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Health Sciences profile

Associate Professor Jo Kirman

PositionAssociate Professor, and Academic Leader, Flow Cytometry, for Otago Micro and Nanoscale Imaging (OMNI)
DepartmentDepartment of Microbiology and Immunology
QualificationsBSc Hons, PhD
Research summaryImmunology

Research

Tuberculosis (TB) caused by Mycobacterium tuberculosis is a deadly lung disease killing more people every year than any other bacterial infection. One third of the world's population is estimated to be infected, and New Zealand is not exempt. We believe the best way to control the global TB epidemic is through vaccination. Our lab's research is focused on understanding the generation and maintenance of immunological memory in order to improve vaccination against TB. Our lab is also interested in other respiratory pathogens, such as respiratory syncytial virus (RSV), which causes bronchiolitis in infants.

Publications

Ryder, B. M., Sandford, S. K., Manners, K. M., Dalton, J. P., Wiles, S., & Kirman, J. R. (2019). Gr1int/high cells dominate the early phagocyte response to mycobacterial lung infection in mice. Frontiers in Microbiology, 10, 402. doi: 10.3389/fmicb.2019.00402

Steigler, P., Daniels, N. J., McCulloch, T. R., Ryder, B. M., Sandford, S. K., & Kirman, J. R. (2018). BCG vaccination drives accumulation and effector function of innate lymphoid cells in murine lungs. Immunology & Cell Biology, 96(4), 379-389. doi: 10.1111/imcb.12007

Prendergast, K. A., Daniels, N. J., Petersen, T. R., Hermans, I. F., & Kirman, J. R. (2018). Langerin+ CD8α+ dendritic cells drive early CD8+ T cell activation and IL-12 production during systemic bacterial infection. Frontiers in Immunology, 9, 953. doi: 10.3389/fimmu.2018.00953

Kirman, J. R., Henao-Tamayo, M. I., & Agger, E. M. (2016). The memory immune response to tuberculosis. Microbiology Spectrum, 4(6), TBTB2-0009-2016. doi: 10.1128/microbiolspec.TBTB2-0009-2016

Kuhn, S., Yang, J., Hyde, E. J., Harper, J. L., Kirman, J. R., & Ronchese, F. (2015). IL-1βR-dependent priming of antitumor CD4+ T cells and sustained antitumor immunity after peri-tumoral treatment with MSU and mycobacteria. OncoImmunology, 4(10), e1042199. doi: 10.1080/2162402X.2015.1042199

Journal - Research Article

Ryder, B. M., Sandford, S. K., Manners, K. M., Dalton, J. P., Wiles, S., & Kirman, J. R. (2019). Gr1int/high cells dominate the early phagocyte response to mycobacterial lung infection in mice. Frontiers in Microbiology, 10, 402. doi: 10.3389/fmicb.2019.00402

Steigler, P., Daniels, N. J., McCulloch, T. R., Ryder, B. M., Sandford, S. K., & Kirman, J. R. (2018). BCG vaccination drives accumulation and effector function of innate lymphoid cells in murine lungs. Immunology & Cell Biology, 96(4), 379-389. doi: 10.1111/imcb.12007

Prendergast, K. A., Daniels, N. J., Petersen, T. R., Hermans, I. F., & Kirman, J. R. (2018). Langerin+ CD8α+ dendritic cells drive early CD8+ T cell activation and IL-12 production during systemic bacterial infection. Frontiers in Immunology, 9, 953. doi: 10.3389/fimmu.2018.00953

Kirman, J. R., Henao-Tamayo, M. I., & Agger, E. M. (2016). The memory immune response to tuberculosis. Microbiology Spectrum, 4(6), TBTB2-0009-2016. doi: 10.1128/microbiolspec.TBTB2-0009-2016

