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Health Sciences profile

Professor Richard Cannon

PositionProfessor of Molecular Microbiology
DepartmentDepartment of Oral Sciences
QualificationsMA PhD(Cantab)
Research summaryOral microbiology and antifungal drug resistance

Research

Professor Cannon is a molecular microbiologist interested in how microorganisms cause oral diseases and in how treatments for patients with these diseases can be improved. His research has a number of themes, one being oral adhesion. He is interested in how oral microbes, particularly yeast, adhere and colonize surfaces in the oral cavity.

He has found that saliva increases the adhesion of the yeast Candida albicans to several oral surfaces, including denture acrylics and voice prosthesis silicone. He is interested in the formation of oral biofilms, how microorganisms communicate within biofilms, and ways of inhibiting pathogenic biofilm formation.

C. albicans is a polymorphic fungus that grows mainly as yeast or mycelia. Professor Cannon is using metabolomics to investigate the changes in metabolism that are associated with the change from yeast to hyphal growth. A major focus of his research is the drug resistance of human fungal pathogens. He has found that clinically significant fungal drug resistance is due to energy-dependent drug efflux from the cell. His research group has developed a unique system for expressing and studying these efflux pumps in baker's yeast Saccharomyces cerevisiae.

They are currently using S. cerevisiae strains expressing efflux pumps from a variety of fungi to study pump function and to search for pump inhibitors. Professor Cannon is also using the S. cerevisiae expression system to investigate the resistance of sheep intestinal nematodes to antihelmintics.

Publications

James, J. E., Lamping, E., Santhanam, J., & Cannon, R. D. (2021). PDR transporter ABC1 is involved in the innate azole resistance of the human fungal pathogen Fusarium keratoplasticum. Frontiers in Microbiology, 12, 673206. doi: 10.3389/fmicb.2021.673206

Madani, G., Lamping, E., Lee, H. J., Niimi, M., Mitra, A. K., & Cannon, R. D. (2021). Small-scale plasma membrane preparation for the analysis of Candida albicans Cdr1-mGFPHis. Journal of Visualized Experiments, 172, e62592. doi: 10.3791/62592

Atieh, M. A., Guirguis, M., Alsabeeha, N. H. M., & Cannon, R. D. (2021). The diagnostic accuracy of saliva testing for SARS-CoV-2: A systematic review and meta-analysis. Oral Diseases. Advance online publication. doi: 10.1111/odi.13934

Skilbeck, M. G., Mei, L., Mohammed, H., Cannon, R. D., & Farella, M. (2021). The effect of ligation methods on biofilm formation in patients undergoing multi-bracketed fixed orthodontic therapy: A systematic review. Orthodontics & Craniofacial Research. Advance online publication. doi: 10.1111/ocr.12503

Nguyen, H. T., Zhang, R., Inokawa, N., Oura, T., Chen, X., Iwatani, S., … Holmes, A. R., Cannon, R. D., & Kajiwara, S. (2021). Candida albicans Bgl2p, Ecm33p, and Als1p proteins are involved in adhesion to saliva-coated hydroxyapatite. Journal of Oral Microbiology, 13(1), 1879497. doi: 10.1080/20002297.2021.1879497

Cannon, R. D., Lyons, K. M., Chong, K., Newsham-West, K., Niimi, K., & Holmes, A. R. (2017). Adhesion of yeast and bacteria to oral surfaces. In G. J. Seymour, M. P. Cullinan & N. C. K. Heng (Eds.), Oral biology: Molecular techniques and applications: Methods in molecular biology (Vol. 1537). (2nd ed.) (pp. 165-190). New York, NY: Springer. doi: 10.1007/978-1-4939-6685-1_10

Chapter in Book - Research

Lamping, E., Madani, G., Lee, H. J., Niimi, M., & Cannon, R. D. (2017). Structure-function analyses of multidrug tansporters. In R. Prasad (Ed.), Candida albicans: Cellular and molecular biology. (2nd ed.) (pp. 379-406). Springer. doi: 10.1007/978-3-319-50409-4

Chapter in Book - Research

Monk, B. C., Niimi, K., Holmes, A. R., Strouse, J. J., Sklar, L. A., & Cannon, R. D. (2012). Fungal efflux-mediated resistance: From targets to inhibitors. In G. Tegos & E. Mylonakis (Eds.), Antimicrobial drug discovery: Emerging strategies. (pp. 77-88). Oxford, UK: CABI.

