Professor Stephen Duffull
Position | Professor |
---|---|
Qualifications | DipPharm(CIT) MPharm PhD(Otago) FNZCP FISOP MPS RegPharmNZ |
Research summary | Clinical pharmacy; pharmacometrics |
Teaching | Clinical pharmacy to undergraduate and postgraduate students; including undergraduate papers on Principles of Pharmacy Practice and Quality Use of Medicines, pharmacokinetics and clinical decision making |
Clinical | Expertise in pharmacometrics |
Research
Expertise in pharmacometrics. Pharmacometrics involves the quantitative design, analysis and inference from pharmacological studies. In particular this involves optimal design and population analysis techniques for pharmacokinetic and pharmacodynamic data.
Currently my research involves the development of pharmacological models, modelling of data and the design of clinical studies. These foci essentially revolve around the therapeutic areas of coagulation, malaria and clinical toxicology.
I also have an education arm to my research with an interest in therapeutic decision-making.
Professor Duffull on Google Scholar
Current PhD students
- Salma Bahnasawy
- Abdallah Derbalah
- Isabelle Kuan
- Lisa Li
- Sudeep Pradhan
- Suchaya Sanjariya
- Sepi Sharif
- David Wang
- Liang Yang
- Xiao (Derek) Zhu
Biography
Stephen Duffull registered as a pharmacist in 1986. He has practiced in hospital and community pharmacy and worked and trained in the Department of Clinical Pharmacology at Christchurch Hospital for 10 years. During this time he completed his Masters and PhD degrees. His PhD involved the design and analysis of clinical pharmacokinetic studies.
Dr Duffull took up a postdoctoral position at the University of Manchester working with Dr Leon Aarons in the area of pharmacometrics. He was then appointed to as a Lecturer at the University of Queensland Dept of Pharmacy. In 2006 he was then offered a position as a Professor of clinical pharmacy at the University of Otago where he has worked since.
Publications
Derbalah, A., Duffull, S., Sherwin, C. M., Job, K., & Al-Sallami, H. (2022). Optimal dosing of enoxaparin in overweight and obese children. British Journal of Clinical Pharmacology. Advance online publication. doi: 10.1111/bcp.15459
Sharif, S., Hasegawa, C., & Duffull, S. B. (2022). Exploring Inductive Linearization for simulation and estimation with an application to the Michaelis-Menten model. Journal of Pharmacokinetics & Pharmacodynamics. Advance online publication. doi: 10.1007/s10928-022-09813-z
Duffull, S., & Isbister, G. (2022). Challenges faced when modeling clinical toxicology and toxinology events. Clinical & Translational Science. Advance online publication. doi: 10.1002/psp4.12792
Duffull, S. (2022). Dose Banding: Weighing up benefits, risks and therapeutic failure. British Journal of Clinical Pharmacology. Advance online publication. doi: 10.1111/bcp.15307
Gwee, A., Duffull, S. B., Daley, A. J., Lim, M., Germano, S., Bilal, H., … Zhu, X. (2022). Identifying a therapeutic target for vancomycin against staphylococci in young infants. Journal of Antimicrobial Chemotherapy. Advance online publication. doi: 10.1093/jac/dkab469
Heydon, S., & Duffull, S. (2013). Pharmacy at Otago: The first 50 years: The school, the profession and the people. Dunedin, New Zealand: National School of Pharmacy, University of Otago, 80p.
Authored Book - Research
Kimko, H. C., & Duffull, S. B. (Eds.). (2003). Simulation for designing clinical trials: A pharmacokinetic-pharmacodynamic modeling perspective. New York, NY: Marcel Dekker, 416p.
Edited Book - Research
Vajjah, P., Isbister, G. K., & Duffull, S. B. (2012). Introduction to pharmacokinetics in clinical toxicology. In B. Reisfeld & A. N. Mayeno (Eds.), Computational toxicology: Volume I: Methods in molecular biology (Vol. 929). (pp. 289-312). Humana Press. doi: 10.1007/978-1-62703-050-2_12
Chapter in Book - Research
Foo, L.-K., & Duffull, S. B. (2011). Optimal design of pharmacokinetic-pharmacodynamic studies. In P. L. Bonate & D. R. Howard (Eds.), Pharmacokinetics in drug development: Advances and applications (Vol. 3). (pp. 175-193). New York: Springer. doi: 10.1007/978-1-4419-7937-7_8
Chapter in Book - Research
Kimko, H. C., & Duffull, S. B. (2003). Introduction to simulation for design of clinical trials. In H. C. Kimko & S. B. Duffull (Eds.), Simulation for designing clinical trials: A pharmacokinetic-pharmacodynamic modeling perspective. (pp. 1-16). New York, NY: Marcel Dekker.
