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Health Sciences profile

Professor Stephen Duffull

PositionProfessor and Associate Dean (Research, and Postgraduate), School of Pharmacy
QualificationsDipPharm(CIT) MPharm PhD(Otago) FNZCP FISOP MPS RegPharmNZ
Research summaryClinical pharmacy; pharmacometrics
Teaching

Clinical pharmacy to undergraduate and postgraduate students; including undergraduate papers on Principles of Pharmacy Practice and Quality Use of Medicines, pharmacokinetics and clinical decision making
ClinicalExpertise in pharmacometrics

Research

Expertise in pharmacometrics. Pharmacometrics involves the quantitative design, analysis and inference from pharmacological studies. In particular this involves optimal design and population analysis techniques for pharmacokinetic and pharmacodynamic data.

Currently my research involves the development of pharmacological models, modelling of data and the design of clinical studies. These foci essentially revolve around the therapeutic areas of coagulation, malaria and clinical toxicology.

I also have an education arm to my research with an interest in therapeutic decision-making.

Professor Duffull on Google Scholar

Professor Duffull on PubMed

Current PhD students

Biography

Stephen Duffull registered as a pharmacist in 1986. He has practiced in hospital and community pharmacy and worked and trained in the Department of Clinical Pharmacology at Christchurch Hospital for 10 years. During this time he completed his Masters and PhD degrees. His PhD involved the design and analysis of clinical pharmacokinetic studies.

Dr Duffull took up a postdoctoral position at the University of Manchester working with Dr Leon Aarons in the area of pharmacometrics. He was then appointed to as a Lecturer at the University of Queensland Dept of Pharmacy. In 2006 he was then offered a position as a Professor of clinical pharmacy at the University of Otago where he has worked since.

Publications

Wright, D. F. B., Duffull, S. B., Wilby, K. J., Peterson, A. K., & Anakin, M. G. (2020). Measuring the development of therapeutic-decision-making skills by practicing pharmacists undertaking a university-based postgraduate clinical qualification at distance. Pharmacy, 8(2), 83. doi: 10.3390/pharmacy8020083

Anakin, M. G., Duffull, S. B., & Wright, D. F. B. (2020). Therapeutic decision-making in primary care pharmacy practice. Research in Social & Administrative Pharmacy. Advance online publication. doi: 10.1016/j.sapharm.2020.04.005

Zhu, X., Finlay, D. B., Glass, M., & Duffull, S. B. (2020). Evaluation of the profiles of CB1 cannabinoid receptor signalling bias using joint kinetic modelling. British Journal of Pharmacology. Advance online publication. doi: 10.1111/bph.15066

Sanhajariya, S., Isbister, G. K., & Duffull, S. B. (2020). The influence of the different disposition characteristics of snake toxins on the pharmacokinetics of snake venom. Toxins, 12(3), 188. doi: 10.3390/toxins12030188

Gwee, A., Autmizguine, J., Curtis, N., & Duffull, S. B. (2020). Twice-and thrice-daily cephalexin dosing for Staphylococcus aureus infections in children. Pediatric Infectious Disease Journal. Advance online publication.

Authored Book - Research

Heydon, S., & Duffull, S. (2013). Pharmacy at Otago: The first 50 years: The school, the profession and the people. Dunedin, New Zealand: National School of Pharmacy, University of Otago, 80p.

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Edited Book - Research

Kimko, H. C., & Duffull, S. B. (Eds.). (2003). Simulation for designing clinical trials: A pharmacokinetic-pharmacodynamic modeling perspective. New York, NY: Marcel Dekker, 416p.

