Associate Professor Matloob Husain
| Position | Associate Professor |
|---|---|
| Department | Department of Microbiology and Immunology |
| Qualifications | MSc, PhD |
| Research summary | Molecular virology, viral pathogenesis and epidemiology |
Research
I am an Associate Professor in Virology. My laboratory is interested in understanding the virus-host cell interactions at molecular level. Viruses are obligate intracellular parasites that exploit and dysregulate host factors and signalling pathways to complete a replication cycle and cause disease. Current research in the lab focuses on the identification of novel host factors and signalling pathways involved in the replication and pathogenesis of influenza virus and vaccinia virus.Publications
Nagesh, P. T., & Husain, M. (2016). Influenza A virus dysregulates host histone deacetylase 1 that inhibits viral infection in lung epithelial cells. Journal of Virology, 90(9), 4614-4625. doi: 10.1128/jvi.00126-16
Husain, M., & Cheung, C.-Y. (2014). Histone deacetylase 6 inhibits influenza A virus release by downregulating the trafficking of viral components to the plasma membrane via its substrate, acetylated microtubules. Journal of Virology, 88(19), 11229-11239. doi: 10.1128/jvi.00727-14
Chen, D.-Y., & Husain, M. (2016). Caspase-mediated degradation of host cortactin that promotes influenza A virus infection in epithelial cells. Virology, 497, 146-156. doi: 10.1016/j.virol.2016.07.017
Husain, M. (2014). Avian influenza A (H7N9) virus infection in humans: Epidemiology, evolution, and pathogenesis. Infection, Genetics & Evolution, 28, 304-312. doi: 10.1016/j.meegid.2014.10.016
Husain, M., & Harrod, K. S. (2011). Enhanced acetylation of alpha-tubulin in influenza A virus infected epithelial cells. FEBS Letters, 585(1), 128-132. doi: 10.1016/j.febslet.2010.11.023
Journal - Research Article
Chen, D.-Y., & Husain, M. (2016). Caspase-mediated degradation of host cortactin that promotes influenza A virus infection in epithelial cells. Virology, 497, 146-156. doi: 10.1016/j.virol.2016.07.017
Nagesh, P. T., & Husain, M. (2016). Influenza A virus dysregulates host histone deacetylase 1 that inhibits viral infection in lung epithelial cells. Journal of Virology, 90(9), 4614-4625. doi: 10.1128/jvi.00126-16
Zaraket, H., Baranovich, T., Kaplan, B. S., Carter, R., Song, M.-S., Paulson, J. C., … Husain, M., … Webby, R. J. (2015). Mammalian adaptation of influenza A(H7N9) virus is limited by a narrow genetic bottleneck. Nature Communications, 6, 6553. doi: 10.1038/ncomms7553
Husain, M., & Cheung, C.-Y. (2014). Histone deacetylase 6 inhibits influenza A virus release by downregulating the trafficking of viral components to the plasma membrane via its substrate, acetylated microtubules. Journal of Virology, 88(19), 11229-11239. doi: 10.1128/jvi.00727-14
Husain, M. (2014). Avian influenza A (H7N9) virus infection in humans: Epidemiology, evolution, and pathogenesis. Infection, Genetics & Evolution, 28, 304-312. doi: 10.1016/j.meegid.2014.10.016
Singh, S. P., Gundavarapu, S., Smith, K. R., Chand, H. S., Saeed, A. I., Mishra, N. C., … Husain, M., … Sopori, M. L. (2013). Gestational exposure of mice to secondhand cigarette smoke causes bronchopulmonary dysplasia blocked by the nicotinic receptor antagonist mecamylamin. Environmental Health Perspectives, 121(8), 957-964. doi: 10.1289/ehp.1306611
Husain, M., & Harrod, K. S. (2011). Enhanced acetylation of alpha-tubulin in influenza A virus infected epithelial cells. FEBS Letters, 585(1), 128-132. doi: 10.1016/j.febslet.2010.11.023
Husain, M., & Harrod, K. S. (2009). Influenza A virus-induced caspase-3 cleaves the histone deacetylase 6 in infected epithelial cells. FEBS Letters, 583(15), 2517-2520. doi: 10.1016/j.febslet.2009.07.005
Husain, M., Weisberg, A. S., & Moss, B. (2007). Sequence-independent targeting of transmembrane proteins synthesized within vaccinia virus factories to nascent viral membranes. Journal of Virology, 81(6), 2646-2655. doi: 10.1128/JVI.02631-06
Husain, M., Weisberg, A. S., & Moss, B. (2007). Resistance of a vaccinia virus A34R deletion mutant to spontaneous rupture of the outer membrane of progeny virions on the surface of infected cells. Virology, 366(2), 424-432. doi: 10.1016/j.virol.2007.05.015
Husain, M., Weisberg, A. S., & Moss, B. (2006). Existence of an operative pathway from the endoplasmic reticulum to the immature poxvirus membrane. PNAS, 103(51), 19506-19511. doi: 10.1073/pnas.0609406103
