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Health Sciences profile

Dr Matloob Husain

PositionSenior Lecturer
DepartmentDepartment of Microbiology and Immunology
QualificationsMSc, PhD
Research summaryMolecular virology, viral pathogenesis and epidemiology

Research

I am a Senior Lecturer in Virology. My laboratory is interested in understanding the virus-host cell interactions at molecular level. Viruses are obligate intracellular parasites that exploit and dysregulate host factors and signalling pathways to complete a replication cycle and cause disease. Current research in the lab focuses on the identification of novel host factors and signalling pathways involved in the replication and pathogenesis of influenza virus and vaccinia virus.

Publications

Nagesh, P. T., & Husain, M. (2016). Influenza A virus dysregulates host histone deacetylase 1 that inhibits viral infection in lung epithelial cells. Journal of Virology, 90(9), 4614-4625. doi: 10.1128/jvi.00126-16

Husain, M., & Cheung, C.-Y. (2014). Histone deacetylase 6 inhibits influenza A virus release by downregulating the trafficking of viral components to the plasma membrane via its substrate, acetylated microtubules. Journal of Virology, 88(19), 11229-11239. doi: 10.1128/jvi.00727-14

Chen, D.-Y., & Husain, M. (2016). Caspase-mediated degradation of host cortactin that promotes influenza A virus infection in epithelial cells. Virology, 497, 146-156. doi: 10.1016/j.virol.2016.07.017

Husain, M. (2014). Avian influenza A (H7N9) virus infection in humans: Epidemiology, evolution, and pathogenesis. Infection, Genetics & Evolution, 28, 304-312. doi: 10.1016/j.meegid.2014.10.016

Husain, M., & Harrod, K. S. (2011). Enhanced acetylation of alpha-tubulin in influenza A virus infected epithelial cells. FEBS Letters, 585(1), 128-132. doi: 10.1016/j.febslet.2010.11.023

Journal - Research Article

Chen, D.-Y., & Husain, M. (2016). Caspase-mediated degradation of host cortactin that promotes influenza A virus infection in epithelial cells. Virology, 497, 146-156. doi: 10.1016/j.virol.2016.07.017

Nagesh, P. T., & Husain, M. (2016). Influenza A virus dysregulates host histone deacetylase 1 that inhibits viral infection in lung epithelial cells. Journal of Virology, 90(9), 4614-4625. doi: 10.1128/jvi.00126-16

Zaraket, H., Baranovich, T., Kaplan, B. S., Carter, R., Song, M.-S., Paulson, J. C., … Husain, M., … Webby, R. J. (2015). Mammalian adaptation of influenza A(H7N9) virus is limited by a narrow genetic bottleneck. Nature Communications, 6, 6553. doi: 10.1038/ncomms7553

Husain, M., & Cheung, C.-Y. (2014). Histone deacetylase 6 inhibits influenza A virus release by downregulating the trafficking of viral components to the plasma membrane via its substrate, acetylated microtubules. Journal of Virology, 88(19), 11229-11239. doi: 10.1128/jvi.00727-14

Husain, M. (2014). Avian influenza A (H7N9) virus infection in humans: Epidemiology, evolution, and pathogenesis. Infection, Genetics & Evolution, 28, 304-312. doi: 10.1016/j.meegid.2014.10.016

Singh, S. P., Gundavarapu, S., Smith, K. R., Chand, H. S., Saeed, A. I., Mishra, N. C., … Husain, M., … Sopori, M. L. (2013). Gestational exposure of mice to secondhand cigarette smoke causes bronchopulmonary dysplasia blocked by the nicotinic receptor antagonist mecamylamin. Environmental Health Perspectives, 121(8), 957-964. doi: 10.1289/ehp.1306611

Husain, M., & Harrod, K. S. (2011). Enhanced acetylation of alpha-tubulin in influenza A virus infected epithelial cells. FEBS Letters, 585(1), 128-132. doi: 10.1016/j.febslet.2010.11.023

Husain, M., & Harrod, K. S. (2009). Influenza A virus-induced caspase-3 cleaves the histone deacetylase 6 in infected epithelial cells. FEBS Letters, 583(15), 2517-2520. doi: 10.1016/j.febslet.2009.07.005

Husain, M., Weisberg, A. S., & Moss, B. (2007). Sequence-independent targeting of transmembrane proteins synthesized within vaccinia virus factories to nascent viral membranes. Journal of Virology, 81(6), 2646-2655. doi: 10.1128/JVI.02631-06

Husain, M., Weisberg, A. S., & Moss, B. (2007). Resistance of a vaccinia virus A34R deletion mutant to spontaneous rupture of the outer membrane of progeny virions on the surface of infected cells. Virology, 366(2), 424-432. doi: 10.1016/j.virol.2007.05.015

Husain, M., Weisberg, A. S., & Moss, B. (2006). Existence of an operative pathway from the endoplasmic reticulum to the immature poxvirus membrane. PNAS, 103(51), 19506-19511. doi: 10.1073/pnas.0609406103

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