Associate Professor Tania Slatter

Position	Associate Professor and Academic Leader, Histology, for Otago Micro and Nanoscale Imaging (OMNI)
Department	Department of Pathology (Dunedin)
Qualifications	BSc MSc(Dist) PhD
Research summary	Molecular pathology with a special interest in cancer, perinatal medicine, and autoimmune disease
Memberships	Associate Investigator, Gravida: National Centre for Growth and Development
Clinical	Brain cancer Breast cancer Perinatal disease Autoimmune disease

Research

Our goal is to understand how the mechanisms that regulate DNA damage lead to molecular changes that predispose to life-long health effects. For this research we use molecular and histo-pathological techniques in combination with collaborative clinical studies.

Within the Department of Pathology, Associate Professor Slatter works as a member of the Molecular Pathology Group alongside Dr Noelyn Hung and Dr Janice Royds with local, national, and international collaborators.

Specific projects in the laboratory are outlined below:

Determining how telomere integrity is controlled in normal cells and how this changes with DNA damage. The goal of this study is to identify cancerous changes, or a predisposition to other diseases early.
Identifying and characterising molecular sub-types of brain, breast, and other tumours to provide improved patient management and treatment options. This study identifies acquired and inherited genetic variants and then tests how these variants work toward tumour development, and whether these variants could be targeted for treatment.
Investigating DNA damage to the placenta and how this affects fetal and maternal health outcomes. This study is part of the Otago Placental Study in collaboration with the Department of Women's and Children's Health.
Investigating DNA damage in autoimmune disease and how this leads to further health complications.

Publications

Evans, G. E., Mahajan, V., Wakeman, S., Slatter, T., Ponnampalam, A. P., Anderson, T. P., Sarwar, M., & Evans, J. J. (2023). A pilot study using unique targeted testing of the urogenital microbiome has potential as a predictive test during IVF for implantation outcome. Archives of Gynecology & Obstetrics. Advance online publication. doi: 10.1007/s00404-023-06987-w

Boix De Jesus, A. N., Taha, A., Wang, D., Mehta, P. M., Mehta, S., Reily-Bell, A., Polwatta Lekamlage, S., Machado Saraiva, A., Tahmeedzaman, T., … Royds, J., Braithwaite, A., Hung, N., & Slatter, T. L. (2023). Increased expression of the Δ133p53ß isoform enhances brain metastasis. International Journal of Molecular Sciences, 24, 1267. doi: 10.3390/ijms24021267

Barzegar-Fallah, A., Gandhi, K., Rizwan, S. B., Slatter, T. L., & Reynolds, J. N. J. (2022). Harnessing ultrasound for targeting drug delivery to the brain and breaching the blood–brain tumour barrier. Pharmaceutics, 14(10), 2231. doi: 10.3390/pharmaceutics14102231

Crake, R. L. I., Burgess, E. R., Wiggins, G. A. R., Magon, N. J., Das, A. B., Vissers, M. C. M., Morrin, H. R., Royds, J. A., Slatter, T. L., Robinson, B. A., Phillips, E., & Dachs, G. U. (2022). Ascorbate content of clinical glioma tissues is related to tumour grade and to global levels of 5-hydroxymethyl cytosine. Scientific Reports, 12, 14845. doi: 10.1038/s41598-022-19032-8

Mehta, P. M., Gimenez, G., Walker, R. J., & Slatter, T. L. (2022). Reduction of lithium induced interstitial fibrosis on co-administration with amiloride. Scientific Reports, 12(1), 14598. doi: 10.1038/s41598-022-18825-1

Hung, N., & Slatter, T. (2013). Histopathology in biomolecular research. In A. Divan & J. Royds (Eds.), Tools and techniques in biomolecular science. (pp. 418-437). Oxford, UK: Oxford University Press.

Chapter in Book - Research

Slatter, T., & Fitches, A. (2013). DNA sequencing. In A. Divan & J. Royds (Eds.), Tools and techniques in biomolecular science. (pp. 66-87). Oxford University Press.

