (fibrinogen Al duPont) associated with hepatic fibrinogen storage disease and hypofibrinogenaemia. Liver International, 30(10), 1541-1547. doi: 10.1111/j.1478-3231.2010.02312.x

Journal - Research Article

Brennan, S. O., Ryken, S., & Chan, T. (2010). Hb Koya Dora [α142, Term→Ser (TAA>TCA in α2)]: A rare mutation of the α2 gene stop codon associated with α-thalassemia. Hemoglobin, 34(4), 402-405. doi: 10.3109/03630269.2010.486344

Journal - Research Article

Sheen, C. R., Dear, A., & Brennan, S. O. (2010). Expression of four mutant fibrinogen γC domains in Pichia pastoris confirms them as causes of hypofibrinogenaemia. Protein Expression & Purification, 73, 184-188. doi: 10.1016/j.pep.2010.05.008

Journal - Research Article

Brennan, S. O., Chan, T., Ryken, S., & Ruskova, A. (2009). A second case of HB Fontainebleau [α21(B2)Ala→Pro] in an individual with microcytosis. Hemoglobin, 33(3), 258-261. doi: 10.1080/03630260903061135

Journal - Research Article

Brennan, S. O., Davis, R. L., Lowen, R., & Ruskova, A. (2009). Deletion of five residues from the coiled coil of fibrinogen (Bβ Asn167_Glu171del) associated with bleeding and hypodysfibrinogenemia. Haematologica, 94(4), 585-588. doi: 10.3324/haematol.2008.001412

Journal - Research Article

Davis, R. L., Homer, V. M., George, P. M., & Brennan, S. O. (2009). A deep intronic mutation in FGB creates a consensus exonic splicing enhancer motif that results in afibrinogenemia caused by aberrant mRNA splicing, which can be corrected in vitro with antisense oligonucleotide treatment. Human Mutation, 30(2), 221-227. doi: 10.1002/humu.20839

Journal - Research Article

Davis, R. L., May, S., Chunilal, S., & Brennan, S. O. (2009). Two novel mutations at contiguous codons in the fibrinogen Ββ chain associated with hypofibrinogenaemia. Thrombosis & Haemostasis, 101(5), 980-982. doi: 10.1160/th08-11-0727

Journal - Research Article

Dempfle, C.-E., George, P. M., Borggrefe, M., Neumaier, M., & Brennan, S. O. (2009). Demonstration of heterodimeric fibrinogen molecules partially conjugated with albumin in a novel dysfibrinogen: Fibrinogen Mannheim V. Thrombosis & Haemostasis, 102, 29-34. doi: 10.1160/TH08-09-0559

Journal - Research Article

Brennan, S. O., Owen, M. C., Chan, T., & Ruskova, A. (2008). Novel hemoglobin α chain elongation resulting from a 15-residue insertion and tandem duplication of the F helix. Clinical Biochemistry, 41, 1156-1161. doi: 10.1016/j.clinbiochem.2008.05.011

Journal - Research Article

Davis, R. L., Baker, B., & Brennan, S. O. (2008). Fibrinogen Foxton: A novel BβA277V mutation causing low normal plasma fibrinogen concentration. Thrombosis & Haemostasis, 100(4), 708-710. doi: 10.1160/TH08-05-0304

Journal - Research Article

Davis, R. L., Peters, Jr, T., & Brennan, S. O. (2008). Novel frameshift in the serum albumin gene results in analbuminemia through premature truncation and post translational modification. Clinical Biochemistry, 41(18), 1482-1485. doi: 10.1016/j.clinbiochem.2008.08.082

Journal - Research Article

Brennan, S. O., Davis, R. L., Mosesson, M. W., Hernandez, I., Lowen, R., & Alexander, S. J. (2007). Congenital hypodysfibrinogenaemia (Fibrinogen Des Moines) due to a γ320Asp deletion at the Ca2+ binding site. Thrombosis & Haemostasis, 98, 467-469.