Chapter in Book - Research

Cannon, R. D., Lyons, K. M., Chong, K., & Holmes, A. R. (2010). Adhesion of yeast and bacteria to oral surfaces. In G. J. Seymour, M. P. Cullinan & N. C. K. Heng (Eds.), Oral Biology. (pp. 103-124). New York: Springer. doi: 10.1007/978-1-60761-820-1_8

Chapter in Book - Research

Lamping, E., & Cannon, R. D. (2010). Use of a yeast-based membrane protein expression technology to overexpress drug resistance efflux pumps. In G. J. Seymour, M. P. Cullinan & N. C. K. Heng (Eds.), Oral Biology. (pp. 219-250). New York: Springer. doi: 10.1007/978-1-60761-820-1_15

Chapter in Book - Research

Niimi, M., Cannon, R. D., & Monk, B. C. (2001). Candida albicans pathology: A proteomic perspective. In M. J. Dunn (Ed.), Proteomics Reviews 2001. (pp. 28-37). Weinheim, Germany: Wiley-VCH.

Chapter in Book - Research

Cannon, R. D., Albertson, G. D., Niimi, M., & Jenkinson, H. F. A. (1996). Fluconazole uptake and resistance in Candida. In K. Tanaka, H. Yamaguchi & P. T. Magee (Eds.), Genes and Genomes in Medically Important Fungi. (pp. 157-165). Foundation for Advancement of International Scienc.

Chapter in Book - Research

Cannon, R. D., & Firth, N. A. (2013). Fungi and fungal infections of the oral cavity. In R. J. Lamont, G. N. Hajishengallis & H. F. Jenkinson (Eds.), Oral microbiology and immunology. (2nd ed.) (pp. 343-360). Washington, DC: ASM Press. doi: 10.1128/9781555818906

Chapter in Book - Other

Cannon, R. D., & Firth, N. A. (2006). Fungi and fungal infections of the oral cavity. In R. J. Lamont, R. A. Burne, M. S. Lantz & D. J. LeBlanc (Eds.), Oral microbiology and immunology. (pp. 333-348). Washington, DC: American Society for Microbiology.

Chapter in Book - Other

Atieh, M. A., Guirguis, M., Alsabeeha, N. H. M., & Cannon, R. D. (2021). The diagnostic accuracy of saliva testing for SARS-CoV-2: A systematic review and meta-analysis. Oral Diseases. Advance online publication. doi: 10.1111/odi.13934

Journal - Research Article

James, J. E., Lamping, E., Santhanam, J., & Cannon, R. D. (2021). PDR transporter ABC1 is involved in the innate azole resistance of the human fungal pathogen Fusarium keratoplasticum. Frontiers in Microbiology, 12, 673206. doi: 10.3389/fmicb.2021.673206

Journal - Research Article

Madani, G., Lamping, E., & Cannon, R. D. (2021). Engineering a cysteine-deficient functional Candida albicans Cdr1 molecule reveals a conserved region at the cytosolic apex of ABCG transporters important for correct folding and trafficking of Cdr1. mSphere, 6(1), e01318-20. doi: 10.1128/mSphere.01318-20

Journal - Research Article

Madani, G., Lamping, E., Lee, H. J., Niimi, M., Mitra, A. K., & Cannon, R. D. (2021). Small-scale plasma membrane preparation for the analysis of Candida albicans Cdr1-mGFPHis. Journal of Visualized Experiments, 172, e62592. doi: 10.3791/62592

Journal - Research Article

Nguyen, H. T., Zhang, R., Inokawa, N., Oura, T., Chen, X., Iwatani, S., … Holmes, A. R., Cannon, R. D., & Kajiwara, S. (2021). Candida albicans Bgl2p, Ecm33p, and Als1p proteins are involved in adhesion to saliva-coated hydroxyapatite. Journal of Oral Microbiology, 13(1), 1879497. doi: 10.1080/20002297.2021.1879497

Journal - Research Article

Prasad, S., Ramanan, D., Bennani, H., Paulin, M., Cannon, R. D., Palla, S., & Farella, M. (2021). Associations among masticatory muscle activity, physical activity and self-reported oral behaviours in adult women. Clinical Oral Investigations. Advance online publication. doi: 10.1007/s00784-021-03816-9

Journal - Research Article

Skilbeck, M. G., Mei, L., Mohammed, H., Cannon, R. D., & Farella, M. (2021). The effect of ligation methods on biofilm formation in patients undergoing multi-bracketed fixed orthodontic therapy: A systematic review. Orthodontics & Craniofacial Research. Advance online publication. doi: 10.1111/ocr.12503

Journal - Research Article

Zhang, T., Jiang, W.-R., Xia, Y.-Y., Mansell, T., Saffery, R., Cannon, R. D., … Baker, P. N. (2021). Complex patterns of circulating fatty acid levels in gestational diabetes mellitus subclasses across pregnancy. Clinical Nutrition. Advance online publication. doi: 10.1016/j.clnu.2021.01.046

Journal - Research Article

James, J. E., Lamping, E., Santhanam, J., Milne, T. J., Razak, M. F. A., Zakaria, L., & Cannon, R. D. (2020). A 23 bp cyp51A promoter deletion associated with voriconazole resistance in clinical and environmental isolates of Neocosmospora keratoplastica. Frontiers in Microbiology, 11, 272. doi: 10.3389/fmicb.2020.00272

