Professor Christopher Jackson
Position | Consultant Medical Oncologist |
---|---|
Department | Department of Medicine (Dunedin) |
Qualifications | MB ChB FRACP |
Research summary | Gastrointestinal cancers, particularly colorectal cancer; clinical trials in cancer. |
Clinical | Gastrointestinal cancer, lymphoma, melanoma, genitourinary cancer. |
Research
Clinical aspects of Colorectal Cancer and its management, as well as health services research. Collaborating with lab-based scientists on genetic aspects of cancer, treatment and toxicity, as well as immunotherapy in a variety of solid tumours.
Publications
Fitzgerald, S., Blenkiron, C., Stephens, R., Mathy, J. A., Somers-Edgar, T., Rolfe, G., … Jackson, C., Eccles, M., … Rodger, E., … Guilford, P., … Print, C. G. (2023). Dynamic ctDNA mutational complexity in patients with melanoma receiving immunotherapy. Molecular Diagnosis & Therapy. Advance online publication. doi: 10.1007/s40291-023-00651-4
Gurney, J., Davies, A., Stanley, J., Signal, V., Costello, S., Dawkins, P., … Jackson, C., … Koea, J. (2023). Emergency presentation prior to lung cancer diagnosis: A national-level examination of disparities and survival outcomes. Lung Cancer, 179, 107174. doi: 10.1016/j.lungcan.2023.03.010
Hossain, S. M., Gimenez, G., Stockwell, P. A., Tsai, P., Print, C. G., Rys, J., … Jackson, C., Chatterjee, A., & Eccles, M. R. (2022). Innate immune checkpoint inhibitor resistance is associated with melanoma sub-types exhibiting invasive and de-differentiated gene expression signatures. Frontiers in Immunology, 13, 955063. doi: 10.3389/fimmu.2022.955063
Pavlakis, N., Tincknell, G., Lim, L. E., Muro, K., Obermannova, R., Lorenzen, S., … Jackson, C., … Lordick, F. (2022). European-Australasian consensus on the management of advanced gastric and gastro-oesophageal junction cancer: Current practice and new directions. Therapeutic Advances in Medical Oncology, 14. doi: 10.1177/17588359221118874
Mason, K., Kelly, L., Jackson, C., Read, D., & Borman, B. (2022). Did new treatments contribute to a decrease in melanoma deaths? New Zealand Medical Journal, 135(1558), 90-95. Retrieved from https://journal.nzma.org.nz
Fitzgerald, S., Blenkiron, C., Stephens, R., Mathy, J. A., Somers-Edgar, T., Rolfe, G., … Jackson, C., Eccles, M., … Rodger, E., … Guilford, P., … Print, C. G. (2023). Dynamic ctDNA mutational complexity in patients with melanoma receiving immunotherapy. Molecular Diagnosis & Therapy. Advance online publication. doi: 10.1007/s40291-023-00651-4
Journal - Research Article
Gurney, J., Davies, A., Stanley, J., Signal, V., Costello, S., Dawkins, P., … Jackson, C., … Koea, J. (2023). Emergency presentation prior to lung cancer diagnosis: A national-level examination of disparities and survival outcomes. Lung Cancer, 179, 107174. doi: 10.1016/j.lungcan.2023.03.010
Journal - Research Article
Gurney, J. K., Dunn, A., Liu, M., Mako, M., Millar, E., Ruka, M., Crengle, S., … Jackson, C., … Sarfati, D. (2022). The impact of COVID-19 on lung cancer detection, diagnosis and treatment for Māori in Aotearoa New Zealand. New Zealand Medical Journal, 135(1556), 23-43. Retrieved from https://www.nzma.org.nz/journal
Journal - Research Article
He, J., Jackson, C. G. C. A., Deva, S., Hung, T., Clarke, K., Segelov, E., … Zhi, J. (2022). Population pharmacokinetics for oral paclitaxel in patients with advanced/metastatic solid tumors. Clinical & Translational Science. Advance online publication. doi: 10.1002/psp4.12799
Journal - Research Article
Hossain, S. M., Gimenez, G., Stockwell, P. A., Tsai, P., Print, C. G., Rys, J., … Jackson, C., Chatterjee, A., & Eccles, M. R. (2022). Innate immune checkpoint inhibitor resistance is associated with melanoma sub-types exhibiting invasive and de-differentiated gene expression signatures. Frontiers in Immunology, 13, 955063. doi: 10.3389/fimmu.2022.955063
Journal - Research Article