Journal - Research Article

Davis, R. L., & Brennan, S. O. (2007). Fibrinogen Tolaga Bay: A novel γAla341Val mutation causing hypofibrinogenaemia. Journal of Thrombosis & Haemostasis, 98, 1136-1138.

Journal - Research Article

Dear, A., Brennan, S. O., Sheat, M. J., Faed, J. M., & George, P. M. (2007). Acquired dysfibrinogenemia caused by monoclonal production of immunoglobulin λ light chain. Haematologica, 92, e111-e117. doi: 10.3324/haematol.11837

Journal - Research Article

Liew, O. W., Chong, P. C. J., Lim, Y. Z., Ang, C. X., Lau, Y. C. A., Yandle, T. G., & Brennan, S. O. (2007). An SRLLR motif downstream of the scissile bond enhances enterokinase cleavage efficiency. Biochimie, 89, 21-29.

Journal - Research Article

Metcalf, V. J., George, P. M., & Brennan, S. O. (2007). Lungfish albumin is more similar to tetrapod than to teleost albumins: Purification and characterisation of albumin from the Australian lungfish, Neoceratodus forsteri. Comparative Biochemistry & Physiology Part B, 147, 428-437.

Journal - Research Article

Meyer, M., Dietzel, H., Kaetzel, R., Schmidt, D., Liebscher, K., & Brennan, S. O. (2007). Fibrinogen Leipzig II (γ351Gly→Ser and γ82Ala→Gly): Hypodysfibrinogenaemia due to two independent amino acid substitutions within the same polypeptide chain. Thrombosis & Haemostasis, 98(4), 903-905.

Journal - Research Article

Schmidt, D., & Brennan, S. O. (2007). Modified form of the fibrinogen Bβ chain (des-Gln Bβ), a potential long-lived marker of pancreatitis. Clinical Chemistry, 53(12), 2105-2111.

Journal - Research Article

Sheen, C. R., Jewell, U. R., Morris, C. M., Brennan, S. O., Férec, C., George, P. M., Smith, M. P., & Chen, J.-M. (2007). Double complex mutations involving F8 and FUNDC2 caused by distinct break-induced replication. Human Mutation, 28(12), 1198-1206.

Journal - Research Article

Tennent, G. A., Brennan, S. O., Stangou, A. J., O'Grady, J., Hawkins, P. N., & Pepys, M. B. (2007). Human plasma fibrinogen is synthesized in the liver. Blood, 109(5), 1971-1974.

Journal - Research Article

Testro, A. G., Brennan, S. O., MacDonell, R. A. L., Hawkins, P. N., & Angus, P. W. (2007). Hereditary amyloidosis with progressive peripheral neuropathy associated with apolipoprotein A1 Gly26Arg: Outcome of hepatorenal transplantation. Liver Transplantation, 13, 1028-1031.

Journal - Research Article

Brennan, S. O., Homer, V. M., Davis, R. L., Meyer, M., & George, P. M. (2006). Hypofibrinogenaemia associated with common γ82Ala→Gly mutation is not mediated by altered mRNA splicing. Thrombosis & Haemostasis, 96, 535-537.

Journal - Research Article

Brennan, S. O., Mosesson, M. W., Lowen, R., & Frantz, C. (2006). Dysfibrinogenemia (fibrinogen Wilmington) due to a novel Aα chain truncation causing decreased plasma expression and impaired fibrin polymerisation. Thrombosis & Haemostasis, 96, 88-89.

Journal - Research Article

Brennan, S. O., Mosesson, M. W., Lowen, R., Siebenlist, K. R., & Matsunaga, A. (2006). Hypofibrinogenaemia resulting from novel single nucleotide deletion at codon Bβ58 (3404del A) associated with thrombotic stroke in infancy. Thrombosis & Haemostasis, 95, 738-739.

Journal - Research Article

Dear, A., Daly, J., Brennan, S. O., Tuckfield, A., & George, P. M. (2006). An intronic mutation within FGB (IVS1+2076 a → g) is associated with afibrinogenemia and recurrent transient ischemic attacks. Journal of Thrombosis & Haemostasis, 4, 471-472.

