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Health Sciences profile

Dr Indranil Basak

PositionPostdoctoral Fellow
DepartmentDepartment of Biochemistry
Research summaryBatten Disease; Neurodegeneration

Research

Indranil is a postdoctoral fellow in Dr Stephanie Hughes's lab in the Department of Biochemistry. He joined the University of Otago in June 2018 with an aim to understand the underlying mechanisms involved in neurodegeneration in Batten disease. Indranil has a PhD in Biological Sciences from St. John's University, New York, focusing on neurodegeneration in Parkinson's disease.

Indranil has a keen interest in non-coding RNAs, especially microRNAs. After the completion of his PhD, Indranil pursued a postdoctoral training at the University of Utah on microRNAs in hematology.

Indranil moved to New Zealand to reunite with his family and to follow his passion to study genetics and neurodegeneration.

At the University of Otago, he is investigating differential proteomic, epigenetic and transcriptomic profiles in Batten disease, using induced pluripotent stem cell derived neurons and CRISPR-Cas9 technologies, with an aim to identify potential therapeutic targets for this devastating childhood brain disease.

Publications

Basak, I., Wicky, H. E., McDonald, K. O., Xu, J. B., Palmer, J. E., Best, H. L., … Schoderboeck, L., & Hughes, S. M. (2021). A lysosomal enigma CLN5 and its significance in understanding neuronal ceroid lipofuscinosis. Cellular & Molecular Life Sciences. Advance online publication. doi: 10.1007/s00018-021-03813-x

Bhatlekar, S., Manne, B. K., Basak, I., Edelstein, L. C., Tugolukova, E., Stoller, M. L., … Bray, P. F. (2020). miR-125a-5p regulates megakaryocyte proplatelet formation via the actin bundling protein L-plastin. Blood. Advance online publication. doi: 10.1182/blood.2020005230

Basak, I., Bhatlekar, S., Manne, B. K., Stoller, M., Hugo, S., Kong, X., … Bray, P. F. (2019). miR-15a-5p regulates expression of multiple proteins in the megakaryocyte GPVI signaling pathway. Journal of Thrombosis & Haemostasis, 17(3), 511-524. doi: 10.1111/jth.14382

Bhatlekar, S., Basak, I., Edelstein, L. C., Campbell, R. A., Lindsey, C. R., Italiano, Jr, J. E., … Bray, P. F. (2019). Anti-apoptotic BCL2L2 increases megakaryocyte proplatelet formation in cultures of human cord blood. Haematologica, 104(10), 2075-2083. doi: 10.3324/haematol.2018.204685

Patil, K. S., Basak, I., Dalen, I., Hoedt, E., Lange, J., Lunde, K. A., … Møller, S. G. (2019). Combinatory microRNA serum signatures as classifiers of Parkinson's disease. Parkinsonism & Related Disorders, 64, 202-210. doi: 10.1016/j.parkreldis.2019.04.010

Basak, I., & Møller, S. G. (2018). Plant thermotolerance proteins, misfolded proteins, and neurodegenerative diseases. In A. R. Kermode & L. Jiang (Eds.), Molecular pharming: Applications, challenges, and emerging areas. (pp. 457-474). Hoboken, NJ: John Wiley & Sons. doi: 10.1002/9781118801512.ch18

Chapter in Book - Research

Bhatlekar, S., Manne, B. K., Basak, I., Edelstein, L. C., Tugolukova, E., Stoller, M. L., … Bray, P. F. (2020). miR-125a-5p regulates megakaryocyte proplatelet formation via the actin bundling protein L-plastin. Blood. Advance online publication. doi: 10.1182/blood.2020005230

Journal - Research Article

Basak, I., Bhatlekar, S., Manne, B. K., Stoller, M., Hugo, S., Kong, X., … Bray, P. F. (2019). miR-15a-5p regulates expression of multiple proteins in the megakaryocyte GPVI signaling pathway. Journal of Thrombosis & Haemostasis, 17(3), 511-524. doi: 10.1111/jth.14382

Journal - Research Article

Bhatlekar, S., Basak, I., Edelstein, L. C., Campbell, R. A., Lindsey, C. R., Italiano, Jr, J. E., … Bray, P. F. (2019). Anti-apoptotic BCL2L2 increases megakaryocyte proplatelet formation in cultures of human cord blood. Haematologica, 104(10), 2075-2083. doi: 10.3324/haematol.2018.204685

Journal - Research Article

Patil, K. S., Basak, I., Dalen, I., Hoedt, E., Lange, J., Lunde, K. A., … Møller, S. G. (2019). Combinatory microRNA serum signatures as classifiers of Parkinson's disease. Parkinsonism & Related Disorders, 64, 202-210. doi: 10.1016/j.parkreldis.2019.04.010

Journal - Research Article

Abdullah, R., Patil, K. S., Rosen, B., Pal, R., Prabhudesai, S., Lee, S., Basak, I., … Møller, S. G. (2017). Subcellular Parkinson’s disease-specific alpha-synuclein species show altered behavior in neurodegeneration. Molecular Neurobiology, 54(10), 7639-7655. doi: 10.1007/s12035-016-0266-8

Journal - Research Article

Basak, I., Patil, K. S., Alves, G., Larsen, J. P., & Møller, S. G. (2016). MicroRNAs as neuroregulators, biomarkers and therapeutic agents in neurodegenerative diseases. Cellular & Molecular Life Sciences, 73(4), 811-827. doi: 10.1007/s00018-015-2093-x

Journal - Research Article

Prabhudesai, S., Bensabeur, F. Z., Abdullah, R., Basak, I., Baez, S., Alves, G., … Møller, S. G. (2016). LRRK2 knockdown in zebrafish causes developmental defects, neuronal loss, and synuclein aggregation. Journal of Neuroscience Research, 94(8), 717-735. doi: 10.1002/jnr.23754

Journal - Research Article

Patil, K. S., Basak, I., Pal, R., Ho, H.-P., Alves, G., Chang, E. J., … Møller, S. G. (2015). A proteomics approach to investigate miR-153-3p and miR-205-5p targets in neuroblastoma cells. PLoS ONE, 10(12), e0143969. doi: 10.1371/journal.pone.0143969

Journal - Research Article

Basak, I., Pal, R., Patil, K. S., Dunne, A., Ho, H.-P., Lee, S., … Møller, S. G. (2014). Arabidopsis AtPARK13, which confers thermotolerance, targets misfolded proteins. Journal of Biological Chemistry, 289(21), 14458-14469. doi: 10.1074/jbc.M114.548156

Journal - Research Article

Patil, K. S., Basak, I., Lee, S., Abdullah, R., Larsen, J. P., & Møller, S. G. (2014). PARK13 regulates PINK1 and subcellular relocation patterns under oxidative stress in neurons. Journal of Neuroscience Research, 92(9), 1167-1177. doi: 10.1002/jnr.23396

Journal - Research Article

Basak, I., Wicky, H. E., McDonald, K. O., Xu, J. B., Palmer, J. E., Best, H. L., … Schoderboeck, L., & Hughes, S. M. (2021). A lysosomal enigma CLN5 and its significance in understanding neuronal ceroid lipofuscinosis. Cellular & Molecular Life Sciences. Advance online publication. doi: 10.1007/s00018-021-03813-x

Journal - Research Other

Basak, I., & Møller, S. G. (2013). Emerging facets of plastid division regulation. Planta, 237(2), 389-398. doi: 10.1007/s00425-012-1743-6

Journal - Research Other

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