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Contact Details

Phone
64 3 479 7081
Email
richard.cannon@otago.ac.nz
Position
Professor of Molecular Microbiology
Department
Department of Oral Sciences
Qualifications
MA PhD(Cantab)
Research summary
Oral microbiology and antifungal drug resistance

Research

Professor Cannon is a molecular microbiologist interested in how microorganisms cause oral diseases and in how treatments for patients with these diseases can be improved. His research has a number of themes, one being oral adhesion. He is interested in how oral microbes, particularly yeast, adhere and colonize surfaces in the oral cavity.

He has found that saliva increases the adhesion of the yeast Candida albicans to several oral surfaces, including denture acrylics and voice prosthesis silicone. He is interested in the formation of oral biofilms, how microorganisms communicate within biofilms, and ways of inhibiting pathogenic biofilm formation.

C. albicans is a polymorphic fungus that grows mainly as yeast or mycelia. Professor Cannon is using metabolomics to investigate the changes in metabolism that are associated with the change from yeast to hyphal growth. A major focus of his research is the drug resistance of human fungal pathogens. He has found that clinically significant fungal drug resistance is due to energy-dependent drug efflux from the cell. His research group has developed a unique system for expressing and studying these efflux pumps in baker's yeast Saccharomyces cerevisiae.

They are currently using S. cerevisiae strains expressing efflux pumps from a variety of fungi to study pump function and to search for pump inhibitors. Professor Cannon is also using the S. cerevisiae expression system to investigate the resistance of sheep intestinal nematodes to antihelmintics.

Publications

Chen, X., He, Q., Zhai, Q., Tang, H., Li, D., Zhu, X., … Cannon, R. D., Mei, L., … Chen, T. (2023). Adaptive nanoparticle-mediated modulation of mitochondrial homeostasis and inflammation to enhance infected bone defect healing. ACS Nano. Advance online publication. doi: 10.1021/acsnano.3c08165

Li, M., Li, D., Jiang, Y., He, P., Li, Y., Wu, Y., … Cannon, R. D., Mei, L., … Yuan, H. (2023). The genetic background determines material-induced bone formation through the macrophage-osteoclast axis. Biomaterials, 302, 122356. doi: 10.1016/j.biomaterials.2023.122356

Friedlander, L. T., Wallace, W. D. A., Broadbent, J. M., Hanlin, S. M., Lyons, K. M., Cannon, R. D., & Cooper, P. R. (2023). Preparedness and competency of New Zealand graduates for general dental practice: Perceptions from the workforce. Australian Dental Journal. Advance online publication. doi: 10.1111/adj.12981

Krishnan, C. S., Tompkins, G. R., Lyons, K. M., & Cannon, R. D. (2023). Electrolysed oxidising water as a multi-purpose biocide in dental healthcare: A scoping review. Gerodontology, 40, 422-462. doi: 10.1111/ger.12712

Krishnan, C. S., Lyons, K. M., Tompkins, G. R., & Cannon, R. D. (2023). Storage-related stability and antimicrobial efficacy of bottled, neutral-pH Electrolysed Oxidising Water. Journal of Dentistry, 137, 104656. doi: 10.1016/j.jdent.2023.104656

Cannon, R. D., Lyons, K. M., Chong, K., Newsham-West, K., Niimi, K., & Holmes, A. R. (2017). Adhesion of yeast and bacteria to oral surfaces. In G. J. Seymour, M. P. Cullinan & N. C. K. Heng (Eds.), Oral biology: Molecular techniques and applications: Methods in molecular biology (Vol. 1537). (2nd ed.) (pp. 165-190). New York, NY: Springer. doi: 10.1007/978-1-4939-6685-1_10

Chapter in Book - Research

Lamping, E., Madani, G., Lee, H. J., Niimi, M., & Cannon, R. D. (2017). Structure-function analyses of multidrug tansporters. In R. Prasad (Ed.), Candida albicans: Cellular and molecular biology. (2nd ed.) (pp. 379-406). Springer. doi: 10.1007/978-3-319-50409-4

Chapter in Book - Research

Monk, B. C., Niimi, K., Holmes, A. R., Strouse, J. J., Sklar, L. A., & Cannon, R. D. (2012). Fungal efflux-mediated resistance: From targets to inhibitors. In G. Tegos & E. Mylonakis (Eds.), Antimicrobial drug discovery: Emerging strategies. (pp. 77-88). Oxford, UK: CABI.

Chapter in Book - Research

Cannon, R. D., Lyons, K. M., Chong, K., & Holmes, A. R. (2010). Adhesion of yeast and bacteria to oral surfaces. In G. J. Seymour, M. P. Cullinan & N. C. K. Heng (Eds.), Oral Biology. (pp. 103-124). New York: Springer. doi: 10.1007/978-1-60761-820-1_8

Chapter in Book - Research

Lamping, E., & Cannon, R. D. (2010). Use of a yeast-based membrane protein expression technology to overexpress drug resistance efflux pumps. In G. J. Seymour, M. P. Cullinan & N. C. K. Heng (Eds.), Oral Biology. (pp. 219-250). New York: Springer. doi: 10.1007/978-1-60761-820-1_15

Chapter in Book - Research

Niimi, M., Cannon, R. D., & Monk, B. C. (2001). Candida albicans pathology: A proteomic perspective. In M. J. Dunn (Ed.), Proteomics Reviews 2001. (pp. 28-37). Weinheim, Germany: Wiley-VCH.