McPhail, S., Swann, R., Johnson, S. A., Barday, M. E., Elkader, H. A., Alvi, R., … Jackson, C. G. C. A., … ICBP Module 9 Emergency Presentations Working Group. (2022). Risk factors and prognostic implications of diagnosis of cancer within 30 days after an emergency hospital admission (emergency presentation): An International Cancer Benchmarking Partnership (ICBP) population-based study. Lancet Oncology. Advance online publication. doi: 10.1016/s1470-2045(22)00127-9
Journal - Research Article
Gurney, J. K., Millar, E., Dunn, A., Pirie, R., Mako, M., Manderson, J., … Jackson, C. G. C. A., … Sarfati, D. (2021). The impact of the COVID-19 pandemic on cancer diagnosis and service access in New Zealand: A country pursuing COVID-19 elimination. Lancet Regional Health: Western Pacific, 10, 100127. doi: 10.1016/j.lanwpc.2021.100127
Journal - Research Article
Jackson, C. G. C. A., Hung, T., Segelov, E., Barlow, P., Prenen, H., McLaren, B., Hung, N. A., Clarke, K., … Deva, S. (2021). Oral paclitaxel with encequidar compared to intravenous paclitaxel in patients with advanced cancer: A randomised crossover pharmacokinetic study. British Journal of Clinical Pharmacology, 87, 4673-4683. doi: 10.1111/bcp.14886
Journal - Research Article
Millar, E., Gurney, J., Beuker, S., Goza, M., Hamilton, M.-A., Hardie, C., Jackson, C. G. C. A., … Sarfati, D. (2021). Maintaining cancer services during the COVID-19 pandemic: The Aotearoa New Zealand experience. Lancet Regional Health: Western Pacific, 11, 100172. doi: 10.1016/j.lanwpc.2021.100172
Journal - Research Article
Morgan, E., Soerjomataram, I., Gavin, A. T., Rutherford, M. J., Gatenby, P., Bardot, A., … Jackson, C., … Arnold, M. (2021). International trends in oesophageal cancer survival by histological subtype between 1995 and 2014. Gut, 70, 234-242. doi: 10.1136/gutjnl-2020-321089
Journal - Research Article
Blackmore, T., Norman, K., Kidd, J., Cassim, S., Chepulis, L., Keenan, R., … Jackson, C., Stokes, T., … Lawrenson, R. (2020). Barriers and facilitators to colorectal cancer diagnosis in New Zealand: A qualitative study. BMC Family Practice, 21, 206. doi: 10.1186/s12875-020-01276-w
Journal - Research Article
Gurney, J., Stanley, J., Jackson, C., & Sarfati, D. (2020). Stage at diagnosis for Māori cancer patients: Disparities, similarities and data limitations. New Zealand Medical Journal, 133(1508), 43-64. Retrieved from https://www.nzma.org.nz/journal
Journal - Research Article
Gurney, J., Stanley, J., McLeod, M., Koea, J., Jackson, C., & Sarfati, D. (2020). Disparities in cancer-specific survival between Māori and non-Māori New Zealanders, 2007-2016. JCO Global Oncology, 6, 766-774. doi: 10.1200/go.20.00028
Journal - Research Article
Jackson, C. G. C. A., Bissett, I., Macfarlane, S., & Costello, S. (2020). Improving cancer services and survival in New Zealand. Journal of Cancer Policy, 23, 100216. doi: 10.1016/j.jcpo.2020.100216
Journal - Research Article
Segelov, E., Underhill, C., Prenen, H., Karapetis, C., Jackson, C., Nott, L., … MacIntyre, C. R. (2020). Practical considerations for treating patients with cancer in the COVID-19 pandemic. JCO Oncology Practice, 16(8), 467-482. doi: 10.1200/op.20.00229
Journal - Research Article
Walker, S., Egan, R., Young, J., Jaye, C., & Jackson, C. (2020). A citizens' jury on euthanasia/assisted dying: Does informed deliberation change people's views? Health Expectations, 23, 388-395. doi: 10.1111/hex.13008
Journal - Research Article
Zou, D., Day, R., Cocadiz, J. A., Parackal, S., Mitchell, W., Black, M. A., … Jackson, C., & Guilford, P. (2020). Circulating tumor DNA is a sensitive marker for routine monitoring of treatment response in advanced colorectal cancer. Carcinogenesis, 41(11), 1507-1517. doi: 10.1093/carcin/bgaa102
Journal - Research Article
So, Y. J., Jameson, M., Newton, V., O'Donnell, A., Jeffery, M., Jackson, C., … Wilson, M. K. (2019). Investigating strategies to improve clinical trial opportunities for patients with cancer in New Zealand: INSIGHT. New Zealand Medical Journal, 132(1498), 10-31. Retrieved from https://www.nzma.org.nz/journal