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Chapter in Book - Research

Vajjah, P., Isbister, G. K., & Duffull, S. B. (2012). Introduction to pharmacokinetics in clinical toxicology. In B. Reisfeld & A. N. Mayeno (Eds.), Computational toxicology: Volume I: Methods in molecular biology (Vol. 929). (pp. 289-312). Humana Press. doi: 10.1007/978-1-62703-050-2_12

Foo, L.-K., & Duffull, S. B. (2011). Optimal design of pharmacokinetic-pharmacodynamic studies. In P. L. Bonate & D. R. Howard (Eds.), Pharmacokinetics in drug development: Advances and applications (Vol. 3). (pp. 175-193). New York: Springer. doi: 10.1007/978-1-4419-7937-7_8

Nestorov, I. A., Graham, G., Aarons, L., & Duffull, S. B. (2003). Model-based integration for clinical trial simulation and design: A phase II case study for naratriptan. In H. C. Kimko & S. B. Duffull (Eds.), Simulation for designing clinical trials: A pharmacokinetic-pharmacodynamic modeling perspective. (pp. 313-325). New York, NY: Marcel Dekker.

Kimko, H. C., & Duffull, S. B. (2003). Introduction to simulation for design of clinical trials. In H. C. Kimko & S. B. Duffull (Eds.), Simulation for designing clinical trials: A pharmacokinetic-pharmacodynamic modeling perspective. (pp. 1-16). New York, NY: Marcel Dekker.

Monteleone, J. P. R., & Duffull, S. B. (2003). Choice of best design. In H. C. Kimko & S. B. Duffull (Eds.), Simulation for designing clinical trials: A pharmacokinetic-pharmacodynamic modeling perspective. (pp. 173-200). New York, NY: Marcel Dekker.

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Journal - Research Article

Wright, D. F. B., Duffull, S. B., Wilby, K. J., Peterson, A. K., & Anakin, M. G. (2020). Measuring the development of therapeutic-decision-making skills by practicing pharmacists undertaking a university-based postgraduate clinical qualification at distance. Pharmacy, 8(2), 83. doi: 10.3390/pharmacy8020083

Gwee, A., Autmizguine, J., Curtis, N., & Duffull, S. B. (2020). Twice-and thrice-daily cephalexin dosing for Staphylococcus aureus infections in children. Pediatric Infectious Disease Journal. Advance online publication.

Sanhajariya, S., Isbister, G. K., & Duffull, S. B. (2020). The influence of the different disposition characteristics of snake toxins on the pharmacokinetics of snake venom. Toxins, 12(3), 188. doi: 10.3390/toxins12030188

Zhu, X., Finlay, D. B., Glass, M., & Duffull, S. B. (2020). Evaluation of the profiles of CB1 cannabinoid receptor signalling bias using joint kinetic modelling. British Journal of Pharmacology. Advance online publication. doi: 10.1111/bph.15066

Anakin, M. G., Duffull, S. B., & Wright, D. F. B. (2020). Therapeutic decision-making in primary care pharmacy practice. Research in Social & Administrative Pharmacy. Advance online publication. doi: 10.1016/j.sapharm.2020.04.005

Sinha, J., Al-Sallami, H. S., & Duffull, S. B. (2020). An extension of Janmahasatian’s Fat-Free Mass model for universal application across populations of different ethnicities. Clinical Pharmacokinetics. Advance online publication. doi: 10.1007/s40262-020-00883-1

Abdul Aziz, Y. H., Heydon, S. J., Duffull, S. B., & Marra, C. A. (2020). What free services do pharmacists offer? Investigating the provision of unfunded pharmacy services provided in community pharmacies. Research in Social & Administrative Pharmacy. Advance online publication.

Sinha, J., Duffull, S. B., Green, B., & Al-Sallami, H. S. (2020). Evaluating the relationship between lean liver volume and fat-free mass. Clinical Pharmacokinetics, 59, 475-483. doi: 10.1007/s40262-019-00824-7

Donnellan, S., Wright, D. F. B., Roberts, J. A., Duffull, S. B., Schollum, J. B. W., Putt, T. L., … Walker, R. J. (2020). The pharmacokinetics of meropenem and piperacillin-tazobactam during sustained low efficiency haemodiafiltration (SLED-HDF). European Journal of Clinical Pharmacology, 76, 239-247. doi: 10.1007/s00228-019-02792-0

