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Health Sciences profile

Dr Chris Baldi

PositionSenior Research Fellow
DepartmentDepartment of Medicine (DSM)
QualificationsMSc PhD FACSM
Research summaryDiabetes and cardiovascular dysfunction

Research

My general area of research is to examine the causes and prevention of cardiovascular dysfunction in patients with diabetes (type 1 and 2). Interests include:

Exercise intolerance in diabetes
Myocardial and pulmonary dysfunction in diabetes
Paediatric diabetes research

Publications

Daniels, L. J., Wallace, R. S., Nicholson, O. M., Wilson, G. A., McDonald, F. J., Jones, P. P., Baldi, J. C., Lamberts, R. R., & Erickson, J. R. (2018). Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats. Cardiovascular Diabetology, 17, 89. doi: 10.1186/s12933-018-0732-x

Woodfield, J., Zacharias, M., Wilson, G., Munro, F., Thomas, K., Gray, A., & Baldi, J. (2018). Protocol, and practical challenges, for a randomised controlled trial comparing the impact of high intensity interval training against standard care before major abdominal surgery: Study protocol for a randomised controlled trial. Trials, 19(1), 331. doi: 10.1186/s13063-018-2701-9

Wilson, L. C., Peebles, K. C., Hoye, N. A., Manning, P., Sheat, C., Williams, M. J. A., Wilkins, G. T., Wilson, G. A., & Baldi, J. C. (2017). Resting heart rate variability and exercise capacity in Type 1 diabetes. Physiological Reports, 5(8), e13248. doi: 10.14814/phy2.13248

Wilson, G. A., Wilson, L. C., Lamberts, R. R., Majeed, K., Lal, S., Wilkins, G. T., & Baldi, J. C. (2017). β-adrenergic responsiveness in the type 2 diabetic heart: Effects on cardiac reserve. Medicine & Science in Sports & Exercise, 49(5), 907-914. doi: 10.1249/mss.0000000000001184

Wilson, G. A., Wilkins, G. T., Cotter, J. D., Lamberts, R. R., Lal, S., & Baldi, J. C. (2017). Impaired ventricular filling limits cardiac reserve during submaximal exercise in people with type 2 diabetes. Cardiovascular Diabetology, 16, 160. doi: 10.1186/s12933-017-0644-1

Journal - Research Article

Daniels, L. J., Wallace, R. S., Nicholson, O. M., Wilson, G. A., McDonald, F. J., Jones, P. P., Baldi, J. C., Lamberts, R. R., & Erickson, J. R. (2018). Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats. Cardiovascular Diabetology, 17, 89. doi: 10.1186/s12933-018-0732-x

Wilson, L. C., Peebles, K. C., Hoye, N. A., Manning, P., Sheat, C., Williams, M. J. A., Wilkins, G. T., Wilson, G. A., & Baldi, J. C. (2017). Resting heart rate variability and exercise capacity in Type 1 diabetes. Physiological Reports, 5(8), e13248. doi: 10.14814/phy2.13248

Wilson, G. A., Wilkins, G. T., Cotter, J. D., Lamberts, R. R., Lal, S., & Baldi, J. C. (2017). Impaired ventricular filling limits cardiac reserve during submaximal exercise in people with type 2 diabetes. Cardiovascular Diabetology, 16, 160. doi: 10.1186/s12933-017-0644-1

Wilson, G. A., Wilson, L. C., Lamberts, R. R., Majeed, K., Lal, S., Wilkins, G. T., & Baldi, J. C. (2017). β-adrenergic responsiveness in the type 2 diabetic heart: Effects on cardiac reserve. Medicine & Science in Sports & Exercise, 49(5), 907-914. doi: 10.1249/mss.0000000000001184

Gusso, S., Pinto, T., Baldi, J. C., Derraik, J. G. B., Cutfield, W. S., Hornung, T., & Hofman, P. L. (2017). Exercise training improves but does not normalize left ventricular systolic and diastolic function in adolescents With Type 1 diabetes. Diabetes Care. Advance online publication. doi: 10.2337/dc16-2347

Baldi, J. C., Wilson, G. A., Wilson, L. C., Wilkins, G. T., & Lamberts, R. R. (2016). The type 2 diabetic heart: Its role in exercise intolerance and the challenge to find effective exercise interventions. Sports Medicine, 46, 1605-1617. doi: 10.1007/s40279-016-0542-9

Thaung, H. P. A., Baldi, J. C., Wang, H.-Y., Hughes, G., Cook, R. F., Bussey, C. T., Sheard, P. W., Bahn, A., Jones, P. P., Schwenke, D. O., & Lamberts, R. R. (2015). Increased efferent cardiac sympathetic nerve activity and defective intrinsic heart rate regulation in type 2 diabetes. Diabetes, 64(8), 2944-2956. doi: 10.2337/db14-0955

Green, S., Egaña, M., Baldi, J. C., Lamberts, R., & Regensteiner, J. G. (2015). Cardiovascular control during exercise in type 2 diabetes mellitus. Journal of Diabetes Research, 2015, 654204. doi: 10.1155/2015/654204