Chapter in Book - Research

Cannon, R. D., Albertson, G. D., Niimi, M., & Jenkinson, H. F. A. (1996). Fluconazole uptake and resistance in Candida. In K. Tanaka, H. Yamaguchi & P. T. Magee (Eds.), Genes and Genomes in Medically Important Fungi. (pp. 157-165). Foundation for Advancement of International Scienc.

Chapter in Book - Research

Cannon, R. D., Lyons, K. M., Chong, K., Newsham-West, K., Niimi, K., & Holmes, A. R. (2023). Adhesion of yeast and bacteria to oral surfaces. In G. J. Seymour, M. P. Cullinan, N. C. K. Heng & P. R. Cooper (Eds.), Oral biology: Molecular techniques and applications: Methods in molecular biology (Vol. 2588). (3rd ed.) (pp. 131-156). New York, NY: Springer. doi: 10.1007/978-1-0716-2780-8_9

Chapter in Book - Other

Cannon, R. D., & Firth, N. A. (2013). Fungi and fungal infections of the oral cavity. In R. J. Lamont, G. N. Hajishengallis & H. F. Jenkinson (Eds.), Oral microbiology and immunology. (2nd ed.) (pp. 343-360). Washington, DC: ASM Press. doi: 10.1128/9781555818906

Chapter in Book - Other

Cannon, R. D., & Firth, N. A. (2006). Fungi and fungal infections of the oral cavity. In R. J. Lamont, R. A. Burne, M. S. Lantz & D. J. LeBlanc (Eds.), Oral microbiology and immunology. (pp. 333-348). Washington, DC: American Society for Microbiology.

Chapter in Book - Other

Chen, X., He, Q., Zhai, Q., Tang, H., Li, D., Zhu, X., … Cannon, R. D., Mei, L., … Chen, T. (2023). Adaptive nanoparticle-mediated modulation of mitochondrial homeostasis and inflammation to enhance infected bone defect healing. ACS Nano. Advance online publication. doi: 10.1021/acsnano.3c08165

Journal - Research Article

Friedlander, L. T., Wallace, W. D. A., Broadbent, J. M., Hanlin, S. M., Lyons, K. M., Cannon, R. D., & Cooper, P. R. (2023). Preparedness and competency of New Zealand graduates for general dental practice: Perceptions from the workforce. Australian Dental Journal. Advance online publication. doi: 10.1111/adj.12981

Journal - Research Article

Hu, S., Wang, S., He, Q., Li, D., Xin, L., Xu, C., … Mei, L., Cannon, R. D., … Chen, T. (2023). A mechanically reinforced super bone glue makes a leap in hard tissue strong adhesion and augmented bone regeneration. Advanced Science, 10, 2206450. doi: 10.1002/advs.202206450

Journal - Research Article

Hu, S., Yang, Z., Zhai, Q., Li, D., Zhu, X., He, Q., … Cannon, R. D., … Chen, T. (2023). An all-in-one “4A Hydrogel”: Through first-aid hemostatic, antibacterial, antioxidant, and angiogenic to promoting infected wound healing. Small. Advance online publication. doi: 10.1002/smll.202207437

Journal - Research Article

Jian, G., Li, D., Ying, Q., Chen, X., Zhai, Q., Wang, S., Mei, L., Cannon, R. D., … Chen, T. (2023). Dual photo-enhanced interpenetrating network hydrogel with biophysical and biochemical signals for infected bone defect healing. Advanced Healthcare Materials, 2300469. Advance online publication. doi: 10.1002/adhm.202300469

Journal - Research Article

Krishnan, C. S., Lyons, K. M., Tompkins, G. R., & Cannon, R. D. (2023). Storage-related stability and antimicrobial efficacy of bottled, neutral-pH Electrolysed Oxidising Water. Journal of Dentistry, 137, 104656. doi: 10.1016/j.jdent.2023.104656

Journal - Research Article

Li, M., Li, D., Jiang, Y., He, P., Li, Y., Wu, Y., … Cannon, R. D., Mei, L., … Yuan, H. (2023). The genetic background determines material-induced bone formation through the macrophage-osteoclast axis. Biomaterials, 302, 122356. doi: 10.1016/j.biomaterials.2023.122356

Journal - Research Article

Liu, N., Zhong, Y., Pang, X., Li, M., Cannon, R. D., Mei, L., … Ji, P. (2023). The nano-windmill exerts superior anti-inflammatory effects via reducing choline uptake to inhibit macrophage activation. Cell Proliferation, 56, e13470. doi: 10.1111/cpr.13470