Chapter in Book - Research
Monteleone, J. P. R., & Duffull, S. B. (2003). Choice of best design. In H. C. Kimko & S. B. Duffull (Eds.), Simulation for designing clinical trials: A pharmacokinetic-pharmacodynamic modeling perspective. (pp. 173-200). New York, NY: Marcel Dekker.
Chapter in Book - Research
Nestorov, I. A., Graham, G., Aarons, L., & Duffull, S. B. (2003). Model-based integration for clinical trial simulation and design: A phase II case study for naratriptan. In H. C. Kimko & S. B. Duffull (Eds.), Simulation for designing clinical trials: A pharmacokinetic-pharmacodynamic modeling perspective. (pp. 313-325). New York, NY: Marcel Dekker.
Chapter in Book - Research
Derbalah, A., Duffull, S., Sherwin, C. M., Job, K., & Al-Sallami, H. (2022). Optimal dosing of enoxaparin in overweight and obese children. British Journal of Clinical Pharmacology. Advance online publication. doi: 10.1111/bcp.15459
Journal - Research Article
Duffull, S. (2022). Dose Banding: Weighing up benefits, risks and therapeutic failure. British Journal of Clinical Pharmacology. Advance online publication. doi: 10.1111/bcp.15307
Journal - Research Article
Gwee, A., Duffull, S. B., Daley, A. J., Lim, M., Germano, S., Bilal, H., … Zhu, X. (2022). Identifying a therapeutic target for vancomycin against staphylococci in young infants. Journal of Antimicrobial Chemotherapy. Advance online publication. doi: 10.1093/jac/dkab469
Journal - Research Article
Sharif, S., Hasegawa, C., & Duffull, S. B. (2022). Exploring Inductive Linearization for simulation and estimation with an application to the Michaelis-Menten model. Journal of Pharmacokinetics & Pharmacodynamics. Advance online publication. doi: 10.1007/s10928-022-09813-z
Journal - Research Article
Abdul Aziz, Y. H., Heydon, S. J., Duffull, S. B., & Marra, C. A. (2021). Are professional pharmacy services being offered for free in pharmacies? A feasibility study exploring the use of a time motion study in New Zealand. Pharmacy Practice, 19(3), 2422. doi: 10.18549/PharmPract.2021.3.2422
Journal - Research Article
Abdul Aziz, Y. H., Heydon, S. J., Duffull, S. B., & Marra, C. A. (2021). What free services do pharmacists offer? Investigating the provision of unfunded pharmacy services provided in community pharmacies. Research in Social & Administrative Pharmacy, 17, 588-594. doi: 10.1016/j.sapharm.2020.05.007
Journal - Research Article
Anakin, M. G., Duffull, S. B., & Wright, D. F. B. (2021). Therapeutic decision-making in primary care pharmacy practice. Research in Social & Administrative Pharmacy, 17, 326-331. doi: 10.1016/j.sapharm.2020.04.005
Journal - Research Article
Bahnasawy, S., Al-Sallami, H., & Duffull, S. (2021). A minimal model to describe short-term haemodynamic changes of the cardiovascular system. British Journal of Clinical Pharmacology, 87, 1411-1421. doi: 10.1111/bcp.14541
Journal - Research Article
Derbalah, A., Al-Sallami, H. S., & Duffull, S. B. (2021). Reduction of quantitative systems pharmacology models using artificial neural networks. Journal of Pharmacokinetics & Pharmacodynamics, 48, 509-523. doi: 10.1007/s10928-021-09742-3
Journal - Research Article
Derbalah, A., Duffull, S., Moynihan, K., & Al-Sallami, H. (2021). The influence of haemostatic system maturation on the dose-response relationship of unfractionated heparin. Clinical Pharmacokinetics, 60, 491-499. doi: 10.1007/s40262-020-00949-0
Journal - Research Article
Li, J., Chiew, A. L., Isbister, G. K., & Duffull, S. B. (2021). Population pharmacokinetics of immediate-release and modified-release paracetamol and its major metabolites in a supratherapeutic dosing study. Clinical Toxicology. Advance online publication. doi: 10.1080/15563650.2021.1928163
Journal - Research Article
Li, J., Karlsson, M. O., Sanhajariya, S., Isbister, G. K., & Duffull, S. B. (2021). A general model for cell death and biomarker release from injured tissues. Journal of Pharmacokinetics & Pharmacodynamics, 48, 69-82. doi: 10.1007/s10928-020-09720-1