Bussey, C. T., Hughes, G., Saxena, P., Galvin, I. F., Bunton, R. W., Noye, M. K., Coffey, S., Williams, M. J. A., Baldi, J. C., Jones, P. P., & Lamberts, R. R. (2015). Chamber-specific changes in calcium-handling proteins in the type 2 diabetic human heart with preserved ejection fraction. International Journal of Cardiology, 193, 53-55. doi: 10.1016/j.ijcard.2015.05.053

Pinto, T. E., Gusso, S., Hofman, P. L., Derraik, J. G. B., Hornung, T. S., Cutfield, W. S., & Baldi, J. C. (2014). Systolic and diastolic abnormalities reduce the cardiac response to exercise in adolescents with type 2 diabetes. Diabetes Care, 37(5), 1439-1446. doi: 10.2337/dc13-2031

Baldi, J. C., Dacey, M. J., Lee, M. J., & Coast, J. R. (2014). Prior maximal exercise decreases pulmonary diffusing capacity during subsequent exercise. International Journal of Sports Medicine, 35(12), 982-986. doi: 10.1055/s-0034-1372635

Hoye, N. A., Baldi, J. C., Putt, T. L., Schollum, J. B., Wilkins, G. T., & Walker, R. J. (2014). Endovascular renal denervation: A novel sympatholytic with relevance to chronic kidney disease. Clinical Kidney Journal, 7(1), 3-10. doi: 10.1093/ckj/sft130

Francois, M. E., Baldi, J. C., Manning, P. J., Lucas, S. J. E., Hawley, J. A., Williams, M. J. A., & Cotter, J. D. (2014). ‘Exercise snacks’ before meals: A novel strategy to improve glycaemic control in individuals with insulin resistance. Diabetologia, 57(7), 1437-1445. doi: 10.1007/s00125-014-3244-6

Lamberts, R. R., Lingam, S. J., Wang, H.-Y., Bollen, I. A. E., Hughes, G., Galvin, I. F., Bunton, R. W., Bahn, A., Katare, R., Baldi, J. C., Williams, M. J. A., Saxena, P., Coffey, S., & Jones, P. P. (2014). Impaired relaxation despite upregulated calcium-handling protein atrial myocardium from type 2 diabetic patients with preserved ejection fraction. Cardiovascular Diabetology, 13, 72. doi: 10.1186/1475-2840-13-72

Jones, L. M., Stoner, L., Brown, C., Baldi, C., & McLaren, B. (2013). Cardiovascular disease among breast cancer survivors: The call for a clinical vascular health toolbox. Breast Cancer Research & Treatment, 142(3), 645-653. doi: 10.1007/s10549-013-2766-9

Wimer, G. S., & Baldi, J. C. (2012). Limb-specific training affects exercise hyperemia but not sympathetic vasoconstriction. European Journal of Applied Physiology, 112(11), 3819-3828.

Gusso, S., Pinto, T. E., Baldi, J. C., Robinson, E., Cutfield, W. S., & Hofman, P. L. (2012). Diastolic function is reduced in adolescents with type 1 diabetes in response to exercise. Diabetes Care, 35(10), 2089-2094. doi: 10.2337/dc11-2331

Carrick-Ranson, G., Doughty, R. N., Whalley, G. A., Walsh, H. J., Gamble, G. D., & Baldi, J. C. (2012). The larger exercise stroke volume in endurance-trained men does not result from increased left ventricular early or late inflow or tissue velocities. Acta Physiologica, 205(4), 520-531. doi: 10.1111/j.1748-1716.2012.02430.x

Hopkins, S. A., Baldi, J. C., Cutfield, W. S., McCowan, L., & Hofman, P. L. (2011). Effects of exercise training on maternal hormonal changes in pregnancy. Clinical Endocrinology, 74(4), 495-500. doi: 10.1111/j.1365-2265.2010.03964.x

Wheatley, C. M., Baldi, J. C., Cassuto, N. A., Foxx-Lupo, W. T., & Snyder, E. M. (2011). Glycemic control influences lung membrane diffusion and oxygen saturation in exercise-trained subjects with type 1 diabetes: Alveolar-capillary membrane conductance in type 1 diabetes. European Journal of Applied Physiology, 111(3), 567-578. doi: 10.1007/s00421-010-1663-8

Baldi, J. C., Cassuto, N. A., Foxx-Lupo, W. T., Wheatley, C. M., & Snyder, E. M. (2010). Glycemic status affects cardiopulmonary exercise response in athletes with type 1 diabetes. Medicine & Science in Sports & Exercise, 42(8), 1454-1459. doi: 10.1249/MSS.0b013e3181d1fdb3

Hopkins, S. A., Baldi, J. C., Cutfield, W. S., McCowan, L., & Hofman, P. L. (2010). Exercise training in pregnancy reduces offspring size without changes in maternal insulin sensitivity. Journal of Clinical Endocrinology & Metabolism, 95(5), 2080-2088. doi: 10.1210/jc.2009-2255

