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Health Sciences profile

Professor Paul Cooper

PositionDean of the Faculty of Dentistry, Professor of Oral Biology
DepartmentDepartment of Oral Sciences
QualificationsBSc(Hons) (Leeds) PhD (Birmingham) PGCILTHE (Birmingham)
Research summaryTissue engineering, pulp biology, periodontal inflammation, photobiomodulation
TeachingOral Biology
MembershipsIADR, PBRG

Research

My research is within the field of oral and dental tissue inflammation and repair. Current areas of research interest include:

1. Dentine-Pulp complex biology
Paul has led projects studying the molecular changes which occur in the dentine-pulp complex as a result of disease, dental injury and repair, and in its response to dental materials. PhD projects he has supervised have characterised dental pulp stem cells (DPSC) responses with the aim of developing novel treatment technologies.

2. Molecular and Cellular aspects of Periodontal Disease
Paul has led studies characterising oral epithelial or neutrophil responses to periodontal bacteria. In collaboration his work has shown that elevated systemic levels of IFNs are associated with the disease. Subsequently this has led to further studies on the roles of Neutrophil Extracellular Traps (NETs), auto-immunity/-inflammation, DNAse deficiency, epigenetics and efferocytosis in periodontitis and its comorbidities.

3. Low Level Light/Laser Therapy (LLLT) / photobiomodulation / phototherapy
Recent studies indicate the utility of phototherapies in promoting oral and dental tissue health as well as for disinfection. Different light delivery approaches are being explored to identify delivery parameters which modulate dentine-pulp complex, gingival and immune cell responses relevant to tissue health.

4. Assessment of toothpaste cleaning
Industry funded studies have utilised profilometry, gloss analyses, stain models and SEM to investigate mechanistic actions of dental dentifrices for oral hygiene.

Additional details

Professor Cooper has over 200 research peer reviewed publications and has authored and edited 12 book chapters in oral and pulp biology. He has delivered over 40 invited lectures globally. He has supervised over 40 Doctoral students and been awarded over NZ$10-million (equivalent) in research funding.

In 2010, Paul was awarded the IADR Distinguished Scientist Young Investigator Award and he has recently been the President of the Pulp Biology and Regeneration Group of IADR and he is currently the vice-president of the IADR-ANZ Division.

He has visiting chairs at several universities around the world and serves as editor and on editorial boards for several leading dental journals.

Paul also completed a postgraduate certificate in learning and teaching in higher education (PGCILTHE) in 2003 and is a Fellow of the Higher Education Academy.

Publications

Li, J., Wang, Z., Wang, J., Guo, Q., Fu, Y., Dai, Z., … Cooper, P. R., … He, W. (2022). Amphiregulin regulates odontogenic differentiation of dental pulp stem cells by activation of mitogen-activated protein kinase and the phosphatidylinositol 3-kinase signaling pathways. Stem Cell Research & Therapy, 13(1), 304. doi: 10.1186/s13287-022-02971-4

Pelepenko, L. E., Marciano, M. A., Francati, T. M., Bombarda, G., Antunes, T. B. M., Sorrentino, F., … Cooper, P. R., … Camilleri, J. (2022). Can strontium replace calcium in bioactive materials for dental applications? Journal of Biomedical Materials Research Part A. Advance online publication. doi: 10.1002/jbm.a.37421

Mohamad, S. A., Milward, M. R., Hadis, M. A., Kuehne, S. A., & Cooper, P. R. (2022). Blue light photobiomodulation of dental pulp cells. Lasers in Dental Science. Advance online publication. doi: 10.1007/s41547-022-00152-3

Yong, D., Choi, J. J. E., Cathro, P., Cooper, P. R., Dias, G., Huang, J., & Ratnayake, J. (2022). Development and analysis of a hydroxyapatite supplemented calcium silicate cement for endodontic treatment. Materials, 15(3), 1176. doi: 10.3390/ma15031176

Arora, S., Cooper, P. R., Ratnayake, J. T., Friedlander, L. T., Rizwan, S. B., Seo, B., & Hussaini, H. M. (2022). A critical review of in vitro research methodologies used to study mineralization in human dental pulp cell cultures. International Endodontic Journal, 55(Suppl. 1), 3-13. doi: 10.1111/iej.13684

Smith, A. J., & Cooper, P. R. (2015). Cellular signaling in dentin repair and regeneration. In A. Vishwakarma, P. Sharpe, S. Shi & M. Ramalingam (Eds.), Stem cell biology and tissue engineering in dental sciences. (pp. 405-417). London, UK: Elsevier. doi: 10.1016/B978-0-12-397157-9.00036-9

Chapter in Book - Research

Cooper, P. R., & Smith, A. J. (2014). Inflammatory processes in the dental pulp. In M. Goldberg (Ed.), The dental pulp: Biology, pathology, and regenerative therapies. (pp. 97-112). Berlin, Germany: Springer. doi: 10.1007/978-3-642-55160-4_7