Journal - Research Article

Benic, G. Z., Farella, M., Morgan, X. C., Viswam, J., Heng, N. C., Cannon, R. D., & Mei, L. (2019). Oral probiotics reduce halitosis in patients wearing orthodontic braces: A randomized, triple-blind, placebo-controlled trial. Journal of Breath Research, 13, 036010. doi: 10.1088/1752-7163/ab1c81

Journal - Research Article

Ghazal, A. R. A., Idris, G., Hajeer, M. Y., Alawer, K., & Cannon, R. D. (2019). Efficacy of removing Candida albicans from orthodontic acrylic bases: An in vitro study. BMC Oral Health, 19, 71. doi: 10.1186/s12903-019-0765-x

Journal - Research Article

Han, T.-L., Cannon, R. D., Gallo, S. M., & Villas-Bôas, S. G. (2019). A metabolomic study of the effect of Candida albicans glutamate dehydrogenase deletion on growth and morphogenesis. npj Biofilms & Microbiomes, 5, 13. doi: 10.1038/s41522-019-0086-5

Journal - Research Article

Jiang, Q., Mei, L., Zou, Y., Ding, Q., Cannon, R. D., Chen, H., & Li, H. (2019). Genetic polymorphisms in FGFR2 underlie skeletal malocclusion. Journal of Dental Research, 98(12), 1340-1347. doi: 10.1177/0022034519872951

Journal - Research Article

Meredith, L., Mei, L., Farella, M., & Cannon, R. D. (2019). Bacterial adhesion to human enamel after enameloplasty. New Zealand Dental Journal, 115(3), 103-107.

Journal - Research Article

Mohd Thiyahuddin, N., Lamping, E., Rich, A. M., & Cannon, R. D. (2019). Yeast species in the oral cavities of older people: A comparison between people living in their own homes and those in rest homes. Journal of Fungi, 5(2), 30. doi: 10.3390/jof5020030

Journal - Research Article

Prasad, S., Paulin, M., Cannon, R. D., Palla, S., & Farella, M. (2019). Smartphone-assisted monitoring of masticatory muscle activity in freely moving individuals. Clinical Oral Investigations, 23, 3601-3611. doi: 10.1007/s00784-018-2785-3

Journal - Research Article

Tanabe, K., Bonus, M., Tomiyama, S., Miyoshi, K., Nagi, M., Niimi, K., … Cannon, R. D., Niimi, M., & Lamping, E. (2019). FK506 resistance of Saccharomyces cerevisiae Pdr5 and Candida albicans Cdr1 involves mutations in the transmembrane domains and extracellular loops. Antimicrobial Agents & Chemotherapy, 63(1), e01146-18. doi: 10.1128/aac.01146-18

Journal - Research Article

Al-Dujaili, M., Milne, T. J., Cannon, R. D., & Farella, M. (2018). Postnatal expression of chondrogenic and osteogenic regulatory factor mRNA in the rat condylar cartilage. Archives of Oral Biology, 93, 126-132. doi: 10.1016/j.archoralbio.2018.05.019

Journal - Research Article

Zhang, N., Wheeler, D., Truglio, M., Lazzarini, C., Upritchard, J., McKinney, W., … Cannon, R. D., Broadbent, R. S., … Schmid, J. (2018). Multi-locus next-generation sequence typing of DNA extracted from pooled colonies detects multiple unrelated Candida albicans strains in a significant proportion of patient samples. Frontiers in Microbiology, 9, 1179. doi: 10.3389/fmicb.2018.01179

Journal - Research Article

Choo, K. H., Lee, H. J., Knight, N. J., Holmes, A. R., & Cannon, R. D. (2017). Multilocus sequence typing (MLST) analysis of Candida albicans isolates colonizing acrylic dentures before and after denture replacement. Medical Mycology, 55(6), 673-679. doi: 10.1093/mmy/myw128

Journal - Research Article

Lamping, E., Zhu, J.-y., Niimi, M., & Cannon, R. D. (2017). Role of ectopic gene conversion in the evolution of a Candida krusei pleiotropic drug resistance transporter family. Genetics, 205(4), 1619-1639. doi: 10.1534/genetics.116.194811

Journal - Research Article

Meredith, L., Farella, M., Lowrey, S., Cannon, R. D., & Mei, L. (2017). Atomic force microscopy analysis of enamel nanotopography after interproximal reduction. American Journal of Orthodontics & Dentofacial Orthopedics, 151(4), 750-757. doi: 10.1016/j.ajodo.2016.09.021

Journal - Research Article

Meredith, L., Mei, L., Cannon, R. D., & Farella, M. (2017). Interproximal reduction in orthodontics: Why, where, how much to remove? Australasian Orthodontic Journal, 33(2), 150-157.