Journal - Research Article

Hill, M. B., Brennan, S. O., Dear, A., Strong, J., Nejim, T., & Dolan, G. (2006). Fibrinogen Nottingham II: A novel Bβ Arg264gly substitution causing hypofibrinogenaemia. Thrombosis & Haemostasis, 96, 378-380.

Journal - Research Article

Kruse, K. B., Dear, A., Kaltenbrun, E. R., Crum, B. E., George, P. M., Brennan, S. O., & McCracken, A. A. (2006). Mutant fibrinogen cleared from the endoplasmic reticulum via endoplasmic reticulum-associated protein degradation and autophagy. American Journal of Pathology, 168(4), 1299-1308.

Journal - Research Article

Meyer, M., Bergmann, F., & Brennan, S. O. (2006). Novel fibrinogen mutation ([gamma] 313 Ser->Asn) associated with hypofibrinogenemia in two unrelated families. Blood Coagulation & Fibrinolysis, 17(1), 63-67.

Journal - Research Article

Sheen, C. R., Brennan, S. O., Jabado, N., & George, P. M. (2006). Fibrinogen Montreal: A novel missense mutation (Aα D496N) associated with hypofibrinogenaemia. Thrombosis & Haemostasis, 96, 231-232.

Journal - Research Article

Sheen, C. R., Low, J., Joseph, J., Kotlyar, E., George, P. M., & Brennan, S. O. (2006). Fibrinogen Darlinghurst: Hypofibrinogenaemia caused by a W253G mutation in the gamma chain in a patient with both bleeding and thrombotic complications. Thrombosis & Haemostasis, 96, 685-687.

Journal - Research Article

Blacklock, H. A., Case, J., Chan, T., Raizis, T., Doocey, R., Fellowes, A., … Brennan, S., & George, P. (2005). Novel sequence insertion in a Māori patient with transfusion-dependent β-thalassaemia. British Journal of Haematology, 131, 400-402.

Journal - Research Article

Brennan, S. O., Chan, T., Obele, M., & George, P. M. (2005). Hb Riccarton [α51(CE9)Gly→Ser]: A variant arising from a novel mutation in the α1 gene. Hemoglobin, 29(1), 61-64.

Journal - Research Article

Brennan, S. O., Sheen, C. R., & George, P. M. (2005). Novel γ230 Asn→Asp substitution in fibrinogen Middlemore associated hypofibrinogenaemia. Thrombosis & Haemostasis, 93, 1196-1197.

Journal - Research Article

Brennan, S. O., Sheen, C., Chan, T., & George, P. M. (2005). Hb Taradale [β82(EF6)Lys→Arg]: A novel mutation at a 2,3-diphosphoglycerate binding site. Hemoglobin, 29(4), 281-284.

Journal - Research Article

de Raucourt, E., de Mazancourt, P., Maghzal, G. J., Brennan, S. O., & Mosesson, M. W. (2005). Fibrinogen Saint-Germain II: Hypofibrinogenemia due to heterozygous γ N345S mutation. Thrombosis & Haemostasis, 94, 965-968.

Journal - Research Article

Dear, A., Brennan, S. O., & George, P. M. (2005). Familial hypodysfibrinogenaemia associated with second occurrence of γ326 Cys→Tyr mutation. Thrombosis & Haemostasis, 93, 612-613.

Journal - Research Article

Liew, O. W., Chong, J. P. C., Yandle, T. G., & Brennan, S. O. (2005). Preparation of recombinant thioredoxin fused N-terminal proCNP: Analysis of enterokinase cleavage products reveals new enterokinase cleavage sites. Protein Expression & Purification, 41, 332-340.

Journal - Research Article

Maghzal, G. J., Brennan, S. O., & George, P. M. (2005). The sialic acid content of fibrinogen decreases during pregnancy and increases in response to fibrate therapy. Thrombosis Research, 115, 293-299.