Chapter in Book - Research

Simon, S., Smith, A. J., Lumley, P. J., Cooper, P. R., & Berdal, A. (2012). The pulp healing process: From generation to regeneration. In H. Larjava (Ed.), Oral wound healing: Cell biology and clinical management. (pp. 313-332). Oxford, UK: Wiley Blackwell. doi: 10.1002/9781118704509.ch13

Chapter in Book - Research

Simon, S., Cooper, P., & Berdal, I. A. (2011). Tissue engineering and endodontics. In J. Ferri & E. B. Hunziker (Eds.), Preprosthetic and maxillofacial surgery: Biomaterials, bone grafting and tissue engineering. (pp. 336-362). Cambridge, UK: Woodhead. doi: 10.1016/B978-1-84569-589-7.50018-3

Chapter in Book - Research

Aral, K., Milward, M. R., & Cooper, P. R. (2022). Inflammasome dysregulation in human gingival fibroblasts in response to periodontal pathogens. Oral Diseases, 28, 216-224. doi: 10.1111/odi.13760

Journal - Research Article

Li, J., Wang, Z., Wang, J., Guo, Q., Fu, Y., Dai, Z., … Cooper, P. R., … He, W. (2022). Amphiregulin regulates odontogenic differentiation of dental pulp stem cells by activation of mitogen-activated protein kinase and the phosphatidylinositol 3-kinase signaling pathways. Stem Cell Research & Therapy, 13(1), 304. doi: 10.1186/s13287-022-02971-4

Journal - Research Article

Mohamad, S. A., Milward, M. R., Hadis, M. A., Kuehne, S. A., & Cooper, P. R. (2022). Blue light photobiomodulation of dental pulp cells. Lasers in Dental Science. Advance online publication. doi: 10.1007/s41547-022-00152-3

Journal - Research Article

Pelepenko, L. E., Marciano, M. A., Francati, T. M., Bombarda, G., Antunes, T. B. M., Sorrentino, F., … Cooper, P. R., … Camilleri, J. (2022). Can strontium replace calcium in bioactive materials for dental applications? Journal of Biomedical Materials Research Part A. Advance online publication. doi: 10.1002/jbm.a.37421

Journal - Research Article

Yong, D., Choi, J. J. E., Cathro, P., Cooper, P. R., Dias, G., Huang, J., & Ratnayake, J. (2022). Development and analysis of a hydroxyapatite supplemented calcium silicate cement for endodontic treatment. Materials, 15(3), 1176. doi: 10.3390/ma15031176

Journal - Research Article

Aral, K., Milward, M. R., & Cooper, P. R. (2021). Gene expression profiles of mitochondria-endoplasmic reticulum tethering in human gingival fibroblasts in response to periodontal pathogens. Archives of Oral Biology, 128, 105173. doi: 10.1016/j.archoralbio.2021.105173

Journal - Research Article

Arora, S., Cooper, P. R., Friedlander, L. T., Rizwan, S., Seo, B., Rich, A. M., & Hussaini, H. M. (2021). Potential application of immunotherapy for modulation of pulp inflammation: Opportunities for Vital Pulp Treatment. International Endodontic Journal. Advance online publication. doi: 10.1111/iej.13524

Journal - Research Article

Arruda-Vasconcelos, R., Louzada, L. M., Feres, M., Tomson, P. L., Cooper, P. R., & Gomes, B. P. F. A. (2021). Investigation of microbial profile, levels of endotoxin and lipoteichoic acid in teeth with symptomatic irreversible pulpitis: A clinical study. International Endodontic Journal, 54, 46-60. doi: 10.1111/iej.13402

Journal - Research Article

Gleneadie, H. J., Baker, A. H., Batis, N., Bryant, J., Jiang, Y., Clokie, S. J. H., … Cooper, P. R., … Wiench, M. (2021). The anti-tumour activity of DNA methylation inhibitor 5-aza-2'-deoxycytidine is enhanced by the common analgesic paracetamol through induction of oxidative stress. Cancer Letters, 501, 172-186. doi: 10.1016/j.canlet.2020.12.029

Journal - Research Article

Jayash, S. N., Cooper, P. R., Shelton, R. M., Kuehne, S. A., & Poologasundarampillai, G. (2021). Novel chitosan-silica hybrid hydrogels for cell encapsulation and drug delivery. International Journal of Molecular Sciences, 22, 12267. doi: 10.3390/ijms222212267

Journal - Research Article

Mohamad, S. A., Milward, M. R., Kuehne, S. A., Hadis, M. A., Palin, W. M., & Cooper, P. R. (2021). Potential for direct application of blue light for photo-disinfection of dentine. Journal of Photochemistry & Photobiology B, 215, 112123. doi: 10.1016/j.jphotobiol.2021.112123