Journal - Research Article
Pradhan, S., Duffull, S. B., Wilson, L. C., Kuan, I. H. S., Walker, R. J., Putt, T. L., Schollum, J. B. W., & Wright, D. F. B. (2021). Does the intact nephron hypothesis provide a reasonable model for metformin dosing in chronic kidney disease? British Journal of Clinical Pharmacology. Advance online publication. doi: 10.1111/bcp.14919
Journal - Research Article
Pradhan, S., Wright, D. F. B., & Duffull, S. B. (2021). Evaluation of designs for renal drug studies based on the European Medicines Agency and Food and Drug Administration guidelines for drugs that are predominantly secreted. British Journal of Clinical Pharmacology, 87, 1401-1410. doi: 10.1111/bcp.14536
Journal - Research Article
Sanhajariya, S., Duffull, S. B., & Isbister, G. K. (2021). Investigating myotoxicity following Australian red-bellied black snake (Pseudechis porphyriacus) envenomation. PLoS ONE, 16(9), e0256653. doi: 10.1371/journal.pone.0256653
Journal - Research Article
Sanhajariya, S., Duffull, S. B., & Isbister, G. K. (2021). Population pharmacokinetics of Pseudechis porphyriacus (red-bellied black snake) venom in snakebite patients. Clinical Toxicology. Advance online publication. doi: 10.1080/15563650.2021.1896731
Journal - Research Article
Yang, L., Zhu, X., Finlay, D. B., Glass, M., & Duffull, S. B. (2021). Exploring group size for statistical analysis of real-time signalling experiments. British Journal of Pharmacology. Advance online publication. doi: 10.1111/bph.15572
Journal - Research Article
Donnellan, S., Wright, D. F. B., Roberts, J. A., Duffull, S. B., Schollum, J. B. W., Putt, T. L., … Walker, R. J. (2020). The pharmacokinetics of meropenem and piperacillin-tazobactam during sustained low efficiency haemodiafiltration (SLED-HDF). European Journal of Clinical Pharmacology, 76, 239-247. doi: 10.1007/s00228-019-02792-0
Journal - Research Article
Gwee, A., Autmizguine, J., Curtis, N., & Duffull, S. B. (2020). Twice-and thrice-daily cephalexin dosing for Staphylococcus aureus infections in children. Pediatric Infectious Disease Journal, 39, 519-522. doi: 10.1097/INF.0000000000002646
Journal - Research Article
Gwee, A., Duffull, S., Zhu, X., Tong, S. Y. C., Cranswick, N., McWhinney, B., … Steer, A. C. (2020). Population pharmacokinetics of ivermectin for the treatment of scabies in Indigenous Australian children. PLoS Neglected Tropical Diseases, 14(12), e0008886. doi: 10.1371/journal.pntd.0008886
Journal - Research Article
Sanhajariya, S., Isbister, G. K., & Duffull, S. B. (2020). The influence of the different disposition characteristics of snake toxins on the pharmacokinetics of snake venom. Toxins, 12(3), 188. doi: 10.3390/toxins12030188
Journal - Research Article
Sinha, J., Al-Sallami, H. S., & Duffull, S. B. (2020). An extension of Janmahasatian’s Fat-Free Mass model for universal application across populations of different ethnicities. Clinical Pharmacokinetics, 59, 1161-1170. doi: 10.1007/s40262-020-00883-1
Journal - Research Article
Sinha, J., Duffull, S. B., Green, B., & Al-Sallami, H. S. (2020). Evaluating the relationship between lean liver volume and fat-free mass. Clinical Pharmacokinetics, 59, 475-483. doi: 10.1007/s40262-019-00824-7
Journal - Research Article
Stamp, L. K., Chapman, P., Frampton, C., Duffull, S. B., Drake, J., Zhang, Y., & Neogi, T. (2020). Lack of effect of tart cherry concentrate dose on serum urate in people with gout. Rheumatology, 59, 2374-2380. doi: 10.1093/rheumatology/kez606
Journal - Research Article
Wright, D. F. B., Duffull, S. B., Wilby, K. J., Peterson, A. K., & Anakin, M. G. (2020). Measuring the development of therapeutic-decision-making skills by practicing pharmacists undertaking a university-based postgraduate clinical qualification at distance. Pharmacy, 8(2), 83. doi: 10.3390/pharmacy8020083