Chapter in Book - Research

Journal - Research Article

Burgess, E. R., Crake, R. L. I., Phillips, E., Morrin, H. R., Royds, J. A., Slatter, T. L., Wiggins, G. A. R., Vissers, M. C. M., Robinson, B. A., & Dachs, G. U. (2022). Increased ascorbate content of glioblastoma is associated with a suppressed hypoxic response and improved patient survival. Frontiers in Oncology, 12, 829524. doi: 10.3389/fonc.2022.829524

Journal - Research Article

Almomani, S. N., Alsaleh, A. A., Weeks, R. J., Chatterjee, A., Day, R. C., Honda, I., … Fukuzawa, R., Slatter, T. L., Hung, N. A., Devenish, C., Morison, I. M., & Macaulay, E. C. (2021). Identification and validation of DNA methylation changes in pre-eclampsia. Placenta, 110, 16-23. doi: 10.1016/j.placenta.2021.05.005

Journal - Research Article

Arsic, N., Slatter, T., Gadea, G., Villain, E., Fournet, A., Kazantseva, M., … Mehta, S., … Braithwaite, A., & Roux, P. (2021). Δ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells. Nature Communications, 12, 5463. doi: 10.1038/s41467-021-25550-2

Journal - Research Article

Ware, A. W., Harris, J. J., Slatter, T. L., Cunliffe, H. E., & McDonald, F. J. (2021). The epithelial sodium channel has a role in breast cancer cell proliferation. Breast Cancer Research & Treatment, 187, 31-43. doi: 10.1007/s10549-021-06133-7

Journal - Research Article

Eiholzer, R. A., Mehta, S., Kazantseva, M., Drummond, C. J., McKinney, C., Young, K., … Fleming, N., Morrin, H. R., Reader, K., Royds, J. A., Landmann, M., Petrich, S., … Taha, A., Hung, N. A., Slatter, T. L., & Braithwaite, A. W. (2020). Intronic TP53 polymorphisms are associated with increased Δ133TP53 transcript, immune infiltration and cancer risk. Cancers, 12(9), 2472. doi: 10.3390/cancers12092472

Journal - Research Article

Fabre, M.-S., Stanton, N. M., Slatter, T. L., Lee, S., Senanayake, D., Gordon, R. M. A., … Taha, A., Royds, J. A., Hung, N., … McConnell, M. J. (2020). The oncogene BCL6 is up-regulated in glioblastoma in response to DNA damage, and drives survival after therapy. PLoS ONE, 15(4), e0231470. doi: 10.1371/journal.pone.0231470

Journal - Research Article

Reily-Bell, A. L., Fisher, A., Harrison, B., Bowie, S., Ray, S., Hawkes, M., … Fukuzawa, R., Macaulay, E. C., Devenish, C. J., Hung, N. A., & Slatter, T. L. (2020). Human papillomavirus E6/E7 expression in preeclampsia-affected placentae. Pathogens, 9(3), 239. doi: 10.3390/pathogens9030239

Journal - Research Article

Weeks, R. J., Ludgate, J. L., Le Mée, G., Khanal, R., Mehta, S., Williams, G., Slatter, T. L., Braithwaite, A. W., & Morison, I. M. (2020). Silencing of Testin expression is a frequent event in spontaneous lymphomas from Trp53-mutant mice. Scientific Reports, 10, 16255. doi: 10.1038/s41598-020-73229-3

Journal - Research Article

Kazantseva, M., Mehta, S., Eiholzer, R. A., Gimenez, G., Bowie, S., Campbell, H., Reily-Bell, A. L., … Ray, S., Drummond, C. J., Reid, G., … Wiles, A., Morrin, H. R., Reader, K. L., Hung, N. A., Baird, M. A., Slatter, T. L., & Braithwaite, A. W. (2019). The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer. Cell Death & Disease, 10, 631. doi: 10.1038/s41419-019-1861-1

Journal - Research Article

Mehta-Mujoo, P. P., Cunliffe, H. E., Hung, N. A., & Slatter, T. L. (2019). Long non-coding RNA ANRIL in the nucleus associates with periostin expression in breast cancer. Frontiers in Oncology, 9, 885. doi: 10.3389/fonc.2019.00885