Kuan, I. H. S., Savage, R. L., Duffull, S. B., Walker, R. J., & Wright, D. F. B. (2019). The association between metformin therapy and lactic acidosis. Drug Safety, 42, 1449-1469. doi: 10.1007/s40264-019-00854-x

Zhu, X., Finlay, D. B., Glass, M., & Duffull, S. B. (2019). An intact model for quantifying functional selectivity. Scientific Reports, 9, 2557. doi: 10.1038/s41598-019-39000-z

Zhu, X., Finlay, D. B., Glass, M., & Duffull, S. B. (2019). Model-free and kinetic modelling approaches for characterising non-equilibrium pharmacological pathway activity: Internalisation of cannabinoid CB1 receptors. British Journal of Pharmacology, 176, 2593-2607. doi: 10.1111/bph.14684

Sinha, J., Al-Sallami, H. S., & Duffull, S. B. (2019). Choosing the allometric exponent in covariate model building. Clinical Pharmacokinetics, 28(1), 89-100. doi: 10.1007/s40262-018-0667-0

Liu, Z., Diana, A., Slater, C., Preston, T., Gibson, R. S., Houghton, L., & Duffull, S. B. (2019). Development of a parsimonious design for optimal classification of exclusive breastfeeding. Clinical & Translational Science, 8, 596-605. doi: 10.1002/psp4.12428

Stamp, L. K., Chapman, P., Frampton, C., Duffull, S. B., Drake, J., Zhang, Y., & Neogi, T. (2019). Lack of effect of tart cherry concentrate dose on serum urate in people with gout. Rheumatology. Advance online publication. doi: 10.1093/rheumatology/kez606

Pan, S., & Duffull, S. B. (2019). Automated proper lumping for simplification of linear physiologically based pharmacokinetic systems. Journal of Pharmacokinetics & Pharmacodynamics, 46, 361-370. doi: 10.1007/s10928-019-09644-5

Pradhan, S., Duffull, S. B., Walker, R. J., & Wright, D. F. B. (2019). The intact nephron hypothesis as a model for renal drug handling. European Journal of Clinical Pharmacology, 75(2), 147-156. doi: 10.1007/s00228-018-2572-8

Liu, Z., Diana, A., Slater, C., Preston, T., Gibson, R. S., Houghton, L., & Duffull, S. B. (2019). Development of a nonlinear hierarchical model to describe the disposition of deuterium in mother-infant pairs to assess exclusive breastfeeding practice. Journal of Pharmacokinetics & Pharmacodynamics, 46, 1-13. doi: 10.1007/s10928-018-9613-x

Hasegawa, C., & Duffull, S. B. (2018). Selection and qualification of simplified QSP models when using model order reduction techniques. AAPS Journal, 20, 2. doi: 10.1208/s12248-017-0170-9

Ng, D. P. J., Duffull, S. B., Faed, J. M., Isbister, G. K., & Gulati, A. (2018). An evaluation of a factor Xa-based clotting time test for enoxaparin: A proof-of-concept study. Clinical & Applied Thrombosis/Hemostasis, 24(4), 669-676. doi: 10.1177/1076029617711802

Hasegawa, C., & Duffull, S. B. (2018). Automated scale reduction of nonlinear QSP models with an illustrative application to a bone biology system. CPT: Pharmacometrics & Systems Pharmacology, 7, 562-572. doi: 10.1002/psp4.12324

Ooi, Q. X., Wright, D. F. B., Isbister, G. K., & Duffull, S. B. (2018). A factor VII-based method for the prediction of anticoagulant response to warfarin. Scientific Reports, 8, 12041. doi: 10.1038/s41598-018-30516-4

Zufferey, P. J., Ollier, E., Delavenne, X., Laporte, S., Mismetti, P., & Duffull, S. B. (2018). Incidence and risk factors of major bleeding following major orthopaedic surgery with fondaparinux thromboprophylaxis: A time-to-event analysis. British Journal of Clinical Pharmacology, 84(10), 2242-2251. doi: 10.1111/bcp.13663

Zhu, X., Finlay, D. B., Glass, M., & Duffull, S. B. (2018). An evaluation of the operational model when applied to quantify functional selectivity. British Journal of Pharmacology, 175, 1654-1668. doi: 10.1111/bph.14171