Journal - Research Article
Zhu, X., Finlay, D. B., Glass, M., & Duffull, S. B. (2020). Evaluation of the profiles of CB1 cannabinoid receptor signalling bias using joint kinetic modelling. British Journal of Pharmacology, 177, 3449-3463. doi: 10.1111/bph.15066
Journal - Research Article
Kuan, I. H. S., Savage, R. L., Duffull, S. B., Walker, R. J., & Wright, D. F. B. (2019). The association between metformin therapy and lactic acidosis. Drug Safety, 42, 1449-1469. doi: 10.1007/s40264-019-00854-x
Journal - Research Article
Liu, Z., Diana, A., Slater, C., Preston, T., Gibson, R. S., Houghton, L., & Duffull, S. B. (2019). Development of a nonlinear hierarchical model to describe the disposition of deuterium in mother-infant pairs to assess exclusive breastfeeding practice. Journal of Pharmacokinetics & Pharmacodynamics, 46, 1-13. doi: 10.1007/s10928-018-9613-x
Journal - Research Article
Liu, Z., Diana, A., Slater, C., Preston, T., Gibson, R. S., Houghton, L., & Duffull, S. B. (2019). Development of a parsimonious design for optimal classification of exclusive breastfeeding. Clinical & Translational Science, 8, 596-605. doi: 10.1002/psp4.12428
Journal - Research Article
Pan, S., & Duffull, S. B. (2019). Automated proper lumping for simplification of linear physiologically based pharmacokinetic systems. Journal of Pharmacokinetics & Pharmacodynamics, 46, 361-370. doi: 10.1007/s10928-019-09644-5
Journal - Research Article
Pradhan, S., Duffull, S. B., Walker, R. J., & Wright, D. F. B. (2019). The intact nephron hypothesis as a model for renal drug handling. European Journal of Clinical Pharmacology, 75(2), 147-156. doi: 10.1007/s00228-018-2572-8
Journal - Research Article
Sinha, J., Al-Sallami, H. S., & Duffull, S. B. (2019). Choosing the allometric exponent in covariate model building. Clinical Pharmacokinetics, 28(1), 89-100. doi: 10.1007/s40262-018-0667-0
Journal - Research Article
Zhu, X., Finlay, D. B., Glass, M., & Duffull, S. B. (2019). An intact model for quantifying functional selectivity. Scientific Reports, 9, 2557. doi: 10.1038/s41598-019-39000-z
Journal - Research Article
Zhu, X., Finlay, D. B., Glass, M., & Duffull, S. B. (2019). Model-free and kinetic modelling approaches for characterising non-equilibrium pharmacological pathway activity: Internalisation of cannabinoid CB1 receptors. British Journal of Pharmacology, 176, 2593-2607. doi: 10.1111/bph.14684
Journal - Research Article
Duffull, S. B., Wright, D. F. B., Marra, C. A., & Anakin, M. G. (2018). A philosophical framework for pharmacy in the 21st century guided by ethical principles. Research in Social & Administrative Pharmacy, 14(3), 309-316. doi: 10.1016/j.sapharm.2017.04.049
Journal - Research Article
Hasegawa, C., & Duffull, S. B. (2018). Automated scale reduction of nonlinear QSP models with an illustrative application to a bone biology system. CPT: Pharmacometrics & Systems Pharmacology, 7, 562-572. doi: 10.1002/psp4.12324
Journal - Research Article
Hasegawa, C., & Duffull, S. B. (2018). Selection and qualification of simplified QSP models when using model order reduction techniques. AAPS Journal, 20, 2. doi: 10.1208/s12248-017-0170-9
Journal - Research Article
Ng, D. P. J., Duffull, S. B., Faed, J. M., Isbister, G. K., & Gulati, A. (2018). An evaluation of a factor Xa-based clotting time test for enoxaparin: A proof-of-concept study. Clinical & Applied Thrombosis/Hemostasis, 24(4), 669-676. doi: 10.1177/1076029617711802
Journal - Research Article
Ooi, Q. X., Wright, D. F. B., Isbister, G. K., & Duffull, S. B. (2018). A factor VII-based method for the prediction of anticoagulant response to warfarin. Scientific Reports, 8, 12041. doi: 10.1038/s41598-018-30516-4
Journal - Research Article
Zhu, X., Finlay, D. B., Glass, M., & Duffull, S. B. (2018). An evaluation of the operational model when applied to quantify functional selectivity. British Journal of Pharmacology, 175, 1654-1668. doi: 10.1111/bph.14171