Journal - Research Article

Ngah, N. A., Dias, G. J., Tong, D. C., Mohd Noor, S. N. F., Ratnayake, J., Cooper, P. R., & Hussaini, H. M. (2021). Lyophilised platelet-rich fibrin: Physical and biological characterisation. Molecules, 26(23), 7131. doi: 10.3390/molecules26237131

Journal - Research Article

Paduano, F., Aiello, E., Cooper, P. R., Marrelli, B., Makeeva, I., Islam, M., … Tatullo, M. (2021). A dedifferentiation strategy to enhance the osteogenic potential of dental derived stem cells. Frontiers in Cell & Developmental Biology, 9, 668558. doi: 10.3389/fcell.2021.668558

Journal - Research Article

Serrage, H. J., Cooper, P. R., Palin, W. M., Horstman, P., Hadis, M., & Milward, M. R. (2021). Photobiomodulation of oral fibroblasts stimulated with periodontal pathogens. Lasers in Medical Science. Advance online publication. doi: 10.1007/s10103-021-03331-z

Journal - Research Article

Virdee, S. S., Bashir, N., Cooper, P. R., & Tomson, P. L. (2021). Exploiting dentine matrix proteins in cell-free approaches for periradicular tissue engineering. Tissue Engineering Part B: Reviews. Advance online publication. doi: 10.1089/ten.TEB.2021.0074

Journal - Research Article

Wang, C., Lucas, R., Milward, M., & Cooper, P. R. (2021). Particle size effects on abrasion, surface polishing and stain removal efficacy in a tooth model system. Biotribology, 28, 100196. doi: 10.1016/j.biotri.2021.100196

Journal - Research Article

Aral, K., Güler, O. C., Cooper, P. R., Shoker, S., Kuehne, S. A., & Milward, M. R. (2020). Antimicrobial effects of boric acid against periodontal pathogens [Borik Asitin Periodontal Patojenler Üzerine Olan Antimikrobiyal Etkileri]. Ege Üniversitesi Diş Hekimliği Fakültesi Dergisi, 41(1), 20-25. doi: 10.5505/eudfd.2020.04935

Journal - Research Article

Aral, K., Milward, M. R., & Cooper, P. R. (2020). Dysregulation of inflammasomes in human dental pulp cells exposed to Porphyromonas gingivalis and Fusobacterium nucleatum. Journal of Endodontics, 46(9), 1265-1272. doi: 10.1016/j.joen.2020.06.008

Journal - Research Article

Aral, K., Milward, M. R., Cooper, P. R., & Guler, O. C. (2020). Evaluation of psychological stress and cortisol levels in males with and without gingivitis. Annals of Medical Research, 27(5), 1459-1464. doi: 10.5455/annalsmedres.2019.11.710

Journal - Research Article

Aral, K., Milward, M. R., Gupta, D., & Cooper, P. R. (2020). Effects of Porphyromonas gingivalis and Fusobacterium nucleatum on inflammasomes and their regulators in H400 cells. Molecular Oral Microbiology, 35, 158-167. doi: 10.1111/omi.12302

Journal - Research Article

Heboyan, A., Syed, A. U. Y., Rokaya, D., Cooper, P. R., Manrikyan, M., & Markaryan, M. (2020). Cytomorphometric analysis of inflammation dynamics in the periodontium following the use of fixed dental prostheses. Molecules, 25, 4650. doi: 10.3390/molecules25204650

Journal - Research Article

Virdee, S. S., Farnell, D. J. J., Silva, M. A., Camilleri, J., Cooper, P. R., & Tomson, P. L. (2020). The influence of irrigant activation, concentration and contact time on sodium hypochlorite penetration into root dentine: An ex vivo experiment. International Endodontic Journal, 53, 986-997. doi: 10.1111/iej.13290

Journal - Research Article

Virdee, S. S., Ravaghi, V., Camilleri, J., Cooper, P., & Tomson, P. (2020). Current trends in endodontic irrigation amongst general dental practitioners and dental schools within the United Kingdom and Ireland: A cross-sectional survey. British Dental Journal. Advance online publication. doi: 10.1038/s41415-020-1984-x

Journal - Research Article

Holder, M. J., Wright, H. J., Couve, E., Milward, M. R., & Cooper, P. R. (2019). Neutrophil extracellular traps exert potential cytotoxic and proinflammatory effects in the dental pulp. Journal of Endodontics, 45(5), 513-520.e3. doi: 10.1016/j.joen.2019.02.014

Journal - Research Article

Koutroulis, A., Batchelor, H., Kuehne, S. A., Cooper, P. R., & Camilleri, J. (2019). Investigation of the effect of the water to powder ratio on hydraulic cement properties. Dental Materials, 35(8), 1146-1154. doi: 10.1016/j.dental.2019.05.011