Duffull, S. B., Wright, D. F. B., Marra, C. A., & Anakin, M. G. (2018). A philosophical framework for pharmacy in the 21st century guided by ethical principles. Research in Social & Administrative Pharmacy, 14(3), 309-316. doi: 10.1016/j.sapharm.2017.04.049

Saffian, S. M., Duffull, S. B., & Wright, D. F. B. (2017). Warfarin dosing algorithms underpredict dose requirements in patients requiring ≥ 7mg daily: A systematic review and meta-analysis. Clinical Pharmacology & Therapeutics, 102(2), 297-304. doi: 10.1002/cpt.649

Ooi, Q. X., Wright, D. F. B., Tait, R. C., Isbister, G. K., & Duffull, S. B. (2017). A joint model for vitamin K-dependent clotting factors and anticoagulation proteins. Clinical Pharmacokinetics, 56(12), 1555-1556. doi: 10.1007/s40262-017-0541-5

Hasegawa, C., & Duffull, S. B. (2017). Exploring inductive linearization for pharmacokinetic-pharmacodynamic systems of nonlinear ordinary differential equations. Journal of Pharmacokinetics & Pharmacodynamics, 45(1), 35-47. doi: 10.1007/s10928-017-9527-z

Foo, L. K., & Duffull, S. (2017). Designs to balance cost and success rate for an early phase clinical study. Journal of Biopharmaceutical Statistics, 27(1), 148-158. doi: 10.1080/10543406.2016.1148703

Siripuram, V. K., Wright, D. F. B., Barclay, M. L., & Duffull, S. B. (2017). Deterministic identifiability of population pharmacokinetic and pharmacokinetic-pharmacodynamic models. Journal of Pharmacokinetics & Pharmacodynamics, 44(5), 415-423. doi: 10.1007/s10928-017-9530-4

Kuan, I. H. S., Duffull, S. B., Putt, T. L., Schollum, J. B. W., Walker, R. J., & Wright, D. F. B. (2017). A population pharmacokinetic model for 51Cr EDTA to estimate renal function. Clinical Pharmacokinetics, 56(6), 671-678. doi: 10.1007/s40262-016-0489-x

Duffull, S. B., & Hooker, A. C. (2017). Assessing robustness of designs for random effects parameters for nonlinear mixed-effects models. Journal of Pharmacokinetics & Pharmacodynamics, 44(6), 611-616. doi: 10.1007/s10928-017-9552-y

Assawasuwannakit, P., Braund, R., & Duffull, S. B. (2016). A framework for quantifying the influence of adherence and dose individualization. Clinical Pharmacology & Therapeutics, 99(4), 452-459. doi: 10.1002/cpt.268

Wright, D. F. B., Duffull, S. B., Merriman, T. R., Dalbeth, N., Barclay, M. L., & Stamp, L. K. (2016). Predicting allopurinol response in patients with gout. British Journal of Clinical Pharmacology, 81(2), 277-289. doi: 10.1111/bcp.12799

Shivva, V., Cox, P. J., Clarke, K., Veech, R. L., Tucker, I. G., & Duffull, S. B. (2016). The population pharmacokinetics of D-β-hydroxybutyrate following administration of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate. AAPS Journal, 18(3), 678-688. doi: 10.1208/s12248-016-9879-0

Brussee, J. M., Yeo, T. W., Lampah, D. A., Anstey, N. M., & Duffull, S. B. (2016). A pharmacokinetic-pharmacodynamic model for the effect of L-arginine on endothelial function in patients with moderately severe falciparum malaria. Antimicrobial Agents & Chemotherapy, 60(1), 198-205. doi: 10.1128/aac.01479-15

Foo, L.-K., Duffull, S. B., Calver, L., Schneider, J., & Isbister, G. K. (2016). Population pharmacokinetics of intramuscular droperidol in acutely agitated patients. British Journal of Clinical Pharmacology, 82(6), 1550-1556. doi: 10.1111/bcp.13093