Journal - Research Article

Dear, A., Brennan, S. O., Dempfle, C.-E., Kirschstein, W., & George, P. M. (2004). Hypofibrinogenaemia associated with a novel heterozygous γ289 Ala→Val substitution (fibrinogen Dorfen). Journal of Thrombosis & Haemostasis, 92, 1291-1295.

Journal - Research Article

Dear, A., Dempfle, C. E., Brennan, S. O., Kirschstein, W., & George, P. M. (2004). Fibrinogen Mannheim II: A novel γ307 His → Tyr substitution in the γD domain causes hypofibrinogenemia. Journal of Thrombosis & Haemostasis, 2, 2194-2199.

Journal - Research Article

Lefebvre, P., Velasco, P. T., Dear, A., Lounes, K. C., Lord, S. T., Brennan, S. O., … Lorand, L. (2004). Severe hypodysfibrinogenemia in compound heterozygotes of the fibrinogen AαIVS4 + 1 G>T mutation and an AαGln328 truncation (fibrinogen Keokuk). Blood, 103(7), 2571-2576.

Journal - Research Article

Maghzal, G. J., Brennan, S. O., Homer, V. M., & George, P. M. (2004). The molecular mechanisms of congenital hypofibrinogenaemia. Cellular & Molecular Life Sciences, 61, 1427-1438.

Journal - Research Article

Mushunje, A., Evans, G., Brennan, S. O., Carrell, R. W., & Zhou, A. (2004). Latent antithrombin and its detection, formation and turnover in the circulation. Journal of Thrombosis & Haemostasis, 2(12), 2170-2177. doi: 10.1111/j.1538-7836.2004.01047.x

Journal - Research Article

Brennan, S., Chan, T., Sheen, C., & Rae, L. (2003). Hb Lusaka [α131(H14)Ser→Phe (α1)]: A new variant found in a woman heterozygous for Hb S [β6(A3)Glu→Val]. Hemoglobin, 27(3), 177-180.

Journal - Research Article

Chapman, A. L. P., Winterbourn, C. C., Brennan, S., Jordan, T. W., & Kettle, A. J. (2003). Characterization of non-covalent oligomers of proteins treated with hypochlorous acid. Biochemical Journal, 375, 33-40.

Journal - Research Article

Florkowski, C. M., Walmsley, T. A., Brennan, S., & George, P. M. (2003). Haemoglobin Marseille-Long Island and interpretation of HbA1c: Which HbA1c result is the 'right answer'? Postgraduate Medical Journal, 79, 174-175.

Journal - Research Article

Homer, V. M., Mullin, J. L., Brennan, S., Barr, A., & George, P. M. (2003). Novel Aα chain truncation (fibrinogen Perth) resulting in low expression and impaired fibrinogen polymerization. Journal of Thrombosis & Haemostasis, 1, 1245-1250.

Journal - Research Article

Maghzal, G. J., Brennan, S., & George, P. M. (2003). Fibrinogen Bβ polymorphisms do not directly contribute to an altered in vitro clot structure in humans. Thrombosis & Haemostasis, 90(6), 1021-1028.

Journal - Research Article

Maghzal, G. J., Brennan, S., Fellowes, A. P., Spearing, R. L., & George, P. M. (2003). Familial hypofibrinogenaemia associated with heterozygous substitution of a conserved arginine residue; Bβ255 Arg→His (Fibrinogen Merivale). Biochimica et Biophysica Acta: Proteins & Proteomics, 1645, 146-151.

Journal - Research Article

Metcalf, V., Brennan, S., & George, P. M. (2003). Using serum albumin to infer vertebrate phylogenies. Applied Bioinformatics, 2(3 Suppl.), 97-107.

Journal - Research Article

Brennan, S., Homer, V. M., Ockelford, P., & George, P. M. (2002). Low expression of truncated Aα Chain variant in circulating Fibrinogen. Thrombosis & Haemostasis, 88, 533-534.

Journal - Research Article

Brennan, S., Maghzal, G. J., Shneider, B. L., Gordon, R., Magid, M. S., & George, P. M. (2002). Novel Fibrinogen γ375 Arg→Trp mutation (Fibrinogen Aguadilla) causes hepatic endoplasmic reticulum storage and hypofibrinogenemia. Hepatology, 36, 652-658.