Journal - Research Article

Campbell, H., Fleming, N., Roth, I., Mehta, S., Wiles, A., Williams, G., … Munro, F., McNoe, L., Black, M., McCall, J., Slatter, T. L., … Braithwaite, A. W. (2018). Δ133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling. Nature Communications, 9(1), 254. doi: 10.1038/s41467-017-02408-0

Journal - Research Article

Kazantseva, M., Eiholzer, R. A., Mehta, S., Taha, A., Bowie, S., Roth, I., Zhou, J., … Royds, J. A., Hung, N. A., Slatter, T. L., & Braithwaite, A. W. (2018). Elevation of the TP53 isoform Δ133p53β in glioblastomas: An alternative to mutant p53 in promoting tumour development. Journal of Pathology, 246(1), 77-88. doi: 10.1002/path.5111

Journal - Research Article

Kazantseva, M., Mehta, S., Eiholzer, R. A., Hung, N., Wiles, A., Slatter, T. L., & Braithwaite, A. W. (2018). A mouse model of the Δ133p53 isoform: Roles in cancer progression and inflammation. Mammalian Genome, 29, 831-842. doi: 10.1007/s00335-018-9758-3

Journal - Research Article

Zhou, J., Reddy, M. V., Wilson, B. K. J., Blair, D. A., Taha, A., Frampton, C. M., Eiholzer, R. A., … Hung, N. A., Royds, J. A., & Slatter, T. L. (2018). MR imaging characteristics associate with tumor-associated macrophages in glioblastoma and provide an improved signature for survival prognostication. American Journal of Neuroradiology, 39(2), 252-259. doi: 10.3174/ajnr.A5441

Journal - Research Article

Kazantseva, M., Hung, N. A., Mehta, S., Roth, I., Eiholzer, R., Rich, A. M., Seo, B., Baird, M. A., Braithwaite, A. W., & Slatter, T. L. (2017). Tumor protein 53 mutations are enriched in diffuse large B-cell lymphoma with irregular CD19 marker expression. Scientific Reports, 7, 1566. doi: 10.1038/s41598-017-01800-6

Journal - Research Article

Chatterjee, A., Macaulay, E. C., Rodger, E. J., Stockwell, P. A., Parry, M. F., Roberts, H. E., Slatter, T. L., Hung, N. A., Devenish, C. J., & Morison, I. M. (2016). Placental hypomethylation is more pronounced in genomic loci devoid of retroelements. Genes Genomes Genetics, 6(7), 1911-1921. doi: 10.1534/g3.116.030379

Journal - Research Article

Hung, N. A., Eiholzer, R. A., Kirs, S., Zhou, J., Ward-Hartstonge, K., Wiles, A. K., Frampton, C. M., Taha, A., Royds, J. A., & Slatter, T. L. (2016). Telomere profiles and tumor-associated macrophages with different immune signatures affect prognosis in glioblastoma. Modern Pathology, 29, 212-226. doi: 10.1038/modpathol.2015.156

Journal - Research Article

Royds, J. A., Pilbrow, A. P., Morrin, H. R., Frampton, C., Russell, I. A., Moravec, C. S., … Currie, M. J., Hung, N. A., & Slatter, T. L. (2016). The rs11515 polymorphism is more frequent and associated with aggressive breast tumors with increased ANRIL and decreased p16^INK4a expression. Frontiers in Oncology, 5, 306. doi: 10.3389/fonc.2015.00306

Journal - Research Article

Slatter, T. L., Wilson, M., Tang, C., Campbell, H. G., Ward, V. K., Young, V. L., … Fleming, N. I., Braithwaite, A. W., & Baird, M. A. (2016). Antitumor cytotoxicity induced by bone-marrow-derived antigen-presenting cells is facilitated by the tumor suppressor protein p53 via regulation of IL-12. OncoImmunology, 5(3), e1112941. doi: 10.1080/2162402X.2015.1112941