Al-Sallami, H., Newall, F., Monagle, P., Ignjatovic, V., Cranswick, N., & Duffull, S. (2016). Development of a population pharmacokinetic-pharmacodynamic model of a single bolus dose of unfractionated heparin in paediatric patients. British Journal of Clinical Pharmacology, 82(1), 178-184. doi: 10.1111/bcp.12930

Shivva, V., Tucker, I. G., & Duffull, S. B. (2016). An in silico knockout model for gastrointestinal absorption using a systems pharmacology approach: Development and application for ketones. PLoS ONE, 11(9), e0163795. doi: 10.1371/journal.pone.0163795

Saffian, S. M., Duffull, S. B., Roberts, R. L., Tait, R. C., Black, L., Lund, K. A., … Wright, D. F. B. (2016). Influence of genotype on warfarin maintenance dose predictions produced using a Bayesian dose individualization tool. Therapeutic Drug Monitoring, 38(6), 677-683. doi: 10.1097/ftd.0000000000000347

Chiew, A. L., Isbister, G. K., Duffull, S. B., & Buckley, N. A. (2016). Evidence for the changing regimens of acetylcysteine. British Journal of Clinical Pharmacology, 81(3), 471-481. doi: 10.1111/bcp.12789

Lagishetty, C. V., & Duffull, S. B. (2015). Evaluation of approaches to deal with low-frequency nuisance covariates in population pharmacokinetic analyses. AAPS Journal, 17(6), 1388-1394. doi: 10.1208/s12248-015-9793-x

Pan, S., Korell, J., Stamp, L. K., & Duffull, S. B. (2015). Simplification of a pharmacokinetic model for red blood cell methotrexate disposition. European Journal of Clinical Pharmacology, 71(12), 1509-1516. doi: 10.1007/s00228-015-1951-7

Assawasuwannakit, P., Braund, R., & Duffull, S. B. (2015). A model-based meta-analysis of the influence of factors that impact adherence to medications. Journal of Clinical Pharmacy & Therapeutics, 40(1), 24-31. doi: 10.1111/jcpt.12219

Duffull, S. B., & Wright, D. F. B. (2015). What do we learn from repeated population analyses? British Journal of Clinical Pharmacology, 79(1), 40-47. doi: 10.1111/bcp.12233

Saffian, S. M., Wright, D. F. B., Roberts, R. L., & Duffull, S. B. (2015). Methods for predicting warfarin dose requirements. Therapeutic Drug Monitoring, 37(4), 531-538. doi: 10.1097/ftd.0000000000000177

Gulati, A., Faed, J. M., Isbister, G. K., & Duffull, S. B. (2015). Application of adaptive DP-optimality to design a pilot study for a clotting time test for enoxaparin. Pharmaceutical Research, 32(10), 3391-3402. doi: 10.1007/s11095-015-1715-1

Assawasuwannakit, P., Braund, R., & Duffull, S. B. (2015). Quantification of the forgiveness of drugs to imperfect adherence. CPT: Pharmacometrics & Systems Pharmacology, 4(3), 204-211. doi: 10.1002/psp4.4

Cooper, J. M., Duffull, S. B., Saiao, A. S., & Isbister, G. K. (2015). The pharmacokinetics of sertraline in overdose and the effect of activated charcoal. British Journal of Clinical Pharmacology, 79(2), 307-315. doi: 10.1111/bcp.12500

Salahudeen, M. S., Nishtala, P. S., & Duffull, S. B. (2015). The influence of patient characteristics on anticholinergic events in older people. Dementia & Geriatric Cognitive Disorders Extra, 5(3), 530-541. doi: 10.1159/000441718

Nyberg, J., Bazzoli, C., Ogungbenro, K., Aliev, A., Leonov, S., Duffull, S., … Mentré, F. (2015). Methods and software tools for design evaluation for population pharmacokinetics-pharmacodynamics studies. British Journal of Clinical Pharmacology, 79(1), 6-17. doi: 10.1111/bcp.12352