Journal - Research Article

Wang, Y., Li, J., Sun, W., Li, H., Cannon, R. D., & Mei, L. (2017). Effect of non-fluoride agents on the prevention of dental caries in primary dentition: A systematic review. PLoS ONE, 12(8), e0182221. doi: 10.1371/journal.pone.0182221

Journal - Research Article

Weerasekera, M. M., Sissons, C. H., Wong, L., Anderson, S. A., & Cannon, R. D. (2017). Denaturant gradient gel electrophoresis profiles of bacteria from the saliva of twenty four different individuals form clusters that showed no relationship to the yeasts present. Archives of Oral Biology, 82, 6-10. doi: 10.1016/j.archoralbio.2017.05.014

Journal - Research Article

Farella, M., Loke, C., Sander, S., Songini, A., Allen, M., Mei, L., & Cannon, R. D. (2016). Simultaneous wireless assessment of intra-oral pH and temperature. Journal of Dentistry, 51, 49-55. doi: 10.1016/j.jdent.2016.05.012

Journal - Research Article

Holmes, A. R., Cardno, T. S., Strouse, J. J., Ivnitski-Steele, I., Keniya, M. V., Lackovic, K., Monk, B. C., … Cannon, R. D. (2016). Targeting efflux pumps to overcome antifungal drug resistance. Future Medicinal Chemistry, 8(12), 1485-1501. doi: 10.4155/fmc-2016-0050

Journal - Research Article

Panapruksachat, S., Iwatani, S., Oura, T., Vanittanakom, N., Chindamporn, A., Niimi, K., Niimi, M., Lamping, E., Cannon, R. D., & Kajiwara, S. (2016). Identification and functional characterization of Penicillium marneffei pleiotropic drug resistance transporters ABC1 and ABC2. Medical Mycology, 54, 478-491. doi: 10.1093/mmy/myv117

Journal - Research Article

Rawal, M. K., Banerjee, A., Shah, A. H., Khan, M. F., Sen, S., Saxena, A. K., Monk, B. C., Cannon, R. D., … Prasad, R. (2016). Newly identified motifs in Candida albicans Cdr1 protein nucleotide binding domains are pleiotropic drug resistance subfamily-specific and functionally asymmetric. Scientific Reports, 6, 27132. doi: 10.1038/srep27132

Journal - Research Article

Schmid, J., Magee, P. T., Holland, B. R., Zhang, N., Cannon, R. D., & Magee, B. B. (2016). Last hope for the doomed? Thoughts on the importance of a parasexual cycle for the yeast Candida albicans. Current Genetics, 62(1), 81-85. doi: 10.1007/s00294-015-0516-8

Journal - Research Article

Tong, Y., Liu, M., Zhang, Y., Liu, X., Huang, R., Song, F., … Cannon, R. D., … Zhang, L. (2016). Beauvericin counteracted multi-drug resistant Candida albicans by blocking ABC transporters. Synthetic and Systems Biotechnology, 1(3), 158-168. doi: 10.1016/j.synbio.2016.10.001

Journal - Research Article

Watanasrisin, W., Iwatani, S., Oura, T., Tomita, Y., Ikushima, S., Chindamporn, A., Niimi, M., Niimi, K., Lamping, E., Cannon, R. D., & Kajiwara, S. (2016). Identification and characterization of Candida utilis multidrug efflux transporter CuCdr1p. FEMS Yeast Research, 16, fow042. doi: 10.1093/femsyr/fow042

Journal - Research Article

van der Wielen, P. A., Holmes, A. R., & Cannon, R. D. (2016). Secretory component mediates Candida albicans binding to epithelial cells. Oral Diseases, 22(1), 69-74. doi: 10.1111/odi.12397

Journal - Research Article

Bakri, M. M., Rich, A. M., Cannon, R. D., & Holmes, A. R. (2015). In vitro expression of Candida albicans alcohol dehydrogenase genes involved in acetaldehyde metabolism. Molecular Oral Microbiology, 30(1), 27-38. doi: 10.1111/omi.12064

Journal - Research Article

Bennani, V., Hwang, L., Tawse-Smith, A., Dias, G. J., & Cannon, R. D. (2015). Effect of air-polishing on titanium surfaces, biofilm removal, and biocompatibility: A pilot study. BioMed Research International, 2015, 491047. doi: 10.1155/2015/491047

Journal - Research Article

Cannon, R. D., & Holmes, A. R. (2015). Learning the ABC of oral fungal drug resistance [Invited review]. Molecular Oral Microbiology, 30(6), 425-437. doi: 10.1111/omi.12109