Journal - Research Article

Sawhney, S., Hood, K., Shaw, A., Braithwaite, A. W., Stubbs, R., Hung, N. A., Royds, J. A., & Slatter, T. L. (2015). Alpha-enolase is upregulated on the cell surface and responds to plasminogen activation in mice expressing a Δ133p53α mimic. PLoS ONE, 10(2), e0116270. doi: 10.1371/journal.pone.0116270

Journal - Research Article

Slatter, T. L., Hsia, H., Samaranayaka, A., Sykes, P., Clow, W., Devenish, C. J., … Royds, J. A., … Hung, N. A. (2015). Loss of ATRX and DAXX expression identifies poor prognosis for smooth muscle tumours of uncertain malignant potential and early stage uterine leiomyosarcoma. Journal of Pathology: Clinical Research, 1(2), 95-105. doi: 10.1002/cjp2.11

Journal - Research Article

Slatter, T. L., Hung, N. G. L. Y., Clow, W. M., Royds, J. A., Devenish, C. J., & Hung, N. A. (2015). A clinicopathological study of episomal papillomavirus infection of the human placenta and pregnancy complications. Modern Pathology, 28, 1369-1382. doi: 10.1038/modpathol.2015.88

Journal - Research Article

Slatter, T. L., Hung, N., Bowie, S., Campbell, H., Rubio, C., Speidel, D., Wilson, M., Baird, M., Royds, J. A., & Braithwaite, A. W. (2015). Δ122p53, a mouse model of Δ133p53α, enhances the tumor-suppressor activities of an attenuated p53 mutant. Cell Death & Disease, 6, e1783. doi: 10.1038/cddis.2015.149

Journal - Research Article

Berney-Meyer, L., Hung, N., Slatter, T., Schollum, J. B. W., Kitching, A. R., & Walker, R. J. (2014). Omeprazole-induced acute interstitial nephritis: A possible Th1–Th17-mediated injury? Nephrology, 19(6), 359-365. doi: 10.1111/nep.12226

Journal - Research Article

Hung, N., Chen, Y.-J., Taha, A., Olivecrona, M., Boet, R., Wiles, A., … Shaw, A., Eiholzer, R., Baguley, B. C., Eccles, M. R., Braithwaite, A. W., MacFarlane, M., Royds, J. A., & Slatter, T. (2014). Increased paired box transcription factor 8 has a survival function in Glioma. BMC Cancer, 14, 159. doi: 10.1186/1471-2407-14-159

Journal - Research Article

Slatter, T. L., Park, L., Anderson, K., Lailai-Tasmania, V., Herbison, P., Clow, W., Royds, J. A., Devenish, C., & Hung, N. A. (2014). Smoking during pregnancy causes double-strand DNA break damage to the placenta. Human Pathology, 45(1), 17-26. doi: 10.1016/j.humpath.2013.07.024

Journal - Research Article

Campbell, H. G., Mehta, R., Neumann, A. A., Rubio, C., Baird, M., Slatter, T. L., & Braithwaite, A. W. (2013). Activation of p53 following ionizing radiation, but not other stressors, is dependent on the proline-rich domain (PRD). Oncogene, 32(7), 827-836. doi: 10.1038/onc.2012.102

Journal - Research Article

Ferrandon, S., Saultier, P., Carras, J., Battiston-Montagne, P., Alphonse, G., Beuve, M., … Slatter, T., Hung, N., Royds, J., … Poncet, D. (2013). Telomere profiling: Toward glioblastoma personalized medicine. Molecular Neurobiology, 47(1), 64-76. doi: 10.1007/s12035-012-8363-9

Journal - Research Article

Hung, N. A., Hsia, H., Royds, J. A., & Slatter, T. L. (2013). Telomere maintenance mechanisms: Prognostic and therapeutic implications for the pathologist and oncologist. Open Journal of Pathology, 3(1), 10-20. doi: 10.4236/ojpathology.2013.31003

Journal - Research Article

Hung, N. A., Royds, J. A., & Slatter, T. L. (2013). Molecular markers of glioblastoma and the potential for integration with imaging: The future for assigning prognosis and best treatment strategy. Current Molecular Imaging, 2(2), 107-116. doi: 10.2174/2211555211302020001