Journal - Research Article
Young, J., Egan, R., Walker, S., Graham-DeMello, A., & Jackson, C. (2019). The euthanasia debate: Synthesising the evidence on New Zealander's attitudes. Kōtuitui, 14(1), 1-21. doi: 10.1080/1177083X.2018.1532915
Journal - Research Article
Gibbs, P., Heinemann, V., Sharma, N. K., Taieb, J., Ricke, J., Peeters, M., … Robinson, B., Jackson, C., … for the SIRFLOX and FOXFIRE Global Trial Investigators, including Perez, D. (2018). Effect of primary tumor side on survival outcomes in untreated patients with metastatic colorectal cancer when selective internal radiation therapy is added to chemotherapy: Combined analysis of two randomized controlled studies. Clinical Colorectal Cancer, 17(4), e617-e629. doi: 10.1016/j.clcc.2018.06.001
Journal - Research Article
Hill, A. G., Findlay, M. P., Burge, M. E., Jackson, C., Alfonso, P. G., Samuel, L., … Tabernero, J. (2018). Phase II study of the dual EGFR/HER3 inhibitor duligotuzumab (MEHD7945A) versus cetuximab in combination with FOLFIRI in second-line RAS wild-type metastatic colorectal cancer. Clinical Cancer Research, 24(10), 2276-2284. doi: 10.1158/1078-0432.Ccr-17-0646
Journal - Research Article
Lawrence, B., Blenkiron, C., Parker, K., Tsai, P., Fitzgerald, S., Shields, P., … Black, M., … Robinson, B., … Carroll, R., … Morrin, H., … Jackson, C., … Print, C. (2018). Recurrent loss of heterozygosity correlates with clinical outcome in pancreatic neuroendocrine cancer. npj Genomic Medicine, 3, 18. doi: 10.1038/s41525-018-0058-3
Journal - Research Article
Sharples, K., Firth, M., Hinder, V., Hill, A., Jeffery, M., Sarfati, D., … Atmore, C., … Derrett, S., … Keating, J., … Jackson, C., & Findlay, M. (2018). The New Zealand PIPER Project: Colorectal cancer survival according to rurality, ethnicity and socioeconomic deprivation: Results from a retrospective cohort study. New Zealand Medical Journal, 1476(131), 24-39. Retrieved from https://www.nzma.org.nz/journal
Journal - Research Article
Grant, M. L., Shields, N., Neumann, S., Kramer, K., Bonato, A., Jackson, C., Baird, M. A., & Young, S. L. (2017). Combining dendritic cells and B cells for presentation of oxidised tumour antigens to CD8+ T cells. Clinical & Translational Immunology, 6(7), e149. doi: 10.1038/cti.2017.28
Journal - Research Article
Li, K., Donaldson, B., Young, V., Ward, V., Jackson, C., Baird, M., & Young, S. (2017). Adoptive cell therapy with CD4+ T helper 1 cells and CD8+ cytotoxic T cells enhances complete rejection of an established tumour, leading to generation of endogenous memory responses to non-targeted tumour epitopes. Clinical & Translational Immunology, 6(10), e160. doi: 10.1038/cti.2017.37
Journal - Research Article
Segelov, E., Chan, D., Lawrence, B., Pavlakis, N., Kennecke, H. F., Jackson, C., … Singh, S. (2017). Identifying and prioritizing gaps in neuroendocrine tumor research: A modified Delphi process with patients and health care providers to set the research action plan for the newly formed Commonwealth Neuroendocrine Tumor Collaboration. Journal of Global Oncology, 3(4), 380-388. doi: 10.1200/jgo.2016.006916
Journal - Research Article
Tiong, J., Gray, A., Jackson, C., Thompson-Fawcett, M., & Schultz, M. (2017). Audit of the association between length of time spent on diagnostic work-up and tumour stage in patients with symptomatic colon cancer. ANZ Journal of Surgery, 87(3), 138-142. doi: 10.1111/ans.12804
Journal - Research Article
Firth, M. J., Sharples, K. J., Hinder, V. A., Macapagal, J., Sarfati, D., Derrett, S. L., … Atmore, C., Keating, J. P., Jeffery, M., … Jackson, C. G. C. A., & Findlay, M. P. N. (2016). Methods of a national colorectal cancer cohort study: The PIPER Project. New Zealand Medical Journal, 129(1440), 25-36. Retrieved from https://www.nzma.org.nz/journal