Journal - Research Article
Zufferey, P. J., Ollier, E., Delavenne, X., Laporte, S., Mismetti, P., & Duffull, S. B. (2018). Incidence and risk factors of major bleeding following major orthopaedic surgery with fondaparinux thromboprophylaxis: A time-to-event analysis. British Journal of Clinical Pharmacology, 84(10), 2242-2251. doi: 10.1111/bcp.13663
Journal - Research Article
Duffull, S. B., & Hooker, A. C. (2017). Assessing robustness of designs for random effects parameters for nonlinear mixed-effects models. Journal of Pharmacokinetics & Pharmacodynamics, 44(6), 611-616. doi: 10.1007/s10928-017-9552-y
Journal - Research Article
Foo, L. K., & Duffull, S. (2017). Designs to balance cost and success rate for an early phase clinical study. Journal of Biopharmaceutical Statistics, 27(1), 148-158. doi: 10.1080/10543406.2016.1148703
Journal - Research Article
Hasegawa, C., & Duffull, S. B. (2017). Exploring inductive linearization for pharmacokinetic-pharmacodynamic systems of nonlinear ordinary differential equations. Journal of Pharmacokinetics & Pharmacodynamics, 45(1), 35-47. doi: 10.1007/s10928-017-9527-z
Journal - Research Article
Kuan, I. H. S., Duffull, S. B., Putt, T. L., Schollum, J. B. W., Walker, R. J., & Wright, D. F. B. (2017). A population pharmacokinetic model for 51Cr EDTA to estimate renal function. Clinical Pharmacokinetics, 56(6), 671-678. doi: 10.1007/s40262-016-0489-x
Journal - Research Article
Ooi, Q. X., Wright, D. F. B., Tait, R. C., Isbister, G. K., & Duffull, S. B. (2017). A joint model for vitamin K-dependent clotting factors and anticoagulation proteins. Clinical Pharmacokinetics, 56(12), 1555-1556. doi: 10.1007/s40262-017-0541-5
Journal - Research Article
Saffian, S. M., Duffull, S. B., & Wright, D. F. B. (2017). Warfarin dosing algorithms underpredict dose requirements in patients requiring ≥ 7mg daily: A systematic review and meta-analysis. Clinical Pharmacology & Therapeutics, 102(2), 297-304. doi: 10.1002/cpt.649
Journal - Research Article
Siripuram, V. K., Wright, D. F. B., Barclay, M. L., & Duffull, S. B. (2017). Deterministic identifiability of population pharmacokinetic and pharmacokinetic-pharmacodynamic models. Journal of Pharmacokinetics & Pharmacodynamics, 44(5), 415-423. doi: 10.1007/s10928-017-9530-4
Journal - Research Article
Al-Sallami, H., Newall, F., Monagle, P., Ignjatovic, V., Cranswick, N., & Duffull, S. (2016). Development of a population pharmacokinetic-pharmacodynamic model of a single bolus dose of unfractionated heparin in paediatric patients. British Journal of Clinical Pharmacology, 82(1), 178-184. doi: 10.1111/bcp.12930
Journal - Research Article
Assawasuwannakit, P., Braund, R., & Duffull, S. B. (2016). A framework for quantifying the influence of adherence and dose individualization. Clinical Pharmacology & Therapeutics, 99(4), 452-459. doi: 10.1002/cpt.268
Journal - Research Article
Brussee, J. M., Yeo, T. W., Lampah, D. A., Anstey, N. M., & Duffull, S. B. (2016). A pharmacokinetic-pharmacodynamic model for the effect of L-arginine on endothelial function in patients with moderately severe falciparum malaria. Antimicrobial Agents & Chemotherapy, 60(1), 198-205. doi: 10.1128/aac.01479-15
Journal - Research Article
Chiew, A. L., Isbister, G. K., Duffull, S. B., & Buckley, N. A. (2016). Evidence for the changing regimens of acetylcysteine. British Journal of Clinical Pharmacology, 81(3), 471-481. doi: 10.1111/bcp.12789
Journal - Research Article
Foo, L.-K., Duffull, S. B., Calver, L., Schneider, J., & Isbister, G. K. (2016). Population pharmacokinetics of intramuscular droperidol in acutely agitated patients. British Journal of Clinical Pharmacology, 82(6), 1550-1556. doi: 10.1111/bcp.13093
Journal - Research Article