Journal - Research Article

Campbell, H. G., Slatter, T. L., Jeffs, A., Mehta, R., Rubio, C., Baird, M., & Braithwaite, A. W. (2012). Does Δ133p53 isoform trigger inflammation and autoimmunity? Cell Cycle, 11(3), 446-450. doi: 10.4161/cc.11.3.19054

Journal - Research Article

Slatter, T. L., Tan, X., Yuen, Y. C., Gunningham, S., Ma, S. S., Daly, E., Packer, S., Devenish, C., Royds, J. A., & Hung, N. A. (2012). The alternative lengthening of telomeres pathway operates in non-neoplastic human cells. Journal of Pathology, 226(3), 509-518. doi: 10.1002/path.2981

Journal - Research Article

Royds, J. A., Al Nadaf, S., Wiles, A. K., Chen, Y.-J., Ahn, A., Shaw, A., Bowie, S., … Braithwaite, A. W., … Hung, N. A., & Slatter, T. L. (2011). The CDKN2A G500 allele is more frequent in GBM patients with no defined telomere maintenance mechanism tumors and is associated with poorer survival. PLoS ONE, 6(10), e26737. doi: 10.1371/journal.pone.0026737

Journal - Research Article

Slatter, T. L., Hung, N., Campbell, H., Rubio, C., Mehta, R., Renshaw, P., Williams, G., Wilson, M., … Jeffs, A., Royds, J. A., Baird, M. A., & Braithwaite, A. W. (2011). Hyperproliferation, cancer, and inflammation in mice expressing a Δ133p53-like isoform. Blood, 117(19), 5166-5177. doi: 10.1182/blood-2010-11-321851

Journal - Research Article

Slatter, T. L., Ganesan, P., Holzhauer, C., Mehta, R., Rubio, C., Williams, G., Wilson, M., Royds, J. A., Baird, M. A., & Braithwaite, A. W. (2010). p53-mediated apoptosis prevents the accumulation of progenitor B cells and B-cell tumors. Cell Death & Differentiation, 17, 540-550. doi: 10.1038/cdd.2009.136

Journal - Research Article

Slatter, T., Gifford-Garner, J., Wiles, A., Tan, X., Chen, Y.-J., MacFarlane, M., Sullivan, M., Royds, J., & Hung, N. (2010). Pilocytic astrocytomas have telomere-associated promyelocytic leukemia bodies without alternatively lengthened telomeres. American Journal of Pathology, 177(6), 2694-2700. doi: 10.2353/ajpath.2010.100468

Journal - Research Article

Slatter, T. L., Jones, G. T., Williams, M. J. A., van Rij, A. M., & McCormick, S. P. A. (2008). Novel rare mutations and promoter haplotypes in ABCA1 contribute to low-HDL-C levels. Clinical Genetics, 73, 179-184. doi: 10.1111/j.1399-0004.2007.00940.x

Journal - Research Article

Slatter, T. L., Williams, M. J. A., Frikke-Schmidt, R., Tybjærg-Hansen, A., Morison, I. M., & McCormick, S. P. A. (2006). Promoter haplotype of a new ABCA1 mutant influences expression of familial hypoalphalipoproteinemia. Atherosclerosis, 187, 393-400.

Journal - Research Article

Journal - Research Other

Mehta, S., Campbell, H., Drummond, C. J., Li, K., Murray, K., Slatter, T., … Braithwaite, A. W. (2021). Adaptive homeostasis and the p53 isoform network. EMBO Reports, 22, e53085. doi: 10.15252/embr.202153085

Journal - Research Other

Cornwall, J., Slatter, T., Guilford, P., Print, C. G., Henaghan, M., & Wee, R. (2014). Culture, law, ethics, and social implications: Is society ready for advanced genomic medicine? Australasian Medical Journal, 7(4), 200-202. doi: 10.4066/amj.2014.2069

Journal - Research Other

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Associate Professor Tania Slatter

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