Journal - Research Article

Keniya, M. V., Fleischer, E., Klinger, A., Cannon, R. D., & Monk, B. C. (2015). Inhibitors of the Candida albicans Major Facilitator Superfamily transporter Mdr1p responsible for fluconazole resistance. PLoS ONE, e0126350. doi: 10.1371/journal.pone.0126350

Journal - Research Article

Zhang, N., Magee, B. B., Magee, P. T., Holland, B. R., Rodrigues, E., Holmes, A. R., Cannon, R. D., & Schmid, J. (2015). Selective advantages of a parasexual cycle for the yeast Candida albicans. Genetics, 200(4), 1117-1132. doi: 10.1534/genetics.115.177170

Journal - Research Article

Bakri, M. M., Cannon, R. D., Holmes, A. R., & Rich, A. M. (2014). Detection of Candida albicans ADH1 and ADH2 mRNAs in human archival oral biopsy samples. Journal of Oral Pathology & Medicine, 43(9), 704-710. doi: 10.1111/jop.12193

Journal - Research Article

Holmes, A. R., Rodrigues, E., van der Wielen, P., Lyons, K. M., Haigh, B. J., Wheeler, T. T., Dawes, P. J. D., & Cannon, R. D. (2014). Adherence of Candida albicans to silicone is promoted by the human salivary protein SPLUNC2/PSP/BPIFA2. Molecular Oral Microbiology, 29(2), 90-98. doi: 10.1111/mom.12048

Journal - Research Article

Inger, M., Bennani, V., Farella, M., Bennani, F., & Cannon, R. D. (2014). Efficacy of air/water syringe tip sterilization. Australian Dental Journal, 59(1), 87-92. doi: 10.1111/adj.12146

Journal - Research Article

Keniya, M. V., Holmes, A. R., Niimi, M., Lamping, E., Gillet, J.-P., Gottesman, M. M., & Cannon, R. D. (2014). Drug resistance is conferred on the model yeast Saccharomyces cerevisiae by expression of full-length melanoma-associated human ATP-binding cassette transporter ABCB5. Molecular Pharmaceutics, 11(10), 3452-3462. doi: 10.1021/mp500230b

Journal - Research Article

Monk, B. C., Tomasiak, T. M., Keniya, M. V., Huschmann, F. U., Tyndall, J. D. A., O'Connell, III, J. D., Cannon, R. D., … Stroud, R. M. (2014). Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer. PNAS, 111(10), 3865-3870. doi: 10.1073/pnas.1324245111

Journal - Research Article

Pei, Z., Wang, B., Zhang, F., Niu, Z., Shi, S., Cannon, R. D., & Mei, L. (2014). Response of human periodontal ligament cells to baicalin. Journal of Periodontology, 85(9), 1283-1290. doi: 10.1902/jop.2014.130635

Journal - Research Article

Yuan, H., Li, J., Chen, L., Cheng, L., Cannon, R. D., & Mei, L. (2014). Esthetic comparison of white-spot lesion treatment modalities using spectrometry and fluorescence. Angle Orthodontist, 84(2), 343-349. doi: 10.2319/032113-232.1

Journal - Research Article

Han, T.-L., Tumanov, S., Cannon, R. D., & Villas-Boas, S. G. (2013). Metabolic response of Candida albicans to phenylethyl alcohol under hyphae-inducing conditions. PLoS ONE, 8(8), e71364. doi: 10.1371/journal.pone.0071364

Journal - Research Article

Keniya, M. V., Cannon, R. D., Nguyễn, Ấ., Tyndall, J. D. A., & Monk, B. C. (2013). Heterologous expression of Candida albicans Pma1p in Saccharomyces cerevisiae. FEMS Yeast Research, 13(3), 302-311. doi: 10.1111/1567-1364.12035

Journal - Research Article

Lamping, E., Niimi, M., & Cannon, R. D. (2013). Small, synthetic, GC-rich mRNA stem-loop modules 5' proximal to the AUG start-codon predictably tune gene expression in yeast. Microbial Cell Factories, 12, 74. doi: 10.1186/1475-2859-12-74

Journal - Research Article

Rawal, M. K., Khan, M. F., Kapoor, K., Goyal, N., Sen, S., Saxena, A. K., … Tyndall, J. D. A., Monk, B. C., Cannon, R. D., … Prasad, R. (2013). Insight into pleiotropic drug resistance ATP-binding cassette pump drug transport through mutagenesis of Cdr1p transmembrane domains. Journal of Biological Chemistry, 288(34), 24480-24493. doi: 10.1074/jbc.M113.488353

Journal - Research Article

Weerasekera, M. M., Sissons, C. H., Wong, L., Anderson, S., Holmes, A. R., & Cannon, R. D. (2013). Use of denaturing gradient gel electrophoresis for the identification of mixed oral yeasts in human saliva. Journal of Medical Microbiology, 62, 319-330. doi: 10.1099/jmm.0.050237-0