Saffian, S. M., Duffull, S. B., Roberts, R. L., Tait, R. C., Black, L., Lund, K. A., … Wright, D. F. B. (2016). Influence of genotype on warfarin maintenance dose predictions produced using a Bayesian dose individualization tool. Therapeutic Drug Monitoring, 38(6), 677-683. doi: 10.1097/ftd.0000000000000347
Journal - Research Article
Shivva, V., Cox, P. J., Clarke, K., Veech, R. L., Tucker, I. G., & Duffull, S. B. (2016). The population pharmacokinetics of D-β-hydroxybutyrate following administration of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate. AAPS Journal, 18(3), 678-688. doi: 10.1208/s12248-016-9879-0
Journal - Research Article
Shivva, V., Tucker, I. G., & Duffull, S. B. (2016). An in silico knockout model for gastrointestinal absorption using a systems pharmacology approach: Development and application for ketones. PLoS ONE, 11(9), e0163795. doi: 10.1371/journal.pone.0163795
Journal - Research Article
Wright, D. F. B., Duffull, S. B., Merriman, T. R., Dalbeth, N., Barclay, M. L., & Stamp, L. K. (2016). Predicting allopurinol response in patients with gout. British Journal of Clinical Pharmacology, 81(2), 277-289. doi: 10.1111/bcp.12799
Journal - Research Article
Al-Sallami, H. S., Goulding, A., Grant, A., Taylor, R., Holford, N., & Duffull, S. B. (2015). Prediction of fat-free mass in children. Clinical Pharmacokinetics, 54(11), 1169-1178. doi: 10.1007/s40262-015-0277-z
Journal - Research Article
Assawasuwannakit, P., Braund, R., & Duffull, S. B. (2015). A model-based meta-analysis of the influence of factors that impact adherence to medications. Journal of Clinical Pharmacy & Therapeutics, 40(1), 24-31. doi: 10.1111/jcpt.12219
Journal - Research Article
Assawasuwannakit, P., Braund, R., & Duffull, S. B. (2015). Quantification of the forgiveness of drugs to imperfect adherence. CPT: Pharmacometrics & Systems Pharmacology, 4(3), 204-211. doi: 10.1002/psp4.4
Journal - Research Article
Cooper, J. M., Duffull, S. B., Saiao, A. S., & Isbister, G. K. (2015). The pharmacokinetics of sertraline in overdose and the effect of activated charcoal. British Journal of Clinical Pharmacology, 79(2), 307-315. doi: 10.1111/bcp.12500
Journal - Research Article
Duffull, S. B., & Wright, D. F. B. (2015). What do we learn from repeated population analyses? British Journal of Clinical Pharmacology, 79(1), 40-47. doi: 10.1111/bcp.12233
Journal - Research Article
Gulati, A., Faed, J. M., Isbister, G. K., & Duffull, S. B. (2015). Application of adaptive DP-optimality to design a pilot study for a clotting time test for enoxaparin. Pharmaceutical Research, 32(10), 3391-3402. doi: 10.1007/s11095-015-1715-1
Journal - Research Article
Lagishetty, C. V., & Duffull, S. B. (2015). Evaluation of approaches to deal with low-frequency nuisance covariates in population pharmacokinetic analyses. AAPS Journal, 17(6), 1388-1394. doi: 10.1208/s12248-015-9793-x
Journal - Research Article
Nyberg, J., Bazzoli, C., Ogungbenro, K., Aliev, A., Leonov, S., Duffull, S., … Mentré, F. (2015). Methods and software tools for design evaluation for population pharmacokinetics-pharmacodynamics studies. British Journal of Clinical Pharmacology, 79(1), 6-17. doi: 10.1111/bcp.12352
Journal - Research Article
Pan, S., Korell, J., Stamp, L. K., & Duffull, S. B. (2015). Simplification of a pharmacokinetic model for red blood cell methotrexate disposition. European Journal of Clinical Pharmacology, 71(12), 1509-1516. doi: 10.1007/s00228-015-1951-7
Journal - Research Article
Saffian, S. M., Wright, D. F. B., Roberts, R. L., & Duffull, S. B. (2015). Methods for predicting warfarin dose requirements. Therapeutic Drug Monitoring, 37(4), 531-538. doi: 10.1097/ftd.0000000000000177
Journal - Research Article
Salahudeen, M. S., Duffull, S. B., & Nishtala, P. S. (2015). Anticholinergic burden quantified by anticholinergic risk scales and adverse outcomes in older people: A systematic review. BMC Geriatrics, 15, 31. doi: 10.1186/s12877-015-0029-9