Journal - Research Article

Koutroulis, A., Kuehne, S. A., Cooper, P. R., & Camilleri, J. (2019). The role of calcium ion release on biocompatibility and antimicrobial properties of hydraulic cements. Scientific Reports, 9, 19019. doi: 10.1038/s41598-019-55288-3

Journal - Research Article

Serrage, H. J., Joanisse, S., Cooper, P. R., Palin, W., Hadis, M., Darch, O., … Milward, M. R. (2019). Differential responses of myoblasts and myotubes to photobiomodulation are associated with mitochondrial number. Journal of Biophotonics, 12(6), e201800411. doi: 10.1002/jbio.201800411

Journal - Research Article

Abdulkareem, A., Shelton, R. M., Landini, G., Cooper, P. R., & Milward, M. R. (2018). Periodontal pathogens promote epithelial-mesenchymal transition in oral squamous carcinoma cells in vitro. Cell Adhesion & Migration, 12(2), 127-137. doi: 10.1080/19336918.2017.1322253

Journal - Research Article

Chicca, I. J., Milward, M. R., Chapple, I. L. C., Griffiths, G., Benson, R., Dietrich, T., & Cooper, P. R. (2018). Development and application of high-content biological screening for modulators of NET production. Frontiers in Immunology, 9, 337. doi: 10.3389/fimmu.2018.00337

Journal - Research Article

Flight, R., Landini, G., Styles, I. B., Shelton, R. M., Milward, M. R., & Cooper, P. R. (2018). Automated noninvasive epithelial cell counting in phase contrast microscopy images with automated parameter selection. Journal of Microscopy, 271(3), 345-354. doi: 10.1111/jmi.12726

Journal - Research Article

Luo, Z., Wang, Z., He, X., Liu, N., Liu, B., Sun, L., … Cooper, P. (2018). Effects of histone deacetylase inhibitors on regenerative cell responses in human dental pulp cells. International Endodontic Journal, 51(7), 767-778. doi: 10.1111/iej.12779

Journal - Research Article

Okamoto, M., Takahashi, Y., Komichi, S., Cooper, P. R., & Hayashi, M. (2018). Dentinogenic effects of extracted dentin matrix components digested with matrix metalloproteinases. Scientific Reports, 8, 10690. doi: 10.1038/s41598-018-29112-3

Journal - Research Article

Robinson, J. P., Macedo, R. G., Verhaagen, B., Versluis, M., Cooper, P. R., van der Sluis, L. W. M., & Walmsley, A. D. (2018). Cleaning lateral morphological features of the root canal: The role of streaming and cavitation. International Endodontic Journal, 51(Suppl. 1), e55-e64. doi: 10.1111/iej.12804

Journal - Research Article

White, P. C., Hirschfeld, J., Milward, M. R., Cooper, P. R., Wright, H. J., Matthews, J. B., & Chapple, I. L. C. (2018). Cigarette smoke modifies neutrophil chemotaxis, neutrophil extracellular trap formation and inflammatory response-related gene expression. Journal of Periodontal Research, 53(4), 525-535. doi: 10.1111/jre.12542

Journal - Research Article

Andreev, P. S., Coates, M. I., Karatajūtė-Talimaa, V., Shelton, R. M., Cooper, P. R., & Sansom, I. J. (2017). Elegestolepis and its kin, the earliest monodontode chondrichthyans. Journal of Vertebrate Paleontology, 37(1), e1245664. doi: 10.1080/02724634.2017.1245664

Journal - Research Article

Castro, S. A., Collighan, R., Lambert, P. A., Dias, I. H. K., Chauhan, P., Bland, C. E., … Cooper, P. R., & Devitt, A. (2017). Porphyromonas gingivalis gingipains cause defective macrophage migration towards apoptotic cells and inhibit phagocytosis of primary apoptotic neutrophils. Cell Death & Disease, 8, e2644. doi: 10.1038/cddis.2016.481

Journal - Research Article

Duncan, H. F., Smith, A. J., Fleming, G. J. P., Reid, C., Smith, G., & Cooper, P. R. (2017). Release of bio-active dentine extracellular matrix components by histone deacetylase inhibitors (HDACi). International Endodontic Journal, 50(1), 24-38. doi: 10.1111/iej.12588

Journal - Research Article

Gao, Q., Cooper, P. R., Walmsley, A. D., & Scheven, B. A. (2017). Role of Piezo channels in ultrasound-stimulated dental stem cells. Journal of Endodontics, 43(7), 1130-1136. doi: 10.1016/j.joen.2017.02.022

Journal - Research Article

Hadis, M. A., Cooper, P. R., Milward, M. R., Gorecki, P. C., Tarte, E., Churm, J., & Palin, W. M. (2017). Development and application of LED arrays for use in phototherapy research. Journal of Biophotonics, 10(11), 1514-1525. doi: 10.1002/jbio.201600273