Journal - Research Article

Han, T.-L., Cannon, R. D., & Villas-Bôas, S. G. (2012). Metabolome analysis during the morphological transition of Candida albicans. Metabolomics, 8(6), 1204-1217. doi: 10.1007/s11306-012-0416-6

Journal - Research Article

Han, T.-L., Cannon, R. D., & Villas-Bôas, S. G. (2012). The metabolic response of Candida albicans to farnesol under hyphae-inducing conditions. FEMS Yeast Research, 12(8), 879-889. doi: 10.1111/j.1567-1364.2012.00837.x

Journal - Research Article

Hayama, K., Ishibashi, H., Ishijima, S. A., Niimi, K., Tansho, S., Ono, Y., Monk, B. C., Holmes, A. R., … Cannon, R. D., & Abe, S. (2012). A D-octapeptide drug efflux pump inhibitor acts synergistically with azoles in a murine oral candidiasis infection model. FEMS Microbiology Letters, 328(2), 130-137. doi: 10.1111/j.1574-6968.2011.02490.x

Journal - Research Article

Holmes, A. R., Chong, K., Rodrigues, E., Cannon, R. D., Carpenter, E., Ruske, D. R., & Dawes, P. J. D. (2012). Yeast colonization of voice prostheses: Pilot study investigating effect of a bovine milk product containing anti-Candida albicans immunoglobulin A antibodies on yeast colonization and valve leakage. Annals of Otology, Rhinology & Laryngology, 121(1), 61-66. doi: 10.1177/000348941212100111

Journal - Research Article

Ishijima, S. A., Hayama, K., Takahashi, M., Holmes, A. R., Cannon, R. D., & Abe, S. (2012). N-acetylglucosamine increases symptoms and fungal burden in a murine model of oral candidiasis. Medical Mycology, 50(3), 252-258. doi: 10.3109/13693786.2011.598194

Journal - Research Article

Niimi, K., Harding, D. R. K., Holmes, A. R., Lamping, E., Niimi, M., Tyndall, J. D. A., Cannon, R. D., & Monk, B. C. (2012). Specific interactions between the Candida albicans ABC transporter Cdr1p ectodomain and a D-octapeptide derivative inhibitor. Molecular Microbiology, 85(4), 747-767. doi: 10.1111/j.1365-2958.2012.08140.x

Journal - Research Article

Niimi, K., Woods, M. A., Maki, K., Nakayama, H., Hatakenaka, K., Chibana, H., … Niimi, M., Cannon, R. D., & Monk, B. C. (2012). Reconstitution of high-level micafungin resistance detected in a clinical isolate of Candida glabrata identifies functional homozygosity in glucan synthase gene expression. Journal of Antimicrobial Chemotherapy, 67(7), 1666-1676. doi: 10.1093/jac/dks112

Journal - Research Article

Han, T.-L., Cannon, R. D., & Villas-Bôas, S. G. (2011). The metabolic basis of Candida albicans morphogenesis and quorum sensing. Fungal Genetics & Biology, 48(8), 747-763. doi: 10.1016/j.fgb.2011.04.002

Journal - Research Article

Holmes, A. R., Keniya, M. V., Ivnitski-Steele, I., Monk, B. C., Lamping, E., Sklar, L. A., & Cannon, R. D. (2011). The monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolates. Antimicrobial Agents & Chemotherapy, 56(3), 1508-1515. doi: 10.1128/aac.05706-11

Journal - Research Article

Tanabe, K., Lamping, E., Nagi, M., Okawada, A., Holmes, A. R., Miyazaki, Y., Cannon, R. D., Monk, B. C., & Niimi, M. (2011). Chimeras of Candida albicans Cdr1p and Cdr2p reveal features of pleiotropic drug resistance transporter structure and function. Molecular Microbiology, 82(2), 416-433. doi: 10.1111/j.1365-2958.2011.07820.x

Journal - Research Article

Lamping, E., Baret, P. V., Holmes, A. R., Monk, B. C., Goffeau, A., & Cannon, R. D. (2010). Fungal PDR transporters: Phylogeny, topology, motifs and function. Fungal Genetics & Biology, 47(2), 127-142. doi: 10.1016/j.fgb.2009.10.007

Journal - Research Article

Mohd Bakri, M., Hussaini, H. M., Holmes, A. R., Cannon, R. D., & Rich, A. M. (2010). Revisiting the association between candidal infection and carcinoma, particularly oral squamous cell carcinoma. Journal of Oral Microbiology, 2, 5780. doi: 10.3402/jom.v2i0.5780

Journal - Research Article

Niimi, K., Monk, B. C., Hirai, A., Hatakenaka, K., Umeyama, T., Lamping, E., … Cannon, R. D., & Niimi, M. (2010). Clinically significant micafungin resistance in Candida albicans involves modification of a glucan synthase catalytic subunit GSC1 (FKS1) allele followed by loss of heterozygosity. Journal of Antimicrobial Chemotherapy, 65, 842-852. doi: 10.1093/jac/dkq073