Journal - Research Article
Salahudeen, M. S., Nishtala, P. S., & Duffull, S. B. (2015). The influence of patient characteristics on anticholinergic events in older people. Dementia & Geriatric Cognitive Disorders Extra, 5(3), 530-541. doi: 10.1159/000441718
Journal - Research Article
Duffull, S. B., & Hegarty, G. (2014). An inductive approximation to the solution of systems of nonlinear ordinary differential equations in pharmacokinetics-pharmacodynamics. Journal of Theoretical & Computational Science, 1(4), 1000119. doi: 10.4172/jtco.1000119
Journal - Research Article
Gulati, A., Isbister, G. K., & Duffull, S. B. (2014). Scale reduction of a systems coagulation model with an application to modeling pharmacokinetic-pharmacodynamic data. CPT: Pharmacometrics & Systems Pharmacology, 3, e90. doi: 10.1038/psp.2013.67
Journal - Research Article
Hatah, E., Braund, R., Tordoff, J., & Duffull, S. B. (2014). A systematic review and meta-analysis of pharmacist-led fee-for-services medication review. British Journal of Clinical Pharmacology, 77(1), 102-115. doi: 10.1111/bcp.12140
Journal - Research Article
Hatah, E., Tordoff, J., Duffull, S. B., & Braund, R. (2014). Pharmacists' performance of clinical interventions during adherence support medication reviews. Research in Social & Administrative Pharmacy, 10(1), 185-194. doi: 10.1016/j.sapharm.2013.04.008
Journal - Research Article
Hatah, E., Tordoff, J., Duffull, S. B., Cameron, C., & Braund, R. (2014). Retrospective examination of selected outcomes of Medicines Use Review (MUR) services in New Zealand. International Journal of Clinical Pharmacy, 36(3), 503-512. doi: 10.1007/s11096-014-9913-1
Journal - Research Article
Korell, J., Duffull, S. B., Dalrymple, J. M., Drake, J., Zhang, M., Barclay, M. L., & Stamp, L. K. (2014). Comparison of intracellular methotrexate kinetics in red blood cells with the kinetics in other cell types. British Journal of Clinical Pharmacology, 77(3), 493-497. doi: 10.1111/bcp.12209
Journal - Research Article
Pan, S., Stamp, L. K., Duffull, S. B., Barclay, M. L., Dalrymple, J. M., Drake, J., Zhang, M., & Korell, J. (2014). Assessment of the relationship between methotrexate polyglutamates in red blood cells and clinical response in patients commencing methotrexate for rheumatoid arthritis. Clinical Pharmacokinetics, 53(12), 1161-1170. doi: 10.1007/s40262-014-0179-5
Journal - Research Article
Putt, T. L., Duffull, S. B., Schollum, J. B. W., & Walker, R. J. (2014). GFR may not accurately predict aspects of proximal tubule drug handling. European Journal of Clinical Pharmacology, 70(10), 1221-1226. doi: 10.1007/s00228-014-1733-7
Journal - Research Article
Salahudeen, M. S., Duffull, S. B., & Nishtala, P. S. (2014). Impact of anticholinergic discontinuation on cognitive outcomes in older people: A systematic review. Drugs & Aging, 31(3), 185-192. doi: 10.1007/s40266-014-0158-4
Journal - Research Article
Shivva, V., Korell, J., Tucker, I. G., & Duffull, S. B. (2014). Parameterisation affects identifiability of population models. Journal of Pharmacokinetics & Pharmacodynamics, 41, 81-86. doi: 10.1007/s10928-013-9347-8
Journal - Research Article
Duffull, S. B., & Isbister, G. K. (2013). Predicting the requirement for N-acetylcysteine in paracetamol poisoning from reported dose. Clinical Toxicology, 51(8), 772-776. doi: 10.3109/15563650.2013.830733
Journal - Research Article
Gulati, A., Isbister, G. K., & Duffull, S. B. (2013). Effect of Australian elapid venoms on blood coagulation: Australian Snakebite Project (ASP-17). Toxicon, 61, 94-104. doi: 10.1016/j.toxicon.2012.11.001
Journal - Research Article
Hatah, E., Braund, R., Duffull, S. B., & Tordoff, J. (2013). General practitioners' views of pharmacists' current and potential contributions to medication review and prescribing in New Zealand. Journal of Primary Health Care, 5(3), 223-233.