Journal - Research Article

Lyons, K. M., Cannon, R. D., Beumer, III, J., Bakr, M. M., & Love, R. M. (2023). Microbial analysis of obturators during maxillofacial prosthodontic treatment over an 8-year period. Cleft Palate Craniofacial Journal, 30(11), 1426-1441. doi: 10.1177/10556656221104940

Journal - Research Article

Shi, J., Ma, D., Gao, S., Long, F., Wang, X., Pu, X., Cannon, R. D., & Han, T.-L. (2023). Probiotic Escherichia coli Nissle 1917-derived outer membrane vesicles modulate the intestinal microbiome and host gut-liver metabolome in obese and diabetic mice. Frontiers in Microbiology, 14, 1219763. doi: 10.3389/fmicb.2023.1219763

Journal - Research Article

Skilbeck, M. G., Cannon, R. D., Farella, M., & Mei, L. (2023). The effect of surface roughening of orthodontic elastomers on hydrophobicity and in vitro adherence of Streptococcus gordonii. Journal of the Mechanical Behavior of Biomedical Materials, 143, 105881. doi: 10.1016/j.jmbbm.2023.105881

Journal - Research Article

Atieh, M. A., Guirguis, M., Alsabeeha, N. H. M., & Cannon, R. D. (2022). The diagnostic accuracy of saliva testing for SARS-CoV-2: A systematic review and meta-analysis. Oral Diseases, 28(Suppl. 2), 2347-2361. doi: 10.1111/odi.13934

Journal - Research Article

Chen, X., Zhao, X., Jones, M. B., Harper, A., de Seymour, J. V., Yang, Y., … Cannon, R. D., … Baker, P. N. (2022). The relationship between hair metabolites, air pollution exposure and gestational diabetes mellitus: A longitudinal study from pre-conception to third trimester. Frontiers in Endocrinology, 13, 1060309. doi: 10.3389/fendo.2022.1060309

Journal - Research Article

Gil, F., Laiolo, J., Bayona-Pacheco, B., Cannon, R. D., Ferreira-Pereira, A., & Carpinella, M. C. (2022). Extracts from Argentinian native plants reverse fluconazole resistance in Candida species by inhibiting the efflux transporters Mdr1 and Cdr1. BMC Complementary Medicine & Therapies, 22(1), 264. doi: 10.1186/s12906-022-03745-4

Journal - Research Article

James, J. E., Santhanam, J., Cannon, R. D., & Lamping, E. (2022). Voriconazole treatment induces a conserved sterol/pleiotropic drug resistance regulatory network, including an alternative ergosterol biosynthesis pathway, in the clinically important FSSC species, Fusarium keratoplasticum. Journal of Fungi, 8(10), 1070. doi: 10.3390/jof8101070

Journal - Research Article

James, J. E., Santhanam, J., Zakaria, L., Mamat Rusli, N., Abu Bakar, M., Suetrong, S., … Lamping, E., & Cannon, R. D. (2022). Morphology, phenotype, and molecular identification of clinical and environmental Fusarium solani species complex isolates from Malaysia. Journal of Fungi, 8(8), 845. doi: 10.3390/jof8080845

Journal - Research Article

Li, D., Chen, K., Tang, H., Hu, S., Xin, L., Jing, X., … Mei, L., Cannon, R. D., … Chen, T. (2022). A logic-based diagnostic and therapeutic hydrogel with multi-stimuli responsiveness to orchestrate diabetic bone regeneration. Advanced Materials, 34, 2108430. doi: 10.1002/adma.202108430

Journal - Research Article

Liu, Y., Xia, Y.-Y., Zhang, T., Yang, Y., Cannon, R. D., Mansell, T., … Baker, P. N. (2022). Complex interactions between circulating fatty acid levels, desaturase activities, and the risk of gestational diabetes mellitus: A prospective cohort study. Frontiers in Nutrition, 9, 919357. doi: 10.3389/fnut.2022.919357

Journal - Research Article

Niimi, M., Niimi, K., Tanabe, K., Cannon, R. D., & Lamping, E. (2022). Inhibitor resistant mutants give important insights into Candida albicans ABC transporter Cdr1 substrate specificity and help elucidate efflux pump inhibition. Antimicrobial Agents & Chemotherapy, 66(1), e01748-21. doi: 10.1128/aac.01748-21

Journal - Research Article

Ratnayake, J., Veerasamy, A., Ahmed, H., Coburn, D., Loch, C., Gray, A. R., Lyons, K. M., Heng, N. C. K., Cannon, R. D., … Brunton, P. A. (2022). Clinical and microbiological evaluation of a chlorhexidine-modified glass ionomer cement (GIC-CHX) restoration placed using the atraumatic restorative treatment (ART) technique. Materials, 15, 5044. doi: 10.3390/ma15145044