Journal - Research Article

He, X., Jiang, W., Luo, Z., Qu, T., Wang, Z., Liu, N., … Cooper, P. R., & He, W. (2017). IFN-γ 3 regulates human dental pulp stem cells behavior via NF-κB and MAPK signaling. Scientific Reports, 7, 40681. doi: 10.1038/srep40681

Journal - Research Article

Tomson, P. L., Lumley, P. J., Smith, A. J., & Cooper, P. R. (2017). Growth factor release from dentine matrix by pulp-capping agents promotes pulp tissue repair-associated events. International Endodontic Journal, 50(3), 281-292. doi: 10.1111/iej.12624

Journal - Research Article

Wang, C., Lucas, R., Smith, A. J., & Cooper, P. R. (2017). An in vitro screening assay for dental stain cleaning. BMC Oral Health, 17, 37. doi: 10.1186/s12903-016-0328-3

Journal - Research Article

Andreev, P., Coates, M. I., Karatajūtė-Talimaa, V., Shelton, R. M., Cooper, P. R., Wang, N.-Z., & Sansom, I. J. (2016). The systematics of the Mongolepidida (Chondrichthyes) and the Ordovician origins of the clade. PeerJ, 4, e1850. doi: 10.7717/peerj.1850

Journal - Research Article

Duncan, H. F., Smith, A. J., Fleming, G. J. P., Partridge, N. C., Shimizu, E., Moran, G. P., & Cooper, P. R. (2016). The histone-deacetylase-inhibitor suberoylanilide hydroxamic acid promotes dental pulp repair mechanisms through modulation of matrix metalloproteinase-13 activity. Journal of Cellular Physiology, 231(4), 798-816. doi: 10.1002/jcp.25128

Journal - Research Article

Gao, Q., Walmsley, A. D., Cooper, P. R., & Scheven, B. A. (2016). Ultrasound stimulation of different dental stem cell populations: Role of mitogen-activated protein kinase signaling. Journal of Endodontics, 42(3), 425-431. doi: 10.1016/j.joen.2015.12.019

Journal - Research Article

Salehi, S., Cooper, P., Smith, A., & Ferracane, J. (2016). Dentin matrix components extracted with phosphoric acid enhance cell proliferation and mineralization. Dental Materials, 32(3), 334-342. doi: 10.1016/j.dental.2015.11.004

Journal - Research Article

White, P., Sakellari, D., Roberts, H., Risafi, I., Ling, M., Cooper, P., … Chapple, I. (2016). Peripheral blood neutrophil extracellular trap production and degradation in chronic periodontitis. Journal of Clinical Periodontology, 43(12), 1041-1049. doi: 10.1111/jcpe.12628

Journal - Research Article

Andreev, P. S., Coates, M. I., Shelton, R. M., Cooper, P. R., Smith, M. P., & Sansom, I. J. (2015). Upper Ordovician chondrichthyan-like scales from North America. Palaeontology, 58(4), 691-704. doi: 10.1111/pala.12167

Journal - Research Article

Davies, O. G., Cooper, P. R., Shelton, R. M., Smith, A. J., & Scheven, B. A. (2015). A comparison of the in vitro mineralisation and dentinogenic potential of mesenchymal stem cells derived from adipose tissue, bone marrow and dental pulp. Journal of Bone & Mineral Metabolism, 33(4), 371-382. doi: 10.1007/s00774-014-0601-y

Journal - Research Article

Davies, O. G., Cooper, P. R., Shelton, R. M., Smith, A. J., & Scheven, B. A. (2015). Isolation of adipose and bone marrow mesenchymal stem cells using CD29 and CD90 modifies their capacity for osteogenic and adipogenic differentiation. Journal of Tissue Engineering, 6, 1-10. doi: 10.1177/2041731415592356

Journal - Research Article

He, W., Wang, Z., Luo, Z., Yu, Q., Jiang, Y., Zhang, Y., … Cooper, P. R. (2015). LPS promote the odontoblastic differentiation of human dental pulp stem cells via MAPK signaling pathway. Journal of Cellular Physiology, 230(3), 554-561. doi: 10.1002/jcp.24732

Journal - Research Article

Spengler, J., Lugonja, B., Ytterberg, A. J., Zubarev, R. A., Creese, A. J., Pearson, M. J., … Cooper, P. R., … Scheel-Toellner, D. (2015). Release of active peptidyl arginine deiminases by neutrophils can explain production of extracellular citrullinated autoantigens in rheumatoid arthritis synovial fluid. Arthritis & Rheumatology, 67(12), 3135-3145. doi: 10.1002/art.39313

Journal - Research Article

Wang, Z., Ma, F., Wang, J., Zhou, Z., Liu, B., He, X., … Cooper, P. R. (2015). Extracellular signal-regulated kinase mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt signaling are required for lipopolysaccharide-mediated mineralization in murine odontoblast-like cells. Journal of Endodontics, 41(6), 871-876. doi: 10.1016/j.joen.2015.01.006