Journal - Research Article
Jamsen, K. M., Duffull, S. B., Tarning, J., Price, R. N., & Simpson, J. (2013). A robust design for identification of the Parasite Clearance Estimator. Malaria Journal, 12, 410. doi: 10.1186/1475-2875-12-410
Journal - Research Article
Korell, J., & Duffull, S. B. (2013). A semi-mechanistic red blood cell survival model provides some insight into red blood cell destruction mechanisms. Journal of Pharmacokinetics & Pharmacodynamics, 40(4), 469-478. doi: 10.1007/s10928-013-9322-4
Journal - Research Article
Korell, J., Stamp, L. K., Barclay, M. L., Dalrymple, J. M., Drake, J., Zhang, M., & Duffull, S. B. (2013). A population pharmacokinetic model for low-dose methotrexate and its polyglutamated metabolites in red blood cells. Clinical Pharmacokinetics, 52(6), 475-485. doi: 10.1007/s40262-013-0052-y
Journal - Research Article
Shaw, J. P., Print, S. A., & Duffull, S. B. (2013). Development of a postgraduate educational program for pharmacist prescribers in New Zealand. Journal of Pharmacy Practice & Research, 43(2), 122-127.
Journal - Research Article
Shivva, V., Korell, J., Tucker, I. G., & Duffull, S. B. (2013). An approach for identifiability of population pharmacokinetic–pharmacodynamic models. CPT: Pharmacometrics & Systems Pharmacology, 2(6), e49. doi: 10.1038/psp.2013.25
Journal - Research Article
Wright, D. F. B., & Duffull, S. B. (2013). A bayesian dose-individualization method for warfarin. Clinical Pharmacokinetics, 52(1), 59-68. doi: 10.1007/s40262-012-0017-6
Journal - Research Article
Wright, D. F. B., Stamp, L. K., Merriman, T. R., Barclay, M. L., Duffull, S. B., & Holford, N. H. G. (2013). The population pharmacokinetics of allopurinol and oxypurinol in patients with gout. European Journal of Clinical Pharmacology, 69(7), 1411-1421. doi: 10.1007/s00228-013-1478-8
Journal - Research Article
Yeo, T. W., Lampah, D. A., Rooslamiati, I., Gitawati, R., Tjitra, E., Kenangalem, E., … Duffull, S. B., & Anstey, N. A. (2013). A randomized pilot study of L-arginine infusion in severe falciparum malaria: Preliminary safety, efficacy and pharmacokinetics. PLoS ONE, 8(7), e69587. doi: 10.1371/journal.pone.0069587
Journal - Research Article
Alskär, O., Korell, J., & Duffull, S. B. (2012). A pharmacokinetic model for the glycation of albumin. Journal of Pharmacokinetics & Pharmacodynamics, 39(3), 273-282. doi: 10.1007/s10928-012-9249-1
Journal - Research Article
Duffull, S. B., Graham, G., Mengersen, K., & Eccleston, J. (2012). Evaluation of the pre-posterior distribution of optimized sampling times for the design of pharmacokinetic studies. Journal of Biopharmaceutical Statistics, 22(1), 16-29. doi: 10.1080/10543406.2010.500065
Journal - Research Article
Foo, L. K., & Duffull, S. (2012). Adaptive optimal design for bridging studies with an application to population pharmacokinetic studies. Pharmaceutical Research, 29(6), 1530-1543. doi: 10.1007/s11095-011-0659-3
Journal - Research Article