Journal - Research Article
Li, K., Baird, M., Yang, J., Jackson, C., Ronchese, F., & Young, S. (2016). Conditions for the generation of cytotoxic CD4+ Th cells that enhance CD8+ CTL-mediated tumor regression. Clinical & Translational Immunology, 5(8), e95. doi: 10.1038/cti.2016.46
Journal - Research Article
Sarfati, D., Koczwara, B., & Jackson, C. (2016). The impact of comorbidity on cancer and its treatment. CA: A Cancer Journal for Clinicians, 66(4), 337-350. doi: 10.3322/caac.21342
Journal - Research Article
Stairmand, J., Signal, L., Sarfati, D., Jackson, C., Batten, L., Holdaway, M., & Cunningham, C. (2015). Consideration of comorbidity in treatment decision making in multidisciplinary cancer team meetings: A systematic review. Annals of Oncology, 26, 1325-1332. doi: 10.1093/annonc/mdv025
Journal - Research Article
Jackson, C. G. C. A., Sharples, K., Thompson, P. I., O'Donnell, A., Robinson, B. A., Perez, D. J., … Findlay, M. P. (2014). Dose-intense capecitabine, oxaliplatin and bevacizumab as first line treatment for metastatic, unresectable colorectal cancer: A multi-centre phase II study. BMC Cancer, 14, 737. doi: 10.1186/1471-2407-14-737
Journal - Research Article
Bidwell, S., Simpson, A., Sullivan, R., Robinson, B., Thomas, W., Jackson, C., … Clarke, T. (2013). A workforce survey of New Zealand medical oncologists. New Zealand Medical Journal, 126(1371). Retrieved from http://www.nzma.org.nz/journal
Journal - Research Article
Moorcraft, S. Y., Chau, I., Peckitt, C., Cunningham, D., Rao, S., Yim, K. L., … Jackson, C. G. C. A., … Swanton, C. (2013). Patupilone in patients with pretreated metastatic/locally recurrent colorectal cancer: Results of the Phase II CINATRA trial. Investigational New Drugs, 31(5), 1339-1344. doi: 10.1007/s10637-013-9990-3
Journal - Research Article
Pullar, J. M., Chisholm, A., & Jackson, C. (2012). Dietary information for colorectal cancer survivors: An unmet need. New Zealand Medical Journal, 125(1356). Retrieved from http://www.nzma.org.nz/journal
Journal - Research Article
Richter, K. K., Dempster, A., Tos, A. P. D., Premkumar, R., & Jackson, C. (2011). Challenging differential diagnosis of a wild-type gastrointestinal stromal tumour (GIST) or rare reticular perineurioma of the stomach? The role for mutational analysis. New Zealand Medical Journal, 124(1331). Retrieved from http://journal.nzma.org.nz/journal/124-1331/4583/content.pdf
Journal - Research Article
Jackson, C., Sirohi, B., Cunningham, D., Horwich, A., Thomas, K., & Wotherspoon, A. (2010). Lymphocyte-predominant Hodgkin lymphoma: Clinical features and treatment outcomes from a 30-year experience. Annals of Oncology, 21(10), 2061-2068. doi: 10.1093/annonc/mdq063
Journal - Research Article
Jackson, C., Cunningham, D., Oliveira, J., on behalf of the ESMO Guidelines Working Group. (2009). Gastric cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up. Annals of Oncology, 20(Suppl. 4), iv34-iv36. doi: 10.1093/annonc/mdp119
Journal - Research Article
Jackson, C., & Cunningham, D. (2008). Where to position monoclonal antibodies in first-line treatment of advanced colorectal cancer. European Journal of Cancer, 44, 652-662. doi: 10.1016/j.ejca.2008.01.021
Journal - Research Article
Kong, G., Jackson, C., Koh, D. M., Lewington, V., Sharma, B., Brown, G., … Cook, G. J. R. (2008). The use of 18F-FDG PET/CT in colorectal liver metastases—comparison with CT and liver MRI. European Journal of Nuclear Medicine & Molecular Imaging, 35(7), 1323-1329. doi: 10.1007/s00259-008-0743-z
Journal - Research Article
Jackson, C., Mochlinski, K., & Cunningham, D. (2007). Therapeutic options in gastric cancer: Neoadjuvant chemotherapy vs postoperative chemoradiotherapy. Oncology, 21(9), 1084-1087.
Journal - Research Article
Jackson, C., Starling, N., Chua, Y. J., & Cunningham, D. (2007). Pharmacotherapy for oesophagogastric cancer. Drugs, 67(17), 2539-2556.