Journal - Research Article

Skilbeck, M. G., Mei, L., Mohammed, H., Cannon, R. D., & Farella, M. (2022). The effect of ligation methods on biofilm formation in patients undergoing multi-bracketed fixed orthodontic therapy: A systematic review. Orthodontics & Craniofacial Research, 25, 14-30. doi: 10.1111/ocr.12503

Journal - Research Article

Yu, W. W., Goh, R., Cheong, E., Guan, G., Jin, C., Cannon, R. D., Farella, M., & Mei, L. (2022). Prevalence of halitosis among young adults in Dunedin, New Zealand. International Journal of Dental Hygiene, 20, 700-707. doi: 10.1111/idh.12609

Journal - Research Article

Zhong, W., Wang, X., Yang, L., Wang, Y., Xiao, Q., Yu, S., Cannon, R. D., … Song, J. (2022). Nanocarrier-assisted delivery of metformin boosts remodeling of diabetic periodontal tissue via cellular exocytosis-mediated regulation of endoplasmic reticulum homeostasis. ACS Nano, 16, 19096-19113. doi: 10.1021/acsnano.2c08146

Journal - Research Article

Zhu, J., Song, G., Zhou, X., Han, T.-L., Yu, X., Chen, H., … Cannon, R. D., … Zhang, H. (2022). CD39/CD73 dysregulation of adenosine metabolism increases decidual natural killer cell cytotoxicity: Implications in unexplained recurrent spontaneous abortion. Frontiers in Immunology, 13, 813218. doi: 10.3389/fimmu.2022.813218

Journal - Research Article

Itskovich, Y., Meikle, M. C., Cannon, R. D., Farella, M., Coates, D. E., & Milne, T. J. (2021). Differential behaviour and gene expression in 3D cultures of femoral- and calvarial-derived human osteoblasts under a cyclic compressive mechanical load. European Journal of Oral Sciences, 129, e12818. doi: 10.1111/eos.12818

Journal - Research Article

James, J. E., Lamping, E., Santhanam, J., & Cannon, R. D. (2021). PDR transporter ABC1 is involved in the innate azole resistance of the human fungal pathogen Fusarium keratoplasticum. Frontiers in Microbiology, 12, 673206. doi: 10.3389/fmicb.2021.673206

Journal - Research Article

Loch, C., Beckett, D., Kawe-Small, T., Cannon, R. D., Foster Page, L. A., Te Morenga, L., & Smith, L. A. (2021). Sugar in your diet: Kino te pai! An evaluation of oral health science outreach and community impact. International Journal of Health Promotion & Education. Advance online publication. doi: 10.1080/14635240.2021.2004439

Journal - Research Article

Madani, G., Lamping, E., & Cannon, R. D. (2021). Engineering a cysteine-deficient functional Candida albicans Cdr1 molecule reveals a conserved region at the cytosolic apex of ABCG transporters important for correct folding and trafficking of Cdr1. mSphere, 6(1), e01318-20. doi: 10.1128/mSphere.01318-20

Journal - Research Article

Madani, G., Lamping, E., Lee, H. J., Niimi, M., Mitra, A. K., & Cannon, R. D. (2021). Small-scale plasma membrane preparation for the analysis of Candida albicans Cdr1-mGFPHis. Journal of Visualized Experiments, 172, e62592. doi: 10.3791/62592

Journal - Research Article

Nguyen, H. T., Zhang, R., Inokawa, N., Oura, T., Chen, X., Iwatani, S., … Holmes, A. R., Cannon, R. D., & Kajiwara, S. (2021). Candida albicans Bgl2p, Ecm33p, and Als1p proteins are involved in adhesion to saliva-coated hydroxyapatite. Journal of Oral Microbiology, 13(1), 1879497. doi: 10.1080/20002297.2021.1879497

Journal - Research Article

Prasad, S., Ramanan, D., Bennani, H., Paulin, M., Cannon, R. D., Palla, S., & Farella, M. (2021). Associations among masticatory muscle activity, physical activity and self-reported oral behaviours in adult women. Clinical Oral Investigations, 25, 5049-5059. doi: 10.1007/s00784-021-03816-9

Journal - Research Article

Zhang, T., Jiang, W.-R., Xia, Y.-Y., Mansell, T., Saffery, R., Cannon, R. D., … Baker, P. N. (2021). Complex patterns of circulating fatty acid levels in gestational diabetes mellitus subclasses across pregnancy. Clinical Nutrition, 40, 4140-4148. doi: 10.1016/j.clnu.2021.01.046

Journal - Research Article

James, J. E., Lamping, E., Santhanam, J., Milne, T. J., Razak, M. F. A., Zakaria, L., & Cannon, R. D. (2020). A 23 bp cyp51A promoter deletion associated with voriconazole resistance in clinical and environmental isolates of Neocosmospora keratoplastica. Frontiers in Microbiology, 11, 272. doi: 10.3389/fmicb.2020.00272

Journal - Research Article

Benic, G. Z., Farella, M., Morgan, X. C., Viswam, J., Heng, N. C., Cannon, R. D., & Mei, L. (2019). Oral probiotics reduce halitosis in patients wearing orthodontic braces: A randomized, triple-blind, placebo-controlled trial. Journal of Breath Research, 13, 036010. doi: 10.1088/1752-7163/ab1c81