Journal - Research Article

Brennan, S., Potter, H. C., Kubala, L. M., Carnoutsos, S. A., & Ferguson, M. M. (2002). Hb Canterbury [beta112(G14)Cys-->Phe]: A new, mildly unstable variant. Hemoglobin, 26, 67-69.

Journal - Research Article

Brennan, S., Sheen, C., & Johnson, S. (2002). Hb Manawatu [α37(C2)Pro→Leu] A new mildly unstable mutation at an invariant proline residue. Hemoglobin, 26, 389-392.

Journal - Research Article

Copplestone, S., Mackay, R., & Brennan, S. (2002). Normal glycated haemoglobin in a patient with poorly controlled diabetes mellitus and haemoglobin D Punjab: Implications for assessment of control. New Zealand Medical Journal, 115(1157), U25. Retrieved from http://www.nzma.org.nz/journal/115-1157/25

Journal - Research Article

Homer, V. M., Brennan, S., & George, P. M. (2002). Four novel polymorphisms in the fibrinogen Aα gene. Thrombosis & Haemostasis, 87, 354-355.

Journal - Research Article

Homer, V. M., Brennan, S., & George, P. M. (2002). Novel fibrinogen Bβ chain mutation causing hypofibrinogenaemia. Thrombosis & Haemostasis, 88, 1066-1067.

Journal - Research Article

Homer, V. M., Brennan, S., Ockelford, P., & George, P. M. (2002). Novel Fibrinogen truncation with deletion of Bβ chain residues 440-461 causes hypofibrinogenaemia. Thrombosis & Haemostasis, 88, 427-431.

Journal - Research Article

Mullin, J. L., Brennan, S., Ganly, P. S., & George, P. M. (2002). Fibrinogen Hillsborough: A Novel γ309Gly→ Asp Dysfibrinogen. Blood, 99, 3597-3610.

Journal - Research Article

Beard, M. E. J., Potter, H. C., Spearing, R. L., & Brennan, S. (2001). Haemoglobin Pierre-Benite, a high affinity variant associated with relative polycythaemia. Clinical Laboratory Medicine, 23, 407-409.

Journal - Research Article

Brennan, S. O., Fellowes, A. P., & George, P. M. (2001). Molecular mechanisms of hypo- and afibrinogenemia. Annals of the New York Academy of Sciences, 936, 91-100.

Journal - Research Article

Brennan, S. O., Wyatt, J. M., Fellowes, A. P., Dlott, J. S., Triplett, D. A., & George, P. M. (2001). γ371 Thr → Ile substitution in the fibrinogen γD domain causes hypofibrinogenaemia. Biochimica et Biophysica Acta: Protein Structure & Molecular Enzymology, 1550, 183-188.

Journal - Research Article

Brennan, S. O., Wyatt, J. M., May, S. J., De Caigney, S., & George, P. M. (2001). Hypofibrinogenemia due to novel 316 Asp-Tyr substitution in the fibrinogen B beta chain. Thrombosis & Haemostasis, 85, 450-453.

Journal - Research Article

Fellowes, A. P., Brennan, S., & George, P. M. (2001). Identification and characterisation of five new fibrinogen gene polymorphisms. Annals of the New York Academy of Sciences, 936, 536-541.

Journal - Research Article

Hill, R. M., Brennan, S. O., & Birch, N. P. (2001). Expression, purification, and functional characterisatiion of the serine protease inhibitor neuroserpin expressed in drosophila S2 cells. Protein Expression & Purification, 22, 406-413.

Journal - Research Article

Medicina, D., Fabberetti, G., Brennan, S. O., George, P. M., Kudryk, B., & Callea, F. (2001). Genetic and immunological characterization of fibrinogen inclusion bodies in patients with hepatic storage and liver disease. Annals of the New York Academy of Sciences, 936, 522-525.

Journal - Research Article

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