Journal - Research Article

Zhang, J., Wang, Z., Jiang, Y., Niu, Z., Fu, L., Luo, Z., Cooper, P. R., … He, W. (2015). Nuclear Factor I-C promotes proliferation and differentiation of apical papilla-derived human stem cells in vitro. Experimental Cell Research, 332(2), 259-266. doi: 10.1016/j.yexcr.2015.01.020

Journal - Research Article

Asif, I. M., Shelton, R. M., Cooper, P. R., Addison, O., & Martin, R. A. (2014). In vitro bioactivity of titanium-doped bioglass. Journal of Materials Science: Materials in Medicine, 25(8), 1865-1873. doi: 10.1007/s10856-014-5230-4

Journal - Research Article

He, W., Wang, Z., Zhou, Z., Zhang, Y., Zhu, Q., Wei, K., … Cooper, P. R., … Yu, Q. (2014). Lipopolysaccharide enhances Wnt5a expression through toll-like receptor 4, myeloid differentiating factor 88, phosphatidylinositol 3-OH kinase/AKT and nuclear factor kappa B pathways in human dental pulp stem cells. Journal of Endodontics, 40(1), 69-75. doi: 10.1016/j.joen.2013.09.011

Journal - Research Article

He, W., Zhang, J., Niu, Z., Yu, Q., Wang, Z., Zhang, R., … Cooper, P. R. (2014). Regulatory interplay between NFIC and TGF-β1 in apical papilla-derived stem cells. Journal of Dental Research, 93(5), 496-501. doi: 10.1177/0022034514525200

Journal - Research Article

Li, D., Fu, L., Zhang, Y., Yu, Q., Ma, F., Wang, Z., … Cooper, P. R., & He, W. (2014). The effects of LPS on adhesion and migration of human dental pulp stem cells in vitro. Journal of Dentistry, 42(10), 1327-1334. doi: 10.1016/j.jdent.2014.07.007

Journal - Research Article

Macedo, R. G., Robinson, J. P., Verhaagen, B., Walmsley, A. D., Versluis, M., Cooper, P. R., & van der Sluis, L. W. M. (2014). A novel methodology providing insights into removal of biofilm-mimicking hydrogel from lateral morphological features of the root canal during irrigation procedures. International Endodontic Journal, 47(11), 1040-1051. doi: 10.1111/iej.12246

Journal - Research Article

Milward, M. R., Holder, M. J., Palin, W. M., Hadis, M. A., Carroll, J. D., & Cooper, P. R. (2014). Low Level Light Therapy (LLLT) for the treatment and management of dental and oral diseases. Dental Update, 41(9), 763-772. doi: 10.12968/denu.2014.41.9.763

Journal - Research Article

Nicolae, L. C., Shelton, R. M., Cooper, P. R., Martin, R. A., & Palin, W. M. (2014). The effect of Bioglass addition on mechanical and physical properties of photoactive UDMA-TEGDMA resin composites. Key Engineering Materials, 587, 215-221. doi: 10.4028/www.scientific.net/KEM.587.215

Journal - Research Article

Yu, Y., Wang, L., Yu, J., Lei, G., Yan, M., Smith, G., Cooper, P. R., … Smith, A. J. (2014). Dentin matrix proteins (DMPs) enhance differentiation of BMMSCs via ERK and P38 MAPK pathways. Cell & Tissue Research, 356(1), 171-182. doi: 10.1007/s00441-013-1790-8

Journal - Research Article

Cooper, P. R., Palmer, L. J., & Chapple, I. L. C. (2013). Neutrophil extracellular traps as a new paradigm in innate immunity: Friend or foe? Periodontology 2000, 63(1), 165-197. doi: 10.1111/prd.12025

Journal - Research Article

Duncan, H. F., Smith, A. J., Fleming, G. J. P., & Cooper, P. R. (2013). Histone deacetylase inhibitors epigenetically promote reparative events in primary dental pulp cells. Experimental Cell Research, 319(10), 1534-1543. doi: 10.1016/j.yexcr.2013.02.022

Journal - Research Article

Ferracane, J. L., Cooper, P. R., & Smith, A. J. (2013). Dentin matrix component solubilization by solutions at pH relevant to self-etching dental adhesives. Journal of Adhesive Dentistry, 15(5), 407-412. doi: 10.3290/j.jad.a29536

Journal - Research Article

Lei, G., Yu, Y., Jiang, Y., Wang, S., Yan, M., Smith, A. J., … Cooper, P. R., … Yu, J. (2013). Differentiation of BMMSCs into odontoblast-like cells induced by natural dentine matrix. Archives of Oral Biology, 58(7), 862-870. doi: 10.1016/j.archoralbio.2013.01.002