Journal - Research Article

Ghazal, A. R. A., Idris, G., Hajeer, M. Y., Alawer, K., & Cannon, R. D. (2019). Efficacy of removing Candida albicans from orthodontic acrylic bases: An in vitro study. BMC Oral Health, 19, 71. doi: 10.1186/s12903-019-0765-x

Journal - Research Article

Han, T.-L., Cannon, R. D., Gallo, S. M., & Villas-Bôas, S. G. (2019). A metabolomic study of the effect of Candida albicans glutamate dehydrogenase deletion on growth and morphogenesis. npj Biofilms & Microbiomes, 5, 13. doi: 10.1038/s41522-019-0086-5

Journal - Research Article

Jiang, Q., Mei, L., Zou, Y., Ding, Q., Cannon, R. D., Chen, H., & Li, H. (2019). Genetic polymorphisms in FGFR2 underlie skeletal malocclusion. Journal of Dental Research, 98(12), 1340-1347. doi: 10.1177/0022034519872951

Journal - Research Article

Meredith, L., Mei, L., Farella, M., & Cannon, R. D. (2019). Bacterial adhesion to human enamel after enameloplasty. New Zealand Dental Journal, 115(3), 103-107.

Journal - Research Article

Mohd Thiyahuddin, N., Lamping, E., Rich, A. M., & Cannon, R. D. (2019). Yeast species in the oral cavities of older people: A comparison between people living in their own homes and those in rest homes. Journal of Fungi, 5(2), 30. doi: 10.3390/jof5020030

Journal - Research Article

Prasad, S., Paulin, M., Cannon, R. D., Palla, S., & Farella, M. (2019). Smartphone-assisted monitoring of masticatory muscle activity in freely moving individuals. Clinical Oral Investigations, 23, 3601-3611. doi: 10.1007/s00784-018-2785-3

Journal - Research Article

Tanabe, K., Bonus, M., Tomiyama, S., Miyoshi, K., Nagi, M., Niimi, K., … Cannon, R. D., Niimi, M., & Lamping, E. (2019). FK506 resistance of Saccharomyces cerevisiae Pdr5 and Candida albicans Cdr1 involves mutations in the transmembrane domains and extracellular loops. Antimicrobial Agents & Chemotherapy, 63(1), e01146-18. doi: 10.1128/aac.01146-18

Journal - Research Article

Al-Dujaili, M., Milne, T. J., Cannon, R. D., & Farella, M. (2018). Postnatal expression of chondrogenic and osteogenic regulatory factor mRNA in the rat condylar cartilage. Archives of Oral Biology, 93, 126-132. doi: 10.1016/j.archoralbio.2018.05.019

Journal - Research Article

Zhang, N., Wheeler, D., Truglio, M., Lazzarini, C., Upritchard, J., McKinney, W., … Cannon, R. D., Broadbent, R. S., … Schmid, J. (2018). Multi-locus next-generation sequence typing of DNA extracted from pooled colonies detects multiple unrelated Candida albicans strains in a significant proportion of patient samples. Frontiers in Microbiology, 9, 1179. doi: 10.3389/fmicb.2018.01179

Journal - Research Article

Choo, K. H., Lee, H. J., Knight, N. J., Holmes, A. R., & Cannon, R. D. (2017). Multilocus sequence typing (MLST) analysis of Candida albicans isolates colonizing acrylic dentures before and after denture replacement. Medical Mycology, 55(6), 673-679. doi: 10.1093/mmy/myw128

Journal - Research Article

Lamping, E., Zhu, J.-y., Niimi, M., & Cannon, R. D. (2017). Role of ectopic gene conversion in the evolution of a Candida krusei pleiotropic drug resistance transporter family. Genetics, 205(4), 1619-1639. doi: 10.1534/genetics.116.194811

Journal - Research Article

Meredith, L., Farella, M., Lowrey, S., Cannon, R. D., & Mei, L. (2017). Atomic force microscopy analysis of enamel nanotopography after interproximal reduction. American Journal of Orthodontics & Dentofacial Orthopedics, 151(4), 750-757. doi: 10.1016/j.ajodo.2016.09.021

Journal - Research Article

Meredith, L., Mei, L., Cannon, R. D., & Farella, M. (2017). Interproximal reduction in orthodontics: Why, where, how much to remove? Australasian Orthodontic Journal, 33(2), 150-157.