Al-Sallami, H. S., Goulding, A., Grant, A., Taylor, R., Holford, N., & Duffull, S. B. (2015). Prediction of fat-free mass in children. Clinical Pharmacokinetics, 54(11), 1169-1178. doi: 10.1007/s40262-015-0277-z

Salahudeen, M. S., Duffull, S. B., & Nishtala, P. S. (2015). Anticholinergic burden quantified by anticholinergic risk scales and adverse outcomes in older people: A systematic review. BMC Geriatrics, 15, 31. doi: 10.1186/s12877-015-0029-9

Korell, J., Duffull, S. B., Dalrymple, J. M., Drake, J., Zhang, M., Barclay, M. L., & Stamp, L. K. (2014). Comparison of intracellular methotrexate kinetics in red blood cells with the kinetics in other cell types. British Journal of Clinical Pharmacology, 77(3), 493-497. doi: 10.1111/bcp.12209

Hatah, E., Braund, R., Tordoff, J., & Duffull, S. B. (2014). A systematic review and meta-analysis of pharmacist-led fee-for-services medication review. British Journal of Clinical Pharmacology, 77(1), 102-115. doi: 10.1111/bcp.12140

Gulati, A., Isbister, G. K., & Duffull, S. B. (2014). Scale reduction of a systems coagulation model with an application to modeling pharmacokinetic-pharmacodynamic data. CPT: Pharmacometrics & Systems Pharmacology, 3, e90. doi: 10.1038/psp.2013.67

Salahudeen, M. S., Duffull, S. B., & Nishtala, P. S. (2014). Impact of anticholinergic discontinuation on cognitive outcomes in older people: A systematic review. Drugs & Aging, 31(3), 185-192. doi: 10.1007/s40266-014-0158-4

Putt, T. L., Duffull, S. B., Schollum, J. B. W., & Walker, R. J. (2014). GFR may not accurately predict aspects of proximal tubule drug handling. European Journal of Clinical Pharmacology, 70(10), 1221-1226. doi: 10.1007/s00228-014-1733-7

Hatah, E., Tordoff, J., Duffull, S. B., & Braund, R. (2014). Pharmacists' performance of clinical interventions during adherence support medication reviews. Research in Social & Administrative Pharmacy, 10(1), 185-194. doi: 10.1016/j.sapharm.2013.04.008

Shivva, V., Korell, J., Tucker, I. G., & Duffull, S. B. (2014). Parameterisation affects identifiability of population models. Journal of Pharmacokinetics & Pharmacodynamics, 41, 81-86. doi: 10.1007/s10928-013-9347-8

Duffull, S. B., & Hegarty, G. (2014). An inductive approximation to the solution of systems of nonlinear ordinary differential equations in pharmacokinetics-pharmacodynamics. Journal of Theoretical & Computational Science, 1(4), 1000119. doi: 10.4172/jtco.1000119

Pan, S., Stamp, L. K., Duffull, S. B., Barclay, M. L., Dalrymple, J. M., Drake, J., Zhang, M., & Korell, J. (2014). Assessment of the relationship between methotrexate polyglutamates in red blood cells and clinical response in patients commencing methotrexate for rheumatoid arthritis. Clinical Pharmacokinetics, 53(12), 1161-1170. doi: 10.1007/s40262-014-0179-5

Hatah, E., Tordoff, J., Duffull, S. B., Cameron, C., & Braund, R. (2014). Retrospective examination of selected outcomes of Medicines Use Review (MUR) services in New Zealand. International Journal of Clinical Pharmacy, 36(3), 503-512. doi: 10.1007/s11096-014-9913-1

Shivva, V., Korell, J., Tucker, I. G., & Duffull, S. B. (2013). An approach for identifiability of population pharmacokinetic–pharmacodynamic models. CPT: Pharmacometrics & Systems Pharmacology, 2(6), e49. doi: 10.1038/psp.2013.25

Shaw, J. P., Print, S. A., & Duffull, S. B. (2013). Development of a postgraduate educational program for pharmacist prescribers in New Zealand. Journal of Pharmacy Practice & Research, 43(2), 122-127.