Journal - Research Article

Milward, M. R., Chapple, I. L. C., Carter, K., Matthews, J. B., & Cooper, P. R. (2013). Micronutrient modulation of NF-κB in oral keratinocytes exposed to periodontal bacteria. Innate Immunity, 19(2), 140-151. doi: 10.1177/1753425912454761

Journal - Research Article

Robinson, J. P., Lumley, P. J., Cooper, P. R., Grover, L. M., & Walmsley, A. D. (2013). Reciprocating root canal technique induces greater debris accumulation than a continuous rotary technique as assessed by 3-dimensional micro-computed tomography. Journal of Endodontics, 39(8), 1067-1070. doi: 10.1016/j.joen.2013.04.003

Journal - Research Article

Tomson, P. L., Lumley, P. J., Alexander, M. Y., Smith, A. J., & Cooper, P. R. (2013). Hepatocyte growth factor is sequestered in dentine matrix and promotes regeneration-associated events in dental pulp cells. Cytokine, 61(2), 622-629. doi: 10.1016/j.cyto.2012.11.009

Journal - Research Article

Zhang, J., Zhang, Y., Lv, H., Yu, Q., Zhou, Z., Zhu, Q., … Cooper, P. R., … He, W. (2013). Human stem cells from the apical papilla response to bacterial lipopolysaccharide exposure and anti-inflammatory effects of nuclear factor I C. Journal of Endodontics, 39(11), 1416-1422. doi: 10.1016/j.joen.2013.07.018

Journal - Research Article

Zhang, J., Zhu, Q. L., Huang, P., Yu, Q., Wang, Z. H., Cooper, P. R., … He, W. (2013). CpG ODN-induced matrix metalloproteinase-13 expression is mediated via activation of the ERK and NF-κB signalling pathways in odontoblast cells. International Endodontic Journal, 46(7), 666-674. doi: 10.1111/iej.12043

Journal - Research Article

Duncan, H. F., Smith, A. J., Fleming, G. J. P., & Cooper, P. R. (2012). Histone deacetylase inhibitors induced differentiation and accelerated mineralization of pulp-derived cells. Journal of Endodontics, 38(3), 339-345. doi: 10.1016/j.joen.2011.12.014

Journal - Research Article

Gale, Z., Cooper, P. R., & Scheven, B. A. (2012). Glial cell line-derived neurotrophic factor influences proliferation of osteoblastic cells. Cytokine, 57(2), 276-281. doi: 10.1016/j.cyto.2011.10.023

Journal - Research Article

Holder, M. J., Milward, M. R., Palin, W. M., Hadis, M. A., & Cooper, P. R. (2012). Effects of red light-emitting diode irradiation on dental pulp cells. Journal of Dental Research, 91(10), 961-966. doi: 10.1177/0022034512456040

Journal - Research Article

Khan, E., Shelton, R. M., Cooper, P. R., Hamburger, J., & Landini, G. (2012). Architectural characterization of Organotypic cultures of H400 and primary rat keratinocytes. Journal of Biomedical Materials Research Part A, 100A(12), 3227-3238. doi: 10.1002/jbm.a.34263

Journal - Research Article

Man, J., Shelton, R. M., Cooper, P. R., & Scheven, B. A. (2012). Low-intensity low-frequency ultrasound promotes proliferation and differentiation of odontoblast-like cells. Journal of Endodontics, 38(5), 608-613. doi: 10.1016/j.joen.2012.01.015

Journal - Research Article

Palmer, L. J., Chapple, I. L. C., Wright, H. J., Roberts, A., & Cooper, P. R. (2012). Extracellular deoxyribonuclease production by periodontal bacteria. Journal of Periodontal Research, 47(4), 439-445. doi: 10.1111/j.1600-0765.2011.01451.x

Journal - Research Article

Palmer, L. J., Cooper, P. R., Ling, M. R., Wright, H. J., Huissoon, A., & Chapple, I. L. C. (2012). Hypochlorous acid regulates neutrophil extracellular trap release in humans. Clinical & Experimental Immunology, 167(2), 261-268. doi: 10.1111/j.1365-2249.2011.04518.x

Journal - Research Article

Robinson, J. P., Lumley, P. J., Claridge, E., Cooper, P. R., Grover, L. M., Williams, R. L., & Walmsley, A. D. (2012). An analytical Micro CT methodology for quantifying inorganic dentine debris following internal tooth preparation. Journal of Dentistry, 40(11), 999-1005. doi: 10.1016/j.jdent.2012.08.007

Journal - Research Article

Smith, A. J., Smith, J. G., Shelton, R. M., & Cooper, P. R. (2012). Harnessing the natural regenerative potential of the dental pulp. Dental Clinics of North America, 56(3), 589-601. doi: 10.1016/j.cden.2012.05.011