Journal - Research Article

Wang, Y., Li, J., Sun, W., Li, H., Cannon, R. D., & Mei, L. (2017). Effect of non-fluoride agents on the prevention of dental caries in primary dentition: A systematic review. PLoS ONE, 12(8), e0182221. doi: 10.1371/journal.pone.0182221

Journal - Research Article

Weerasekera, M. M., Sissons, C. H., Wong, L., Anderson, S. A., & Cannon, R. D. (2017). Denaturant gradient gel electrophoresis profiles of bacteria from the saliva of twenty four different individuals form clusters that showed no relationship to the yeasts present. Archives of Oral Biology, 82, 6-10. doi: 10.1016/j.archoralbio.2017.05.014

Journal - Research Article

Farella, M., Loke, C., Sander, S., Songini, A., Allen, M., Mei, L., & Cannon, R. D. (2016). Simultaneous wireless assessment of intra-oral pH and temperature. Journal of Dentistry, 51, 49-55. doi: 10.1016/j.jdent.2016.05.012

Journal - Research Article

Holmes, A. R., Cardno, T. S., Strouse, J. J., Ivnitski-Steele, I., Keniya, M. V., Lackovic, K., Monk, B. C., … Cannon, R. D. (2016). Targeting efflux pumps to overcome antifungal drug resistance. Future Medicinal Chemistry, 8(12), 1485-1501. doi: 10.4155/fmc-2016-0050

Journal - Research Article

Panapruksachat, S., Iwatani, S., Oura, T., Vanittanakom, N., Chindamporn, A., Niimi, K., Niimi, M., Lamping, E., Cannon, R. D., & Kajiwara, S. (2016). Identification and functional characterization of Penicillium marneffei pleiotropic drug resistance transporters ABC1 and ABC2. Medical Mycology, 54, 478-491. doi: 10.1093/mmy/myv117

Journal - Research Article

Rawal, M. K., Banerjee, A., Shah, A. H., Khan, M. F., Sen, S., Saxena, A. K., Monk, B. C., Cannon, R. D., … Prasad, R. (2016). Newly identified motifs in Candida albicans Cdr1 protein nucleotide binding domains are pleiotropic drug resistance subfamily-specific and functionally asymmetric. Scientific Reports, 6, 27132. doi: 10.1038/srep27132

Journal - Research Article

Schmid, J., Magee, P. T., Holland, B. R., Zhang, N., Cannon, R. D., & Magee, B. B. (2016). Last hope for the doomed? Thoughts on the importance of a parasexual cycle for the yeast Candida albicans. Current Genetics, 62(1), 81-85. doi: 10.1007/s00294-015-0516-8

Journal - Research Article

Tong, Y., Liu, M., Zhang, Y., Liu, X., Huang, R., Song, F., … Cannon, R. D., … Zhang, L. (2016). Beauvericin counteracted multi-drug resistant Candida albicans by blocking ABC transporters. Synthetic & Systems Biotechnology, 1(3), 158-168. doi: 10.1016/j.synbio.2016.10.001

Journal - Research Article

van der Wielen, P. A., Holmes, A. R., & Cannon, R. D. (2016). Secretory component mediates Candida albicans binding to epithelial cells. Oral Diseases, 22(1), 69-74. doi: 10.1111/odi.12397

Journal - Research Article

Watanasrisin, W., Iwatani, S., Oura, T., Tomita, Y., Ikushima, S., Chindamporn, A., Niimi, M., Niimi, K., Lamping, E., Cannon, R. D., & Kajiwara, S. (2016). Identification and characterization of Candida utilis multidrug efflux transporter CuCdr1p. FEMS Yeast Research, 16, fow042. doi: 10.1093/femsyr/fow042

Journal - Research Article

Bakri, M. M., Rich, A. M., Cannon, R. D., & Holmes, A. R. (2015). In vitro expression of Candida albicans alcohol dehydrogenase genes involved in acetaldehyde metabolism. Molecular Oral Microbiology, 30(1), 27-38. doi: 10.1111/omi.12064

Journal - Research Article

Bennani, V., Hwang, L., Tawse-Smith, A., Dias, G. J., & Cannon, R. D. (2015). Effect of air-polishing on titanium surfaces, biofilm removal, and biocompatibility: A pilot study. BioMed Research International, 2015, 491047. doi: 10.1155/2015/491047

Journal - Research Article

Cannon, R. D., & Holmes, A. R. (2015). Learning the ABC of oral fungal drug resistance [Invited review]. Molecular Oral Microbiology, 30(6), 425-437. doi: 10.1111/omi.12109

Journal - Research Article

Keniya, M. V., Fleischer, E., Klinger, A., Cannon, R. D., & Monk, B. C. (2015). Inhibitors of the Candida albicans Major Facilitator Superfamily transporter Mdr1p responsible for fluconazole resistance. PLoS ONE, e0126350. doi: 10.1371/journal.pone.0126350

Journal - Research Article

Zhang, N., Magee, B. B., Magee, P. T., Holland, B. R., Rodrigues, E., Holmes, A. R., Cannon, R. D., & Schmid, J. (2015). Selective advantages of a parasexual cycle for the yeast Candida albicans. Genetics, 200(4), 1117-1132. doi: 10.1534/genetics.115.177170

Journal - Research Article

Bakri, M. M., Cannon, R. D., Holmes, A. R., & Rich, A. M. (2014). Detection of Candida albicans ADH1 and ADH2 mRNAs in human archival oral biopsy samples. Journal of Oral Pathology & Medicine, 43(9), 704-710. doi: 10.1111/jop.12193