Kuhn, S., Yang, J., Hyde, E. J., Harper, J. L., Kirman, J. R., & Ronchese, F. (2015). IL-1βR-dependent priming of antitumor CD4+ T cells and sustained antitumor immunity after peri-tumoral treatment with MSU and mycobacteria. OncoImmunology, 4(10), e1042199. doi: 10.1080/2162402X.2015.1042199

Prendergast, K. A., Osmond, T. L., Ochiai, S., Hermans, I. F., & Kirman, J. R. (2014). Sustained in vivo depletion of splenic langerin+ CD8α+ dendritic cells is well-tolerated by lang-DTREGFP mice. Journal of Immunological Methods, 406, 104-109. doi: 10.1016/j.jim.2014.02.005

Kuhn, S., Hyde, E. J., Yang, J., Rich, F. J., Harper, J. L., Kirman, J. R., & Ronchese, F. (2013). Increased numbers of monocyte-derived dendritic cells during successful tumor immunotherapy with immune-activating agents. Journal of Immunology, 191(4), 1984-1992. doi: 10.4049/jimmunol.1301135

Bassett, I. M., Lun, S., Bishai, W. R., Guo, H., Kirman, J. R., Altaf, M., & O'Toole, R. F. (2013). Detection of inhibitors of phenotypically drug-tolerant Mycobacterium tuberculosis using an in vitro bactericidal screen. Journal of Microbiology, 51(5), 651-658. doi: 10.1007/s12275-013-3099-4

Prendergast, K. A., & Kirman, J. R. (2012). Dendritic cell subsets in mycobacterial infection: Control of bacterial growth and T cell responses. Tuberculosis, 93(2), 115-122. doi: 10.1016/j.tube.2012.10.008

Ancelet, L. R., Aldwell, F. E., Rich, F. J., & Kirman, J. R. (2012). Oral vaccination with lipid-formulated BCG induces a long-lived, multifunctional CD4+ T cell memory immune response. PLoS ONE, 7(9), e45888. doi: 10.1371/journal.pone.0045888

Rich, F. J., Kuhn, S., Hyde, E. J., Harper, J. L., Ronchese, F., & Kirman, J. R. (2012). Induction of T cell responses and recruitment of an inflammatory dendritic cell subset following tumor immunotherapy with Mycobacterium smegmatis. Cancer Immunology, Immunotherapy, 61(12), 2333-2342. doi: 10.1007/s00262-012-1291-8

Ancelet, L., Rich, F. J., Delahunt, B., & Kirman, J. R. (2012). Dissecting memory T cell responses to TB: Concerns using adoptive transfer into immunodeficient mice. Tuberculosis, 92(5), 422-433. doi: 10.1016/j.tube.2012.05.008

Ancelet, L., & Kirman, J. (2012). Shaping the CD4+ memory immune response against tuberculosis: The role of antigen persistence, location and multi-functionality. Biomolecular Concepts, 3(1), 13-20. doi: 10.1515/BMC.2011.051

Chandrahasen, C., Grimwood, K., Redshaw, N., Rich, F. J., Wood, C., Stanley, J., Kirman, J. R., on behalf of the New Zealand Rotavirus Study Group. (2010). Geographical differences in the proportion of human group A rotavirus strains within New Zealand during one epidemic season. Journal of Medical Virology, 82(5), 897-902. doi: 10.1002/jmv.21739

Connor, L. M., Harvie, M. C., Rich, F. J., Quinn, K. M., Brinkmann, V., Le Gros, G., & Kirman, J. R. (2010). A key role for lung-resident memory lymphocytes in protective immune responses after BCG vaccination. European Journal of Immunology, 40, 2482-2492. doi: 10.1002/eji.200940279

Quinn, K. M., Rich, F., Goldsack, L. M., de Lisle, G. W., Buddle, B. M., Delahunt, B., & Kirman, J. R. (2008). Accelerating the secondary immune response by inactivating CD4+CD25+ T regulatory cells prior to BCG vaccination does not enhance protection against tuberculosis. European Journal of Immunology, 38(3), 695-705.