Journal - Research Article

Smith, J. G., Smith, A. J., Shelton, R. M., & Cooper, P. R. (2012). Antibacterial activity of dentine and pulp extracellular matrix extracts. International Endodontic Journal, 45(8), 749-755. doi: 10.1111/j.1365-2591.2012.02031.x

Journal - Research Article

Smith, J. G., Smith, A. J., Shelton, R. M., & Cooper, P. R. (2012). Recruitment of dental pulp cells by dentine and pulp extracellular matrix components. Experimental Cell Research, 318(18), 2397-2406. doi: 10.1016/j.yexcr.2012.07.008

Journal - Research Article

Cooper, P. R., McLachlan, J. L., Simon, S., Graham, L. W., & Smith, A. J. (2011). Mediators of inflammation and regeneration. Advances in Dental Research, 23(3), 290-295. doi: 10.1177/0022034511405389

Journal - Research Article

Duncan, H. F., Smith, A. J., Fleming, G. J. P., & Cooper, P. R. (2011). HDACi: Cellular effects, opportunities for restorative dentistry. Journal of Dental Research, 90(12), 1377-1388. doi: 10.1177/0022034511406919

Journal - Research Article

Gale, Z., Cooper, P. R., & Scheven, B. A. A. (2011). Effects of glial cell line-derived neurotrophic factor on dental pulp cells. Journal of Dental Research, 90(10), 1240-1245. doi: 10.1177/0022034511417443

Journal - Research Article

Simon, S. R. J., Berdal, A., Cooper, P. R., Lumley, P. J., Tomson, P. L., & Smith, A. J. (2011). Dentin-pulp complex regeneration: From lab to clinic. Advances in Dental Research, 23(3), 340-345. doi: 10.1177/0022034511405327

Journal - Research Article

Wright, H. J., Chapple, I. L. C., Matthews, J. B., & Cooper, P. R. (2011). Fusobacterium nucleatum regulation of neutrophil transcription. Journal of Periodontal Research, 46(1), 1-12. doi: 10.1111/j.1600-0765.2010.01299.x

Journal - Research Article

Zhang, R., Cooper, P. R., Smith, G., Nör, J. E., & Smith, A. J. (2011). Angiogenic activity of dentin matrix components. Journal of Endodontics, 37(1), 26-30. doi: 10.1016/j.joen.2010.08.042

Journal - Research Article

Musson, D. S., McLachlan, J. L., Sloan, A. J., Smith, A. J., & Cooper, P. R. (2010). Adrenomedullin is expressed during rodent dental tissue development and promotes cell growth and mineralization. Biology of the Cell, 102(3), 145-157. doi: 10.1042/BC20090122

Journal - Research Article

Simon, S., Smith, A. J., Berdal, A., Lumley, P. J., & Cooper, P. R. (2010). The MAP kinase pathway is involved in odontoblast stimulation via p38 phosphorylation. Journal of Endodontics, 36(2), 256-259. doi: 10.1016/j.joen.2009.09.019

Journal - Research Article

Wylie, C. M., Davenport, A. J., Cooper, P. R., & Shelton, R. M. (2010). Oral keratinocyte responses to nickel-based dental casting alloys in vitro. Journal of Biomaterials Applications, 25(3), 251-267. doi: 10.1177/0885328209349870

Journal - Research Article

Baker, S. M., Sugars, R. V., Wendel, M., Smith, A. J., Waddington, R. J., Cooper, P. R., & Sloan, A. J. (2009). TGF-β/extracellular matrix interactions in dentin matrix: A role in regulating sequestration and protection of bioactivity. Calcified Tissue International, 85(1), 66-74. doi: 10.1007/s00223-009-9248-4

Journal - Research Article

Patel, M., Smith, A. J., Sloan, A. J., Smith, G., & Cooper, P. R. (2009). Phenotype and behaviour of dental pulp cells during expansion culture. Archives of Oral Biology, 54(10), 898-908. doi: 10.1016/j.archoralbio.2009.06.008

Journal - Research Article

Scheven, B. A. A., Shelton, R. M., Cooper, P. R., Walmsley, A. D., & Smith, A. J. (2009). Therapeutic ultrasound for dental tissue repair. Medical Hypotheses, 73(4), 591-593. doi: 10.1016/j.mehy.2009.05.032

Journal - Research Article

Scheven, B. A., Man, J., Millard, J. L., Cooper, P. R., Lea, S. C., Walmsley, A. D., & Smith, A. J. (2009). VEGF and odontoblast-like cells: Stimulation by low frequency ultrasound. Archives of Oral Biology, 54(2), 185-191. doi: 10.1016/j.archoralbio.2008.09.008

Journal - Research Article

Simon, S., Smith, A. J., Lumley, P. J., Berdal, A., Smith, G., Finney, S., & Cooper, P. R. (2009). Molecular characterization of young and mature odontoblasts. Bone, 45(4), 693-703. doi: 10.1016/j.bone.2009.06.018

Journal - Research Article

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