Journal - Research Article

Holmes, A. R., Rodrigues, E., van der Wielen, P., Lyons, K. M., Haigh, B. J., Wheeler, T. T., Dawes, P. J. D., & Cannon, R. D. (2014). Adherence of Candida albicans to silicone is promoted by the human salivary protein SPLUNC2/PSP/BPIFA2. Molecular Oral Microbiology, 29(2), 90-98. doi: 10.1111/mom.12048

Journal - Research Article

Inger, M., Bennani, V., Farella, M., Bennani, F., & Cannon, R. D. (2014). Efficacy of air/water syringe tip sterilization. Australian Dental Journal, 59(1), 87-92. doi: 10.1111/adj.12146

Journal - Research Article

Keniya, M. V., Holmes, A. R., Niimi, M., Lamping, E., Gillet, J.-P., Gottesman, M. M., & Cannon, R. D. (2014). Drug resistance is conferred on the model yeast Saccharomyces cerevisiae by expression of full-length melanoma-associated human ATP-binding cassette transporter ABCB5. Molecular Pharmaceutics, 11(10), 3452-3462. doi: 10.1021/mp500230b

Journal - Research Article

Monk, B. C., Tomasiak, T. M., Keniya, M. V., Huschmann, F. U., Tyndall, J. D. A., O'Connell, III, J. D., Cannon, R. D., … Stroud, R. M. (2014). Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer. PNAS, 111(10), 3865-3870. doi: 10.1073/pnas.1324245111

Journal - Research Article

Pei, Z., Wang, B., Zhang, F., Niu, Z., Shi, S., Cannon, R. D., & Mei, L. (2014). Response of human periodontal ligament cells to baicalin. Journal of Periodontology, 85(9), 1283-1290. doi: 10.1902/jop.2014.130635

Journal - Research Article

Yuan, H., Li, J., Chen, L., Cheng, L., Cannon, R. D., & Mei, L. (2014). Esthetic comparison of white-spot lesion treatment modalities using spectrometry and fluorescence. Angle Orthodontist, 84(2), 343-349. doi: 10.2319/032113-232.1

Journal - Research Article

Han, T.-L., Tumanov, S., Cannon, R. D., & Villas-Boas, S. G. (2013). Metabolic response of Candida albicans to phenylethyl alcohol under hyphae-inducing conditions. PLoS ONE, 8(8), e71364. doi: 10.1371/journal.pone.0071364

Journal - Research Article

Keniya, M. V., Cannon, R. D., Nguyễn, Ấ., Tyndall, J. D. A., & Monk, B. C. (2013). Heterologous expression of Candida albicans Pma1p in Saccharomyces cerevisiae. FEMS Yeast Research, 13(3), 302-311. doi: 10.1111/1567-1364.12035

Journal - Research Article

Lamping, E., Niimi, M., & Cannon, R. D. (2013). Small, synthetic, GC-rich mRNA stem-loop modules 5' proximal to the AUG start-codon predictably tune gene expression in yeast. Microbial Cell Factories, 12, 74. doi: 10.1186/1475-2859-12-74

Journal - Research Article

Rawal, M. K., Khan, M. F., Kapoor, K., Goyal, N., Sen, S., Saxena, A. K., … Tyndall, J. D. A., Monk, B. C., Cannon, R. D., … Prasad, R. (2013). Insight into pleiotropic drug resistance ATP-binding cassette pump drug transport through mutagenesis of Cdr1p transmembrane domains. Journal of Biological Chemistry, 288(34), 24480-24493. doi: 10.1074/jbc.M113.488353

Journal - Research Article

Weerasekera, M. M., Sissons, C. H., Wong, L., Anderson, S., Holmes, A. R., & Cannon, R. D. (2013). Use of denaturing gradient gel electrophoresis for the identification of mixed oral yeasts in human saliva. Journal of Medical Microbiology, 62, 319-330. doi: 10.1099/jmm.0.050237-0

Journal - Research Article

Han, T.-L., Cannon, R. D., & Villas-Bôas, S. G. (2012). Metabolome analysis during the morphological transition of Candida albicans. Metabolomics, 8(6), 1204-1217. doi: 10.1007/s11306-012-0416-6

Journal - Research Article

Han, T.-L., Cannon, R. D., & Villas-Bôas, S. G. (2012). The metabolic response of Candida albicans to farnesol under hyphae-inducing conditions. FEMS Yeast Research, 12(8), 879-889. doi: 10.1111/j.1567-1364.2012.00837.x

Journal - Research Article

Hayama, K., Ishibashi, H., Ishijima, S. A., Niimi, K., Tansho, S., Ono, Y., Monk, B. C., Holmes, A. R., … Cannon, R. D., & Abe, S. (2012). A D-octapeptide drug efflux pump inhibitor acts synergistically with azoles in a murine oral candidiasis infection model. FEMS Microbiology Letters, 328(2), 130-137. doi: 10.1111/j.1574-6968.2011.02490.x