Journal - Research Article
Hung, N. A., Jackson, C., Nicholson, M., & Highton, J. (2006). Pregnancy-related polymyositis and massive perivillous fibrin deposition in the placenta: Are they pathogenetically related? Arthritis & Rheumatism, 55(1), 154-156. doi: 10.1002/art.21710
Journal - Research Article
Mason, K., Kelly, L., Jackson, C., Read, D., & Borman, B. (2022). Did new treatments contribute to a decrease in melanoma deaths? New Zealand Medical Journal, 135(1558), 90-95. Retrieved from https://journal.nzma.org.nz
Journal - Research Other
Pavlakis, N., Tincknell, G., Lim, L. E., Muro, K., Obermannova, R., Lorenzen, S., … Jackson, C., … Lordick, F. (2022). European-Australasian consensus on the management of advanced gastric and gastro-oesophageal junction cancer: Current practice and new directions. Therapeutic Advances in Medical Oncology, 14. doi: 10.1177/17588359221118874
Journal - Research Other
Sarfati, D., & Jackson, C. (2020). Context of cancer control in New Zealand. Journal of Cancer Policy, 23, 100211. doi: 10.1016/j.jcpo.2019.100211
Journal - Research Other
Sarfati, D., & Jackson, C. G. C. A. (2020). Preface to the NZ series on Cancer Control. Journal of Cancer Policy, 23, 100223. doi: 10.1016/j.jcpo.2020.100223
Journal - Research Other
Weinkove, R., McQuilten, Z. K., Adler, J., Agar, M. R., Blyth, E., Cheng, A. C., … Jackson, C., … Teh, B. W. (2020). Managing haematology and oncology patients during the COVID-19 pandemic: Interim consensus guidance. Medical Journal of Australia, 212(10), 481-489. doi: 10.5694/mja2.50607
Journal - Research Other
Gurney, J., Campbell, S., Jackson, C., & Sarfati, D. (2019). Equity by 2030: Achieving equity in survival for Māori cancer patients. New Zealand Medical Journal, 132(1506), 66-76. Retrieved from https://www.nzma.org.nz/journal
Journal - Research Other
Jackson, C. G. C. A., Morris, T., Hung, N., & Hung, T. (2019). Breast milk paclitaxel excretion following intravenous chemotherapy: A case report. British Journal of Cancer, 121, 421-424. doi: 10.1038/s41416-019-0529-z
Journal - Research Other
Sarfati, D., Jackson, C. G. C. A., Macfarlane, S., Bissett, I., Robson, B., Gurney, J., Kemp, R., … McMenamin, J. (2019). Cancer Care at a Crossroads: Time to make a choice. New Zealand Medical Journal, 132(1493), 6-11. Retrieved from https://www.nzma.org.nz/journal
Journal - Research Other
Sarfati, D., & Jackson, C. (2018). Cancer inequalities endure despite NHS reforms. BMJ, 360, k989. doi: 10.1136/bmj.k989
Journal - Research Other
Lim, Y. K., Jackson, C., Dauway, E. L., & Richter, K. K. (2017). Risk factors for adverse outcome for elderly patients undergoing curative oncological resection for gastrointestinal malignancies. Visceral Medicine, 33(4), 254-261. doi: 10.1159/000475938
Journal - Research Other
Jackson, C. G. C. A. (2016). Follow-up of cancer in New Zealand: Time to review the model of care. New Zealand Medical Journal, 129(1440), 18-21. Retrieved from https://www.nzma.org.nz/journal
Journal - Research Other
Jackson, C. G. C. A., & Sarfati, D. (2016). How 'modifiable' are 'modifiable risk factors' for cancer? New Zealand Medical Journal, 129(1447), 7-9. Retrieved from http://www.nzma.org.nz/journal
Journal - Research Other
Jackson, C., Ehrenberg, N., Frizelle, F., Sarfati, D., Balasingham, A., Pearse, M., … Bissett, I. (2014). Rectal cancer: Future directions and priorities for treatment, research and policy in New Zealand. New Zealand Medical Journal, 127(1395). Retrieved from http://www.nzma.org.nz/journal
Journal - Research Other
Jackson, C., Robinson, B., & Findlay, M. (2014). Cancer services to 2025 in New Zealand: Investing in research-driven quality care. New Zealand Medical Journal, 127(1395). Retrieved from http://www.nzma.org.nz/journal
Journal - Research Other
Jackson, C., McCall, J., Robinson, B., Sharples, K., & Findlay, M. (2013). Cancer trials in New Zealand: Patients are not the problem. New Zealand Medical Journal, 126(1381). Retrieved from http://www.nzma.org.nz/journal
Journal - Research Other