Baldi, J. C., & Hofman, P. L. (2010). Does careful glycemic control improve aerobic capacity in subjects with type 1 diabetes? Exercise & Sport Sciences Reviews, 38(4), 161-167. doi: 10.1097/JES.0b013e3181f4501e

Lalande, S., Hofman, P., & Baldi, J. C. (2010). Effect of reduced total blood volume on left ventricular volumes and kinetics in type 2 diabetes. Acta Physiologica, 199(1), 23-30. doi: 10.1111/j.1748-1716.2010.02081.x

Whalley, G. A., Gusso, S., Hofman, P., Cutfield, W., Poppe, K. K., Doughty, R. N., & Baldi, J. C. (2009). Structural and functional cardiac abnormalities in adolescent girls with poorly controlled type 2 diabetes. Diabetes Care, 32(5), 883-888. doi: 10.2337/dc08-2005

Lalande, S., Gusso, S., Hofman, P. L., & Baldi, J. C. (2008). Reduced leg blood flow during submaximal exercise in type 2 diabetes. Medicine & Science in Sports & Exercise, 48(4), 612-617. doi: 10.1249/MSS.0b013e318161aa99

Gusso, S., Hofman, P., Lalande, S., Cutfield, W., Robinson, E., & Baldi, J. C. (2008). Impaired stroke volume and aerobic capacity in female adolescents with type 1 and type 2 diabetes mellitus. Diabetologia, 51(7), 1317-1320. doi: 10.1007/s00125-008-1012-1

Hammett, C. J. K., Prapavessis, H., Baldi, J. C., Ameratunga, R., Schoenbeck, U., Varo, N., … Stewart, R. A. H. (2007). Variation in blood levels of inflammatory markers related and unrelated to smoking cessation in women. Preventive Cardiology, 10(2), 68-75. doi: 10.1111/j.1520-037X.2007.05957.x

Prapavessis, H., Cameron, L., Baldi, J. C., Robinson, S., Borrie, K., Harper, T., & Grove, J. R. (2007). The effects of exercise and nicotine replacement therapy on smoking rates in women. Addictive Behaviors, 32(7), 1416-1432. doi: 10.1016/j.addbeh.2006.10.005

Lalande, S., & Baldi, J. C. (2007). Left ventricular mass in elite Olympic weight lifters. American Journal of Cardiology, 100(7), 1177-1180. doi: 10.1016/j.amjcard.2007.05.036

Baldi, J. C., Lalande, S., Carrick-Ranson, G., & Johnson, B. D. (2007). Postural differences in hemodynamics and diastolic function in healthy older men. European Journal of Applied Physiology, 99(6), 651-657. doi: 10.1007/s00421-006-0384-5

Hammett, C. J. K., Prapavessis, H., Baldi, J. C., Varo, N., Schoenbeck, U., Ameratunga, R., … Stewart, R. A. H. (2006). Effects of exercise training on 5 inflammatory markers associated with cardiovascular risk. American Heart Journal, 151(2), 367 e7-367 e16. doi: 10.1016/j.ahj.2005.08.009

Baldi, J. C., Aoina, J. L., Whalley, G. A., Carrick-Ranson, G., Walsh, H., O'Shaughnessy, H., … Doughty, R. N. (2006). The effect of type 2 diabetes on diastolic function. Medicine & Science in Sports & Exercise, 38(8), 1384-1388. doi: 10.1249/01.mss.0000228954.90591.95

Whalley, G. A., Doughty, R. N., Gamble, G. D., Oxenham, H. C., Walsh, H. J., Reid, I. R., & Baldi, J. C. (2004). Association of fat-free mass and training status with left ventricular size and mass in endurance-trained athletes. JACC, 44(4), 892-896. doi: 10.1016/j.jacc.2004.04.051

Baldi, J. C., McFarlane, K., Oxenham, H. C., Whalley, G. A., Walsh, H. J., & Doughty, R. N. (2003). Left ventricular diastolic filling and systolic function of young and older trained and untrained men. Journal of Applied Physiology, 95, 2570-2575. doi: 10.1152/japplphysiol.00441.2003

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Journal - Research Other

Woodfield, J., Zacharias, M., Wilson, G., Munro, F., Thomas, K., Gray, A., & Baldi, J. (2018). Protocol, and practical challenges, for a randomised controlled trial comparing the impact of high intensity interval training against standard care before major abdominal surgery: Study protocol for a randomised controlled trial. Trials, 19(1), 331. doi: 10.1186/s13063-018-2701-9

Baldi, J. C., Manning, P. J., Hofman, P. L., & Walker, R. J. (2013). Comment on: TODAY Study Group. Effects of Metformin, Metformin plus Rosiglitazone, and Metformin plus lifestyle on insulin sensitivity and β-cell function in TODAY. Diabetes Care 2013;36:1749-1757 [Comment]. Diabetes Care, 36, e223. doi: 10.2337/dc13-1426

Whalley, G. A., Doughty, R. N., & Baldi, J. C. (2005). Detection of pathologic or physiologic left ventricular remodeling in athletes: Reply. JACC, 45(10), 1731. doi: 10.1016/j.jacc.2005.02.048

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