Journal - Research Article

Niimi, M., Firth, N. A., & Cannon, R. D. (2010). Antifungal drug resistance of oral fungi. Odontology, 98(1), 15-25. doi: 10.1007/s10266-009-0118-3

Journal - Research Article

Zhang, N., Cannon, R. D., Holland, B. R., Patchett, M. L., & Schmid, J. (2010). Impact of genetic background on allele selection in a highly mutable Candida albicans gene, PNG2. PLoS ONE, 5(3), e9614. doi: 10.1371/journal.pone.0009614

Journal - Research Article

Cannon, R. D., Lamping, E., Holmes, A. R., Niimi, K., Baret, P. V., Keniya, M. V., … Niimi, M., … Monk, B. C. (2009). Efflux-mediated antifungal drug resistance. Clinical Microbiology Reviews, 22(2), 291-321. doi: 10.1128/cmr.00051-08

Journal - Research Article

Ivnitski-Steele, I., Holmes, A. R., Lamping, E., Monk, B. C., Cannon, R. D., & Sklar, L. A. (2009). Identification of Nile red as a fluorescent substrate of the Candida albicans ATP-binding cassette transporters Cdr1p and Cdr2p and the major facilitator superfamily transporter Mdr1p. Analytical Biochemistry, 394(1), 87-91. doi: 10.1016/j.ab.2009.07.001

Journal - Research Article

Lamping, E., Ranchod, A., Nakamura, K., Tyndall, J. D. A., Niimi, K., Holmes, A. R., Niimi, M., & Cannon, R. D. (2009). Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. Antimicrobial Agents & Chemotherapy, 53(2), 354-369. doi: 10.1128/AAC.01095-08

Journal - Research Article

Rodrigues, E., Chong, K., Holmes, A. R., Cannon, R. D., Ruske, D. R., & Dawes, P. J. D. (2009). An in-vitro device for the assessment of biofilm mediated voice prosthesis damage: How we do it [Letter to the editor]. Clinical Otolaryngology, 34(5), 481-484. doi: 10.1111/j.1749-4486.2009.01996.x

Journal - Research Article

Zhang, N., Upritchard, J. E., Holland, B. R., Fenton, L. E., Ferguson, M. M., Cannon, R. D., & Schmid, J. (2009). Distribution of mutations distinguishing the most prevalent disease-causing Candida albicans genotype from other genotypes. Infection, Genetics & Evolution, 9(4), 493-500. doi: 10.1016/j.meegid.2009.01.007

Journal - Research Article

Deng, D., Lauren, D. R., Cooney, J. M., Jensen, D. J., Wurms, K. V., Upritchard, J. E., Cannon, R. D., … Li, M. Z. (2008). Antifungal saponins from Paris polyphylla Smith. Planta Medica, 74(11), 1397-1402. doi: 10.1055/s-2008-1081345

Journal - Research Article

Holmes, A. R., Lin, Y.-H., Niimi, K., Lamping, E., Keniya, M., Niimi, M., … Monk, B. C., & Cannon, R. D. (2008). ABC transporter Cdr1p contributes more than Cdr2p does to fluconazole efflux in fluconazole-resistant Candida albicans clinical isolates. Antimicrobial Agents & Chemotherapy, 52(11), 3851-3862. doi: 10.1128/AAC.00463-08

Journal - Research Article

Cannon, R. (2007). The Sir John Walsh Research Institute: A national institute for oral health research in New Zealand. New Zealand Dental Journal, 103(1), 17.

Journal - Research Article

Cannon, R. D., Lamping, E., Holmes, A. R., Niimi, K., Tanabe, K., & Monk, B. C. (2007). Candida albicans drug resistance: Another way to cope with stress. Microbiology, 153, 3211-3217.

Journal - Research Article

Hodgkinson, A. J., Cannon, R. D., Holmes, A. R., Fischer, F. J., & Willix-Payne, D. J. (2007). Production from dairy cows of semi-industrial quantities of milk-protein concentrate (MPC) containing efficacious anti-Candida albicans IgA antibodies. Journal of Dairy Research, 74, 269-275.

Journal - Research Article

Lamping, E., Monk, B. C., Niimi, K., Holmes, A. R., Tsao, S., Tanabe, K., Niimi, M., … Cannon, R. D. (2007). Characterization of three classes of membrane proteins involved in fungal azole resistance by functional hyperexpression in Saccharomyces cerevisiae. Eukaryotic Cell, 6(7), 1150-1165.

Journal - Research Article

Holmes, A. R., Tsao, S., Ong, S.-W., Lamping, E., Niimi, K., Monk, B. C., Niimi, M., … Cannon, R. D. (2006). Heterozygosity and functional allelic variation in the Candida albicans efflux pump genes CDR1 and CDR2. Molecular Microbiology, 62(1), 170-186.