Journal - Research Article

Holmes, A. R., Chong, K., Rodrigues, E., Cannon, R. D., Carpenter, E., Ruske, D. R., & Dawes, P. J. D. (2012). Yeast colonization of voice prostheses: Pilot study investigating effect of a bovine milk product containing anti-Candida albicans immunoglobulin A antibodies on yeast colonization and valve leakage. Annals of Otology, Rhinology & Laryngology, 121(1), 61-66. doi: 10.1177/000348941212100111

Journal - Research Article

Ishijima, S. A., Hayama, K., Takahashi, M., Holmes, A. R., Cannon, R. D., & Abe, S. (2012). N-acetylglucosamine increases symptoms and fungal burden in a murine model of oral candidiasis. Medical Mycology, 50(3), 252-258. doi: 10.3109/13693786.2011.598194

Journal - Research Article

Niimi, K., Harding, D. R. K., Holmes, A. R., Lamping, E., Niimi, M., Tyndall, J. D. A., Cannon, R. D., & Monk, B. C. (2012). Specific interactions between the Candida albicans ABC transporter Cdr1p ectodomain and a D-octapeptide derivative inhibitor. Molecular Microbiology, 85(4), 747-767. doi: 10.1111/j.1365-2958.2012.08140.x

Journal - Research Article

Niimi, K., Woods, M. A., Maki, K., Nakayama, H., Hatakenaka, K., Chibana, H., … Niimi, M., Cannon, R. D., & Monk, B. C. (2012). Reconstitution of high-level micafungin resistance detected in a clinical isolate of Candida glabrata identifies functional homozygosity in glucan synthase gene expression. Journal of Antimicrobial Chemotherapy, 67(7), 1666-1676. doi: 10.1093/jac/dks112

Journal - Research Article

Han, T.-L., Cannon, R. D., & Villas-Bôas, S. G. (2011). The metabolic basis of Candida albicans morphogenesis and quorum sensing. Fungal Genetics & Biology, 48(8), 747-763. doi: 10.1016/j.fgb.2011.04.002

Journal - Research Article

Holmes, A. R., Keniya, M. V., Ivnitski-Steele, I., Monk, B. C., Lamping, E., Sklar, L. A., & Cannon, R. D. (2011). The monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolates. Antimicrobial Agents & Chemotherapy, 56(3), 1508-1515. doi: 10.1128/aac.05706-11

Journal - Research Article

Tanabe, K., Lamping, E., Nagi, M., Okawada, A., Holmes, A. R., Miyazaki, Y., Cannon, R. D., Monk, B. C., & Niimi, M. (2011). Chimeras of Candida albicans Cdr1p and Cdr2p reveal features of pleiotropic drug resistance transporter structure and function. Molecular Microbiology, 82(2), 416-433. doi: 10.1111/j.1365-2958.2011.07820.x

Journal - Research Article

Lamping, E., Baret, P. V., Holmes, A. R., Monk, B. C., Goffeau, A., & Cannon, R. D. (2010). Fungal PDR transporters: Phylogeny, topology, motifs and function. Fungal Genetics & Biology, 47(2), 127-142. doi: 10.1016/j.fgb.2009.10.007

Journal - Research Article

Mohd Bakri, M., Hussaini, H. M., Holmes, A. R., Cannon, R. D., & Rich, A. M. (2010). Revisiting the association between candidal infection and carcinoma, particularly oral squamous cell carcinoma. Journal of Oral Microbiology, 2, 5780. doi: 10.3402/jom.v2i0.5780

Journal - Research Article

Niimi, K., Monk, B. C., Hirai, A., Hatakenaka, K., Umeyama, T., Lamping, E., … Cannon, R. D., & Niimi, M. (2010). Clinically significant micafungin resistance in Candida albicans involves modification of a glucan synthase catalytic subunit GSC1 (FKS1) allele followed by loss of heterozygosity. Journal of Antimicrobial Chemotherapy, 65, 842-852. doi: 10.1093/jac/dkq073

Journal - Research Article

Niimi, M., Firth, N. A., & Cannon, R. D. (2010). Antifungal drug resistance of oral fungi. Odontology, 98(1), 15-25. doi: 10.1007/s10266-009-0118-3

Journal - Research Article

Zhang, N., Cannon, R. D., Holland, B. R., Patchett, M. L., & Schmid, J. (2010). Impact of genetic background on allele selection in a highly mutable Candida albicans gene, PNG2. PLoS ONE, 5(3), e9614. doi: 10.1371/journal.pone.0009614

Journal - Research Article

Cannon, R. D., Lamping, E., Holmes, A. R., Niimi, K., Baret, P. V., Keniya, M. V., … Niimi, M., … Monk, B. C. (2009). Efflux-mediated antifungal drug resistance. Clinical Microbiology Reviews, 22(2), 291-321. doi: 10.1128/cmr.00051-08

Journal - Research Article

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