Yeo, T. W., Lampah, D. A., Rooslamiati, I., Gitawati, R., Tjitra, E., Kenangalem, E., … Duffull, S. B., & Anstey, N. A. (2013). A randomized pilot study of L-arginine infusion in severe falciparum malaria: Preliminary safety, efficacy and pharmacokinetics. PLoS ONE, 8(7), e69587. doi: 10.1371/journal.pone.0069587

Hatah, E., Braund, R., Duffull, S. B., & Tordoff, J. (2013). General practitioners' views of pharmacists' current and potential contributions to medication review and prescribing in New Zealand. Journal of Primary Health Care, 5(3), 223-233.

Korell, J., & Duffull, S. B. (2013). A semi-mechanistic red blood cell survival model provides some insight into red blood cell destruction mechanisms. Journal of Pharmacokinetics & Pharmacodynamics, 40(4), 469-478. doi: 10.1007/s10928-013-9322-4

Wright, D. F. B., & Duffull, S. B. (2013). A bayesian dose-individualization method for warfarin. Clinical Pharmacokinetics, 52(1), 59-68. doi: 10.1007/s40262-012-0017-6

Korell, J., Stamp, L. K., Barclay, M. L., Dalrymple, J. M., Drake, J., Zhang, M., & Duffull, S. B. (2013). A population pharmacokinetic model for low-dose methotrexate and its polyglutamated metabolites in red blood cells. Clinical Pharmacokinetics, 52(6), 475-485. doi: 10.1007/s40262-013-0052-y

Wright, D. F. B., Stamp, L. K., Merriman, T. R., Barclay, M. L., Duffull, S. B., & Holford, N. H. G. (2013). The population pharmacokinetics of allopurinol and oxypurinol in patients with gout. European Journal of Clinical Pharmacology, 69(7), 1411-1421. doi: 10.1007/s00228-013-1478-8

Gulati, A., Isbister, G. K., & Duffull, S. B. (2013). Effect of Australian elapid venoms on blood coagulation: Australian Snakebite Project (ASP-17). Toxicon, 61, 94-104. doi: 10.1016/j.toxicon.2012.11.001

Jamsen, K. M., Duffull, S. B., Tarning, J., Price, R. N., & Simpson, J. (2013). A robust design for identification of the Parasite Clearance Estimator. Malaria Journal, 12, 410. doi: 10.1186/1475-2875-12-410

Duffull, S. B., & Isbister, G. K. (2013). Predicting the requirement for N-acetylcysteine in paracetamol poisoning from reported dose. Clinical Toxicology, 51(8), 772-776. doi: 10.3109/15563650.2013.830733

Hatah, E., Braund, R., Duffull, S., & Tordoff, J. (2012). General practitioners' perceptions of pharmacists' new services in New Zealand. International Journal of Clinical Pharmacy, 34(2), 364-373. doi: 10.1007/s11096-012-9617-3

Vos, F. E., Schollum, J. B., Coulter, C. V., Manning, P. J., Duffull, S. B., & Walker, R. J. (2012). Assessment of markers of glycaemic control in diabetic patients with chronic kidney disease using continuous glucose monitoring. Nephrology, 17(2), 182-188. doi: 10.1111/j.1440-1797.2011.01517.x

Gulati, A., Faed, J. M., Isbister, G. K., & Duffull, S. B. (2012). Development and evaluation of a prototype of a novel clotting time test to monitor enoxaparin. Pharmaceutical Research, 29(1), 225-235. doi: 10.1007/s11095-011-0537-z

Foo, L. K., McGree, J., Eccleston, J., & Duffull, S. (2012). Comparison of robust criteria for D-optimal designs. Journal of Biopharmaceutical Statistics, 22(6), 1193-1205. doi: 10.1080/10543406.2011.580484

McGree, J. M., Drovandi, C. C., Thomson, M. H., Eccleston, J. A., Duffull, S. B., Mengersen, K., … Goggin, T. (2012). Adaptive Bayesian compound designs for dose finding studies. Journal of Statistical Planning & Inference, 142(6), 1480-1482. doi: 10.1016/j.jspi.2011.12.029