Journal - Research Article

Holmes, A. R., van der Wielen, P., Cannon, R. D., Ruske, D., & Dawes, P. (2006). Candida albicans binds to saliva proteins selectively adsorbed to silicone. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, & Endodontology, 102(4), 488-494.

Journal - Research Article

Niimi, K., Maki, K., Ikeda, F., Holmes, A. R., Lamping, E., Niimi, M., Monk, B. C., & Cannon, R. D. (2006). Overexpression of Candida albicans CDR1, CDR2, or MDR1 does not produce significant changes in echinocandin susceptibility. Antimicrobial Agents & Chemotherapy, 50(4), 1148-1155.

Journal - Research Article

Jeng, H.-W., Holmes, A. R., & Cannon, R. D. (2005). Characterization of two Candida albicans surface mannoprotein adhesins that bind immobilized saliva components. Medical Mycology, 43, 209-217.

Journal - Research Article

Lamping, E., Tanabe, K., Niimi, M., Uehara, Y., Monk, B. C., & Cannon, R. D. (2005). Characterization of the Saccharomyces cerevisiae sec6-41 mutation and tools to create S. cerevisiae strains containing the sec6-4 allele. Gene, 361, 57-66.

Journal - Research Article

Monk, B. C., Niimi, K., Lin, S., Knight, A., Kardos, T. B., Cannon, R. D., … Harding, D. R. K. (2005). Surface-active fungicidal D-peptide inhibitors of the plasma membrane proton pump that block azole resistance. Antimicrobial Agents & Chemotherapy, 49(1), 57-70. doi: 10.1128/AAC.49.1.57-70.2005

Journal - Research Article

Niimi, M., Tanabe, K., Wada, S.-I., Yamazaki, A., Uehara, Y., Niimi, K., Lamping, E., Holmes, A. R., Monk, B. C., & Cannon, R. D. (2005). ABC transporters of pathogenic fungi: Recent advances in functional analyses. Japanese Journal of Medical Mycology / Nippon Ishinkin Gakkai Zasshi, 46(4), 249-260.

Journal - Research Article

Niimi, M., Wada, S.-I., Tanabe, K., Kaneko, A., Takano, Y., Umeyama, T., … Lamping, E., Niimi, K., Tsao, S., Holmes, A. R., Monk, B. C., & Cannon, R. D. (2005). Functional analysis of fungal drug efflux transporters by heterologous expression in Saccharomyces cerevisiae. Japanese Journal of Infectious Diseases, 58, 1-7.

Journal - Research Article

Wada, S.-I., Tanabe, K., Yamazaki, A., Niimi, M., Uehara, Y., Niimi, K., Lamping, E., Cannon, R. D., & Monk, B. C. (2005). Phosphorylation of Candida glabrata ATP-binding cassette transporter Cdr1p regulates drug efflux activity and ATPase stability. Journal of Biological Chemistry, 280(1), 94-103.

Journal - Research Article

Beggs, K. T., Holmes, A. R., Cannon, R. D., & Rich, A. M. (2004). Detection of Candida albicans mRNA in archival histopathology samples by reverse transcription-PCR. Journal of Clinical Microbiology, 42(5), 2275-2278.

Journal - Research Article

Niimi, K., Harding, D. R. K., Parshot, R., King, A., Lun, D. J., Decottignies, A., Niimi, M., … Cannon, R. D., … Monk, B. C. (2004). Chemosensitization of fluconazole resistance in Saccharomyces cerevisiae and pathogenic fungi by a D-octapeptide derivative. Antimicrobial Agents & Chemotherapy, 48(4), 1256-1271.

Journal - Research Article

Niimi, M., Niimi, K., Takano, Y., Holmes, A. R., Fischer, F. J., Uehara, Y., & Cannon, R. D. (2004). Regulated overexpression of CDR1 in Candida albicans confers multidrug resistance. Journal of Antimicrobial Chemotherapy, 54(6), 999-1006.

Journal - Research Article

Schmid, J., Cannon, R. D., & Holland, B. (2004). A futile act? Thoughts on the reproductive biology of Candida albicans. Mycologist, 18, 158-163.

Journal - Research Article

Zhang, N., Harrex, A. L., Holland, B. R., Fenton, L. E., Cannon, R. D., & Schmid, J. (2003). Sixty alleles of the ALS7 open reading frame in Candida albicans: ALS7 Is a hypermutable contingency locus. Genome Research, 13, 2005-2017.

Journal - Research Article

Holmes, A. R., Bandara, M. K., & Cannon, R. D. (2002). Saliva promotes Candida albicans adherence to human epithelial cells. Journal of Dental Research, 81, 28-32.

Journal - Research Article

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