Grimwood, K., Cohet, C., Rich, F. J., Cheng, S., Wood, C., Redshaw, N., … Kirman, J. R. (2008). Risk factors for respiratory syncytial virus bronchiolitis hospital admission in New Zealand. Epidemiology & Infection, 136(10), 1333-1341. doi: 10.1017/S0950268807000180

Goldsack, L., & Kirman, J. R. (2007). Half-truths and selective memory: Interferon gamma, CD4+ T cells and protective memory against tuberculosis. Tuberculosis, 87, 465-473. doi: 10.1016/j.tube.2007.07.001

Quinn, K. M., McHugh, R. S., Rich, F. J., Goldsack, L. M., de Lisle, G. W., Buddle, B. M., Delahunt, B., & Kirman, J. R. (2006). Inactivation of CD4+CD25+ regulatory T cells during early mycobacterial infection increases cytokine production but does not affect pathogen load. Immunology & Cell Biology, 84, 467-474.

Matheson, J. W., Rich, F. J., Cohet, C., Grimwood, K., Huang, Q. S., Penny, D., Hendy, M. D., & Kirman, J. R. (2006). Distinct patterns of evolution between respiratory syncytial virus subgroups A and B from New Zealand isolates collected over thirty-seven years. Journal of Medical Virology, 78(10), 1354-1364. doi: 10.1002/jmv.20702

Kirman, J., Zakaria, Z., McCoy, K., Delahunt, B., & Le Gros, G. (2000). Role of eosinophils in the pathogenesis of Mycobacterium bovis BCG infection in gamma interferon receptor-deficient mice. Infection & Immunity, 68(5), 2976-2978. doi: 10.1128/IAI.68.5.2976-2978.2000

Erb, K. J., Kirman, J., Delahunt, B., Moll, H., & Le Gros, G. (1999). Infection of mice with Mycobacterium bovis-BCG induces both Th1 and Th2 immune responses in the absence of interferon-gamma signalling. European Cytokine Network, 10(2), 147-154.

Erb, K. J., Hou, S., Hyland, L., Kirman, J., Moll, H., & Le Gros, G. (1999). Constitutive expression of interleukin 4 in vivo does not lead to the development of T helper 2 type CD8+ T cells secreting interleukin 4 or interleukin 5. Immunology Letters, 68(2-3), 383-390. doi: 10.1016/S0165-2478(99)00088-7

Kirman, J., McCoy, K. D., Hook, S., Prout, M., Delahunt, B., Orme, I., … Le Gros, G. (1999). CTLA-4 blockade enhances the immune response induced by mycobacterial infection but does not lead to increased protection. Infection & Immunity, 67(8), 3786-3792.

Erb, K. J., Kirman, J., Delahunt, B., Chen, W. X., & Le Gros, G. (1998). IL-4, IL-5 and IL-10 are not required for the control of M. bovis-BCG infection in mice. Immunology & Cell Biology, 76(1), 41-46. doi: 10.1046/j.1440-1711.1998.00719.x

Erb, K. J., Kirman, J., Woodfield, L., Wilson, T., Watson, J. D., & Le Gros, G. (1998). Identification of potential CD8+ T-cell epitopes of the 19kDa and AhpC proteins from Mycobacterium tuberculosis: No evidence for CD8+ T-cell priming against the identified peptides after DNA-vaccination of mice. Vaccine, 16(7), 692-697.

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Journal - Research Other

Redshaw, N., Wood, C., Rich, F., Grimwood, K., & Kirman, J. R. (2007). Human bocavirus in infants, New Zealand [Letter to the editor]. Emerging Infectious Diseases, 13(11), 1797-1799.

Kirman, J., & Le Gros, G. (1998). Which is the true regulator of Th2 cell development in allergic immune responses? [Editorial]. Clinical & Experimental Allergy, 28(8), 908-910. doi: 10.1046/j.1365-2222.1998.00355.x

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