Lagishetty, C. V., Coulter, C. V., & Duffull, S. B. (2012). Design of pharmacokinetic studies for latent covariates. Journal of Pharmacokinetics & Pharmacodynamics, 39(1), 87-97. doi: 10.1007/s10928-011-9231-3

van Gorp, F., Duffull, S., Hackett, L. P., & Isbister, G. K. (2012). Population pharmacokinetics and pharmacodynamics of escitalopram in overdose and the effect of activated charcoal. British Journal of Clinical Pharmacology, 73(3), 402-410. doi: 10.1111/j.1365-2125.2011.04091.x

Duffull, S. B., Graham, G., Mengersen, K., & Eccleston, J. (2012). Evaluation of the pre-posterior distribution of optimized sampling times for the design of pharmacokinetic studies. Journal of Biopharmaceutical Statistics, 22(1), 16-29. doi: 10.1080/10543406.2010.500065

Loke, S.-K., Al-Sallami, H. S., Wright, D. F. B., McDonald, J., Jadhav, S., & Duffull, S. B. (2012). Challenges in integrating a complex systems computer simulation in class: An educational design research. Australasian Journal of Educational Technology, 28(4), 671-683. doi: 10.14742/ajet.834

Alskär, O., Korell, J., & Duffull, S. B. (2012). A pharmacokinetic model for the glycation of albumin. Journal of Pharmacokinetics & Pharmacodynamics, 39(3), 273-282. doi: 10.1007/s10928-012-9249-1

Foo, L. K., & Duffull, S. (2012). Adaptive optimal design for bridging studies with an application to population pharmacokinetic studies. Pharmaceutical Research, 29(6), 1530-1543. doi: 10.1007/s11095-011-0659-3

Vajjah, P., & Duffull, S. B. (2012). A generalisation of T-optimality for discriminating between competing models with an application to pharmacokinetic studies. Pharmaceutical Statistics, 11(6), 503-510. doi: 10.1002/pst.1542

Foo, L. K., McGree, J., & Duffull, S. (2012). A general method to determine sampling windows for nonlinear mixed effects models with an application to population pharmacokinetic studies. Pharmaceutical Statistics, 11(4), 325-333. doi: 10.1002/pst.1509

Lagishetty, C. V., Vajjah, P., & Duffull, S. B. (2012). A reduction in between subject variability is not mandatory for selecting a new covariate. Journal of Pharmacokinetics & Pharmacodynamics, 39, 383-392.

Shen, F., Coulter, C. V., Isbister, G. K., & Duffull, S. B. (2011). A dosing regimen for immediate N-acetylcysteine treatment for acute paracetamol overdose. Clinical Toxicology, 49(7), 643-647. doi: 10.3109/15563650.2011.604034

Pavan Kumar, V. V., Isbister, G. K., & Duffull, S. B. (2011). The effect of decontamination procedures on the pharmacodynamics of venlafaxine in overdose. British Journal of Clinical Pharmacology, 72(1), 125-132. doi: 10.1111/j.1365-2125.2011.03934.x

Wright, D. F. B., Winter, H. R., & Duffull, S. B. (2011). Understanding the time course of pharmacological effect: A PKPD approach. British Journal of Clinical Pharmacology, 71(6), 815-823. doi: 10.1111/j.1365-2125.2011.03925.x

Pavan Kumar, V. V., & Duffull, S. B. (2011). Evaluation of graphical diagnostics for assessing goodness of fit of logistic regression models. Journal of Pharmacokinetics & Pharmacodynamics, 38(2), 205-222. doi: 10.1007/s10928-010-9189-6

Loke, S.-K., Tordoff, J., Winikoff, M., McDonald, J., Vlugter, P., & Duffull, S. (2011). SimPharm: How pharmacy students made meaning of a clinical case differently in paper- and simulation-based workshops. British Journal of Educational Technology, 42(5), 865-874. doi: 10.1111/j.1467-8535.2010.01113.x

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